Abstract Background Ongoing marginal bone loss is a threat to the longevity of implant‐supported prostheses. Aim The aim of the present study was to retrospectively evaluate the survival rate and factors affecting marginal bone levels at a hydrophilic implant design after 5 years in function. Materials and Methods The study group consisted of 51 consecutive patients previously treated with 159 hydrophilic implants (Neoss Straight Proactive implants) and scheduled for annual check‐ups...
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The dysfunction and decreased number of islet β cells are central to the main pathogenesis of diabetes. Improving islet β cell function and increasing the number of β cells are effective approaches to treat diabetes and constitute the main direction of diabetes drug development. The role of Chinese medicine in the treatment of diabetes began to be recognized. In recent years, Chinese medicine monomers have been found to increase insulin synthesis and secretion, reduce β cell-apoptosis, and protect...
6h
The mortise and tenon joints are the main connection forms used in ancient timber buildings, and damaged joints have a critical effect on the safety of a timber structure. There are three main damaged cases of dovetail joints which are pulling, contraction, and mixing damages. In this study, using a theoretical analysis of the stress distribution in a mortise and tenon joint resulted from the pullout damage, a theoretical equation for the resisting moment of the joint was proposed. A finite element...
6h
Background. Colony-stimulating factor-1 (CSF-1) is a homodimeric glycoprotein. The main role of CSF-1 is as a hematopoietic growth factor that modulates proliferation, differentiation, and survival of macrophages. Moreover, CSF-1 has also been reported to be aberrantly expressed in several human cancers. However, the precise role of CSF-1 in upper tract urothelial carcinomas (UTUC) has not been studied. In this research, we examined the clinical significance of CSF-1 expression in UTUC. Materials...
6h
The problem of artificial potential function (APF) safety and obstacle avoidance guidance for autonomous rendezvous and docking of chaser spacecraft with noncooperative spacecraft is studied. The relative motion equation of the chaser and the target is established based on the line-of-sight coordinate system, the reference state is designed, and the corresponding state error is deduced. The attitude motion equation of the noncooperative target spacecraft in space is established. The safety and obstacle...
7h
The HIV-1 virus (human immunodeficiency virus) affects 36.9 million people worldwide, with approximately 900000 deaths in 2017. The virus carrier can develop severe immunodeficiency since CD4+ T lymphocytes are the main target, leading to acquired immunodeficiency syndrome (AIDS). Despite advances in pharmacological treatment, it is still difficult to eliminate latent reservoirs, becoming one of the main obstacles for viral eradication. The CRISPR- (clustered regularly interspaced short palindromic...
8h
Objectives. The optimization for the screw configurations and bone plate parameters was studied to improve the biomechanical performances such as reliable internal fixation and beneficial callus growth for the clinical treatment of femoral shaft fracture. Methods. The finite element analysis (FEA) of internal fixation system under different screw configurations based on the orthogonal design was performed and so was for the different structural parameters of the locking plate based on the combination...
9h
Purpose. To examine the interaction between a short period of hyperopic defocus and low-dose atropine upon the choroidal thickness and ocular biometrics of healthy myopic subjects. Methods. Twenty young adult myopic subjects had subfoveal choroidal thickness (ChT) and ocular biometry measurements taken before and 30 and 60 min following the introduction of optical blur (0.00 D and −3.00 D) combined with administration of 0.01% atropine or placebo. Each combination of optical blur and drug was tested...
9h
Wheeled mobile robots (WMRs) in real complex environments such as on extraterrestrial planets are confronted with uncertain external disturbances and strong coupling of wheel-ground interactions while tracking commanded trajectories. Methods based on sliding mode control (SMC) are popular approaches for these situations. Traditional SMC has some potential problems, such as slow convergence, poor robustness, and excessive output chattering. In this paper, a kinematic-based feed-forward control model...
16h
The corrosion resistance and hydroabrasive resistance of the developed epoxy composite coatings are investigated in this paper. The analysis of the penetration index change after τ = 50–150 days of immersion in a water medium and 10% sulfuric acid solution is carried out. The optimal ratio of the modifier and nanodispersed (Si3N4, Al2O3, AlN, and TiN) and fibrous (viscose, polyamide, matka silk, rong, and cashmere) fillers in the epoxy binder is determined. It was allowed to slow down the process...
16h
Purpose. To observe the occurrence and influencing factors of the symptoms related to the digestive system of people at the early and middle stages of PD and of healthy controls (HCs) using a questionnaire. Method. The questionnaire was given to 108 PD patients at early and middle stages. Twelve symptoms related to the digestive system, of which seven were listed on the Parkinson’s Disease Non-Motor Symptom Scale (PD-NMSS) and the Scale for Outcomes in Parkinson’s disease-Autonomic (SCOPA-AUT) (dysgeusia,...
19h
In this study, we provide the first Fourier-transform infrared absorption spectroscopy (FTIR) and Raman spectroscopy (RS) analysis of a vibrational fingerprint of erlotinib, a drug which is applied in non-small cell lung cancer therapy, in solid state and solution in different pH conditions. Additionally, the performed DFT theoretical calculations in vacuum and PCM models support the interpretation of vibrational spectra and give insight into an optimized spatial configuration of the investigated...
