Somatostatin Receptor Ligand Therapy—A Potential Therapy for Neurocytoma
Dongyun Zhang Sarah S R Kim Daniel F Kelly Sylvia L Asa Masoud Movassaghi Sergey Mareninov William H Yong Timothy F Cloughesy Fausto J Rodriguez Paul McKeever ... Show more
The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2395–2402, https://doi.org/10.1210/jc.2018-02419
Published: 05 February 2019 Article history
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Abstract
Context
Neurocytoma (NC) is a rare, low-grade tumor of the central nervous system, with a 10-year survival rate of 90% and local control rate of 74%. However, 25% of NCs will be atypical, with an elevated Ki-67 labeling index >2%, and will exhibit a more aggressive course, with a high propensity for local recurrence and/or craniospinal dissemination. Although no standard treatment regimen exists for these atypical cases, adjuvant stereotactic or conventional radiotherapy and/or chemotherapy have been typically offered but have yielded inconsistent results.
Case Description
We have described the case of a patient with a vasopressin-secreting atypical NC of the sellar and cavernous sinus region. After subtotal resection via endoscopic transsphenoidal surgery, the residual tumor showed increased fluorodeoxyglucose uptake and high somatostatin receptor (SSTR) expression on a 68Ga-DOTA-TATE positron emission tomography/CT scan. Somatostatin receptor ligand (SRL) therapy with lanreotide (120 mg every 28 days) was initiated. Four years later, the residual tumor was stable with decreased fluorodeoxyglucose tumor uptake. Immunocytochemical SSTR2 and SSTR5 expression >80% was further confirmed in a series of NC tissues.
Conclusions
To the best of our knowledge, we have described the first use of SRL therapy for an atypical NC. Our results support consideration of adjuvant SRL therapy for NC refractory to surgical removal. Our findings further raise the possibility of SSTR-directed peptide receptor radionuclide therapy as NC therapy.
Issue Section: Pituitary and Neuroendocrinology
Copyright © 2019 Endocrine Society
Dongyun Zhang Sarah S R Kim Daniel F Kelly Sylvia L Asa Masoud Movassaghi Sergey Mareninov William H Yong Timothy F Cloughesy Fausto J Rodriguez Paul McKeever ... Show more
The Journal of Clinical Endocrinology & Metabolism, Volume 104, Issue 6, June 2019, Pages 2395–2402, https://doi.org/10.1210/jc.2018-02419
Published: 05 February 2019 Article history
Cite
Permissions Icon Permissions
Share
Abstract
Context
Neurocytoma (NC) is a rare, low-grade tumor of the central nervous system, with a 10-year survival rate of 90% and local control rate of 74%. However, 25% of NCs will be atypical, with an elevated Ki-67 labeling index >2%, and will exhibit a more aggressive course, with a high propensity for local recurrence and/or craniospinal dissemination. Although no standard treatment regimen exists for these atypical cases, adjuvant stereotactic or conventional radiotherapy and/or chemotherapy have been typically offered but have yielded inconsistent results.
Case Description
We have described the case of a patient with a vasopressin-secreting atypical NC of the sellar and cavernous sinus region. After subtotal resection via endoscopic transsphenoidal surgery, the residual tumor showed increased fluorodeoxyglucose uptake and high somatostatin receptor (SSTR) expression on a 68Ga-DOTA-TATE positron emission tomography/CT scan. Somatostatin receptor ligand (SRL) therapy with lanreotide (120 mg every 28 days) was initiated. Four years later, the residual tumor was stable with decreased fluorodeoxyglucose tumor uptake. Immunocytochemical SSTR2 and SSTR5 expression >80% was further confirmed in a series of NC tissues.
Conclusions
To the best of our knowledge, we have described the first use of SRL therapy for an atypical NC. Our results support consideration of adjuvant SRL therapy for NC refractory to surgical removal. Our findings further raise the possibility of SSTR-directed peptide receptor radionuclide therapy as NC therapy.
Issue Section: Pituitary and Neuroendocrinology
Copyright © 2019 Endocrine Society
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