Increased Maternal Serum Placental Growth Hormone Variant in Pregnancies Complicated by Otosclerosis
Shutan Liao Shan Lu Guangliang Li Ruiying Chen
First published: 31 May 2019 https://doi.org/10.1111/coa.13385
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13385
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Abstract
Objective
To investigate the potential role of maternal serum concentrations of placental growth hormone variant (GH‐V), insulin‐like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 in pregnancies complicated by otosclerosis.
Method
Otosclerosis cases (n = 22) and age, ethnicity‐matched controls (n = 22) were selected in a nested case‐control study. Maternal serum hormone concentrations at 26 and 34 weeks of gestation were determined by enzyme‐linked immunosorbent assay (ELISA).
Results
Concentrations of all measured hormones except IGFBP‐1 were increased as gestation progressed. Maternal serum GH‐V concentrations at 26 and 34 weeks of gestation were significantly increased in the otosclerosis group, when compared to the control group (2.53 ± 0.17 ng/ml vs. 1.78 ± 0.19 ng/ml, p = 0.036; 4.34 ± 0.31 ng/ml vs. 3.12 ± 0.18 ng/ml, p < 0.001, respectively). Maternal serum IGF‐1 concentrations at 34 weeks in otosclerotic patients were significantly higher than in the controls (589.1 ± 21.4 ng/ml vs. 499.7 ± 17.8 ng/ml, p < 0.001). The increase of IGF‐1 was not observed at 26 weeks of gestation. Serum IGF‐2, IGFBP‐1 and IGFBP‐3 at either 26 or 34 weeks were unaltered between the two groups.
Conclusion
Maternal serum concentrations of GH‐V and IGF‐1 were altered in pregnancy complicated by otosclerosis, suggesting that the GH‐IGF axis may contribute to the development of this condition during pregnancy.
This article is protected by copyright. All rights reserved.
Shutan Liao Shan Lu Guangliang Li Ruiying Chen
First published: 31 May 2019 https://doi.org/10.1111/coa.13385
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13385
ePDFPDFTOOLS SHARE
Abstract
Objective
To investigate the potential role of maternal serum concentrations of placental growth hormone variant (GH‐V), insulin‐like growth factor (IGF) 1 and 2, and IGF binding proteins (IGFBP) 1 and 3 in pregnancies complicated by otosclerosis.
Method
Otosclerosis cases (n = 22) and age, ethnicity‐matched controls (n = 22) were selected in a nested case‐control study. Maternal serum hormone concentrations at 26 and 34 weeks of gestation were determined by enzyme‐linked immunosorbent assay (ELISA).
Results
Concentrations of all measured hormones except IGFBP‐1 were increased as gestation progressed. Maternal serum GH‐V concentrations at 26 and 34 weeks of gestation were significantly increased in the otosclerosis group, when compared to the control group (2.53 ± 0.17 ng/ml vs. 1.78 ± 0.19 ng/ml, p = 0.036; 4.34 ± 0.31 ng/ml vs. 3.12 ± 0.18 ng/ml, p < 0.001, respectively). Maternal serum IGF‐1 concentrations at 34 weeks in otosclerotic patients were significantly higher than in the controls (589.1 ± 21.4 ng/ml vs. 499.7 ± 17.8 ng/ml, p < 0.001). The increase of IGF‐1 was not observed at 26 weeks of gestation. Serum IGF‐2, IGFBP‐1 and IGFBP‐3 at either 26 or 34 weeks were unaltered between the two groups.
Conclusion
Maternal serum concentrations of GH‐V and IGF‐1 were altered in pregnancy complicated by otosclerosis, suggesting that the GH‐IGF axis may contribute to the development of this condition during pregnancy.
This article is protected by copyright. All rights reserved.
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