19h
This paper presents a review of relevant medicinal plants used for toothache treatment in Ethiopia. This finding is based on a review of the literature published in scientific journals. A total of 130 medicinal plants, distributed in 117 genera and 62 families, are reported in the reviewed literature. Of the 130 species of medicinal plants reported in the literature, ninety-two (70.7%) were obtained from the wild whereas twelve (9.2%) were from home gardens. Shrubs (34.6%) were the primary source...
19h
Nearest neighbor (NN) models play an important role in the intrusion detection system (IDS). However, with the advent of the era of big data, the NN model has the disadvantages of low efficiency, noise sensitivity, and high storage requirement. This paper presents a neighbor prototype selection method based on CCHPSO for intrusion detection. In the model, the prototype selection and feature weight adjustment are performed simultaneously and k-nearest neighbor (KNN) is used as the basic classifier....
19h
Introduction. Airway management is one of key elements of resuscitation. Endotracheal intubation is still considered the gold standard for airway management during resuscitation. Aim. The aim of the study was to compare success rates and intubation time of different endotracheal intubation methods during emergency intubation with difficult airways in the conditions of cardiopulmonary resuscitation in a standardized manikin model. Methods. The study was designed as a prospective, randomized, cross-over...
19h
Everything is connected in the world. From small groups to global societies, the interactions among people, technology, and policies need sophisticated techniques to be perceived and forecasted. In social network, it has been concluded that the microblog users influence and microblog grade are nonlinearly dependent. However, to the best of our knowledge, the nonlinear influence predication of social network has not been explored in the existing literature. This article proposes a partial autoregression...
19h
Purpose. To describe clinical, molecular genetics, histopathologic and ultrastructural findings of gelatinous drop-like corneal dystrophy (GDLD) (OMIM #204870) in a Sudanese patient. Method. An ocular examination revealed the onset of GDLD in a Sudanese patient (50 years old) at King Khalid Specialist Hospital, Riyadh. The 333 sequence variants in 13 GDLD genes of a DNA sample were screened by Asper Ophthalmics Ltd. It was further confirmed by sequencing. The patient had undergone a penetrating keratoplasty...
19h
Since perfluoroalkyl acids (PFAs) are widely used and harmless to organisms, they have attracted great attention in recent years. The distribution of PFAs in the oceans all around the world is well documented. However, the study of PFAs in Xiamen could be a beneficial complement, for its unique geologies of no rivers that originate from other cities to influence the concentration of PFAs in this area. In this paper, six PFAs were analyzed in water, sediments, and organisms from both freshwater and...
19h
We consider a distributed constrained optimization problem over graphs, where cost function of each agent is private. Moreover, we assume that the graphs are time-varying and directed. In order to address such problem, a fully decentralized stochastic subgradient projection algorithm is proposed over time-varying directed graphs. However, since the graphs are directed, the weight matrix may not be a doubly stochastic matrix. Therefore, we overcome this difficulty by using weight-balancing technique....
19h
A simple, rapid, and reliable method based on dispersive solid-phase extraction (d-SPE) and gas chromatography-mass spectrometry (GC-MS) was developed for quantitating polychlorinated biphenyls (PCBs) in vegetable samples. Parameters affecting both the extraction yields and cleanup efficiency, including the type and volume of extraction solvent, extraction time, type and volume of cleanup sorbent, and cleanup time, were optimized. Matrix effects were evaluated, and matrix-matched calibration was...
19h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11653-4Quantification of shale gas reserves is critical to shape the energy policies of countries. Here, the authors present a new procedure to estimate gas in place and show that important UK gas reserves are actually much lower than previously thought.
16h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11311-9Biomarkers that predict mortality are of interest for clinical as well as research applications. Here, the authors analyze metabolomics data from 44,168 individuals and identify key metabolites independently associated with all-cause mortality risk.
16h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11705-9The genome of double-stranded DNA bacteriophages is delivered to host cells through the viral portal and tail structures. Here the authors describe structures of the bacteriophage T7 portal and the 1.5 MDa tail complex formed by the portal protein, adaptor protein and nozzle, providing insight into how the portal and tail machinery work during DNA packaging and ejection.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11672-1Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11559-1The authors introduce ACT-seq: a Tn5-based method for rapidly profiling epigenetic marks in bulk-cell and single-cell samples. ACT-seq avoids many laborious or time-consuming steps required for similar techniques including chromatin fragmentation and end repair.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11730-8The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment (TME). Here, the authors develop a syringeable immunomodulatory multi-domain nanogel that can reprogram the TME and induce enhanced cancer immunotherapy.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11387-3Air pollution has become a major health risk in China. Here Zhang et al. report that maternal and neonatal exposure to particulate matter increases the risk of neonatal jaundice based on the study of 25,782 newborns born in China between 2014 and 2017.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11276-9The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Here, Alcala and colleagues present a multi-omics analysis of these tumours, revealing distinct molecular and prognostic subgroups.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11733-5The transient receptor potential channel member 2 (TRPM2) ion channel has a function in redox-dependent signaling. Here the authors present the cryo-EM structures of zebrafish TRPM2 in the ligand-free form, with Ca2+ and both ADP-ribose/Ca2+ and observe two-fold symmetric quaternary structure rearrangements in the ligand-bound structures that likely represent intermediate gating states.
22h
Nature Communications, Published online: 20 August 2019; doi:10.1038/s41467-019-11737-1Controlling the rotation direction of individual molecular machines requires precise design and manipulation. Here, the authors describe a surface-adsorbed molecular propeller that, upon excitation with a scanning tunneling microscope tip, can rotate clockwise or anticlockwise depending on its chirality, and directly visualize its stepwise rotation with STM images.
22h
Background and Aims. Recent studies have indicated that circulating miRNAs could serve as accurate biomarkers for diagnosing nonalcoholic fatty liver disease (NAFLD). We aimed to assess the evidence on the probability of circulating miRNAs as new diagnostic biomarkers in patients with NAFLD. Methods. We comprehensively retrieved relevant English literature from the databases of PubMed, Embase, and the Cochrane Library from 2000 to 1 January 2019. The diagnostic accuracy of circulating miRNAs as markers...
19h
Premature ovarian failure (POF) is a common cause of infertility in premenopausal women who are unavoidably exposed to cytotoxic therapy. Radiotherapy is one of the most effective cytotoxic treatments. However, the radiosensitivity of ovarian tissues limits its therapeutic outcome and results in the depletion of the primordial follicle and loss of fertility. Therefore, the need for an effective radioprotective therapy is evident especially when none of the current clinically used modalities for radioprotection...
19h
An urban agglomeration (shorted as UA) is a highly developed spatial form of integrated city and an important driving force for regional economic development. The network of UA mainly reflects the spatial connections and organizational structure of all cities, which is of great significance for understanding the development status of UAs and revealing their development laws. However, there are few horizontal studies comparing the network structure of China’s UAs. This study constructs the economic...
19h
Over the last two decades, advances and adaptation of technology have led to a variety of endoscopic thyroidectomy procedures being performed. The drive for extracervical procedures has been predominantly influenced by the desire for improved cosmesis via avoidance of visible scars. Extracervical techniques have shown considerable evolution with approaches that have included transaxillary, breast, postauricular, and transoral routes. There has been a varied evidence base for each of these approaches...
19h
The Chinese Gaofen-3 (GF-3) synthetic aperture radar (SAR) satellite launched by the China Academy of Space Technology is under continuous operating mode at C-band since September 2016. The main objective of this study was to present a preliminary evaluation of GF-3 quad-polarized SAR imagery for protected wetland classification. Four scenes of GF-3 quad-polarized SAR imageries were collected in this study and analyzed systematically. Besides, the GF-2 optical imagery and in situ survey results were...
19h
Immunoglobulin G4-related disease (IgG4-RD) is a fibroinflammatory disorder which has been first reported in 2001 by Hamano and colleagues in a patient with autoimmune sclerosing pancreatitis. Almost every organ in the human body can be affected by IgG4-RD from infiltration with IgG4-positive plasma cells. Involvement of lungs with IgG4 is reported previously, but still, there is no clear picture of the pathophysiology behind lung involvement. Here, we are presenting a patient who has IgG4-RD presenting...
19h
In the paper, we use the differential game method to test the impact of joint implementation (JI) mechanism on pollution control in two bilateral countries. The Hamilton-Jacobi-Bellman (HJB) equations of the models are obtained by using the dynamic programming principle. We obtain the optimal emissions, optimal local and foreign investments in environment projects, optimal revenues, and optimal trajectories of carbon stock under three situations, namely, situation without JI, with JI (noncooperative),...
19h
In this paper, we derive analytical solutions of the (2+1)-dimensional Kadomtsev-Petviashvili (KP) equation by two different systematic methods. Using the -expansion method, exact solutions of the mentioned equation including hyperbolic, exponential, trigonometric, and rational function solutions have been obtained. Based on the work of Yuan et al., we proposed the extended complex method to seek exact solutions of the (2+1)-dimensional KP equation. The results demonstrate that the applied methods...
19h
For human infertility both male and female factors may be equally important. Searching for molecular biomarkers of male infertility, neglected for decades, and the attempts to explain regulatory mechanisms of fertilization become thus extremely important. Apart from examination of the structure and function of male gametes, also the possible importance of seminal plasma components should be considered. In this article we discuss data that indicate for the substantial significance of active seminal...
19h
This Pro-Con debate will provide the practitioner with an evidence-based knowledge approach to assist the clinician in determining whether to employ (Pro) or not to employ (Con) this technique in the obstetrical suite for labor analgesia. Nitrous oxide has been used safely in dentistry and medicine for many centuries. However, accumulating preclinical and clinical evidence increasingly suggests previously unrecognized adverse maternal and fetal effects of nitrous oxide, which warrants reconsideration...
19h
Introduction. In this study we estimated the cost-effectiveness of adopting 3D Nonfluoroscopic Mapping Systems (NMSs) for catheter ablation (CA). Methods. This study includes patients who underwent supraventricular tachycardia (SVT) CA and atrial fibrillation (AF) CA from 2007 to 2016. A comparison was conducted between a reference year (2007) and the respective years for the two types of procedure in which the maximum optimization of patients’ exposure using NMSs was obtained. We compared the data...
19h
Background. This study aims to develop novel signatures for glioblastoma multiforme (GBM). Methods. GBM expression profiles from The Cancer Genome Atlas (TCGA) were downloaded and DEGs between tumor and normal samples were identified by differential expression analysis (DEA). A risk signature was developed by applying weighted gene coexpression network analysis (WGCNA) and Cox regression analysis. Patients were divided into high and low risk group, followed by evaluating the performance of the signature...
19h
Nowadays, remote user authentication protocol plays a great role in ensuring the security of data transmission and protecting the privacy of users for various network services. In this study, we discover two recently introduced anonymous authentication schemes are not as secure as they claimed, by demonstrating they suffer from offline password guessing attack, desynchronization attack, session key disclosure attack, failure to achieve user anonymity, or forward secrecy. Besides, we reveal two environment-specific...
19h
Background. Evacuation behaviour of human crowds is often characterised by the notion of ‘irrational behaviour’. While the term has been frequently used in the literature, clear definitions and methods for measuring rationality do not exist. Objective. Here, we suggest that rationality, in this context, can alternatively and more effectively be formulated as a question of ‘optimal behaviour’. Decision optimality can potentially be measured and quantified. The main challenges, however, include (i)...
19h
COMSOL Multiphysics has been used to conduct thermal-hydraulic analysis in multiple nuclear applications. The aim of this study is to benchmark the prediction accuracy of COMSOL Multiphysics in performing thermal-hydraulic analysis of TRIGA (Training, Research, Isotopes, General Atomics) reactors such as the Geological Survey TRIGA Reactor (GSTR) by comparing its predictions with RELAP5 (a widely used code in nuclear thermal-hydraulic analysis) results and experimental data. The GSTR type is Mark...
20h
In this study, three simple and accurate spectrophotometric methods for simultaneous determination of pyriproxyfen and chlorothalonil residues in cucumbers and cabbages grown in experimental greenhouse were studied. The first method was based on the zero-crossing technique measurement for first and second derivative spectrophotometry. The second method was based on the first derivative of the ratio spectra. However, the third method was based on mean centering of ratio spectra. These procedures lack...
20h
Network traffic classification is a vital task for service operators, network engineers, and security specialists to manage network traffic, design networks, and detect threats. Identifying the type/name of applications that generate traffic is a challenging task as encrypting traffic becomes the norm for Internet communication. Therefore, relying on conventional techniques such as deep packet inspection (DPI) or port numbers is not efficient anymore. This paper proposes a novel flow statistical-based...
20h
Purpose. This study investigates whether functionality and/or expression changes of transient receptor potential vanilloid 1 (TRPV1) and transient receptor potential ankyrin 1 (TRPA1) channels, oxidative stress, and hydrogen sulfide (H2S) are involved in the bladder dysfunction from an insulin-resistant obese Zucker rat (OZR). Materials and Methods. Detrusor smooth muscle (DSM) samples from the OZR and their respective controls, a lean Zucker rat (LZR), were processed for immunohistochemistry for...
20h
Due to the equipment characteristics (for example, the crane of each span cannot transfer products directly to other spans and path has less turning points and no slash lines) in a slab library, slab transportation is mainly realized by manually operating the crane. Firstly, the grid method is used to model the slab library. Secondly, an improved ant colony algorithm is proposed. The algorithm is used to solve the path planning of the slab library crane, which is improved by integrating the turning...
20h
Leasing has been increasingly seen as a viable alternative to traditional business models. In this paper, we consider a manufacturer making decisions on green product design by accounting for the trade-off between traditional and environmental qualities under three business models, including a pure selling, a pure leasing, and a hybrid model with both selling and leasing. Under leasing, there exists the pooling effect that allows a manufacturer to meet consumer needs with fewer products. Since the...
20h
Management of severe worn dentition in patients with bruxism is challenging as a result of the loss of tooth structure and occlusal vertical dimension, temporomandibular implications, tooth hypersensitivity, and masticatory or aesthetic impairment. This case describes the 4-year follow-up clinical evaluation of a full mouth tooth-supported rehabilitation made on a 66-year-old man with bruxism and tooth wear, with aesthetic complaints and compromised masticatory function. The prosthetic treatment...
20h
The successful adoption of building information modelling (BIM) technology has led to an ever-increasing need for improving management practices in both construction and operation stages of highway project engineering. The most significant aspect of applying BIM technology is establishing the rationality and concise engineering breakdown structure (EBS) coding. However, China has no uniform EBS coding standard for highways, which limits BIM technology development in different construction projects...
