Publication date: Available online 15 September 2020Source: Autoimmunity ReviewsAuthor(s): Antoine Gavoille, Michel Vincent, Lize Kiakouama, Mikael Catinon, Medhi Lamkhioued, Mojgan Devouassoux, Pierre Grumet, Yvan Jamilloux, Pascal Sève
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Tyson H. Holmes
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Hui Fang, Qingyang Li, Gang Wang
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Milena Mimica, Oslando Padilla, Marcela Bravo-Zehnder, Loreto Massardo, Alfonso González
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Meera Ramanujam, Jürgen Steffgen, Sudha Visvanathan, Chandra Mohan, Jay S. Fine, Chaim Putterman
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Zoltán Szekanecz, Izabella Gomez, Boglárka Soós, Levente Bodoki, Szilvia Szamosi, Csilla András, Balázs Juhász, László Váróczy, Péter Antal-Szalmás, Péter Szodoray, Nóra Bittner, Péter Árkosy, Árpád Illés, Gabriella Szűcs, Katalin Dankó, Tamás Bender, László Tamási, Éva Szekanecz, on behalf of the Hungarian OncoRheumatology Network (HORN) initiative
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Gabriele Valentini, Janet E. Pope
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Paola Di Benedetto, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Enrico De Lorenzis, Gerlando Natalello, Laura Gigante, Lucrezia Verardi, Silvia Laura Bosello, Elisa Gremese
Tue Sep 15, 2020 18:54
Publication date: Available online 14 September 2020Source: Autoimmunity ReviewsAuthor(s): Omid Mirmosayyeb, Saeed Vaheb, Mahdi Barzegar, Vahid Shaygannejad, Simona Bonavita, Mahsa Ghajarzadeh
Tue Sep 15, 2020 18:54
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Adalberto Miranda-Filho, Freddie Bray, Hadrien Charvat, Swaminathan Rajaraman, Isabelle Soerjomataram
Tue Sep 15, 2020 18:52
Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Anouk H. Eijkelboom, Jesca G.M. Brouwer, Hans F.A. Vasen, Tanya M. Bisseling, Jan J. Koornstra, Ellen Kampman, Fränzel J.B. van Duijnhoven
Tue Sep 15, 2020 18:52
Abstract In 1980, Seefeldt introduced the concept of a motor skill “proficiency barrier” that provides a conceptual basis for understanding the importance of a motor skill barrier as it relates to critical public health initiatives. While the intent of Seefeldt’s proficiency barrier hypothesis had great potential to advance the field of motor development, the notion of a proficiency barrier was not empirically tested. Instead, this concept lay dormant for several decades. The...
Tue Sep 15, 2020 03:00
The year 2020 has seen disruptions in nearly every aspect of our lives, due to the global pandemic of COVID-19, caused by the virus SARS-CoV-2. As such, we present the following four articles in this special series on COVID-19, Guest Edited by Dr. Zara Patel, to detail what we have learned in this ever-changing landscape, and where we might go from here.
Tue Sep 15, 2020 03:00
Publication date: Available online 14 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): A.R. Scott, J. Hu, C. Gan, J.A. Morris, K.W. Meacham, D.H. Ballard
Tue Sep 15, 2020 18:36
Publication date: Available online 14 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): Piet E. Haers, Gwen R.J. Swennen
Tue Sep 15, 2020 18:36
Publication date: Available online 14 September 2020Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): B.J. Merema, J. Kraeima, M.J.H. Witjes, N.B. van Bakelen, F.K.L. Spijkervet
Tue Sep 15, 2020 18:36
Publication date: Available online 15 September 2020Source: Radiotherapy and OncologyAuthor(s): Yihuai Hu, Chenyi Xie, Hong Yang, Joshua WK Ho, Jing Wen, Lujun Han, Ka-On Lam, Ian YH Wong, Simon YK Law, Keith WH Chiu, Varut Vardhanabhuti, Jianhua Fu
Tue Sep 15, 2020 18:34
Publication date: Available online 15 September 2020Source: Radiotherapy and OncologyAuthor(s): Alejandro García-Consuegra, Marta Gimeno Morales, Mauricio Cambeiro, Luca Tagliaferri, Gyoergy Kovacs, Erik Van Limbergen, Luis I. Ramos, José Manuel Arnaiz, Juan Alcalde, Fernando Lecanda, Rafael Martinez-Monge
Tue Sep 15, 2020 18:34
Publication date: Available online 14 September 2020Source: Radiotherapy and OncologyAuthor(s): Chia-Hsin Lin, Wen-Chi Chou, Yao-Yu Wu, Chien-Yu Lin, Kai-Ping Chang, Chun-Ta Liao, Tsung-Ying Ho, Chiu-Mei Yeh, Chia-Jen Liu, Sheng-Ping Hung, Ching-Hsin Lee, Po-Jui Chen, Yung-Chih Chou, Kang-Hsing Fan, Bing-Shen Huang, Joseph Tung-Chieh Chang, Chun-Chieh Wang, Ngan-Ming Tsang
