Paclitaxel with or without trametinib or pazopanib in advanced wild-type BRAF melanoma (PACMEL): a multicentre, open-label, randomised, controlled phase II trial

Although substantial progress has been achieved in the management of unresectable and metastatic melanoma, it remains a fatal disease. Impressive anticancer activity has been shown by kinase inhibitors, which target aberrant signalling in the 50% of melanomas with BRAF mutations, and antibodies that bind to the immune checkpoints cytotoxic T-lymphocyte antigen 4 (CTLA-4) or programmed death 1 (PD1) [1–3].