Anti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedule. Oncoimmunology. 2020 May 25;9(1):1762465 Authors: Popa X, García B, Fuentes KP, Huerta V, Alvarez K, Viada CE, Neninger E, Rodríguez PC, González Z, González A, Crombet T, Mazorra Z Abstract We previously reported that CIMAvax-EGF vaccine is safe, immunogenic and...
Tue Sep 15, 2020 18:06
Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition. Oncoimmunology. 2020 May 22;9(1):1761229 Authors: Cervera-Carrascon V, Quixabeira DCA, Santos JM, Havunen R, Zafar S, Hemminki O, Heiniö C, Munaro E, Siurala M, Sorsa S, Mirtti T, Järvinen P, Mildh M, Nisen H, Rannikko A, Anttila M, Kanerva A, Hemminki A Abstract Checkpoint inhibitors have revolutionized cancer therapy...
Tue Sep 15, 2020 18:06
Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3. Oncoimmunology. 2020 May 21;9(1):1761205 Authors: Boulpicante M, Darrigrand R, Pierson A, Salgues V, Rouillon M, Gaudineau B, Khaled M, Cattaneo A, Bachi A, Cascio P, Apcher S Abstract The success of CD8+ T cell-based cancer immunotherapy emphasizes the importance of understanding the mechanisms of generation of MHC-I peptide ligands and the possible pathways...
Tue Sep 15, 2020 18:06
Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse. Oncoimmunology. 2020 May 13;9(1):1761176 Authors: Onesti CE, Josse C, Boulet D, Thiry J, Beaumecker B, Bours V, Jerusalem G Abstract Background: Cancer outcome is associated with circulating immune cells, including eosinophils. Here we analyze the relative eosinophil count (REC) in different breast...
Tue Sep 15, 2020 18:06
Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome. Oncoimmunology. 2020 May 13;9(1):1760705 Authors: Brunekreeft KL, Paijens ST, Wouters MCA, Komdeur FL, Eggink FA, Lubbers JM, Workel HH, Van Der Slikke EC, Pröpper NEJ, Leffers N, Adam J, Pijper H, Plat A, Kol A, Nijman HW, De Bruyn M Abstract Epithelial Ovarian cancer (EOC)...
Tue Sep 15, 2020 18:06
COVID-19: a challenge for oncology services. Oncoimmunology. 2020 May 05;9(1):1760686 Authors: Routy B, Derosa L, Zitvogel L, Kroemer G PMID: 32923119 [PubMed]
Tue Sep 15, 2020 18:06
Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide. Oncoimmunology. 2020 May 14;9(1):1760685 Authors: Mirando AC, Patil A, Rafie CI, Christmas BJ, Pandey NB, Stearns V, Jaffee EM, Roussos Torres ET, Popel AS Abstract Triple-negative breast cancer (TNBC) is a highly metastatic and aggressive disease with limited treatment options. Recently, the combination of the immune checkpoint...
Tue Sep 15, 2020 18:06
IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responses. Oncoimmunology. 2020 May 12;9(1):1758606 Authors: Dadaglio G, Fayolle C, Oberkampf M, Tang A, Rudilla F, Couillin I, Torheim EA, Rosenbaum P, Leclerc C Abstract Antitumor immunity is mediated by Th1 CD4+ and CD8+ T lymphocytes, which induce tumor-specific cytolysis, whereas Th17 CD4+ T cells have been described to promote tumor...
Tue Sep 15, 2020 18:06
Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model. Oncoimmunology. 2020 May 13;9(1):1758602 Authors: Ye X, Waite JC, Dhanik A, Gupta N, Zhong M, Adler C, Malahias E, Ni M, Wei Y, Gurer C, Zhang W, Macdonald LE, Murphy AJ, Sleeman MA, Skokos D Abstract Clinical observations suggest that responses to cancer immunotherapy are correlated with intra-tumoral T cell receptor...
Tue Sep 15, 2020 18:06
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer. Oncoimmunology. 2020 May 13;9(1):1758004 Authors: Vormehr M, Lehar S, Kranz LM, Tahtinen S, Oei Y, Javinal V, Delamarre L, Walzer KC, Diken M, Kreiter S, Mellman I, Sahin U, Schartner JM, Türeci Ö Abstract Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development...
Tue Sep 15, 2020 18:06
ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancer. Oncoimmunology. 2020 May 06;9(1):1758003 Authors: Liu Z, Zhao K, Wei S, Liu C, Zhou J, Gou Q, Wu X, Yang Z, Yang Y, Peng Y, Cheng Q, Liu L Abstract Introduction: Despite some of the oncogenic driver mutations that have been associated with increased expression of programmed death-ligand 1 (PD-L1), the correlation between PD-L1 expression...
Tue Sep 15, 2020 18:06
Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model. Oncoimmunology. 2020 May 13;9(1):1757360 Authors: Murty S, Haile ST, Beinat C, Aalipour A, Alam IS, Murty T, Shaffer TM, Patel CB, Graves EE, Mackall CL, Gambhir SS Abstract Recent advances in novel immune strategies, particularly chimeric antigen receptor (CAR)-bearing T-cells, have shown limited efficacy...
Tue Sep 15, 2020 18:06
Heat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravis. Oncoimmunology. 2020 May 13;9(1):1756130 Authors: Thanner J, Bekos C, Veraar C, Janik S, Laggner M, Boehm PM, Schiefer AI, Müllauer L, Klepetko W, Ankersmit HJ, Moser B Abstract Background: Thymic epithelial tumors (TETs) are rare malignancies with unique association to the autoimmune disease myasthenia gravis (MG). Heat shock proteins (HSPs) harbor...
Tue Sep 15, 2020 18:06
Genomic and immunologic correlates of LAG-3 expression in cancer. Oncoimmunology. 2020 May 22;9(1):1756116 Authors: Panda A, Rosenfeld JA, Singer EA, Bhanot G, Ganesan S Abstract Immune checkpoint blockade leads to unprecedented responses in many cancers. Although currently available agents mostly target the PD-1 and CTLA-4 pathways, agents targeting the immune checkpoint protein LAG-3 are under active clinical development, and early clinical...
Tue Sep 15, 2020 18:06
Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation. Oncoimmunology. 2020 May 13;9(1):1746553 Authors: Lee GJ, Jun Y, Yoo HY, Jeon YK, Lee D, Lee S, Kim J Abstract A missense mutation in RHOA encoding p.Gly17 Val has been reported to occur frequently in angioimmunoblastic T-cell lymphoma (AITL). Here, we describe a murine model which expresses the human RHOA mutant gene product...
Tue Sep 15, 2020 18:06
Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancer. Oncoimmunology. 2019 Oct 13;9(1):1673125 Authors: Hos BJ, Camps MGM, van den Bulk J, Tondini E, van den Ende TC, Ruano D, Franken K, Janssen GMC, Ru A, Filippov DV, Arens R, van Veelen PA, Miranda N, Ossendorp F Abstract The murine MC-38 colorectal cancer model is a commonly used model for cancer with high mutational burden, which is...
Tue Sep 15, 2020 18:06
Publication date: Available online 15 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L. Masters, Andrew M. Lew, Sitang Gong, Fan Bai
Tue Sep 15, 2020 17:59
Publication date: April 2021Source: Current Opinion in Neurobiology, Volume 67Author(s): Swathi Shivaram Suratkal, Yu-Hsin Yen, Jun Nishiyama
Tue Sep 15, 2020 17:54
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Ali Eslambol Nassaj, Sara Ghadimi, Bahman Seraj, Nasim Chiniforush
Tue Sep 15, 2020 17:53
Publication date: December 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 32Author(s): Luenna Teixeira Carvalho, Fernanda Vieira Belém, Letícia Machado Gonçalves, Sandra Kalil Bussadori, Marco Aurélio Benini Paschoal
Tue Sep 15, 2020 17:53
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