Metaplastic chondroid breast carcinoma: A diagnostic challenge Milind Anil Bhatkule Clinical Cancer Investigation Journal 2019 8(2):70-72 Metaplastic carcinoma of the breast is a rare entity. Extensive chondroid differentiation is even rarer in metaplastic breast carcinoma (MBC). Here, we report a case of metaplastic chondroid carcinoma of the breast with very few areas showing usual ductal carcinoma and pseudosarcomatous areas. The tumor was characterized by an abundant chondromyxoid matrix. The definitive areas of classic invasive ductal carcinoma were very few. The peripheral portion of the tumor showed increased cellularity with pleomorphism and invasive growth pattern with giant tumor cells. This case is presented for its rarity and also of a diagnostic challenge, especially if the tumor is composed mainly of sarcomatous elements with extensive chondroid differentiation. Standard chemotherapy regimens are ineffective against MBC.