20h
Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation in periodontitis. In this study, we aimed to investigate the anti-inflammatory effects of quercetin on Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide- (LPS-) stimulated human gingival fibroblasts (HGFs). HGFs were pretreated with quercetin prior to LPS stimulation. Cell viability was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium...
20h
Impact of High-Altitude on Truck’s Climbing Speed: Case study in Qinghai-Tibet Plateau Area in China
Truck’s climbing performance is an important consideration in traffic safety, efficiency, and highway geometric design. With the infrastructure development in high-altitude area in China, more attention needs to be paid on truck’s climbing performance in such area. In this article, truck’s climbing speed in high-altitude area was examined through field tests on different grade sections at different altitudes. Truck’s speed-distance curves were built at different altitudes and the impact of altitude...
20h
This study is intended to investigate the influencing factors of injury severity by considering the heterogeneity issue of unobserved factors at different arterials and the spatial attributes in geographically weighted regression models. To achieve the objectives, geographically weighted panel logistic regression model was developed, in which the geographically weighted logistic regression model addressed the injury severity from the spatial perspective, while the panel data model accommodated the...
20h
Maize is the second most widely grown cereal and gaining importance as a highly nutritious crop in Ethiopia. However, it is severely destroyed by storage insect pests and needs further research to minimize losses. In line with this, research was initiated to evaluate the efficacy of two botanical plant powders (Eucalyptus globulus Labill leaf and Chenopodium ambrosioides L. whole plant) against storage insect pests of maize grains of two maize varieties (BH-661 and Limu) in polypropylene sacks storage...
22h
Introduction. Turner syndrome (TS) is assigned to the rare diseases group. Morbidity and mortality of TS patients are high, particularly due to the cardiovascular disorders, so monitoring for cardiovascular complications must be ensured. The data demonstrate a strong correlation between 2-dimensional echocardiographic (2Decho) evaluation and magnetic resonance imaging (MRI); still, according to recent guidelines, MRI remains a gold standard. In this study, we aimed to compare aortic dimensions on...
22h
We study the dynamics of an atomic force microscope (AFM) model, under the Lennard-Jones force with nonlinear damping and harmonic forcing. We establish the bifurcation diagrams for equilibria in a conservative system. Particularly, we present conditions that guarantee the local existence of saddle-node bifurcations. By using the Melnikov method, the region in the space parameters where the homoclinic orbits persist is determined in a nonconservative system.
22h
The linear active disturbance rejection control (LADRC) method is investigated in this paper. Firstly, the integral effect of the ADRC is analyzed under the premise that ADRC was transformed into a new form. Then, ADRC is changed into an internal model control (IMC) framework, and an almost necessary and sufficient condition for stability and tracking performance of the ADRC system are proposed on this basis. In addition, some useful corollaries are proposed so that the traditional open-loop frequency-domain...
22h
Background. Notch/Dll4 involvement in cornea neovascularization (CRNV) and lymphangiogenesis is unclear. This study aimed to explore the role of notch signaling in basic fibroblast growth factor- (bFGF-) induced corneal lymphangiogenesis and hemangiogenesis. Methods. Corneal stroma of C57BL/6 mice was implanted with bFGF- or phosphate-buffered saline- (PBS-) soaked pellets. Corneal lymphangiogenesis and neovascularization were evaluated by immunofluorescence. Vascular endothelial growth factor-A...
22h
Elevated expression of N-acetyltransferase 1 (NAT1) is associated with invasive and lobular breast carcinomas as well as with bone metastasis following an epithelial-to-mesenchymal transition. We investigated the effect of NAT1 gene deletion in three different human breast cancer cell lines, MDA-MB-231, MCF-7, and ZR-75-1. Human NAT1 was knocked out using CRISPR/Cas9 technology and two different guide RNAs. None of the NAT1 knockout (KO) cell lines exhibited detectable NAT1 activity when measured...
22h
The stability control of the rock surrounding recovery roadways guarantees the safety of the extraction of equipment. Roof falling and support crushing are prone to occur in double-key strata (DKS) faces in shallow seams during the extraction of equipment. Therefore, this paper focuses on the stability control of the rock surrounding DKS recovery roadways by combining field observations, theoretical analysis, and numerical simulations. First, pressure relief technology, which can effectively release...
22h
The objective of this study is to develop a highly permeable rejuvenating agent for the recycling of the asphalt pavement. The rheological properties and permeability of recycled asphalt after adding the self-developed rejuvenating agent, as well as two other agents, were compared and evaluated. An improved softening point method was devised to evaluate the permeability. In addition, the recycled asphalt was analyzed using Fourier transform infrared spectroscopy (FTIR). The results showed that the...
22h
Passive electromagnetic devices for vibration damping and isolation are becoming a real alternative to traditional mechanical vibration and isolation methods. These types of devices present good damping capacity, lower cost, null power consumption, and higher reliability. In this work, a state-of-the-art review has been done highlighting advantages and drawbacks, application fields, and technology readiness level of most recent developments. In addition, a general introductory section relates presents...
22h
Background. Approximately 15 to 30% of thyroid nodules evaluated by fine-needle aspiration (FNA) were classified as indeterminate; the accurate diagnostic molecular tests of these nodules remain a challenge. We aimed to evaluate the diagnostic performance of Afirma gene expression classifier (GEC) for the indeterminate thyroid nodules (ITNs). Methods. Studies published from January 2005 to December 2018 were systematically reviewed. The gold reference standard relied on the histopathologic results...
1d
The main object of this paper is to find necessary and sufficient conditions for generalized Bessel functions of first kind to be in the classes and of uniformly spiral-like functions and also give necessary and sufficient conditions for to be in the above classes. Furthermore, we give necessary and sufficient conditions for to be in provided that the function is in the class . Finally, we give conditions for the integral operator to be in the class Several corollaries and consequences of...
1d
Several experimental proposals expect to confirm the recent measurement of the coherent elastic neutrino-nucleus scattering (CEvNS). Motivated in particular by the next generation experiments of the COHERENT collaboration, we study their sensitivity to different tests of the Standard Model and beyond. We analyze the resolution that can be achieved by each future proposed detector in the measurement of the weak mixing angle; we also perform a similar analysis in the context of Nonstandard Interaction...
1d
Currently, the age of the population is increasing as a result of increased life expectancy. Ageing is defined as the progressive loss of physiological integrity, which can be characterized by functional impairment and high vulnerability to various types of diseases, such as diabetes, hypertension, Alzheimer’s disease (AD), Parkinson’s disease (PD), and atherosclerosis. Numerous studies have reported that the presence of oxidative stress and inflammation contributes to the development of these diseases....
1d
Fibrosis is involved in the pathogenesis of kidney diseases. We previously discovered that Rosa roxburghii fruit (Cili) possesses antifibrosis property in chronic renal disease, but the mechanisms are unknown. We hypothesized that Cili might prevent fibrosis development through mediating TGF-β/Smads signaling, which is known to be involved in renal fibrosis. This study aimed to confirm the effects of freeze-dried Cili powder in a rat model of unilateral ureteral obstruction (UUO) and examine TGF-β/Smads...
1d
With the implementation of the Xiongan New Area and the urbanization construction plan surrounding the Beijing-Tianjin satellite, it is urgent to study and apply the sponge-permeable paving materials to solve the “urban waterlogging and heat island effect.” In this paper, the hydration microscopic characteristics of cementitious materials are analyzed by means of the differential scanning calorimetry (DSC) test. The test of water-cement ratio, porosity, and gradation structure on the strength and...
1d
This paper discusses the out lag synchronization of fractional order complex networks (FOCN) including both internal delay and coupling delay and with the employment of pinning control scheme. Using comparison theorem and constructing the auxiliary function, several synchronization criterions by linear feedback pinning control are presented. The model and the obtained results in this work are more general than the previous works. Correctness and effectiveness of the theoretical results are validated...
1d
Background. Yearly influenza epidemics have considerable effects on public health worldwide. The 2017-2018 influenza season in Italy was of greater severity than previous seasons. The aim of this study was to describe the 2017-2018 influenza season in Southern Italy and the molecular characteristics of the circulating viral strains. Methods. The incidence of influenza-like illness (ILI) was analysed. Nasopharyngeal swabs collected from patients with ILI from week 46/2017 to week 17/2018 were tested...
1d
Aims. To assess the bone dimensional changes after extraction and alveolar ridge preservation (ARP) using primary coverage (closed flap technique, CFT) or healing by secondary intention (open flap technique, OFT). Materials and Methods. Ten patients (split mouth design) were planned for extraction and ARP. All sites received ARP with freeze-dried bone allograft (FDBA) and nonresorbable membrane after extraction. Clinical standardized measurements were used to assess the dimensional alterations of...
1d
DPPH• scavenging peptides (
1d
Design. A national tuberculosis- (TB-) designated hospital survey was conducted in 2015 to identify significant changes since 2009 in implementation of TB-testing services within hospitals of various types and administrative levels in various regions in China. Methods. In 2015, all TB-designated hospitals were required to complete questionnaires designed by the National Clinical Center for TB. Community hospitals also completed simplified questionnaires as part of the study. Results. Overall, in...
1d
Purpose. To describe the clinicopathologic features of bilateral sterile pyogranulomatous keratitis in a 16-year-old spayed female rat terrier dog. Methods. The dog presented one year prior due to ulceration of the right and left corneas. The ulcers healed but plaques developed on both eyes which progressed, during the course of one year, to cover both the left and the right corneas. Due to the animal’s loss of sight and its painful condition, bilateral enucleation was performed with submission of...
1d
BACKGROUND: The construction industry has a high risk of occupational accidents and injuries. More randomised controlled trials are needed to identify effective techniques for improving the occupational safety of construction sector workers. New technologi... (Source: SafetyLit)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
17m
INTRODUCTION: A Minnesota union identified to researchers at the University of Minnesota a concern relevant to a possible relation between their daily workload and outcome of occupational injuries among a population of janitors. OBJECTIVE: To asses... (Source: SafetyLit)
17m
This report proposes several recommendations to provide older people and employers with the support needed to unlock the potential of this demographic and enable older people to access the benefits of work. It states that without a concerted effort to increase the opportunities for older workers, individuals, businesses and the economy will suffer. Among the recommendations are enhanced healthcare support through improvements in occupational health, training in mental health first aid and further...
