Pathology - Research and Practice,

Kidney osteoclast factors and matrix metalloproteinase expression in a mice model of diet-induced obesity and diabetes

Publication date: Available online 26 June 2019Source: Pathology - Research and PracticeAuthor(s): Francine dos Santos-Macedo, Bianca Martins-Gregorio, Elan Cardozo Paes-de-Almeida, Leonardo de Souza Mendonça, Rebeca de Souza Azevedo, Caroline Fernandes-SantosABSTRACTThe role of RANKL/RANK/OPG system on bone remodeling is well known, and there is evidence that it is also important to cardiovascular and kidney pathology, although the underlying mechanisms are not elucidated so far. Thus, we investigated...

ScienceDirect Publication: Pathology - Research and Practice

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Arylsulfatases A and B: from normal tissues to malignant tumors

Publication date: Available online 26 June 2019Source: Pathology - Research and PracticeAuthor(s): Zsolt Kovacs, Ioan Jung, Simona GurzuABSTRACTArylsulfatases are lysosomal enzymes with important roles in the cell metabolism. Several subtypes of arylsulfatase are known, from A to K. Congenital deficiencies of arylsulfatases, especially A (ARSA) and B (ARSB), can induce metabolic disorders such as metachromatic leucodystrophy (ARSA deficiency) and Maroteaux-Lamy syndrome (ARSB deficiency). ARSA and...

ScienceDirect Publication: Pathology - Research and Practice

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LINC00205 promotes proliferation, migration and invasion of HCC cells by targeting miR-122-5p

Publication date: Available online 26 June 2019Source: Pathology - Research and PracticeAuthor(s): Lei Zhang, Yun Wang, Jingjing Sun, Hongye Ma, Cheng GuoAbstractLong non-coding RNAs (lncRNAs) have been identified as crucial regulators in the tumorigenesis and progression of hepatocellular carcinoma (HCC). Recently, long intergenic non-protein coding RNA 205 (LINC00205) has been identified as a prognostic biomarker in HCC. However, the biological role of LINC0205 and its potential molecular mechanism...

ScienceDirect Publication: Pathology - Research and Practice

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