Cells, Vol. 8, Pages 648: Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains Cells doi: 10.3390/cells8070648 Authors: Diana N. Raju Jan N. Hansen Sebastian Rassmann Birthe Stüven Jan F. Jikeli Timo Strünker Heinz G. Körschen Andreas Möglich Dagmar Wachten Inside the female genital tract, mammalian sperm undergo a maturation process called capacitation, which primes the sperm to navigate across...
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Cells, Vol. 8, Pages 647: Aberrant Expression of Intracellular let-7e, miR-146a, and miR-155 Correlates with Severity of Depression in Patients with Major Depressive Disorder and Is Ameliorated after Antidepressant Treatment Cells doi: 10.3390/cells8070647 Authors: Yi-Yung Hung Ming-Kung Wu Meng-Chang Tsai Ya-Ling Huang Hong-Yo Kang Chronic inflammation and abnormalities in Toll-like receptor (TLR) signaling pathways are associated with major depressive disorder (MDD). Our...
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Publication date: Available online 27 June 2019Source: Cellular SignallingAuthor(s): X.U. Haiqian, Wenjie Li, Sai Luo, Jian Yuan, Lijun HaoAbstractBreast cancer (BC) metastasis after surgery is associated with the tumor microenvironment and especially with adipose tissue-derived mesenchymal stem cells (ASCs) that have been shown to promote the BC progression. To better understand the role of ASCs in tumor metastasis, our study explored a novel mechanism that mediates the negative regulation of miR20b...
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We were the first to study the effect of miR‐137 on the osteogenic differentiation of human adipose‐derived stem cells (hASCs) and unveil its potential epigenetic mechanisms in this biological process. In conclusion, miR‐137 knockdown promoted the osteogenic differentiation of hASCs via the LSD1/BMP2/SMAD4 coregulatory signaling network, thus providing a novel therapeutic target in the clinical treatment of bone defects. Abstract MicroRNAs are a group of endogenous regulators that participate...
Wed Jun 26, 2019 15:35
In this study, we show that increasing miR‐330 expression in colorectal cancer (CRC) cells induces apoptosis and suppresses cell viability and migration. We also show that miR‐330 suppresses HMGA2 expression and leads to constitutively suppressed Smad3, vascular endothelial growth factor receptors (VEGFR), Snail‐1, p‐AKT, and p‐STAT3 and increase E‐cadherin proteins level in CRC cells. Altogether, these results specify that miR‐330 could be as a TS‐miRNA in CRC. Abstract MicroRNAs (miRNAs) are...
Wed Jun 26, 2019 15:33
The presented results implicate SCD1 expression and activity in the regulation of nucleotide metabolism. SCD1‐dependent changes in the AMP/ATP and NAD + /NADH ratios affect the AMPK/SIRT1 pathway and histone acetylation. Our findings reveal a novel mechanism that links SCD1 with the maintenance of metabolic homeostasis and insulin sensitivity in skeletal muscle. Abstract Stearoyl‐CoA desaturase (SCD) is a rate‐limiting enzyme that catalyzes the synthesis of monounsaturated fatty acids. It plays...
Wed Jun 26, 2019 15:33
Despite that carnitine palmitoyl transferase‐1 levels increased in both muscle types in a similar fashion, l‐carnitine ameliorated muscle atrophy and proteolysis in a muscle‐specific manner in cancer‐induced cachexia. These data reveal the need to study muscles of different fiber type composition and function to better understand whereby l‐carnitine exerts its beneficial effects on the myofibers in muscle wasting processes. These findings also have potential clinical implications, since combinations...
Wed Jun 26, 2019 15:15
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