14h
Sodium azide (NaN3), a colorless-to-white crystalline solid that is odorless and moderately soluble in water, is the most prevalent inorganic compound used as an antibacterial and antimicrobial agent in bulk reagents and stock solutions in the in vitro diagnostics (IVD) industry. If you were to review the composition of almost any phosphate-buffered saline formulation or any other stock solution that needs to have a prolonged shelf life used in the industry, there is a very high probability you will...
18h
This study explores the history of the denial of the vulnerability of non-White workers to risks of heat illness. Defenders of chattel slavery argued for the capacity of workers of African descent to tolerate extreme environmental temperatures. In Hawai'i,... (Source: SafetyLit)
18h
BACKGROUND: The thermal working environment can have direct and in-direct effects on health and safety. Ambient temperatures have been associated with an increased risk of occupational injuries but it is unknown how the relationship can vary by weather, lo... (Source: SafetyLit)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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While transportation planning professionals are interested in exploring ways to increase walking in daily travel, it would be interesting to know whether people desire to walk more or not. This paper addresses a gap in the literature by designing a concept... (Source: SafetyLit)
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Abstract Anticipation of a painful experience can influence brain activity and increase sensitivity to experimental somatosensory stimuli in healthy adults, but this response is poorly understood among individuals with chronic musculoskeletal pain (CMP). Studies of brain and perceptual responses to somatosensory stimuli are used to make inferences about central nervous system dysfunction as a potential mechanism of symptoms. As such, we sought to (a) determine the influence of pain anticipation...
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Abstract Two groups of participants committed the same mock crime in which one of two items, a watch or a ring, was removed from a drawer and concealed. One group, the crime‐familiar group next experienced a three‐stimulus protocol (3SP), a Concealed Information Test (CIT), in which they were tested on the stolen (probe) item presented in a random series of five irrelevant (unseen) stimuli from the same jewelry category. A left‐hand button press, meaning “I don't recognize” was to follow each of...
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Abstract Appetitive Pavlovian conditioning is a learning mechanism of fundamental biological and pathophysiological significance. Nonetheless, its exploration in humans remains sparse, which is partly attributed to the lack of an established psychophysiological parameter that aptly represents conditioned responding. This study evaluated pupil diameter and other ocular response measures (gaze dwelling time, blink duration and count) as indices of conditioning. Additionally, a learning model was used...
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Cardiovascular phenotyping predicts chronic pain relief or aggravation at follow‐up in response to different interventions: yoga or walking. This phenotyping may be useful in personalizing clinical interventions for pain relief and in pointing to autonomic targets for them. Abstract Background Different physical exercise interventions for pain and other related symptoms largely follow non‐personalized guidelines and show a high degree of variability in outcome. These interventions are considered...
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We report three cases of neoplasms with plasmablastic histomorphology involving the oral cavity. The relevant clinical, morphologic, and immunophenotypic features and treatment are presented along with a review of the literature. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionTT and DOI were highly correlated with nodal risk but had different cut-points for prediction. Our findings highlight the need for these parameters to be recognized as discrete entities and reported appropriately. This study supports using the 5mm DOI, currently used for staging, as also the threshold value to guide elective nodal treatment. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
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Publication date: Available online 19 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Lorenz Epprecht, Alexander M. HuberVestibular neurectomy for Meniere's disease is considered as a treatment option when conservative methods fail to control debilitating vestibular symptoms. Most common surgical approaches today consist of transtemporal supralabyrinthine (middle fossa), retrolabyrinthine and retrosigmoid craniotomies. The aim of this article is to describe...
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Publication date: Available online 19 August 2019Source: Operative Techniques in Otolaryngology-Head and Neck SurgeryAuthor(s): Jenny X. Chen, Zizi Yu, Steven D. RauchMeniere's disease is characterized by idiopathic progressive fluctuating hearing loss, tinnitus, and episodic vertigo. Intratympanic gentamicin injection is the preferred therapeutic option for those who have failed conservative management including lifestyle modifications and oral medications. The procedure is simple and can be performed...
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To test the hypothesis that in profile smiling view, for ideal aesthetics, a tangent to the labial face of the maxillary central incisor crowns should be approximately parallel to the true vertical line and th... (Source: Maxillofacial Plastic and Reconstructive Surgery)
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Journal of Oral and Maxillofacial Pathology 2019 23(2):313-313 (Source: Journal of Oral and Maxillofacial Pathology)
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Conclusion: The present study showed higher eosinophil counts in OSCC when compared to dysplasia which should prompt for a thorough evaluation of tumor front for invasiveness. Therefore, tissue eosinophil count may be used as an adjunct to predict the malignant transformation of dysplastic lesions to OSCC. (Source: Journal of Oral and Maxillofacial Pathology)
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Vijay Wadhwan, Arvind Venkatesh, Vandana Reddy, Sangeeta MalikJournal of Oral and Maxillofacial Pathology 2019 23(2):257-266 Oral Submucous Fibrosis (OSMF) is a chronic progressive scarring oral disease predominantly affecting people of South Asian origin. It is characterized by juxtaepithelial inflammatory cell infiltration followed by fibrosis in the lamina propria and submucosa of the oral mucosa. The pathogenesis of the disease is not well established and a number of mechanisms have been proposed...
