The purpose of this study is to determine changes in skin gene expression following exposure to ultraviolet (UV) B radiation. Non-invasive, adhesive patch skin biopsies (DermTech, Inc., La Jolla, CA) were performed on the right and left post-auricular areas of 24 subjects before and 24-hours after UV-B exposure using an excimer laser dosed at 300mJ to mimic UV damage. RNA was isolated from the samples and assessed by reverse transcriptase followed by quantitative polymerase chain reaction to assess...
8h
Hemidesmosomes and focal adhesions attach keratinocytes to the dermis and act as bidirectional signaling centers to control epidermal renewal. Pora and colleagues (Pora et al., 2019) demonstrate that in migrating primary human keratinocytes, hemidesmosomes cluster as ordered arrays consisting of multiple chevrons, flanked by actin-associated focal adhesions. These and related findings have implications for wound healing, cancer invasion, blistering skin diseases, and skin aging.
8h
We previously published a genome-wide association study (GWAS) and meta-analysis to search for common alleles that contribute to risk of AA, and identified several genomic regions harboring potential susceptibility genes. One candidate susceptibility gene expressed in the hair follicle (HF) in AA is peroxiredoxin 5 (PRDX5) (p= of 8.7*10-14), which is also a GWAS gene in Crohn’s disease, sarcoidosis, and psoriasis. PRDX5 is a member of the family of antioxidant enzymes that are crucial for regulating...
8h
LB1055 CRISPR/Cas9 for HTLV-1: A novel therapeutic approach to the first discovered human retrovirus
Human T-cell Leukemia Virus type-1 (HTLV-1) is a potent carcinogenic oncovirus that establishes a lifelong infection in human cells. In select individuals, the virus can lead to devastating complications such as adult T cell leukemia/lymphoma (ATLL) or HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 has historically proven difficult to treat because it incorporates its viral DNA into the host genome and expresses few viral proteins. An ideal treatment for HTLV-1 would...
8h
TIRACLE™ is a unique bacteria fermentation extract from T. Thermophiles and S. Cerevisiae, previously shown to have skin-protecting properties. ACTIVITIS™, a novel botanical extract enriched for PP2A-activating flavonoids, inhibits demethylation of PP2A, which plays a crucial role in regulating oxidative stress in skin. To explore the potential benefits of TIRACLE™ and ACTIVITIS™ in combination, we employed a human Genome Array utilizing the EpiDerm™ FT model. We discovered 2,730 genes to be regulated...
8h
Psoriasis is a common autoimmune disease. Acupuncture-related techniques have been widely used to treat psoriasis since its function of mediating nervous, immune and other systems. This study aims to investigate acupuncture treatment in psoriasis-like skin inflammatory responses, and explore the possible mechanisms. Imiquimod (IMQ)-induced psoriasis-like mice were treated with acupuncture, and methotrexate (MTX) was applied as a positive control. Psoriasis area and severity index (PASI) was scored...
8h
Increased interferon (IFN) signaling is a prominent feature of dermatomyositis (DM), but mechanisms leading to IFN production in DM are not understood. As TLR7/8/9 activation can lead to type I IFN production, TLR7/8/9 antagonism may provide therapeutic benefit in DM. A double-blind, randomized, placebo-controlled, 24-week trial of IMO-8400 (a novel investigational oligonucleotide TLR7/8/9 antagonist [Idera Pharmaceuticals, Inc.]) was conducted with 30 eligible participants randomized to treatment...
8h
Publication date: Available online 21 August 2019Source: Journal of Dermatological ScienceAuthor(s): Satoru Sugihara, Saeko Sugimoto, Kota Tachibana, Mina Kobashi, Hayato Nomura, Tomoko Miyake, Yoji Hirai, Osamu Yamasaki, Shin MorizaneAbstractsBackgroundSerine proteases have important roles in skin barrier function and desquamation, and the aberrant expression or the dysfunction of serine proteases is associated with the pathogenesis of skin diseases. Serine protease activities are tightly regulated...
16h
Abstract Hailey–Hailey disease (HHD) is a rare autosomal dominant inherited keratosis caused by mutations in ATP2C1. The aim of our study was to identify and analyze the features of the mutations in HHD. We examined 52 Chinese Han cases which were diagnosed as HHD based on their clinical and histological findings. Genomic DNA polymerase chain reaction and direct sequencing of ATP2C1 were performed from peripheral blood samples of the patients and 100 unrelated healthy controls. Twenty‐five novel...
22h
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