IJMS, Vol. 20, Pages 3113: Immortalized Human hTert/KER-CT Keratinocytes a Model System for Research on Desmosomal Adhesion and Pathogenesis of Pemphigus Vulgaris International Journal of Molecular Sciences doi: 10.3390/ijms20133113 Authors: Benedikt Beckert Francesca Panico Robert Pollmann Rüdiger Eming Antje Banning Ritva Tikkanen Pemphigus Vulgaris is an autoimmune disease that results in blister formation in the epidermis and in mucosal tissues due to antibodies recognizing...
IJMS, Vol. 20, Pages 3111: Effects of Estrogens on Platelets and Megakaryocytes International Journal of Molecular Sciences doi: 10.3390/ijms20123111 Authors: Dupuis Severin Noirrit-Esclassan Arnal Payrastre Valéra In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to hepatic first pass....
IJMS, Vol. 20, Pages 3109: Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20123109 Authors: Sarah Hirschberg Barbara Gisevius Alexander Duscha Aiden Haghikia Within the last century, human lifestyle and dietary behaviors have changed dramatically. These changes, especially concerning hygiene, have led to a marked decrease in some diseases, i.e., infectious diseases....
IJMS, Vol. 20, Pages 3112: Targeting Quorum Sensing: High-Throughput Screening to Identify Novel LsrK Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20123112 Authors: Viviana Gatta Polina Ilina Alison Porter Stuart McElroy Päivi Tammela Since quorum sensing (QS) is linked to the establishment of bacterial infection, its inactivation represents one of the newest strategies to fight bacterial pathogens. LsrK is a kinase playing a key role in the processing...
IJMS, Vol. 20, Pages 3110: High-Fish Oil and High-Lard Diets Differently Affect Testicular Antioxidant Defense and Mitochondrial Fusion/Fission Balance in Male Wistar Rats: Potential Protective Effect of ω3 Polyunsaturated Fatty Acids Targeting Mitochondria Dynamics International Journal of Molecular Sciences doi: 10.3390/ijms20123110 Authors: Migliaccio Sica Di Gregorio Putti Lionetti High-fat diets rich in fish oil (HFO diet, mainly ω3-PUFAs), in contrast...
IJMS, Vol. 20, Pages 3108: Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis International Journal of Molecular Sciences doi: 10.3390/ijms20123108 Authors: Rana Abdul Razzak Gordon J. Florence Frank J. Gunn-Moore Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this review, a classification of current approaches of clinical or investigational importance...
IJMS, Vol. 20, Pages 3107: MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms20123107 Authors: Mikel Aristorena Eunate Gallardo-Vara Matej Vicen Mateo de Las Casas-Engel Luisa Ojeda-Fernandez Concepción Nieto Francisco J. Blanco Ana C. Valbuena-Diez Luisa M. Botella Petr Nachtigal Angel L. Corbi María Colmenares Carmelo Bernabeu Upon...
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