Tue Sep 15, 2020 18:34
Publication date: Available online 14 September 2020Source: Radiotherapy and OncologyAuthor(s): Yusuke Demizu, Reiko Imai, Hiroki Kiyohara, Akira Matsunobu, Masahiko Okamoto, Tomoaki Okimoto, Hiroshi Tsuji, Tatsuya Ohno, Yoshiyuki Shioyama, Kenji Nemoto, Takashi Nakano, Tadashi Kamada, Japan Carbon-Ion Radiation Oncology Study Group
Tue Sep 15, 2020 18:34
Publication date: Available online 14 September 2020Source: Radiotherapy and OncologyAuthor(s): Kurian Joseph, Sarah Zebak, Veronica Alba, Kayla Mah, Cara Au, Larissa Vos, Sunita Ghosh, Aswin Abraham, Susan Chafe, Ericka Wiebe, Hong-Wei Liu, Carole Chambers, Zsolt Gabos, Keith Tankel, Sasha Lupichuk, Karen King
Tue Sep 15, 2020 18:34
The orthodontics market is expected to realize significant growth in the coming years with projected growth to $9.72 billion by 2026 ($4.06 billion in 2018). Technology advancement in the industry has largely been driven by invisible, clear aligners that can be removed for eating and cleaning. Aligners progressively reposition teeth through controlled force without the tightening required with traditional metal braces. Despite aesthetics and ease of use, an estimated 80% of patients have...
Tue Sep 15, 2020 18:17
Purpose. Arctigenin (ARG) is a natural lignan compound extracted from Arctium lappa and has displayed anticancer function and therapeutic effect in a variety of cancers. Arctigenin is mainly from Arctium lappa extract. It has been shown to induce autophagy in various cancers. However, as for whether arctigenin induces autophagy in gliomas or not, the specific mechanism is still worth exploring. Methods. Using CCK8, the monoclonal experiment was made to detect the proliferation ability. The scratch...
Tue Sep 15, 2020 14:50
Background. This study aims at investigating differences in oral cancer (OC) incidence trends between two populations in Taiwan and Thailand. Methods. We used the population-based cancer registry data from Taiwan (1979-2016) and Khon Kaen (KK), Thailand (1985-2016). We performed joinpoint analyses to detect the trend change points for the OC incidence and to quantify the time trends in both sexes and regions. Age-period-cohort curves were plotted to explain the incidence trends. Results. In Taiwan,...
Tue Sep 15, 2020 14:35
Background. Shock is one of the causes of mortality in the intensive care unit (ICU). Traditionally, hemodynamics related to shock have been monitored by broad-spectrum devices with treatment guided by many inaccurate variables to describe the pathophysiological changes. Critical care ultrasound (CCUS) has been widely advocated as a preferred tool to monitor shock patients. The purpose of this study was to analyze and broaden current knowledge of the characteristics of ultrasonic hemodynamic pattern...
Tue Sep 15, 2020 14:35
Purpose. To highlight the advantages of optical coherence tomography angiography (OCTA) in delineating the morphological features of the retinal and choroidal vascular network during acute, relapsing, and quiescent stages of macular toxoplasma retinochoroiditis. Methods. This prospective study included patients presenting with both active and quiescent ocular toxoplasmoses. OCTA was obtained to diagnose and follow the subsequent vascular network changes at diagnosis and six months after acute presentation....
Tue Sep 15, 2020 08:05
Purpose. The aim of this study is to identify hub genes and miRNAs by the miRNA-mRNA interaction network in dilated cardiomyopathy (DCM) disease. Methods. The differentially expressed miRNAs (DEMis) and mRNAs (DEMs) were selected using data of DCM patients downloaded from the GEO database (GSE112556 and GSE3585). Gene Ontology (GO) pathway analysis and transcription factor enrichment analysis were used for selecting DEMis, and the target mRNAs of DEMis were filtered by using miRDB, miRTarBase, and...
Tue Sep 15, 2020 08:05
Background. Psoriasis is a chronic, inflammatory, and multifactorial dermatosis that impairs quality of life (QoL). Health-related QoL has become an important element in medical decision-making along with the effectiveness and the harmlessness of the treatments. Objective. To assess the impact of psoriasis in the QoL of patients with psoriasis by using the DLQI scales. Methods. A cross-sectional study from January to June 2018 was conducted in the Department of Dermatology of the University Hospital...