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Conclusion: Within the limited numbers of samples used in the current pilot study, we conclude that the direct explant technique appears to be a simple and successful technique for the isolation of oral mucosal keratinocytes if we follow the appropriate protocol. (Source: Journal of Oral and Maxillofacial Pathology)
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Deepa Babji, Ramakant Nayak, Kishore Bhat, Vijayalakshmi KotrashettiJournal of Oral and Maxillofacial Pathology 2019 23(2):273-279 The intention of this review was to condense ongoing findings on the use of circulating DNAs from bodily fluids (blood, serum and plasma) as cancer biomarkers in patients with oral squamous cell carcinoma. Studies were collected after searching databases: PubMed and Google library. Additional search was performed through cross-check on the bibliography of selected articles....
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Conclusion: The isolates of A. actinomycetemcomitans displayed a high level of resistance to azithromycin and clindamycin. Development of resistance against tetracycline also appears to be significant. Variable resistance among the different members of the cephalosporin group is a factor to be investigated further since susceptibility profile against these antibiotics and interpretative criteria for oral bacteria are not available. (Source: Journal of Oral and Maxillofacial Pathology)
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Aashka Sethi, Ankita Tandon, Harshi Mishra, Iqbal SinghJournal of Oral and Maxillofacial Pathology 2019 23(2):284-288 Diffuse large B-cell lymphoma (DLBCL) is an aggressive type of non-Hodgkin's lymphoma (NHL) that develops from the B-cells of the lymphatic system. It is the most common subtype of NHL accounting for 30%–40% of all cases. In addition to determining if NHL is indolent or aggressive and whether it is B-cell, T-cell or NK-cell lymphoma, it is very important to determine the subtype...
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Conclusion: Alpha-SMA can be utilized as reliable IHC markers for salivary gland neoplasms due to its diagnostic importance in tumors with myoepithelial origin indicative of the histogenesis of salivary gland tumors. (Source: Journal of Oral and Maxillofacial Pathology)
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Conclusion: The Foldscope microscope (Foldscope Instruments, Palo Alto, CA, USA) invented by Manu Prakash is an extremely economical, Origami style, fold to assemble microscope available from popular online retailers at approximately Rupees 500 aimed at simplifying and enabling diagnostics and education worldwide. The Foldscope, integrated with a smartphone, allows for easy screen casting thus proving invaluable as an educational tool by creating an effortless bridge between analogue input and digital...
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Conclusion: This study indicates a potent antifungal action of C. longa against C. albicans. (Source: Journal of Oral and Maxillofacial Pathology)
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Conclusion: The present study revealed an increase in mean frequency of cells with micronucleus from healthy individuals however similar studies in larger sample has to be done. This study concludes that MN index can be used as a screening test among high risk groups. (Source: Journal of Oral and Maxillofacial Pathology)
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Conclusion: Epithelial–mesenchymal transition signatures are definitely positive in OSMF cases. (Source: Journal of Oral and Maxillofacial Pathology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Conclusion: MN scoring on the epithelial cells of buccal mucosa can be used as a biomarker in screening procedures for HIV patients. (Source: Journal of Oral and Maxillofacial Pathology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Sandhya Shrivastava, Rupali Naik, Hema Suryawanshi, Neha GuptaJournal of Oral and Maxillofacial Pathology 2019 23(2):311-311 Microchimerism is the presence of cells from one individual in another genetically distinct individual. Pregnancy is the main cause of natural microchimerism through transplacental bi-directional cell trafficking between mother and fetus. In addition to a variety of cell-free substances, it is now well-recognized that some cells are also exchanged in pregnancy. Furthermore,...
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Conclusion: Verrucous carcinoma is a low grade variant of squamous cell carcinoma and the clinical features of both are very similar. The treatment of both differs widely; we fail to diagnose it correctly. This study correlates the clinic-pathologic features of oral verrucous carcinoma by means of statistically analyzing the varied clinical features and pathological impressions. This is helpful in eliminating the diagnostic dilemma and thus channelizing the data to present a clear treatment planning....
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Conclusion: The mean salivary cortisol and DHEA levels were elevated in the RAS patients compared to the healthy controls and were statistically significant. Salivary cortisol and DHEA can serve as oral biomarkers to determine stress in patients with RAS. However, the present study necessitates further studies with larger sample size and an improved protocol to ascertain the actual role of these presumed oral biomarkers as well as anxiety and stress as triggers in the pathogenesis of RAS. (Source:...
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