Publication date: Available online 25 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Xiaorong Huang, Mengmeng Run, Meng-Xiang Sun
Publication date: Available online 24 June 2019Source: Journal of Genetics and GenomicsAuthor(s): Qingwen Jiang, Weimin Zhang, Chenghao Liu, Yicong Lin, Qingyu Wu, Junbiao DaiAbstractProliferating cell nuclear antigen (PCNA), encoded by POL30 in Saccharomyces cerevisiae, is a key component of DNA metabolism. Here, a library consisting of 304 PCNA mutants was designed and constructed to probe the contribution of each residue to the biological function of PCNA. Five regions with elevated sensitivity...
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