Tue Sep 15, 2020 08:05
An increase in left atrial (LA) size in patients with arterial hypertension (AHT) has long been known to be associated with worse cardiovascular morbidity and mortality contributes to various complications, including atrial arrhythmias, stroke, and heart failure. The aim of our study was to evaluate the impact of arterial hypertension (AHT) on the LA size and function. This cross-sectional investigation included one hundred patients with essential hypertension without valvular or structural heart...
Tue Sep 15, 2020 08:05
Background. Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods. A retrospective study among hospitalized patients was conducted in July 2019 based on the Adverse Drug Events Active Surveillance and Assessment System-2 developed by the authors. Four controls...
Tue Sep 15, 2020 08:05
Large quantities of long noncoding RNAs (lncRNAs) have been verified to exert vital functions in the process of breast cancer (BC). lncRNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1) was reported to suppress the development of several cancers. However, its detailed function in BC remained unclear. In the current study, HAND2-AS1 was discovered to be low expressed in BC cell lines, and overexpression of HAND2-AS1 could repress proliferation, migration, and invasion but...
Tue Sep 15, 2020 08:05
Circular RNAs (circRNAs) act as a crucial part in many human diseases, particularly in cancers. circRNA HIPK3 (circHIPK3) is a special circRNA that may participate in the oncogenesis of non-small-cell lung cancer (NSCLC), even though its latent regulatory mechanism is not very clear. Here, we studied the roles of circHIPK3 in NSCLC. qRT-PCR assay was applied to study the expression of circHIPK3 in NSCLC. The influence of circHIPK3 on NSCLC was estimated by silencing circHIPK3 and miR-107 mock transfection...
Tue Sep 15, 2020 08:05
Background. The brain is in many ways an immunologically and pharmacologically privileged site because of the blood-brain barrier (BBB). But for chronic peripheral inflammation, inflammatory signals can be transmitted from the peripheral system into the central nervous system (CNS) through multiple channels and result in neuroinflammation. Leptomeningeal cells that form the BBB can trigger one signaling pathway by releasing cytokines to transmit inflammatory signals. Besides, the Janus kinase (JAK)...
Tue Sep 15, 2020 08:05
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Zeluleko Sibanda, Niloufar Farahani, Ebere Ogbonnaya, Erminia Albanese
Tue Sep 15, 2020 18:23
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Daishiro Abe, Toshihiro Ogiwara, Takuya Nakamura, Shunsuke Ichinose, Yu Fujii, Yoshiki Hanaoka, Kiyoshi Ito, Tetsuyoshi Horiuchi
Tue Sep 15, 2020 18:23
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Karlo M. Pedro, Katrina T. Roberto, Annabell E. Chua
Tue Sep 15, 2020 18:23
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Nolan J. Brown, Shane Shahrestani, Ali R. Tafreshi, Katelynn Tran, Brian V. Lien, Seth C. Ransom, Ryan C. Ransom, Luis Daniel Diaz-Aguilar, Ronald Sahyouni
Tue Sep 15, 2020 18:23
Publication date: December 2020Source: World Neurosurgery, Volume 144Author(s): Atul Goel, Chandrima Biswas, Abhidha Shah, Hardik Darji, Sagar Bhambere, Akshay Hawaldar
Tue Sep 15, 2020 18:23
Publication date: Available online 15 September 2020Source: World NeurosurgeryAuthor(s): Yukihiro Goto, Akihiko Hino, Yokoya Shigeomi, Hideki Oka
Tue Sep 15, 2020 18:23
Publication date: Available online 14 September 2020Source: World NeurosurgeryAuthor(s): Nitesh Damodara, Krishna Amuluru, Rolla Nuoman, Christian A. Bowers, Priyank Khandelwal, Sydney Moseley, Hussein Al-Shammari, Mohammad El-Ghanem, Chirag D. Gandhi, Fawaz Al-Mufti
Tue Sep 15, 2020 18:23
Publication date: Available online 14 September 2020Source: World NeurosurgeryAuthor(s): Christopher Banerjee, Brandy Cross, Jacob Rumley, John Devine, Edmond Ritter, John Vender
Tue Sep 15, 2020 18:23
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN01273D, PaperPauline Lefrançois, Bertrand Goudeau, Stephane ArbaultGiant unilamellar vesicles were used as individual biomimetic micro-reactors wherein a model bi-enzymatic reaction involving a glucose oxidase (GOx) and the horseradish peroxidase (HRP) was monitored by confocal microscopy. These...The content of this RSS Feed (c) The Royal Society of Chemistry
