Abstract Background Preoperative radiotherapy and chemoradiotherapy (PRT/PCRT) represent an increasingly used clinical strategy in different tumor sites. We have previously reported on a PRT/PRCT protocol in patients with locally advanced non-inflammatory breast cancer (LABC) with promising clinical results. However, concerns regarding a possible unfavorable influence on cosmesis still exist. Thus, the aim of the current study was...
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Cancers, Vol. 11, Pages 882: Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAsCancers doi: 10.3390/cancers11060882Authors: Amirnasr Gits van Kuijk Smid Vriends Rutkowski Sciot Schöffski Debiec-Rychter Sleijfer WiemerDespite the success of imatinib in advanced gastrointestinal stromal tumor (GIST) patients, 50% of the patients experience resistance within two years of treatment underscoring the need to get better insight...
Cancers, Vol. 11, Pages 881: (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma—Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer PrognosisCancers doi: 10.3390/cancers11060881Authors:Maider BeitiaJon Danel Solano-IturriPeio ErrarteJulio Calvete-CandenasAlberto LoizateMari Carmen EtxezarragaBegoña SanzGorka Larrinaga(Pro)renin receptor (PRR) is a protein that takes part in several signaling pathways such as Renin Angiotensin System and Wnt signalling....
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Local resident normal fibroblasts (NFs) are the major source of cancer-associated fibroblasts (CAFs), which are distinguishable from NFs by their tumor-supportive properties. However, the mechanism and the eff...
E2A attenuates tumor-initiating capacity of colorectal cancer cells via the Wnt/beta-catenin pathway
The E2A gene, which encodes two basic helix–loop–helix transcription factors, E12 and E47, regulates colorectal cancer progression and epithelial-mesenchymal transition. However, whether E2A regulates the tumo...
The deubiquitinating enzyme ubiquitin-specific protease 3 (USP3) plays a crucial role in numerous biological processes. The aberrant expression of USP3 may have an important role in tumor development. However,...
The current chemotherapy regimens may extend survival for patients with metastatic bladder cancer (BCa) for a few months, but eventually most patients succumb to disease because they develop resistance to thei...
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Purpose: The resistance to differentiation therapy and early death caused by fatal bleeding endangers the health of a significant proportion of APL patients. This study aims to investigate the molecular mechanisms of ATRA resistance and uncover new potential therapeutic strategies to block the rapid progression of early death. Experimental Design: The important role of TWIST1 in APL leukemogenesis was first determined by gain- and loss-of-function assays. We then performed in vivo and in vitro experiments...
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Concurrent chemotherapy and radiation using conventional fractionation is the standard treatment for inoperable, locally advanced non-small-cell lung cancer (NSCLC). We tested accelerated hypofractionated radi...
To evaluate the cost-effectiveness of preoperative short-course radiotherapy (SCRT, 5 × 5 Gy) plus FOLFOX4 versus long-course oxaliplatin and bolus of fluorouracil based preoperative long-course chemoradiother...
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British Journal of Cancer, Published online: 25 June 2019; doi:10.1038/s41416-019-0498-2Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expression
British Journal of Cancer, Published online: 25 June 2019; doi:10.1038/s41416-019-0508-4Claudin-18 expression in oesophagogastric adenocarcinomas: a tissue microarray study of 523 molecularly profiled cases
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0490-xReferee acknowledgement for 2018
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Publication date: Available online 22 June 2019Source: Practical Radiation OncologyAuthor(s): Bindu V. Manyam, Chirag Shah, Neil M. Woody, Chandana A. Reddy, Michael A. Weller, Aditya Juloori, Mihir Naik, Stephanie Valente, Stephen Grobmyer, Paul Durand, Risal Djohan, Rahul D. TendulkarAbstractPurposeThe toxicity profile of breast reconstruction with post-mastectomy radiation therapy (PMRT) varies by technique and timing, and long-term data are limited. We compared rates of complications requiring...
Publication date: Available online 22 June 2019Source: Practical Radiation OncologyAuthor(s): Zhengzheng Xu, Bryan J. Traughber, Elisha Fredman, David Albani, Rodney J. Ellis, Tarun K. PodderAbstractPurposeThis study assessed the appropriateness of full parameter addition (FPA) methods with respect to three-dimensional deformable dose composite method for evaluating combined external beam radiotherapy (EBRT) and intracavitary brachytherapy (ICBT).MethodA total of 22 patients, who received EBRT and...
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