Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy

Publication date: Available online 22 June 2019Source: Behavioural Brain ResearchAuthor(s): Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping MaAbstractMitochondrial dynamics regulate mitochondrial autophagy (mitophagy) and apoptosis, which are important events for the quality control of mitochondria and mitochondrial-associated diseases. Esculetin (ESC) is a natural coumarin that exhibits inspiring biological activities in a variety of animal models, but its...

Behavioural Brain Research

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