Tue Sep 15, 2020 02:00
Publication date: Available online 14 September 2020Source: Journal of Surgical EducationAuthor(s): Helen Kang Morgan, Abigail F. Winkel, Taylor Standiford, Rodrigo Muñoz, Eric A. Strand, David A. Marzano, Tony Ogburn, Carol A. Major, Susan Cox, Maya M. Hammoud
Tue Sep 15, 2020 18:18
Publication date: Available online 14 September 2020Source: Journal of Surgical EducationAuthor(s): Tad A. Manalo, Michelle I. Higgins, Brian Pettitt-Schieber, Barbara J. Pettitt, Akanksha Mehta, Lindsey M. Hartsell
Tue Sep 15, 2020 18:18
Publication date: Available online 14 September 2020Source: Journal of Surgical EducationAuthor(s): Anna Payne, Rafid Rahman, Roberta Bullingham, Sarita Vamadeva, Maryam Alfa-Wali
Tue Sep 15, 2020 18:18
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Amit Kumar, Kamal Sharma, Amit Rai Dixit
Tue Sep 15, 2020 18:11
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): John P. Berdahl, Tanner J. Ferguson, Thomas W. Samuelson
Tue Sep 15, 2020 18:11
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Andrzej Przekwas, Zhijian Chen
Tue Sep 15, 2020 18:11
Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Wee Song Yeo, Qin Xiang Ng
Tue Sep 15, 2020 18:11
Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages. Oncoimmunology. 2020;9(1):1731135 Authors: Smolag KI, Mueni CM, Leandersson K, Jirström K, Hagerling C, Mörgelin M, Barlow PN, Martin M, Blom AM Abstract Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement...
Tue Sep 15, 2020 18:06
Contribution of annexin A1 to anticancer immunosurveillance. Oncoimmunology. 2019;8(11):e1647760 Authors: Baracco EE, Stoll G, Van Endert P, Zitvogel L, Vacchelli E, Kroemer G Abstract Mouse cancers lacking the expression of annexin A1 (ANXA1) fail to respond to immunogenic chemotherapies. This has been initially explained by the requirement of extracellular ANXA1 (which is released from dying cancer cells) to engage formyl peptide receptor-1...
Tue Sep 15, 2020 18:06
Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC). Oncoimmunology. 2020 Aug 23;9(1):1806680 Authors: Schimanski CC, Kasper S, Hegewisch-Becker S, Schröder J, Overkamp F, Kullmann F, Bechstein WO, Vöhringer M, Öllinger R, Lordick F, Heinemann V, Geißler M, Schulz-Abelius A, Bernhard H, Schön MR, Greil R, Galle P, Lang H, Schmidtmann...
Tue Sep 15, 2020 18:06
IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice. Oncoimmunology. 2020 Aug 20;9(1):1806662 Authors: Richardson LG, Nieman LT, Stemmer-Rachamimov AO, Zheng XS, Stafford K, Nagashima H, Miller JJ, Kiyokawa J, Ting DT, Wakimoto H, Cahill DP, Choi BD, Curry WT Abstract The metabolic gene isocitrate dehydrogenase 1 (IDH1) is commonly mutated in lower grade glioma (LGG) and secondary glioblastoma (GBM). Regulatory T cells...
Tue Sep 15, 2020 18:06
NK cells beat T cells at early breast cancer control. Oncoimmunology. 2020 Aug 23;9(1):1806010 Authors: Buque A, Bloy N, Petroni G, Kroemer G, Galluzzi L Abstract Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play...
Tue Sep 15, 2020 18:06
Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse models. Oncoimmunology. 2020 Aug 15;9(1):1806009 Authors: Qin D, Li D, Zhang B, Chen Y, Liao X, Li X, Alexander PB, Wang Y, Li QJ Abstract The tumoricidal efficiency of human CAR-T cells is generally evaluated using immune-deficient mouse models; however, due to their immune-incompetency and the species-specific reactivity of a target antigen,...
Tue Sep 15, 2020 18:06
Metastasis immune-based scores predict patient survival. Oncoimmunology. 2020 Aug 20;9(1):1806000 Authors: Mlecnik B, Bindea G, Van den Eynde M, Galon J Abstract Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. A comprehensive analysis of all metastases of each patient revealed the heterogeneity of the colorectal metastatic disease and its clinical impact. Complex...
Tue Sep 15, 2020 18:06
Tropomyosin autoantibodies associated with checkpoint inhibitor myositis. Oncoimmunology. 2020 Aug 12;9(1):1804703 Authors: Zaenker P, Prentice D, Ziman M Abstract This brief report details the measurement and identification of IgA antibodies to tropomyosin in a case of presumed ocular myositis with paraspinal myositis in a patient with metastatic uveal melanoma treated with checkpoint inhibitors. High-throughput functional protein microarray...
