British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0495-5The role of mouse tumour models in the discovery and development of anticancer drugs
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0500-zObesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0504-8RRx-001 followed by platinum plus etoposide in patients with previously treated small-cell lung cancer
Cancers, Vol. 11, Pages 877: DNAM-1 and the TIGIT/PVRIG/TACTILE Axis: Novel Immune Checkpoints for Natural Killer Cell-Based Cancer ImmunotherapyCancers doi: 10.3390/cancers11060877Authors:Beatriz Sanchez-CorreaIsabel ValhondoFakhri HassounehNelson Lopez-SejasAlejandra PeraJuan M. BerguaMaria Jose ArcosHelena BañasIgnacio Casas-AvilésEsther DuránCorona AlonsoRafael SolanaRaquel TarazonaNatural killer (NK) cells are lymphocytes of the innate immune response characterized by their role in the destruction...
Abstract Changes of nuclear localization of lineage‐specific genes from a transcriptionally inert to permissive environment is a crucial step in establishing the identity of a cell. Noncoding RNA transcription‐mediated genome folding and activation of target gene expression have been found in a variety of cell types. Noncoding RNA ThymoD (Thymocyte Differentiation Factor) transcription at super‐enhancers is essential for mouse T‐cell lineage commitment. The cessation of ThymoD transcription abolishes...
Abstract Cancer‐specific antigens expressed in the cell membrane have been used as targets for several molecular targeted strategies in recent years with remarkable success. To develop more effective cancer treatments, novel targets and strategies for targeted therapies are needed. Here, we examined the cancer cell membrane‐resident “cis‐bimolecular complex” as a possible cancer target (cis‐bimolecular cancer target: BiCAT) using proximity proteomics, a technique that has attracted attention in...
Women with breast cancer are increasingly being cured of the disease but fatigue remains the most frequently reported symptom. The aims of this study were to identify distinct trajectories in 4 fatigue dimensions during 2 years after breast cancer surgery and to explore the demographic, clinical and personality characteristics associated with these profiles. We included women from the prospective longitudinal multicenter FATSEIN cohort in France. They completed the Multidimensional Fatigue Inventory...
DEPTOR is an endogenous inhibitor of mTORC1 and mTORC2 that plays a vital role in the progression of human malignances. However, the biological function of DEPTOR in HCC metastasis and the underlying molecular...
Publication date: June 2019Source: Cancer/Radiothérapie, Volume 23, Issue 3Author(s): A. Rehailia-Blanchard, M.Y. He, C. Rancoule, A. Vallard, S. Espenel, A. Nivet, N. Magné, C. Chargari
Publication date: June 2019Source: Cancer/Radiothérapie, Volume 23, Issue 3Author(s):
Publication date: June 2019Source: Cancer/Radiothérapie, Volume 23, Issue 3Author(s):
Publication date: Available online 22 June 2019Source: European Journal of Surgical OncologyAuthor(s): H.E. Jin, M.S. Kim, C.M. Lee, J.H. Park, C.I. Choi, H.H. Lee, J.S. Min, Y.S. Jee, J. Oh, H.D. Chae, S.I. Choi, Y.T. Lee, J.H. Kim, H. Huang, S.S. ParkAbstractBackgroundThe curative surgical treatment of gastric cancer in the current laparoscopic surgical era relies on the surgeon's preference, technical difficulties, and concerns regarding outcome have led to the availability of totally laparoscopic...
Publication date: Available online 22 June 2019Source: European Journal of Surgical OncologyAuthor(s): Lee S. Kyang, Nayef A. Alzahrani, Mohammad S. Alshahrani, Mohammad K. Rahman, Winston Liauw, David L. MorrisAbstractIntroductionEarly recurrence (ER) is defined as development of loco-regional peritoneal disease within 12-month of the initial CRS/PIC. Our aims were to identify overall survival (OS), recurrence-free survival (RFS) and independent prognostic factors associated with ER in PM of appendiceal...
Publication date: Available online 21 June 2019Source: European Journal of Surgical OncologyAuthor(s): Shigeki Kusamura, Norfarizan Azmi, Luca Fumagalli, Dario Baratti, Marcello Guaglio, Adalberto Cavalleri, Giulia Garrone, Luigi Battaglia, Francesco Barretta, Marcello DeracoAbstractAimsTo evaluate the effects of high intra-abdominal pressure (IAP) during hyperthermic intraperitoneal chemotherapy (HIPEC) on cisplatin uptake by residual tumor and normal tissues, pharmacokinetics, and short-term surgical...
Publication date: Available online 21 June 2019Source: European Journal of Surgical OncologyAuthor(s): Xiao Shi, Xue-Kui Liu, Chang-Ming An, Wen-Jun Wei, Yungan Tao, Yuan Ji, Yan Zhang, Wei Han, Jin-Cai Xue, Nai-Si Huang, Ben Ma, Chen-Ping Zhang, Xi Yang, Ke-Jing Wang, Qin-Jiang Liu, Yang Liu, Yu Wang, Bo-Wen Lei, Peng-Cheng Yu, Jia-Qian HuAbstractBackgroundWe aimed to explore whether the anatomic extent of lymph node metastases (AE-LNM) could independently predict prognosis of node-positive major...
Publication date: August 2019Source: European Journal of Cancer, Volume 117Author(s): F.E. Marti Marti, G.C. Jayson, P. Manoharan, J. O'Connor, A.G. Renehan, A.C. Backen, H. Mistry, F. Ortega, K. Li, K.L. Simpson, J. Allen, J. Connell, S. Underhill, V. Misra, K.J. Williams, I. Stratford, A. Jackson, C. Dive, M.P. SaundersAbstractBackgroundThe DREAMtherapy (Dual REctal Angiogenesis MEK inhibition radiotherapy) trial is a novel intertwined design whereby two tyrosine kinase inhibitors (cediranib and...
Abstract Background Surgery is becoming more practical and effective than conservative treatment in improving the poor outcomes of patients with breast cancer liver metastasis (BCLM). However, there is no generally acknowledged set of standards for identifying BCLM candidates who will benefit from surgery. Methods Between January 2011 and September 2018,...
Publication date: July–August 2019Source: Practical Radiation Oncology, Volume 9, Issue 4Author(s):
Publication date: July–August 2019Source: Practical Radiation Oncology, Volume 9, Issue 4Author(s): Daniel B. Vanderbilt
Publication date: July–August 2019Source: Practical Radiation Oncology, Volume 9, Issue 4Author(s):
Publication date: July–August 2019Source: Practical Radiation Oncology, Volume 9, Issue 4Author(s):
Publication date: Available online 21 June 2019Source: Practical Radiation OncologyAuthor(s): Suzanne B. Evans, Douglas D. Martin, Randi Kudner
Publication date: July–August 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 4Author(s): Yecai Huang, Mei Feng, Jun Yin, Bingyu Fu, Jinyi LangAbstractSacrococcygeal teratoma is the most common germ cell neoplasia that consists of tissues derived from primitive germ layers. Approximately 10–20% of patients are malignant. Because of the high rate of recurrence, treatment strategies for malignant sacrococcygeal teratomas are limited. Hence, we report a case of malignant...
Publication date: July–August 2019Source: Reports of Practical Oncology & Radiotherapy, Volume 24, Issue 4Author(s): Masao Nakayama, Kazuyuki Uehara, Hideki Nishimura, Shuhei Tamura, Yoshiki Munetomo, Shinji Tsudou, Hiroshi Mayahara, Naritoshi Mukumoto, Moshi Geso, Ryohei SasakiAbstractAimTo investigate tumour motion tracking uncertainties in the CyberKnife Synchrony system with single fiducial marker in liver tumours.BackgroundIn the fiducial-based CyberKnife real-time tumour motion tracking...
Cancers, Vol. 11, Pages 875: Can Dendritic Cell Vaccination Prevent Leukemia Relapse?Cancers doi: 10.3390/cancers11060875Authors:Liam J. O’BrienCamille GuillereyKristen J. RadfordLeukemias are clonal proliferative disorders arising from immature leukocytes in the bone marrow. While the advent of targeted therapies has improved survival in certain subtypes, relapse after initial therapy is a major problem. Dendritic cell (DC) vaccination has the potential to induce tumor-specific T cells providing...
Cancers, Vol. 11, Pages 876: Circulating miRNAs in Untreated Breast Cancer: An Exploratory Multimodality Morpho-Functional StudyCancers doi: 10.3390/cancers11060876Authors:Mariarosaria IncoronatoAnna Maria GrimaldiPeppino MirabelliCarlo CavaliereChiara Anna ParenteMonica FranzeseStefania StaibanoGennaro IlardiDaniela RussoAndrea SoricelliOnofrio Antonio CatalanoMarco SalvatoreThe aim of this study was to identify new disease-related circulating miRNAs with high diagnostic accuracy for breast cancer...
Cancers, Vol. 11, Pages 874: Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic CancerCancers doi: 10.3390/cancers11060874Authors:Jiangang ZhaoHans A. SchlößerZhefang WangJie QinJiahui LiFelix PoppMarie Christine PoppHakan AlakusSeung-Hun ChonHinrich P. HansenWolfram F. NeissKarl-Walter JauchChristiane J. BrunsYue ZhaoPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Tumor-derived extracellular vesicles (EVs) induce pre-metastatic...
Abstract Objective The European Organisation for Research and Treatment of Cancer Quality of Life Group (EORTC QLG) has developed a multidimensional instrument measuring cancer related fatigue, the EORTC QLQ‐FA12. The analysis of sensitivity to change is an essential part of psychometric validation. With this study, we investigated the EORTC QLQ‐FA12's sensitivity to change. Methods The methodology follows the EORTC guidelines of EORTC QLG for phase IV validation of modules. We included...
Abstract Objectives This review aimed to systematically evaluate the characteristics of Technology‐Based Interventions (TBIs) and their effectiveness on anxiety, depression, and HRQoL among patients with prostate cancer. Methods We identified eligible research reports published in English language between January 1, 2000 and September 15, 2018 from CINAHL, EMBASE, “Library & Information Science Abstracts,” “Library, Information Science & Technology Abstracts,” “Library & Information...
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