Abstract Background Over 100 million people worldwide suffer from birch pollen allergy. Bet v 1 has been identified as the major birch pollen allergen. However, the molecular mechanisms of birch allergic sensitization, including the roles of Bet v 1 and other components of the birch pollen extract, remain incompletely understood. Here, we examined how known birch pollen‐derived molecules influence the endolysosomal processing of Bet v 1, thereby shaping its allergenicity. Methods We analyzed...
Abstract Atopic dermatitis (AD) is a common inflammatory skin condition that has traditionally been considered a paradigmatic type 2 immunity (T2)‐driven disease. Interleukin (IL)‐4 and IL‐13 are both pivotal cytokines involved in the generation of allergic diseases. Currently, besides dupilumab, which blocks the binding of both cytokines to their receptors, a number of new pharmacologic entities have been designed to target both T2 cytokines and/or their receptors and/or receptor‐associated signal...
Abstract Mobile Health (mHealth) uses mobile communication devices such as smartphones and tablet computers to support and improve health‐related services, data flow and information, patient self‐management, surveillance, and disease management from the moment of first diagnosis to an optimized treatment. The European Academy of Allergy and Clinical Immunology created a task force to assess the state of the art and future potential of mHealth in allergology. The task force endorsed the “Be He@lthy,...
Abstract Background In the house dust mite (HDM) Dermatophagoides pteronyssinus Der p 1, 2, 5, 7, 21 and 23 have been identified as the most important allergens. The aim of this study was to define hypoallergenic peptides derived from the sequences of the six allergens and to use peptides and the complete allergens to study antibody, T cell and cytokine responses in sensitized and non‐sensitized subjects. Methods IgE reactivity of HDM‐allergic and non‐HDM‐sensitized individuals to 15 HDM...
Abstract Background Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of chronic spontaneous urticaria (CSU) in which functional IgG autoantibodies to IgE or its high affinity receptor (FcεRI) induce mast cell degranulation and subsequent symptom development. However, it has not been tightly characterized. This study aimed to better define the clinical and immunological features and to explore potential biomarkers of aiCSU. Methods This was a multinational, multicenter...
An estimated 248 million individuals live with chronic hepatitis B infection worldwide [1]. Chronic hepatitis B infection (CH-B) has a high risk of progression to cirrhosis and hepatocellular carcinoma. Entecavir, a guanosine nucleoside analogue, is often the drug of choice in nucleoside-naïve patients with CH-B because of its low rate of viral resistance. Resistance to entecavir therapy in nucleoside-naïve patients is approximately 1 percent after five years of treatment [2]. The efficacy and safety...
Coexistence of eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) has recently been increasingly recognized, however, literature in pediatrics, especially in-depth characterization of these patient characteristics is scarce (1-3). This case series aims to describe the characteristics of 6 children with coexisting EoE and IBD at a single tertiary care center.
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious drug-induced delayed hypersensitivity reaction. DRESS can present various manifestations, and the major clinical manifestations are fever, skin rash, and the involvement of several internal organs.1, 2
Publication date: Available online 21 June 2019Source: Allergology InternationalAuthor(s): Masami Taniguchi, Chihiro Mitsui, Hiroaki Hayashi, Emiko Ono, Keiichi Kajiwara, Haruhisa Mita, Kentaro Watai, Yosuke Kamide, Yuma Fukutomi, Kiyoshi Sekiya, Noritaka HigashiAbstractThe characteristics in AERD are severe adult-onset asthma, eosinophilic rhinosinusitis with nasal polyposis, and CysLT overproduction. The cause of AERD have remained unclear, however the decrease in the production of PGE2 caused...
Publication date: Available online 21 June 2019Source: Allergology InternationalAuthor(s): Otohiro Katsube, Yuta Kono, Ryuta Tsuzuki, Satoshi Yamawaki, Seiko Soeda, Masako To, Yasuo To
Background Dynamic nasal valve collapse (NVC) is a common factor contributing to nasal obstruction; however, it is often underdiagnosed and untreated. An in‐office, minimally invasive procedure addressing dynamic NVC uses a bioabsorbable implant (Latera) to support the lateral nasal wall. This study aimed to evaluate the safety and effectiveness of the treatment in a randomized controlled trial (RCT) with sham control. Methods In this prospective, multicenter, single‐blinded RCT, 137 patients...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου