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Πέμπτη, 22 Αυγούστου 2019


The basket‐weave pattern is present in the skin for a reason
British Journal of Dermatology
21h
Late-Breaking Abstracts Title Page
Late-Breaking Abstracts
Journal of Investigative Dermatology
8h
LB1057 Ultraviolet B light induces rapid changes in gene expression as detected by non-invasive, adhesive skin biopsies
The purpose of this study is to determine changes in skin gene expression following exposure to ultraviolet (UV) B radiation. Non-invasive, adhesive patch skin biopsies (DermTech, Inc., La Jolla, CA) were performed on the right and left post-auricular areas of 24 subjects before and 24-hours after UV-B exposure using an excimer laser dosed at 300mJ to mimic UV damage. RNA was isolated from the samples and assessed by reverse transcriptase followed by quantitative polymerase chain reaction to assess...
Journal of Investigative Dermatology
8h
Cross-Talk between Hemidesmosomes and Focal Adhesions: A Primer for Wound Healing, Blistering Skin Disease, and Skin Aging
Hemidesmosomes and focal adhesions attach keratinocytes to the dermis and act as bidirectional signaling centers to control epidermal renewal. Pora and colleagues (Pora et al., 2019) demonstrate that in migrating primary human keratinocytes, hemidesmosomes cluster as ordered arrays consisting of multiple chevrons, flanked by actin-associated focal adhesions. These and related findings have implications for wound healing, cancer invasion, blistering skin diseases, and skin aging.
Journal of Investigative Dermatology
8h
LB1053 Dysregulation of antioxidant enzyme PRDX5 in alopecia areata
We previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of AA, and identified several genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= of 8.7*10-14), which is also a GWAS gene in Crohn’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the family of antioxidant enzymes that are crucial for regulating...
Journal of Investigative Dermatology
8h
Author Index
Abdelaziz, Alexa R.LB1053
Journal of Investigative Dermatology
8h
LB1055 CRISPR/Cas9 for HTLV-1: A novel therapeutic approach to the first discovered human retrovirus
Human T-cell Leukemia Virus type-1 (HTLV-1) is a potent carcinogenic oncovirus that establishes a lifelong infection in human cells. In select individuals, the virus can lead to devastating complications such as adult T cell leukemia/lymphoma (ATLL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 has historically proven difficult to treat because it incorporates its viral DNA into the host genome and expresses few viral proteins. An ideal treatment for HTLV-1 would...
Journal of Investigative Dermatology
8h
LB1113 TIRACLE™ and ACTIVITIS™: A novel anti-aging blend
TIRACLE™ is a unique bacteria fermentation extract from T. Thermophiles and S. Cerevisiae, previously shown to have skin-protecting properties. ACTIVITIS™, a novel botanical extract enriched for PP2A-activating flavonoids, inhibits demethylation of PP2A, which plays a crucial role in regulating oxidative stress in skin. To explore the potential benefits of TIRACLE™ and ACTIVITIS™ in combination, we employed a human Genome Array utilizing the EpiDerm™ FT model. We discovered 2,730 genes to be regulated...
Journal of Investigative Dermatology
8h
LB1114 Acupuncture improves Imiquimod-induced psoriasis-like skin lesions through reducing local inflammatory responses
Psoriasis is a common autoimmune disease. Acupuncture-related techniques have been widely used to treat psoriasis since its function of mediating nervous, immune and other systems. This study aims to investigate acupuncture treatment in psoriasis-like skin inflammatory responses, and explore the possible mechanisms. Imiquimod (IMQ)-induced psoriasis-like mice were treated with acupuncture, and methotrexate (MTX) was applied as a positive control. Psoriasis area and severity index (PASI) was scored...
Journal of Investigative Dermatology
8h
LB1115 A double-blind, placebo-controlled, phase 2 trial of IMO-8400, a novel toll-like receptor 7/8/9 antagonist, in dermatomyositis
Increased interferon (IFN) signaling is a prominent feature of dermatomyositis (DM), but mechanisms leading to IFN production in DM are not understood. As TLR7/8/9 activation can lead to type I IFN production, TLR7/8/9 antagonism may provide therapeutic benefit in DM. A double-blind, randomized, placebo-controlled, 24-week trial of IMO-8400 (a novel investigational oligonucleotide TLR7/8/9 antagonist [Idera Pharmaceuticals, Inc.]) was conducted with 30 eligible participants randomized to treatment...
Journal of Investigative Dermatology
8h
TNF-α and IL-17A induce the expression of lympho-epithelial Kazal-type inhibitor in epidermal keratinocytes
Publication date: Available online 21 August 2019Source: Journal of Dermatological ScienceAuthor(s): Satoru Sugihara, Saeko Sugimoto, Kota Tachibana, Mina Kobashi, Hayato Nomura, Tomoko Miyake, Yoji Hirai, Osamu Yamasaki, Shin MorizaneAbstractsBackgroundSerine proteases have important roles in skin barrier function and desquamation, and the aberrant expression or the dysfunction of serine proteases is associated with the pathogenesis of skin diseases. Serine protease activities are tightly regulated...
ScienceDirect Publication: Journal of Dermatological Science
16h
Review of 52 cases with Hailey–Hailey disease identified 25 novel mutations in Chinese Han population
Abstract Hailey–Hailey disease (HHD) is a rare autosomal dominant inherited keratosis caused by mutations in ATP2C1. The aim of our study was to identify and analyze the features of the mutations in HHD. We examined 52 Chinese Han cases which were diagnosed as HHD based on their clinical and histological findings. Genomic DNA polymerase chain reaction and direct sequencing of ATP2C1 were performed from peripheral blood samples of the patients and 100 unrelated healthy controls. Twenty‐five novel...
The Journal of Dermatology
22h
Unresectable local recurrence of dermatofibrosarcoma protuberans with fibrosarcomatous change treated with carbon‐ion radiotherapy after neoadjuvant chemotherapy
The Journal of Dermatology
22h
Ultraviolet recall reaction following ultraviolet A exposure: The first reported case
The Journal of Dermatology
22h

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