We present the case of a 70-year-old patient affected by metastatic castration-resistant prostate cancer. He underwent radical prostatectomy in 2007 and subsequent adjuvant radiotherapy and hormonal therapy for 2 years. In 2011, he developed bilateral lung metastases, and therefore he received chemotherapy (eight cycles of docetaxel 75 mg/sqm every 3 weeks) with partial remission; rechallenge with the same drug was performed 7 months later due to recurrence of lung metastases. In August 2013, abiraterone acetate was started for progression of lung metastases. The patient received abiraterone for almost 5 years with stability of disease. During the 60th cycle of abiraterone, a diagnosis of acute myeloid leukemia was made. Received 10 April 2020 Revised form accepted 25 July 2020 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.anti-cancerdrugs.com. Correspondence to Elena Bolzacchini, MD, U.O. Oncologia Medica, ASST-Lariana, Ospedale Sant’Anna, Via Ravona 20, San Fermo della Battaglia (Como) 22020, Italy, Tel: +00393298597540; e-mail: elena.bolzacchini@hotmail.it Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
ΩτοΡινοΛαρυγγολόγος Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,
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Τρίτη 15 Σεπτεμβρίου 2020
Abiraterone acetate and acute leukemia
Abiraterone acetate and acute leukemia: a casual association?:
We present the case of a 70-year-old patient affected by metastatic castration-resistant prostate cancer. He underwent radical prostatectomy in 2007 and subsequent adjuvant radiotherapy and hormonal therapy for 2 years. In 2011, he developed bilateral lung metastases, and therefore he received chemotherapy (eight cycles of docetaxel 75 mg/sqm every 3 weeks) with partial remission; rechallenge with the same drug was performed 7 months later due to recurrence of lung metastases. In August 2013, abiraterone acetate was started for progression of lung metastases. The patient received abiraterone for almost 5 years with stability of disease. During the 60th cycle of abiraterone, a diagnosis of acute myeloid leukemia was made. Received 10 April 2020 Revised form accepted 25 July 2020 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.anti-cancerdrugs.com. Correspondence to Elena Bolzacchini, MD, U.O. Oncologia Medica, ASST-Lariana, Ospedale Sant’Anna, Via Ravona 20, San Fermo della Battaglia (Como) 22020, Italy, Tel: +00393298597540; e-mail: elena.bolzacchini@hotmail.it Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
We present the case of a 70-year-old patient affected by metastatic castration-resistant prostate cancer. He underwent radical prostatectomy in 2007 and subsequent adjuvant radiotherapy and hormonal therapy for 2 years. In 2011, he developed bilateral lung metastases, and therefore he received chemotherapy (eight cycles of docetaxel 75 mg/sqm every 3 weeks) with partial remission; rechallenge with the same drug was performed 7 months later due to recurrence of lung metastases. In August 2013, abiraterone acetate was started for progression of lung metastases. The patient received abiraterone for almost 5 years with stability of disease. During the 60th cycle of abiraterone, a diagnosis of acute myeloid leukemia was made. Received 10 April 2020 Revised form accepted 25 July 2020 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.anti-cancerdrugs.com. Correspondence to Elena Bolzacchini, MD, U.O. Oncologia Medica, ASST-Lariana, Ospedale Sant’Anna, Via Ravona 20, San Fermo della Battaglia (Como) 22020, Italy, Tel: +00393298597540; e-mail: elena.bolzacchini@hotmail.it Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
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