Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study
Muhammet Avcil PhD Gokhan Akman PhD Jens Klokkers PhD Dohyeon Jeong PhD Ayhan Çelik PhD
First published: 28 May 2019 https://doi.org/10.1111/jocd.13009
Funding information: This study was funded by Imperial Bioscience Ltd.
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Abstract
Background
Aging skin is a gradual physiological process associated with functional and structural changes of the skin. Both intrinsic and extrinsic factors influence skin aging by the involvement of multiple pathways. Restoring natural skin conditions requires a multi‐targeted approach. Recent developments in both bioactive peptides and microneedle delivery system have presented an opportunity for tackling premature skin aging.
Aims
This study was aimed at evaluating the dermal tolerability and efficacy of hyaluronic acid‐based microneedle patches loaded with bioactives for restoration of the skin properties including hydration, wrinkle reduction, density, and thickness.
Patients/Methods
The test product of HA‐MNs comprises arginine/lysine polypeptide, acetyl octapeptide‐3, palmitoyl tripeptide‐5, adenosine, and seaweed extracts. In the monocentric 12‐week clinical trial, the HA‐MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin. Instrumental analysis of skin properties was determined.
Results
The product was tolerated excellently; none of the subjects reported any primary or cumulative skin reactions. Assessment of measurable skin properties provides insight into the general effectiveness: The fine lines/wrinkles showed 25.8% noticeable decrease; the skin hydration measurements demonstrated 15.4% improvement; the skin density and thickness in the dermis increased 14.2% and 12.9%, respectively.
Conclusions
The composition of the microneedle patches works in a multi‐targeted manner and all ingredients might possibly be acted synergistically for the improvement of skin structure, function, and appearance. The study has demonstrated the overall usefulness of the HA‐MNs with careful formulation for skin care applications.
Muhammet Avcil PhD Gokhan Akman PhD Jens Klokkers PhD Dohyeon Jeong PhD Ayhan Çelik PhD
First published: 28 May 2019 https://doi.org/10.1111/jocd.13009
Funding information: This study was funded by Imperial Bioscience Ltd.
Read the full text
ePDFPDFTOOLS SHARE
Abstract
Background
Aging skin is a gradual physiological process associated with functional and structural changes of the skin. Both intrinsic and extrinsic factors influence skin aging by the involvement of multiple pathways. Restoring natural skin conditions requires a multi‐targeted approach. Recent developments in both bioactive peptides and microneedle delivery system have presented an opportunity for tackling premature skin aging.
Aims
This study was aimed at evaluating the dermal tolerability and efficacy of hyaluronic acid‐based microneedle patches loaded with bioactives for restoration of the skin properties including hydration, wrinkle reduction, density, and thickness.
Patients/Methods
The test product of HA‐MNs comprises arginine/lysine polypeptide, acetyl octapeptide‐3, palmitoyl tripeptide‐5, adenosine, and seaweed extracts. In the monocentric 12‐week clinical trial, the HA‐MNs patches were applied to the outer corner of the right and left eye and a defined area on the volar forearm on healthy subjects with aged skin. Instrumental analysis of skin properties was determined.
Results
The product was tolerated excellently; none of the subjects reported any primary or cumulative skin reactions. Assessment of measurable skin properties provides insight into the general effectiveness: The fine lines/wrinkles showed 25.8% noticeable decrease; the skin hydration measurements demonstrated 15.4% improvement; the skin density and thickness in the dermis increased 14.2% and 12.9%, respectively.
Conclusions
The composition of the microneedle patches works in a multi‐targeted manner and all ingredients might possibly be acted synergistically for the improvement of skin structure, function, and appearance. The study has demonstrated the overall usefulness of the HA‐MNs with careful formulation for skin care applications.
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