Monoterpenoid Geraniol improves anti-TB drug efficiency by interfering with lipidome and virulence of mycobacteria. Infect Disord Drug Targets. 2019 Jun 25;: Authors: Sharma S, Hameed S, Fatima Z Abstract BACKGROUND: Tuberculosis (TB) remains a global infectious disorder for which efficient therapeutics are elusive. Nature is a source of novel pharmacologically active compounds with many potential drugs being derived directly or indirectly from plants,...
Related ArticlesTherapeutic strategies for type 2 diabetes mellitus in women after menopause. Maturitas. 2019 Aug;126:69-72 Authors: Paschou SA, Marina LV, Spartalis E, Anagnostis P, Alexandrou A, Goulis DG, Lambrinoudaki I Abstract As type 2 diabetes mellitus (T2DM) is affected by both chronological and ovarian ageing, it is common in postmenopausal women. This review analyses and critically appraises the literature regarding the optimal therapeutic...
Related ArticlesNeuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review. Eur J Pharmacol. 2019 Jun 22;:172500 Authors: Zhang J, Wu J, Liu F, Tong L, Chen Z, Chen J, He H, Xu R, Ma Y, Huang C Abstract Anthocyanins, a class of water soluble flavonoids extracted from plants like berries and soybean seed, have been shown to display obvious anti-oxidative, anti-inflammatory,...
Related ArticlesChronic Ethanol Exposure Disrupts Lactate and Glucose Homeostasis and Induces Dysfunction of the Astrocyte-Neuron Lactate Shuttle in the Brain. Alcohol Clin Exp Res. 2019 Jun 25;: Authors: Lindberg D, Ho AMC, Peyton L, Choi DS Abstract INTRODUCTION: Impairment of monocarboxylate transporter- (MCT) dependent astrocyte-neuron lactate transfer disrupts long-term memory and erases drug-associated memories in mice. However, few studies have...
Related ArticlesThe Association Between the Serum Uric Acid to Creatinine Ratio and Metabolic Syndrome, Liver Function, and Alcohol Intake in Healthy Japanese Subjects. Metab Syndr Relat Disord. 2019 Jun 25;: Authors: Moriyama K Abstract Background: In patients with diabetes mellitus, the serum uric acid (UA) to creatinine (Cr) ratio (UA/Cr) has been reported to be associated with a higher risk of metabolic syndrome (MetS). In healthy subjects, however,...
Related ArticlesFatty acid metabolic flux and lipid peroxidation homeostasis maintain the biomembrane stability to improve citrus fruit storage performance. Food Chem. 2019 Sep 15;292:314-324 Authors: He Y, Li Z, Tan F, Liu H, Zhu M, Yang H, Bi G, Wan H, Wang J, Xu R, Wen W, Zeng Y, Xu J, Guo W, Xue S, Cheng Y, Deng X Abstract Little is known about the variations of fresh fruit biomembrane and its physiological and biochemical characteristics during...
Related Articles[The Sour Patient]. Praxis (Bern 1994). 2019;108(4):283-285 Authors: Oestmann A, Stöppler A Abstract The Sour Patient Abstract. We report the case of a 75-year-old woman presenting with an elevated anion gap metabolic acidosis. The evaluation proved a 5-oxoprolin acidosis due to acetaminophen in therapeutic dose and concomitant risk factors such as malnutrition, chronic alcohol abuse, renal insufficiency, hepatopathy, and female sex....
Related ArticlesSorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes. J Mol Cell Cardiol. 2018 01;114:199-210 Authors: Chen X, Weber C, Farrell ET, Alvarado FJ, Zhao YT, Gómez AM, Valdivia HH Abstract Sorcin, a penta-EF hand Ca2+-binding protein expressed in cardiomyocytes, is known to interact with ryanodine receptors and other Ca2+ regulatory proteins. To investigate sorcin's influence...
Related ArticlesS1P1 deletion differentially affects TH17 and Regulatory T cells. Sci Rep. 2017 10 10;7(1):12905 Authors: Eken A, Duhen R, Singh AK, Fry M, Buckner JH, Kita M, Bettelli E, Oukka M Abstract Sphingosine-1 phosphate receptor 1 (S1P1) is critical for the egress of T and B cells out of lymphoid organs. Although S1P1 agonist fingolimod is currently used for the treatment of multiple sclerosis (MS) little is known how S1P1 signaling regulates...
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