Tue Sep 15, 2020 18:06
Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete response. Oncoimmunology. 2020 Aug 12;9(1):1804169 Authors: Kotsafti A, Scarpa M, Cavallin F, Fassan M, Salmaso R, Porzionato A, Saadeh L, Cagol M, Alfieri R, Castoro C, Rugge M, Castagliuolo I, Scarpa M Abstract After neoadjuvant chemoradiotherapy for esophageal adenocarcinoma, up to 29% of patients have a pathological complete response...
Tue Sep 15, 2020 18:06
Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells. Oncoimmunology. 2020 Aug 20;9(1):1803530 Authors: Chang CL, Wu CC, Hsu YT, Hsu YC Abstract Recurrence of advanced epithelial ovarian cancer is common despite optimal surgical debulking and initial favorable responses to chemotherapy. Evidences suggest that cancer stem cells (CSCs) have inherent resistance to conventional...
Tue Sep 15, 2020 18:06
Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice. Oncoimmunology. 2020 Aug 20;9(1):1802968 Authors: Van Hoecke L, Riederer S, Saelens X, Sutter G, Rojas JJ Abstract Vaccinia viruses (VACV) are a novel class of immune-oncolytic therapeutics and their mechanism of action is based both on their capacity to replicate selectively in cancer cells and to elicit danger signals that can boost...
Tue Sep 15, 2020 18:06
Intratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responses. Oncoimmunology. 2020 Aug 12;9(1):1802176 Authors: Xiang Z, Zhou Q, Zeng H, Wang Z, Zhang H, Liu Z, Huang Q, Chang Y, Bai Q, Xia Y, Wang Y, Liu L, Zhu Y, Xu L, Dai B, Wang J, Guo J, Xu J Abstract Our previous studies revealed tumor-infiltrating neutrophils (TINs) played dichotomous roles in different...
Tue Sep 15, 2020 18:06
Anti-tumor immunity influences cancer cell reliance upon ATG7. Oncoimmunology. 2020 Aug 23;9(1):1800162 Authors: Arensman MD, Yang XS, Zhong W, Bisulco S, Upeslacis E, Rosfjord EC, Deng S, Abraham RT, Eng CH Abstract Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has...
Tue Sep 15, 2020 18:06
Mitochondrial control of innate immune signaling by irradiated cancer cells. Oncoimmunology. 2020 Jul 22;9(1):1797292 Authors: Yamazaki T, Galluzzi L Abstract Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence...
Tue Sep 15, 2020 18:06
Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancer. Oncoimmunology. 2020 Jul 21;9(1):1795995 Authors: Kepp O, Zitvogel L, Kroemer G Abstract Lurbinectedin is a DNA-binding inhibitor of transcription that potently induces immunogenic cell death (ICD). In June 2020, the Federal Drug Administration (FDA) approved lurbinectedin for the salvage treatment of small-cell lung cancer that...
Tue Sep 15, 2020 18:06
Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic? Oncoimmunology. 2020 Jul 16;9(1):1794424 Authors: Gujar S, Pol JG, Kim Y, Kroemer G Abstract The COVID-19 pandemic has afflicted most countries on the planet. As a result, immunity against SARS-CoV-2, induced via natural infections or imminent vaccinations, is expected to develop in a large fraction of the global population....
Tue Sep 15, 2020 18:06
B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinoma. Oncoimmunology. 2020 Jul 16;9(1):1794359 Authors: Minici C, Rigamonti E, Lanzillotta M, Monno A, Rovati L, Maehara T, Kaneko N, Deshpande V, Protti MP, De Monte L, Scielzo C, Crippa S, Arcidiacono PG, Dugnani E, Piemonti L, Falconi M, Pillai S, Manfredi AA, Della-Torre E Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent stromal...
Tue Sep 15, 2020 18:06
Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination. Oncoimmunology. 2020 Jul 11;9(1):1792058 Authors: Lövgren T, Wolodarski M, Wickström S, Edbäck U, Wallin M, Martell E, Markland K, Blomberg P, Nyström M, Lundqvist A, Jacobsson H, Ullenhag G, Ljungman P, Hansson J, Masucci G, Tell R, Poschke I, Adamson L, Mattsson J, Kiessling R ...
