Periodontal disease and hemolysis in glucose-6-phosphate dehydrogenase deficiency: Is there a nexus? Publication date: Available online 22 March 2019 Source: Journal of Oral Biosciences Author(s): Neelesh Singh, Ashita Uppoor, Valliammai Rajendran, Dilip G. Naik Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an erythrocyte enzyme defect that amplifies the susceptibility of erythrocytes to oxidative stress due to excessive levels of reactive oxygen species. Consequently, erythrocyte destruction and hemolysis occur. Highlight The possible mechanism of oxidative stress-mediated destruction of erythrocytes in G6PD deficient individuals induced by periodontal infection is highlighted. Conclusion Periodontal diseases feature systemic loading of reactive oxygen species, and they may increase the risk of hemolysis in individuals with G6PD deficiency.