Cellular and Molecular Bioengineering,

Shaft Function of Kinesin-1’s α4 Helix in the Processive Movement

Abstract Introduction Kinesin-1 motor is a molecular walking machine constructed with amino acids. The understanding of how those structural elements play their mechanical roles is the key to the understanding of kinesin-1 mechanism. Methods Using molecular dynamics simulations, we investigate the role of a helix structure, α4 (also called switch-II helix),...

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