Study Design. Retrospective observational histological study. Objective. To evaluate the reliability of gadolinium enhancement as a marker for inflammation by associating gadolinium enhancement findings with the degree of inflammation as measured by macrophage infiltration in disc material retrieved during disc surgery in patients with sciatica. Summary of Background Data. Disc inflammation often occurs in sciatica patients, a noninvasive tool that is used to assess disc inflammation...
Study Design. A retrospective study. Objective. To describe a new surgical technique for total en bloc spondylectomy (TES) of the fifth lumbar (L5) tumor and evaluate the efficacy and safety of this new technique. Summary of Background Data. TES has been considered an optimal treatment for tumor, including certain spinal tumors, but it requires a combined posterior–anterior approach, which is often complicated by a long operation time, considerable blood loss and severe trauma. Methods....
Study Design. Longitudinal Cohort Study. Objective. Determine 1-year patient-reported outcomes associated with preoperative chronic opioid therapy and high-preoperative opioid dosages in patients undergoing elective spine surgery. Summary of Background Data. Back pain is the most disabling condition worldwide and over half of patients presenting for spine surgery report using opioids. Preoperative dosage has been correlated with poor outcomes, but published studies have not assessed...
Study Design. Prospective case series. Objective. Determine the extent of paraspinal muscle cross-sectional area (CSA) and attenuation change after long-duration spaceflight and recovery on Earth. Determine association between in-flight exercise and muscle atrophy. Summary of Background Data. Long-duration spaceflight leads to marked muscle atrophy. However, another negative consequence of disuse is intramuscular fatty infiltration. Notably, few studies have investigated the effects...
Study Design. Cross-sectional, retrospective, magnetic resonance (MR) imaging study, performed during cadets’ selection procedures of the Italian Air Force Academy. Objective. To assess the prevalence of spinal MR imaging findings in asymptomatic young adults (18–22 yrs) candidate to Air Force Flight. Summary of Background Data. Spinal MR imaging findings are frequently detected in asymptomatic subjects. Literature prevalence data come from studies that analyze different patient populations,...
Study Design. Diagnostic accuracy. Objective. The purpose of this study was to determine if neural axis abnormalities in early onset scoliosis (EOS) patients can be reliably detected with limited magnetic resonance imaging (MRI) sequences (sagittal T1, sagittal T2). Summary of Background Data. MRIs are often performed in EOS patients as studies have shown there are neural axis abnormalities in up to 40% of this population. MRIs are expensive, lengthy, and often require general anesthesia....
Study Design. Retrospective cohort study. Objective. The goals of this study were to (A) evaluate preoperative bone quality assessment and intervention practice over time and (B) review the current evidence for bone evaluation in spine fusion surgery. Summary of Background Data. Deformity spine surgery has demonstrated improved quality of life in patients; however, its cost has made it controversial. If preoperative bone quality can be optimized then potentially these treatments could...
Study Design. Retrospective radiographic study. Objective. To investigate the growth of the vertebrae around distal instrumented vertebra (DIV) in patients with early-onset scoliosis (EOS) who underwent dual growing rod (DGR) treatment. Summary of Background Data. Previous studies indicated that DGR was likely to preserve or even stimulate the spinal growth. However, report pertaining to the effect of growing rod on the growth of individual vertebral body is rare. Methods. The EOS...
Study Design. Retrospective outcomes review. Objective. To analyze and report long-term outcomes in a cohort of patients treated with radiotherapy (RT) for symptomatic hemangioma of a vertebral body. Summary of Background Data. Data are scarce on the rate of tumor control with long-term (>5 yr) follow-up after RT for symptomatic hemangioma of a vertebral body. Methods. We retrospectively reviewed the medical records of patients treated at our institution between 1971 and 2008...
Study Design. A retrospective single-center study. Objective. This study sought to clarify the risk factors and to evaluate the surgical outcome in patients with rapidly progressive cervical spondylotic myelopathy (rp-CSM). Summary of Background Data. CSM is a degenerative spine disease presenting a slow development of myelopathy. Some patients, however, show rapidly progressive neurological deterioration (especially gait disturbances) without any trauma. At present, there is little...
Study Design. Descriptive epidemiology study. Objective. The purpose of this study was to describe the epidemiology of cervical spine injuries in collegiate football players. Summary of Background Data. The incidence and etiology of cervical spine injuries in National Collegiate Athletic Association (NCAA) football players has not been well defined in recent years. Methods. The incidence and characteristics of cervical spine injuries were identified utilizing the NCAA-ISP database....
Study Design. Retrospective study using prospectively collected registry data. Objective. The authors examine the influence of preoperative mental health on outcomes after anterior cervical discectomy and fusion (ACDF) and determine the impact of ACDF on postoperative mental health. Summary of Background Data. While studies have reported a negative correlation between preoperative mental health and outcomes following lumbar spine surgery, the influence on outcomes following cervical...
Study Design. A randomized, double-blind, controlled trial. Objective. Few studies have investigated the changes in mitochondrial dynamics in spinal cord neurons. Meanwhile, the distribution of mitochondria in axons remains unclear. In the present study, the investigators attempted to clarify these questions and focused in observing the changes in mitochondrial spatial distribution under a high-glucose environment. Summary of Background Data. Mitochondrial dynamics disorder is one of...
Study Design. The effect of triptolide on spinal cord injury (SCI) and inflammatory response was observed by establishing SCI rat model. And in vitro experiments were conducted to determine the underlying mechanism of triptolide-mediated in murine microglial cell line BV2. Objective. To determine the underlying mechanism of triptolide in suppressing the microglia activation to improve SCI. Summary of Background Data. Triptolide, as a major active ingredient of Chinese herb Tripterygium...
Study Design. This is a cross-sectional study. Objective. To investigate the oblique corridor to the L1-S1 intervertebral disc space between the psoas muscle and the great vessels in cadaveric specimens bilaterally and the location of genitofemoral nerve and the diaphragmatic crura relative to the oblique corridor. Summary of Background Data. Although use of oblique lumbar interbody fusion is rapidly expanding, the morphometric data related to the procedure are limited. Methods. ...
Study Design. Retrospective comparative study. Objective. This study aimed to compare the clinical effects and imaging features of polymethyl methacrylate (PMMA) bone cement with and without mineralized collagen (MC) in percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs). Summary of Background Data. PKP with PMMA is widely performed for OVCF. However, numerous complications have also been reported about the PMMA bone cement. Moreover, PMMA bone cement...
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