Vitamin D: should public health recommendations also consider cancer outcomes?
A Naska  P Lagiou
Annals of Oncology, Volume 30, Issue 5, May 2019, Pages 667–668, https://doi.org/10.1093/annonc/mdz089
Published: 18 March 2019
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Issue Section: Editorials
Keum et al. [1] present a meta-analysis of randomized controlled trials (RCTs) to assess whether vitamin D supplementation (in the form of cholecalciferol or ergocalciferol, with or without other nutrients) can have an impact on total cancer incidence or mortality. Having included RCTs of long duration and with larger doses of vitamin D, the authors conclude that vitamin D supplementation is not associated with cancer incidence (relative risk 0.98; 95% confidence interval 0.93–1.03), but may reduce cancer mortality (relative risk 0.87; 95% confidence interval 0.79–0.96).

Early evidence that vitamin D status may be associated with cancer risk stemmed from ecological observations...

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