Tue Sep 15, 2020 18:06
An unexpected link between immunogenic cell death and inhibition of gene transcription. Oncoimmunology. 2020 Jul 08;9(1):1792039 Authors: Humeau J, Sauvat A, Kepp O, Kroemer G PMID: 32923155 [PubMed]
Tue Sep 15, 2020 18:06
Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosis. Oncoimmunology. 2020 Jul 20;9(1):1792037 Authors: Kepp O, Liu P, Zhao L, Plo I, Kroemer G Abstract Increased exposure of calreticulin (CALR) on malignant cells is associated with therapy-relevant adaptive immune responses and superior therapeutic outcome in solid tumors and haemato-oncological diseases, because surface-exposed CALR acts as an 'eat-me'...
Tue Sep 15, 2020 18:06
Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma. Oncoimmunology. 2020 Jul 12;9(1):1792036 Authors: Dufresne A, Lesluyes T, Ménétrier-Caux C, Brahmi M, Darbo E, Toulmonde M, Italiano A, Mir O, Le Cesne A, Le Guellec S, Valentin T, Chevreau C, Bonvalot S, Robin YM, Coindre JM, Caux C, Blay JY, Chibon F Abstract Soft tissue sarcomas are a group of rare and aggressive connective...
Tue Sep 15, 2020 18:06
Colon-specific immune microenvironment regulates cancer progression versus rejection. Oncoimmunology. 2020 Jul 12;9(1):1790125 Authors: Trimaglio G, Tilkin-Mariamé AF, Feliu V, Lauzéral-Vizcaino F, Tosolini M, Valle C, Ayyoub M, Neyrolles O, Vergnolle N, Rombouts Y, Devaud C Abstract Immunotherapies have achieved clinical benefit in many types of cancer but remain limited to a subset of patients in colorectal cancer (CRC). Resistance to...
Tue Sep 15, 2020 18:06
Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responses. Oncoimmunology. 2020 Jul 08;9(1):1789284 Authors: Liu P, Zhao L, Ferrere G, Alves-Costa-Silva C, Ly P, Wu Q, Tian AL, Derosa L, Zitvogel L, Kepp O, Kroemer G Abstract Amid controversial reports that COVID-19 can be treated with a combination of the antimalarial drug hydroxychloroquine (HCQ) and the...
Tue Sep 15, 2020 18:06
Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer. Oncoimmunology. 2020 Jun 30;9(1):1788252 Authors: Chen H, Chong W, Yang X, Zhang Y, Sang S, Li X, Lu M Abstract Triple-negative breast cancer (TNBC) is characterized by broad genomic and transcriptional heterogeneity and results in a worse prognosis than other breast cancer types. Here, we integrated genomic...
Tue Sep 15, 2020 18:06
Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapy. Oncoimmunology. 2020 Jul 03;9(1):1785608 Authors: Feldmann A, Hoffmann A, Bergmann R, Koristka S, Berndt N, Arndt C, Rodrigues Loureiro L, Kittel-Boselli E, Mitwasi N, Kegler A, Lamprecht C, González Soto KE, Bachmann M Abstract Chimeric antigen receptor (CAR) T cells show remarkable therapeutic effects in some hematological malignancies. However,...
Tue Sep 15, 2020 18:06
Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world data. Oncoimmunology. 2020 Jun 23;9(1):1784529 Authors: Tian X, Xu W, Wang Y, Anwaier A, Wang H, Wan F, Zhu Y, Cao D, Shi G, Zhu Y, Qu Y, Zhang H, Ye D Abstract Objective: The purpose of this study was to explore the composition of tumor-infiltrating immune...
Tue Sep 15, 2020 18:06
Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer. Oncoimmunology. 2020 Jun 24;9(1):1783046 Authors: Sirniö P, Väyrynen JP, Mutt SJ, Herzig KH, Walkowiak J, Klintrup K, Mäkelä J, Karttunen TJ, Mäkinen MJ, Tuomisto A Abstract Systemic inflammation is a stage-independent marker of poor prognosis in colorectal cancer (CRC), activated in a complex, multifactorial process. It...
Tue Sep 15, 2020 18:06
The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosis. Oncoimmunology. 2020 Jun 23;9(1):1782575 Authors: Barone M, Catani L, Ricci F, Romano M, Forte D, Auteri G, Bartoletti D, Ottaviani E, Tazzari PL, Vianelli N, Cavo M, Palandri F Abstract Myelofibrosis (MF) is characterized by chronic inflammation and hyper-activation of the JAK-STAT pathway. Infections are one of the main...
Tue Sep 15, 2020 18:06
Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapy. Oncoimmunology. 2020 Jun 27;9(1):1782574 Authors: Vila-Leahey A, MacKay A, Portales-Cervantes L, Weir GM, Merkx-Jacques A, Stanford MM Abstract The induction of tumor-targeted, cytotoxic T lymphocytes has been recognized as a key component to successful immunotherapy. DPX-based treatment was previously shown...
