Flow-Pattern Details in an Aneurysm Model Using High-Speed 1000-Frames-per-Second Angiography
J.M. Krebs, A. Shankar, S.V. Setlur Nagesh, J.M. Davies, K.V. Snyder, E.I. Levy, L.N. Hopkins, M. Mokin, D.R. Bednarek, A.H. Siddiqui and S. Rudin
American Journal of Neuroradiology June 2019, DOI: https://doi.org/10.3174/ajnr.A6090
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Abstract
SUMMARY: Traditional digital subtraction angiography provides rather limited evaluation of contrast flow dynamics when studying and treating intracranial brain aneurysms. A 1000-frames-per-second photon-counting x-ray detector was used to image detailed iodine-contrast flow patterns in an internal carotid artery aneurysm of a 3D-printed vascular phantom. High-speed imaging revealed differences in vortex and inflow patterns with and without a Pipeline Embolization Device flow diverter in more detail and clarity than could be seen in standard pulsed angiography. Improved temporal imaging has the potential to impact the outcomes of endovascular interventions by allowing clinicians to better understand and act on flow dynamics in real-time.

ABBREVIATION:
fps
frames per second
Footnotes
Disclosures: Jordan M. Krebs—RELATED: Grant: Canon Medical Systems Corporation, Comments: research grant for Canon Stroke and Vascular Research Center, where the work took place*; Grants/Grants Pending: Canon Medical Systems Corporation, Comments: research grant for Canon Stroke and Vascular Research Center, where the work took place.* Alok Shankar—RELATED: Grant: Canon Medical Systems Corporation, Tokyo, Japan, Comments: research grant. Jason Davies—UNRELATED: Employment: Mr; Grants/grants pending: CTSR KL2.* Elad I. Levy—UNRELATED: Board Membership: Stryker, NeXtGen Biologics, MEDX, Cognition Medical, Endostream Medical, Comments: advisory board; Consultancy: Claret Medical, Gerson Lehrman Group Consulting, Guidepoint Global Consulting, Imperative Care, Medtronic, Rebound Therapeutics, StimMed; Stock/Stock Options: NeXtGen Biologics, Rapid Medical, Claret Medical, Cognition Medical, Imperative Care, Rebound Therapeutics, StimMed, Three Rivers Medical. Leo Nelson Hopkins—UNRELATED: Board Membership: Claret Medical; Consultancy: Boston Scientific, Abbott, Cordis, Medtronic; Employment: University at Buffalo Neurosurgery, Jacobs Institute, Ka-leida Health; Payment for Lectures Including Service on Speakers Bureaus: Memorial Healthcare System, Complete Conference Management; Stock/Stock Options: Boston Scientific, Claret Medical, Augmenix, Endomation, Silk Road Medical, Ostial, Apama Medical, StimSox, Photolitec, ValenTx, Axtria, Ocular Therapeutix, The Stroke Project, Comments: financial interests, no money received. Maxim Mokin—UNRELATED: Consultancy: Cerebrotech Medical Systems, Canon Medical Systems Corporation, Imperative Care; Royalties: Oxford University Press. Daniel R. Bednarek—RELATED: Grant: Canon Medical Systems Corporation*; UNRELATED: Grants/Grants Pending: Canon Medical Systems Corporation*; Royalties: Canon Medical Systems Corporation, Comments: Dose Tracking System (DTS) licensing agreement.* Adnan H. Siddiqui—UNRELATED: Consultancy: Amnis Therapeutics, Boston Scientific, Canon Medical Systems USA, Cerebrotech Medical Systems, Cerenovus, Corindus Vascular Robotics, Endostream Medical, Guidepoint Global Consulting, Imperative Care, Integra, Medtronic, MicroVention, Northwest University: Data and Safety Monitoring Board Chair for the HEAT Trial, Penumbra, Q'Apel Medical, Rapid Medical, Rebound Therapeutics, Serenity Medical, Silk Road Medical, StimMed, Stryker, Three Rivers Medical, Vassol, W.L. Gore & Associates; Stock/Stock Options: Amis Therapeutics, BlinkTBI, Buffalo Technology Partners, Cardinal Consulting, Cerebrotech Medical Systems, Cognition Medical, Endostream Medical, Imperative Care, International Medical Distribution Partners, Neurovascular Diagnostics, Q'Apel Medical, Rebound Therapeutics, Rist Neurovascular, Serenity Medical, Silk Road Medical, StimMed, Synchron, Three Rivers Medical, Viseon Spine. Stephen Rudin—RELATED: Grant: Canon Medical Systems Corporation, Comments: An equipment grant from Canon is provided as well as partial research support*; Provision of Writing Assistance, Medicines, Equipment, or Administrative Support: Canon Medical Systems Corporation, Comments: Some x-ray equipment has been provided*; Other: National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Comments: Partial support was provided in the past*; UNRELATED: Patents (Planned, Pending or Issued): Canon Medical Systems Corporation, Comments: There is an unrelated patent application pending*; Royalties: Canon Medical Systems Corporation, Comments: totally different project involving dose-tracking system software for clinical angiography equipment. *Money paid to the institution.

This work was partially supported by a research grant from Canon Medical Systems Corporation.

© 2019 by American Journal of Neuroradiology