ABSTRACT Objective The aim of the study was to report 12‐month changes after treatment with Nusinersen in a cohort of 85 type I Spinal Muscular Atrophy patients of age ranging from 2 months to 15 years and 11 months. Methods All patients were assessed using the Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) and the Hammersmith Infant Neurological Examination‐Section 2 (HINE‐2). Results Two of the 85 had 1 SMN2 copy, 61 had 2 copies, 18 had...
Abstract Studies using transcranial direct current stimulation (tDCS) typically compare an active protocol relative to a shorter sham (placebo) protocol. Both protocols are presumed to be perceptually identical on the scalp, and thus represent an effective method of delivering double‐blinded experimental designs. However, participants often show above‐chance accuracy when asked which condition involved active/sham retrospectively. We assessed the time course of sham‐blinding during active and sham...
Abstract Among all of the stimuli surrounding us, food is arguably the most rewarding for the essential role it plays in our survival. In previous visual recognition research, it has already been demonstrated that the brain not only differentiates edible stimuli from non‐edible stimuli but also is endowed with the ability to detect foods' idiosyncratic properties such as energy content. Given the contribution of the cooked diet to human evolution, in the present study we investigated whether the...
Abstract The advent of chemogenetics has revolutionized brain research. The ability to discretely and reversibly control neural activity has allowed neuroscientists to probe the function of areas, circuits, and genetically‐defined populations of neurons in ways that would have seemed unimaginable two decades ago. In rodents these techniques have revealed dazzling insights into feeding, defensive threat responses, decision‐making, and visual processing to name just a few (Sternson & Roth, 2014)....
Publication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Yusuke Morinaga, Kouhei Nii, Kimiya Sakamoto, Ritsurou Inoue, Takafumi Mitsutake, Hayatsura HanadaBackgroundPostoperative cerebral embolism after left upper lobectomy caused by a thrombus in the pulmonary vein stump (PVS) is a serious complication. However, it is unclear whether cerebral embolism can develop after other types of lobectomy. We present 2 cases of revascularization for in-hospital acute ischemic stroke...
Publication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Emanuele La Corte, Camilla de Laurentis, Francesco Acerbi, Morgan Broggi, Carlotta Pipolo, Alberto Maccari, Giovanni Felisati, Paolo FerroliObjectivePediatric endoscopic endonasal surgery represents a still-growing discipline to approach complex skull base lesions and is characterized by unfavorable anatomical conditions. Children have very small nostrils and narrow rhinosinusal corridors, which could lead more easily...
Publication date: September 2019Source: World Neurosurgery, Volume 129Author(s): Thomas Zervos, Beverly C. WaltersBackgroundNo widely accepted gold standard for diagnosis of shunt infection exists, with definitions variable among clinicians and publications. This article summarizes the utility of commonly used diagnostic tools and provides a comprehensive review of optimal measures for diagnosis.MethodsA query of PubMed was performed extracting articles related to shunt infection in children. Preferred...
Publication date: Available online 22 June 2019Source: World NeurosurgeryAuthor(s): Yoon Hwan Byun, Ji Hoon Phi, Ji Yeoun Lee, Eun Jin Ha, Kyung Hyun Kim, Jeyul Yang, Hee-Soo Kim, Seul Ki Ryu, Jung Won Choi, Byung-Kyu Cho, Seung-Ki Kim
Publication date: Available online 21 June 2019Source: Brain Research BulletinAuthor(s): Sara Chavoshinezhad, Homa Mohseni Kouchesfahani, Mohammad Saied Salehi, Sareh Pandamooz, Abolhassan Ahmadiani, Leila DargahiAbstractAlzheimer’s disease (AD) is the most common neurodegenerative disorder characterized by progressive cognitive decline. According to the critical role of inflammation in pathogenesis of AD and memory deficits, a cytokine with anti-inflammatory properties like interferon beta (IFNβ),...
Abstract Purpose We evaluated the outcomes after stereotactic radiosurgery (SRS) for patients who developed new or progressive brain disease regardless of whether they had no prior radiation, PCI, or WBRT. Methods We retrospectively identified 90 SCLC patients who had SRS between 1991 and 2018. Thirty-one patients had no evidence of brain disease at the time...
Publication date: Available online 22 June 2019Source: NeuroImageAuthor(s): Meytal Wilf, Andrea Serino, Stephanie Clarke, Sonia Crottaz-HerbetteAbstractPrism adaptation (PA) is a procedure used for studying visuomotor plasticity in healthy individuals, as well as for alleviating spatial neglect in patients. The adaptation is achieved by performing goal-directed movements while wearing prismatic lenses that induce a lateral displacement of visual information. This results in an initial movement error...
Publication date: Available online 21 June 2019Source: NeuroImageAuthor(s): Paula Trujillo, Kalen J. Petersen, Matthew J. Cronin, Ya-Chen Lin, Hakmook Kang, Manus J. Donahue, Seth A. Smith, Daniel O. ClaassenaAbstractThe locus coeruleus (LC) is the major origin of norepinephrine in the central nervous system, and is subject to age-related and neurodegenerative changes, especially in disorders such as Parkinson's disease and Alzheimer's disease. Previous studies have shown that neuromelanin (NM)-sensitive...
Publication date: Available online 21 June 2019Source: NeuroImageAuthor(s): Emanuele Lo Gerfo, Alessia Gallucci, Rosalba Morese, Alessandra Vergallito, Stefania Ottone, Ferruccio Ponzano, Gaia Locatelli, Francesca Bosco, Leonor Josefina Romero LauroAbstractThird parties punish, sacrificing personal interests, offenders who violate either fairness or cooperation norms. This behavior is defined altruistic punishment and the degree of punishment typically increases with the severity of the norm violation....
Publication date: Available online 21 June 2019Source: NeuroImageAuthor(s): Andreas Pedroni, Amirreza Bahreini, Nicolas LangerAbstractElectroencephalography (EEG) recordings have been rarely included in large-scale studies. This is arguably not due to a lack of information that lies in EEG recordings but mainly on account of methodological issues. In many cases, particularly in clinical, pediatric and aging populations, the EEG has a high degree of artifact contamination and the quality of EEG recordings...
Related ArticlesMorphometric changes at the craniocervical junction during childhood. J Neurosurg Pediatr. 2019 Jun 21;:1-9 Authors: Bapuraj JR, Bruzek AK, Tarpeh JK, Pelissier L, Garton HJL, Anderson RCE, Nan B, Ma T, Maher CO Abstract OBJECTIVE: Current understanding of how the pediatric craniocervical junction develops remains incomplete. Measurements of anatomical relationships at the craniocervical junction can influence clinical and surgical decision-making....
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Abstract Objective To determine whether maternal Epstein‐Barr virus (EBV) IgG antibody levels are associated with risk of multiple sclerosis (MS) in the offspring. Methods We conducted a prospective nested case‐control study in the Finnish Maternity Cohort (FMC) with serum samples from over 800,000 women collected during pregnancy since 1983. Cases of MS among offspring born between 1983 and 1991 were identified via hospital and prescription registries; 176 cases were matched to up to 3...
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