This study revealed that metabolomics integrating with network-based approach can facilitate understanding of the anti-metastasis mechanisms of capsaicin against HCC.Graphical abstract (Source: Journal of Functional Foods)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
13:12
Purpose of review Although vitamin C is essentially a nontoxic vitamin; however, it is important to be aware regarding the safety of high doses before the wide clinical use. Recent findings Minor side effects of vitamin C have been reported, many being reported in earlier studies. High doses of vitamin C (up to 1.5 g/kg three times a week as intravenously) were safe in cancer patients with normal renal function and perfect glucose-6-phosphate dehydrogenase activity. As the dose and duration...
13:06
Purpose of review Glutamine (GLN) is a versatile amino acid, long believed to have important implications in ICU and surgical patients. An extensive body of data examining GLN supplementation of TPN demonstrated a consistent signal of improved outcomes. However, recently signals of risk have come from two large-scale multicenter trials evaluating GLN (and other nutrients) at high dose and as primary pharmaconutrients, not as supplementation to complete nutrition. These trials indicate a risk of...
13:06
CONCLUSIONS LPA2 and KLF5 protein expressions were differently expressed in gastric adenocarcinoma, GIN, and normal gastric tissue, and differences were correlated with patients' clinical characteristic. However, LPA2 and KLF5 expressions were not correlated with the patients' prognosis. PMID: 31235682 [PubMed - in process] (Source: Medical Science Monitor)
12:45
In conclusion, miR-663 was up-regulated in CRC patients and may be an effective biomarker for CRC diagnosis. PMID: 31240955 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
12:44
Publication date: Available online 26 June 2019Source: The LancetAuthor(s): Silvia de Sanjose, Sinead Delany-Moretlwe (Source: The Lancet)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
12:12
(Source: BMJ)
12:12
Methanol extract of iSolanum nigrumi Induces Autophagy and Apoptosis in MDAMB468 Breast Cancer Cells
A. Shirkavad, Zahra N. Borojeni and S. E. Aleyasin* (Source: Indian Journal of Pharmaceutical Sciences)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
11:05
A. Kumarasamy and G. A. Kurian* (Source: Indian Journal of Pharmaceutical Sciences)
11:05
Antioxidant Potential and Antitumour Activities of iNendrani Banana Peels in Breast Cancer Cell Line
P. S. Kumar* S. Durgadevi, A. Saravanan and S. Uma (Source: Indian Journal of Pharmaceutical Sciences)
11:05
T. H. Tran, Hanh Thuy Nguyen, C. S. Yong, D. H. Truong* and J. O. Kim* (Source: Indian Journal of Pharmaceutical Sciences)
11:05
(Source: Cancer Management and Research)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
04:35
(Source: OncoTargets and Therapy)
04:25
(Source: Cancer Management and Research)
04:15
The authors have noticed a typographical error in the published article. The term “epithelial-to-mesenchymal transition” should have been used instead of the term “endothelial-to-mesenchymal transition” throughout the manuscript. (Source: Cancer and Metastasis Reviews)
00:00
SummaryRucaparib, a poly(ADP-ribose) polymerase inhibitor, is licensed for use in recurrent ovarian, fallopian tube, or primary peritoneal cancer. We characterized the absorption, distribution, metabolism, and elimination of rucaparib in 6 patients with advanced solid tumors following a single oral dose of [14C]-rucaparib 600 mg (≈140 μCi). Total radioactivity (TRA) in blood, plasma, urine, and feces was measured using liquid scintillation counting. Unchanged rucaparib concentrations in plasma were...
00:00
SummaryPancreatic ductal adenocarcinoma is a highly aggressive malignancy with short survival and limited therapeutic options. Broccoli sulforaphane is a promising new treatment due to the results of recent epidemiological, experimental and patient studies. Upon approval from the ethics committee and registration atClinicalTrials.gov, 40 patients with palliative chemotherapy were placed into a placebo and treatment group in an unblinded fashion. Fifteen capsules with pulverized broccoli sprouts containing...
00:00
In oncology, pre-clinical and early clinical data increasingly support the use of a number of candidate “non-cancer” drugs in an off label setting against multiple tumor types. In particular, metabolically targeted drugs show promise as adjuvant chemo and radio sensitizers, improving or restoring sensitivity to standard therapies. The time has come for large scale clinical studies of off-label drugs in this context. However, it is well recognized that high-cost randomized controlled trials may not...
00:00
Opinion statementCardiac masses and tumors are a heterogenous group of disorders and include primary tumors (both benign and malignant), metastatic disease, and numerous masquerades such as thrombus. Clinical presentation ranges from incidental discovery on imaging tests ordered for other reasons to life-threatening presentations such as cardiac tamponade, arrhythmia, obstruction, and systemic embolization. Of the available imaging modalities, cardiac MRI is generally the most useful for assessment...
00:00
Cancer Gene Therapy, Published online: 27 June 2019; doi:10.1038/s41417-019-0111-0TBL1XR1 is involved in c-Met-mediated tumorigenesis of human nonsmall cell lung cancer (Source: Cancer Gene Therapy)
00:00
AbstractPurpose of review: Exosomes are nano-sized extracellular vesicles ranging from 30 –150 nm in diameter. Exosomes interact with nearby or distantly localized recipient cells by involving ligand/receptor binding at the surface of recipient cells or fusion with plasma membrane of recipient cells. A number of recent literatures support the role of integrins in mediating metastatic p rocess of cancer cell derived exosomes. While exosomes need to dock on the surface of recipient cells to transmit...
08:05
Conclusion: These results provide insights into the importance of chemical modification of unstable genetic therapeutics for HCC treatment. Conjugation of PEGylated GEP siRNA with ARP may be a potential HCC therapeutic agent. (Source: Molecular and Cellular Toxicology)
08:05
Conclusion: Ce6-mediated PDT might be used as a potent therapeutics for AD via restoring Th1/Th2 balance and reducing over expressed immune cells. (Source: Molecular and Cellular Toxicology)
08:05
Conclusion: The above mentioned data suggested that RP11 –6O2.4 was a tumor-suppressor gene in GC. RP11-6O2.4 might play an important role in the cell cycle transformation by regulating the p38-MAPK signaling pathway, thereby representing a specific biomarker and a potential molecular target for the treatment of GC. (Source: Molecular and Cellular Toxicology)
08:05
Claudins are a multigene transmembrane protein family comprising at least 27 members. In gastrointestinal tract, claudins are mainly located in the intestinal epithelia; many types of claudins form a network of strands in tight junction plaques within the intercellular space of neighboring epithelial cells and build paracellular selective channels, while others act as signaling proteins and mediates cell behaviors. Claudin dysfunction may contribute to epithelial permeation disorder and multiple...
00:00
AbstractThe response gene to complement (RGC)-32 acts as a cell cycle regulator and mediator of TGF- β effects. However, recent studies have revealed other functions for RGC-32 in diverse processes such as cellular migration, differentiation, and fibrosis. In addition to its induction by complement activation and the C5b-9 terminal complement complex, RGC-32 expression is also stimulated by growth factors, hormones, and cytokines. RGC-32 is induced by TGF-β through Smad3 and RhoA signaling and plays...
00:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου