Clinical Infectious Diseases Advance Access,

Clinical Relevance and Prognostic Value of Persistently Negative (1,3) β-D-Glucan in Adults with Candidemia: a 5-year experience in a tertiary hospital

AbstractBackagroundThe clinical relevance and the potential prognostic role of persistently negative (1,3)-β-D-glucan (BDG) in adults with proven candidemia is unknown.MethodsRetrospective study including all adults diagnosed with candidemia from 2012-2017, who had at least two serum BDG determinations throughout the episode of fungemia (Fungitell® Assay, USA - positive cut-off ≥80pg/mL). Epidemiology and clinical outcomes were compared between patients with all negative vs. any positive BDG. Poor...

Clinical Infectious Diseases Advance Access

03:00

Lung injury on antiretroviral therapy in adults with HIV/TB

AbstractBackgroundImmune restoration on antiretroviral therapy (ART) can drive inflammation in HIV-infected patients with pulmonary tuberculosis (TB), but the effects on the lungs have not been assessed. We evaluated associations between pulmonary inflammation, recovery of pathogen-specific CD4 T cell function, and lung injury prior to and after ART initiation in adults with HIV and pulmonary TB.MethodsThis was a prospective cohort study in South Africa following adults with HIV and pulmonary TB...

Clinical Infectious Diseases Advance Access

Wed Jun 26, 2019 03:00