Tue Sep 15, 2020 18:06
Tumor mutational burden is not predictive of cytotoxic chemotherapy response. Oncoimmunology. 2020 Jun 24;9(1):1781997 Authors: Nikanjam M, Riviere P, Goodman A, Barkauskas DA, Frampton G, Kurzrock R Abstract Background: High tumor mutational burden (TMB) predicts checkpoint blockade responsiveness, although the association with outcomes may be nuanced in certain tissue contexts. The correlation between TMB and cytotoxic chemotherapy sensitivity...
Tue Sep 15, 2020 18:06
A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapy. Oncoimmunology. 2020 Jun 26;9(1):1781333 Authors: Peng L, Qin BD, Xiao K, Xu S, Yang JS, Zang YS, Stebbing J, Xie LP Abstract Background: Subgroup analysis of clinical trials of PD-1/PD-L1 inhibitors have reported ethnic differences in outcomes. We systematically collected published data and performed a meta-analysis...
Tue Sep 15, 2020 18:06
Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma. Oncoimmunology. 2020 Jun 21;9(1):1779990 Authors: Marinari E, Allard M, Gustave R, Widmer V, Philippin G, Merkler D, Tsantoulis P, Dutoit V, Dietrich PY Abstract Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not...
Tue Sep 15, 2020 18:06
Turning tolerogenic into immunogenic ileal cell death through ileal microbiota: the key to unlock the mystery of colon cancer immunoscore? Oncoimmunology. 2020 Jun 14;9(1):1778834 Authors: Roberti MP, Picard M, Yonekura S, Zitvogel L Abstract Why PD-1 blockade is ineffective in the vast majority of colorectal cancers (CCs) lacking microsatellite instability but harboring high densities of tumor infiltrating T cells and follicular T helper...
Tue Sep 15, 2020 18:06
Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cells. Oncoimmunology. 2020 Jun 11;9(1):1777046 Authors: Sommaggio R, Cappuzzello E, Dalla Pietà A, Tosi A, Palmerini P, Carpanese D, Nicolè L, Rosato A Abstract Cytokine-Induced Killer (CIK) cells share several functional and phenotypical properties of both T and natural killer (NK) cells. They represent an attractive approach for cell-based...
Tue Sep 15, 2020 18:06
Modeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockade. Oncoimmunology. 2020 Jun 05;9(1):1776577 Authors: Lan X, Kedziorek DA, Chu C, Jablonska A, Li S, Kai M, Liang Y, Janowski M, Walczak P Abstract Currently, human glioma tumors are mostly modeled in immunodeficient recipients; however, lack of interactions with adaptive immune system is a serious flaw, particularly in the era when immunotherapies...
Tue Sep 15, 2020 18:06
Serum CCL27 predicts the response to Bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancer. Oncoimmunology. 2020 Jun 27;9(1):1776060 Authors: Zhong W, Wang B, Yu H, Lin J, Xia K, Hou W, Yang M, Chen J, Yang M, Wang X, Huang J, Lin T Abstract The prediction of the response to Bacillus Calmette-Guerin (BCG) can help identify non-muscle-invasive bladder cancer (NMIBC) patients that may be better served with alternative...
Tue Sep 15, 2020 18:06
IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophils. Oncoimmunology. 2020 Jun 16;9(1):1776059 Authors: Kienzl M, Hasenoehrl C, Valadez-Cosmes P, Maitz K, Sarsembayeva A, Sturm E, Heinemann A, Kargl J, Schicho R Abstract In many types of cancer, presence of eosinophils in tumors correlate with an improved disease outcome. In line with this, activated eosinophils have been shown to reduce tumor growth in...
Tue Sep 15, 2020 18:06
Impact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitors. Oncoimmunology. 2020 Jun 19;9(1):1776058 Authors: Won SE, Park HJ, Byun S, Pyo J, Kim JH, Choi CM, Lee JC, Lee DH, Kim SW, Yoon S, Kim KW Abstract Background: Immune checkpoint inhibitors (ICI) have become an important treatment option for non-small cell lung cancer (NSCLC). We aimed...
Tue Sep 15, 2020 18:06
Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patients. Oncoimmunology. 2020 Jun 03;9(1):1774323 Authors: Lazaridou MF, Gonschorek E, Massa C, Friedrich M, Handke D, Mueller A, Jasinski-Bergner S, Dummer R, Koelblinger P, Seliger B Abstract Tumor escape is often associated with abnormalities in the surface expression of the human leukocyte antigen class I...
Tue Sep 15, 2020 18:06
Efficacy and safety of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer (NSCLC): a systematic literature review. Oncoimmunology. 2020 Jun 16;9(1):1774314 Authors: Wagner G, Stollenwerk HK, Klerings I, Pecherstorfer M, Gartlehner G, Singer J Abstract Background: Therapeutic strategies with immune checkpoint inhibitors (ICIs) counteract the immunosuppressive effects of programmed cell death protein-1 (PD-1)...
Tue Sep 15, 2020 18:06
Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization. Oncoimmunology. 2020 Jun 03;9(1):1774281 Authors: He Y, Du J, Dong Z Abstract A large number of heterogeneous macrophages can be observed in solid tumor lesions. Classically activated M1 macrophages are a powerful killer of cancer cells. In contrast, tumor-associated macrophages (TAMs) are often referred...
Tue Sep 15, 2020 18:06
Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells. Oncoimmunology. 2020 Jun 16;9(1):1773204 Authors: Aguirre LA, Montalbán-Hernández K, Avendaño-Ortiz J, Marín E, Lozano R, Toledano V, Sánchez-Maroto L, Terrón V, Valentín J, Pulido E, Casalvilla JC, Rubio C, Diekhorst L, Laso-García F, Del Fresno C, Collazo-Lorduy A, Jiménez-Munarriz B, Gómez-Campelo P, Llanos-González E, Fernández-Velasco M, Rodríguez-Antolín C, Pérez de Diego...
Tue Sep 15, 2020 18:06
Proliferative potential and response to nivolumab in clear cell renal cell carcinoma patients. Oncoimmunology. 2020 Jun 10;9(1):1773200 Authors: Zhang T, Pabla S, Lenzo FL, Conroy JM, Nesline MK, Glenn ST, Papanicolau-Sengos A, Burgher B, Giamo V, Andreas J, Wang Y, Bshara W, Madden KG, Shirai K, Dragnev K, Tafe LJ, Gupta R, Zhu J, Labriola M, McCall S, George DJ, Ghatalia P, Dayyani F, Edwards R, Park MS, Singh R, Jacob R, George S, Xu B, Zibelman M, Kurzrock...
Tue Sep 15, 2020 18:06
Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanisms. Oncoimmunology. 2020 Jun 05;9(1):1773193 Authors: Das M, Stephen-Victor E, Bayry J Abstract Basophils play an important role in orienting Th2 immune response, and in the pathogenesis of allergic and inflammatory disorders. However, the mechanism by which basophils are kept in check remains unclear and hence we explored the role of...
Tue Sep 15, 2020 18:06
Cancer immunotherapy using a polysaccharide from Codium fragile in a murine model. Oncoimmunology. 2020 Jun 01;9(1):1772663 Authors: Park HB, Lim SM, Hwang J, Zhang W, You S, Jin JO Abstract Natural polysaccharides have shown immune modulatory effects with low toxicity in both animal and human models. A previous study has shown that the polysaccharide from Codium fragile (CFP) promotes natural killer (NK) cell activation in mice. Since...
Tue Sep 15, 2020 18:06
A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice. Oncoimmunology. 2020 Jun 22;9(1):1771925 Authors: Salomon N, Vascotto F, Selmi A, Vormehr M, Quinkhardt J, Bukur T, Schrörs B, Löewer M, Diken M, Türeci Ö, Sahin U, Kreiter S Abstract Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression...
Tue Sep 15, 2020 18:06
The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines. Oncoimmunology. 2020 Jun 01;9(1):1771142 Authors: Weis-Banke SE, Hübbe ML, Holmström MO, Jørgensen MA, Bendtsen SK, Martinenaite E, Carretta M, Svane IM, Ødum N, Pedersen AW, Met Ö, Madsen DH, Andersen MH Abstract One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2)....
Tue Sep 15, 2020 18:06
A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy. Oncoimmunology. 2020 Jun 02;9(1):1770565 Authors: Casadesús AV, Deligne C, Diallo BK, Sosa K, Josseaume N, Mesa C, León K, Hernández T, Teillaud JL Abstract Anti-CD20 treatment represents a therapeutic benefit for patients with B-cell lymphomas, although more efficient therapies are needed for refractory or relapsing patients. Among them, the combination of...
Tue Sep 15, 2020 18:06
A novel gene signature to predict immune infiltration and outcome in patients with prostate cancer. Oncoimmunology. 2020 Jun 01;9(1):1762473 Authors: Shao N, Tang H, Mi Y, Zhu Y, Wan F, Ye D Abstract Prostate cancer (PCa) is one of the most common malignancies in male. We aim to establish a novel gene signature for immune infiltration and outcome (biochemical recurrence (BCR) and overall survival (OS)) of patients with prostate cancer...
Tue Sep 15, 2020 18:06
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου