Publication date: Available online 14 September 2020Source: American Journal of OtolaryngologyAuthor(s): Mohamed A. Amer, Hossam S. El-Sherif, Ahmed S. Abdel-Hamid, Saad El-Zayat
Tue Sep 15, 2020 13:17
131 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: head and neck These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 13:13
Microscopic Resection Margins Adversely Influence Survival Rates After Surgery for Colorectal Liver Metastases: An Open Ambidirectional Cohort Study. Int J Surg. 2020 Sep 11;: Authors: Lee KS, Suchett-Kaye I, Abbadi R, Finch-Jones M, Pope I, Strickland A, Rees J Abstract BACKGROUND: Liver resection is the most effective treatment for patients with colorectal liver metastases (CRLMs). Patients with tumour at the resection margin (R1) are reported...
Tue Sep 15, 2020 13:07
An invited commentary: "Charlson Comorbidity Index predicts postoperative complications in surgically treated hip fracture patients in a tertiary care hospital: Retrospective cohort of 1045 patients" (International Journal of Surgery 2020; Epub ahead of Print). Int J Surg. 2020 Sep 11;: Authors: Zhang M, Fu S PMID: 32927148 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
Invited Commentary on ''Bullying and Undermining Behaviours in Surgery: A Qualitative Study of Surgical Trainee experiences in The United Kingdom (UK) & Republic of Ireland (ROI)''. Int J Surg. 2020 Sep 11;: Authors: Al-Saadi H PMID: 32927147 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
An invited commentary on "Comparing Different Kidney Stone Scoring Systems for Predicting Percutaneous Nephrolithotomy Outcomes: A Multicenter Retrospective Cohort Study". (International Journal of Surgery 2020; Epub ahead of Print). Int J Surg. 2020 Sep 11;: Authors: Nazim SM, Talati JJ PMID: 32927146 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
A Commentary on "The effect of increased abdominal pressure on internal jugular vein catheterization under ultrasound-guidance on conscious patients: A randomised controlled trial" (International Journal of Surgery 2020; 77:183-6). Int J Surg. 2020 Sep 11;: Authors: Hu B, Song Y, Duan H PMID: 32927145 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
Comparison of the efficacy and safety of thoracic endovascular aortic repair with open surgical repair and optimal medical therapy for acute type B aortic dissection: A systematic review and meta-analysis. Int J Surg. 2020 Sep 11;: Authors: Liu D, Luo H, Lin S, Zhao L, Qiao C Abstract BACKGROUND: Current treatment approaches for acute type B aortic dissection (TBAD) are diversified. Thoracic endovascular aortic repair (TEVAR) as an effective...
Tue Sep 15, 2020 13:07
Comparative study between P- POSSUM and APACHE II scores in predicting outcomes of perforation peritonitis: Prospective observational cohort study. Int J Surg. 2020 Sep 11;: Authors: Yelamanchi R, Gupta N, Durga CK, Korpal M Abstract BACKGROUND: Scoring systems are needed to prognosticate, compare and audit surgical procedures. Portsmouth Physiological and Operative Severity Score for the Enumeration of Mortality and morbidity (P-POSSUM) and...
Tue Sep 15, 2020 13:07
A Commentary on "A comparative overview of COVID-19, MERS and SARS: Review article" (International Journal of Surgery 2020; 81:1-8). Int J Surg. 2020 Sep 11;: Authors: Awais S, Hussain Shahb SF, Sarwar Shahc D SG PMID: 32927142 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
An Invited Commentary on "Does the intermittent Pringle's maneuver lose its clinical value in reducing bleeding during hepatectomy? A systematic review and meta-analysis" (International Journal of Surgery 2020 Epub ahead of Print) Is there still a role for the intermittent Pringle maneuver during hepatic resections? Int J Surg. 2020 Sep 11;: Authors: Wakam GK, Alam HB PMID: 32927141 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
Invited Commentary on "Impact of Hyperglycemia on Neuronal Apoptosis after Subarachnoid Hemorrhage in Rodent Brain: An Experimental Research". Int J Surg. 2020 Sep 11;: Authors: Kemp MT, Alam HB PMID: 32927140 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
Laparoscopic hepatectomy is safe and effective for the management of patients with colorectal cancer liver metastases in a population-based analysis in Ontario, Canada. A Retrospective Cohort Study. Int J Surg. 2020 Sep 11;: Authors: Griffiths CD, Xu K, Wang J, McKechnie T, Gafni A, Parpia S, Ruo L, Serrano PE Abstract BACKGROUND: Laparoscopic hepatectomy (LH) has been deemed safe, and, in the case of minor hepatectomy, the standard of care....
Tue Sep 15, 2020 13:07
Oblique lateral interbody fusion combined percutaneous pedicle screw fixation in the surgical treatment of single-segment lumbar tuberculosis: a single-center retrospective comparative study. Int J Surg. 2020 Sep 11;: Authors: Du X, Ou YS, Zhu Y, Luo W, Jiang GY, Jiang DM Abstract OBJECTIVE: To evaluate the clinical efficacy of oblique lateral interbody fusion combined posterior percutaneous pedicle screw fixation in the treatment of single...
Tue Sep 15, 2020 13:07
Invited commentary on "Prognostic effect of the new 5-factor modified frailty index in patients undergoing carotid endarterectomy with regional anesthesia-A prospective cohort study". Int J Surg. 2020 Sep 11;: Authors: Baram A PMID: 32927137 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
Importance of hyperglycemia in preoperative, intraoperative and postoperative periods in COVID-19 patients. Int J Surg. 2020 Sep 11;: Authors: Farahani F, Mirzaei F, Khodadadi I, Abbasi-Oshaghi E PMID: 32927136 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:07
Mesh position for hernia prophylaxis after midline laparotomy: A systematic review and network meta-analysis of randomized clinical trials. Int J Surg. 2020 Sep 11;: Authors: Tansawet A, Techapongsatorn S, Wilasrusmee C, Attia J, Thakkinstian A, Numthavaj P Abstract BACKGROUND: Mesh can be used to prevent incisional hernia (IH) occurrence. However, the effect of various mesh positions has never been compared. This study aimed to compare and...
Tue Sep 15, 2020 13:07
MiR-4668 as a Novel Potential Biomarker for Eosinophilic Esophagitis. Allergy Rhinol (Providence). 2020 Jan-Dec;11:2152656720953378 Authors: Bhardwaj N, Sena M, Ghaffari G, Ishmael F Abstract Introduction: Eosinophilic esophagitis (EoE) is a clinico-pathological diagnosis characterized by esophageal dysfunction and eosinophilic infiltration of the esophagus. Demonstration of esophageal eosinophilia (more than 15 eosinophils/hpf) in biopsy...
Tue Sep 15, 2020 13:05
Illustrative Case Series and Narrative Review of Therapeutic Failure of Immunotherapy for Allergic Rhinitis. Allergy Rhinol (Providence). 2020 Jan-Dec;11:2152656720943822 Authors: Campisi L, Yong PFK, Kasternow B, Karim MY Abstract This is a series of 4 cases (3 therapeutic failure and 1 early relapse) in adult patients treated with allergen immunotherapy (AIT) for allergic rhinitis (AR) in our immunotherapy clinic, which treats 110 new...
Tue Sep 15, 2020 13:05
Local therapies for liver metastases of rare head and neck cancers: A monoinstitutional case series.
Local therapies for liver metastases of rare head and neck cancers: A monoinstitutional case series. Tumori. 2020 Sep 14;:300891620952844 Authors: Bergamini C, Cavalieri S, Cascella T, Lanocita R, Alfieri S, Resteghini C, Platini F, Orlandi E, Locati LD, Marchianò A, Licitra L Abstract INTRODUCTION: Transarterial chemoembolization (TACE) and radiofrequency ablation (RFA) are established procedures for treating hepatocellular cancer and selected...
Tue Sep 15, 2020 13:01
Eccrine Porocarcinoma: Avoiding Diagnostic Delay. Foot Ankle Spec. 2020 Oct;13(5):415-419 Authors: Jarocki C, Kozlow J, Harms PW, Schmidt BM Abstract Skin cancer is the most common cancer within the United States. Reports estimate that 1 in 5 Americans will develop some form of skin cancer. Eccrine porocarcinoma is a rare type of skin cancer of sweat gland origin. Eccrine porocarcinoma is most commonly found on the lower extremities. Clinically...
Tue Sep 15, 2020 13:01
Recurrent uterine tumors resembling ovarian sex-cord tumors with the growth regulation by estrogen in breast cancer 1-nuclear receptor coactivator 2 fusion gene: a case report and literature review. Diagn Pathol. 2020 Sep 14;15(1):110 Authors: Chang B, Bai Q, Liang L, Ge H, Yao Q Abstract BACKGROUND: Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare mesenchymal neoplasms predominantly arising in perimenopausal and postmenopausal...
Tue Sep 15, 2020 13:01
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Tue Sep 15, 2020 13:01
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Tue Sep 15, 2020 13:01
Related Articles Phyllodes Tumor of the Breast in Pregnancy and Lactation. Adv Exp Med Biol. 2020;1252:137-142 Authors: Alipour S, Eskandari A Abstract Phyllodes tumor constitutes around 1% of all and 2.5% of fibroepithelial breast lumps. Three types including benign, borderline, and malignant tumors have been described. The benign variant is the most common, is close to fibroadenoma, but is usually larger and recurs more frequently. The rare...
Tue Sep 15, 2020 13:01
Related Articles Local Complications of Breast Surgery during Pregnancy and Lactation. Adv Exp Med Biol. 2020;1252:101-105 Authors: Alipour S Abstract During pregnancy and lactation, breast vascularity increases and edema occurs in the breast . As a consequence, rate of complications of breast biopsy and surgery like bleeding, infection, delayed healing and wound dehiscence is expected to be higher. Milk fistula is a rare event that may complicate...
Tue Sep 15, 2020 13:01
Related Articles Clinical Presentation, Diagnosis and Prognosis of Pregnancy-Associated Breast Cancer. Adv Exp Med Biol. 2020;1252:87-93 Authors: Sun J, Lee MC Abstract Breast cancer in pregnancy is a rare entity generally presenting as a persistent breast mass, but is often a delayed finding due to the expected physiologic changes in the breast related to pregnancy and lactation. The preferred diagnostic workup of a persistent breast mass...
Tue Sep 15, 2020 13:01
Related Articles Benign Disorders of the Breast in Pregnancy and Lactation. Adv Exp Med Biol. 2020;1252:43-51 Authors: Taib NA, Rahmat K Abstract Benign cystic or solid lumps frequently occur in the breasts of young women, and consequently can also be seen during pregnancy and lactation. Simple cysts do not increase the risk of malignancy. The current management is routine follow-up. Complex cysts are thick walled or contain a mass, and should...
Tue Sep 15, 2020 13:01
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Tue Sep 15, 2020 13:01
Related Articles Phase II trial of pazopanib in patients with metastatic or unresectable chemoresistant sarcomas: A Japanese Musculoskeletal Oncology Group study. Cancer Sci. 2020 Sep;111(9):3303-3312 Authors: Urakawa H, Kawai A, Goto T, Hiraga H, Ozaki T, Tsuchiya H, Nakayama R, Naka N, Matsumoto Y, Kobayashi E, Okuma T, Kunisada T, Ando M, Ueda T, Nishida Y Abstract Alveolar soft part sarcoma (ASPS), epithelioid sarcoma (ES), and clear cell...
Tue Sep 15, 2020 13:01
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Tue Sep 15, 2020 13:01
Related Articles Cystic adventitial disease of the common femoral vein: A case report. Vascular. 2020 Aug;28(4):489-493 Authors: Guo F, Guo Y Abstract OBJECTIVES: Cystic adventitial disease is an extremely rare vascular disorder and is often misdiagnosed. In order to improve the knowledge and treatment of this disease, a case of venous cystic adventitial disease was reported. METHODS: The whole processes about the diagnosis and treatment...
Tue Sep 15, 2020 13:01
Related Articles Tenosynovial giant cell tumor of the cervical spine: a case report. Spinal Cord Ser Cases. 2019 02 25;5(1):23 Authors: Furuhata R, Iwanami A, Tsuji O, Nagoshi N, Suzuki S, Okada E, Fujita N, Yagi M, Matsumoto M, Nakamura M, Watanabe K Abstract INTRODUCTION: Tenosynovial giant cell tumors (TSGCTs) generally occur in the limb joints, and only rarely in the spine. This case report describes a patient with TSGCT of the spine at...
Tue Sep 15, 2020 13:01
Related Articles Disseminated, yet dissembled: Rare infections behind the veil of classical hairy cell leukemia. Leuk Res. 2020 03;90:106315 Authors: Shallis RM, Patel TH, Podoltsev NA, Xu ML, Azar MM, Gore SD PMID: 32036123 [PubMed - indexed for MEDLINE]
Tue Sep 15, 2020 13:01
Related Articles Clinical features and treatment outcomes in patients with T-cell large granular lymphocytic leukemia: A single-institution experience. Leuk Res. 2020 03;90:106299 Authors: Zhu Y, Gao Q, Hu J, Liu X, Guan D, Zhang F Abstract AIM: Large granular lymphocyte leukemia (LGLL) is a rare lymphoproliferative disorder associated with failure of hematopoiesis and autoimmune diseases. This study describes the clinical features and treatment...
Tue Sep 15, 2020 13:01
Related Articles Comparative Analysis of Safety and Efficacy of Transarterial Chemoembolization for the Treatment of Hepatocellular Carcinoma in Patients with and without Pre-Existing Transjugular Intrahepatic Portosystemic Shunts. J Vasc Interv Radiol. 2020 Mar;31(3):409-415 Authors: Ruohoniemi DM, Taslakian B, Aaltonen EA, Hickey R, Patel A, Horn JC, Chiarello M, McDermott M Abstract PURPOSE: To compare the safety and efficacy of transarterial...
Tue Sep 15, 2020 13:01
Related Articles Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database. Leuk Res. 2020 02;89:106301 Authors: Qasrawi A, Gomes V, Chacko CA, Mansour A, Kesler M, Arora R, Wei S, Ramlal R, Munker R Abstract Acute undifferentiated leukemia (AUL) is rare and defined by the absence of bona fide myeloid and lymphoid markers. Little is known about its incidence, survival and optimal management in the...
Tue Sep 15, 2020 13:01
Related Articles Hepatobiliary and Pancreatic: Hemosuccus pancreaticus due to an intraductal papillary mucinous neoplasm: A rare cause of obscure gastrointestinal bleeding. J Gastroenterol Hepatol. 2020 Mar;35(3):363 Authors: Sugiura R, Kinoshita K, Naruse H, Yamamoto Y, Hatanaka K, Ito J, Miyamoto S, Higashino M, Hayasaka S, Tsuchida N, Nakanishi K, Ueki S, Umehara M, Shimoyama N, Mitsuhashi T, Sakamoto N PMID: 31958167 [PubMed - indexed for MEDLINE]
Tue Sep 15, 2020 13:01
Related Articles Endobronchial Small-cell Lung Cancer with Intraluminal Growth Pattern Showing "Finger-in-glove" Appearance. Intern Med. 2020 Mar 01;59(5):701-704 Authors: Kitahara Y, Murakami Y, Nakai S, Hiramatsu T, Kishimoto Y, Nihashi F, Aono Y, Eifuku T, Uto T, Sato J, Imokawa S, Suda T Abstract Invasion of the endobronchial mucosa by cancer cells is frequently seen in small cell lung cancer (SCLC), but an intraluminal polypoid growth...
Tue Sep 15, 2020 13:01
Related Articles Corticosteroid-induced Kaposi's Sarcoma Revealed by Severe Anemia: A Case Report and Literature Review. Intern Med. 2020 Mar 01;59(5):625-631 Authors: Endo G, Nagata N Abstract We herein report a case of gastrointestinal (GI) Kaposi's sarcoma (KS) without cutaneous involvement in a 73-year-old man who had received immunosuppressive drugs for granulomatosis with polyangiitis. After one year of prednisolone use, he presented...
Tue Sep 15, 2020 13:01
Related Articles Single Rectal Neuroendocrine Tumor Associated with Multiple Endocrine Cell Micronests. Intern Med. 2020 Mar 01;59(5):619-623 Authors: Suzuki S, Kawakami H, Miike T, Yamamoto S, Abe H, Shimoda K, Ashizuka S, Inatsu H, Kubota Y, Ban T, Yorita K, Kataoka H Abstract Although a few reports of neuroendocrine tumor (NET) in the stomach or appendix with surrounding micronests have been published, cases of rectal NET are rare. We herein...
Tue Sep 15, 2020 13:01
Related Articles Myasthenia gravis: Historical achievements and the "golden age" of clinical trials. J Neurol Sci. 2019 Nov 15;406:116428 Authors: Nguyen-Cao TM, Gelinas D, Griffin R, Mondou E Abstract Since the death of Chief Opechankanough >350 years ago, the myasthenia gravis (MG) community has gained extensive knowledge about MG and how to treat it. This review highlights key milestones in the history of treatment and discusses the...
Tue Sep 15, 2020 13:01
Related Articles Hemophagocytic syndrome, a diagnostic challenge in Gastroenterology. Rev Esp Enferm Dig. 2019 10;111(10):816 Authors: Jiménez Rosales R, Martín-Rodríguez MDM, Redondo-Cerezo E Abstract Hemophagocytic lymphohistiocytosis is a syndrome of severe immune activation with macrophage and T- cell infiltration resulting in multi organ damage. We report the case of a patient successfully treated for a haemophagocytic syndrome triggered...
Tue Sep 15, 2020 13:01
Related Articles Ectopic hepatocellular carcinoma arising from the peritoneum. Rev Esp Enferm Dig. 2019 10;111(10):809-811 Authors: Martínez-Acitores D, Hernández Ainsa M, Cortés García L, Bengochea Martínez ML, Palacios Fanlo MJ Abstract Ectopic hepatocellular carcinoma is a rare entity. Most cases are asymptomatic and are occasionally found during autopsy or laparoscopy. They may sometimes cause relevant clinical problems such as abdominal...
Tue Sep 15, 2020 13:01
Related Articles POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas. J Am Heart Assoc. 2019 09 17;8(18):e012875 Authors: Calvete O, Garcia-Pavia P, Domínguez F, Mosteiro L, Pérez-Cabornero L, Cantalapiedra D, Zorio E, Ramón Y Cajal T, Crespo-Leiro MG, Teulé Á, Lázaro C, Morente MM, Urioste M, Benitez J Abstract Background Mutations in the POT1 gene explain abnormally...
Tue Sep 15, 2020 13:01
Related Articles Intraductal papillary mucinous neoplasm of the biliary tract: a lesion of the bile duct lumen. Rev Esp Enferm Dig. 2019 10;111(10):796-797 Authors: Sánchez Rodríguez E, Caminoa Lizarralde A, Foruny Olcina JR, Vázquez Sequeiros E Abstract Intraductal papillary neoplasm of the bile duct (IPNB) is a rare entity characterized by papillary growth within the bile duct lumen1, currently regarded as a biliary counterpart of intraductal...
Tue Sep 15, 2020 13:01
Related Articles Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood. Cell Rep. 2019 09 03;28(10):2728-2738.e7 Authors: Peng S, Zaretsky JM, Ng AHC, Chour W, Bethune MT, Choi J, Hsu A, Holman E, Ding X, Guo K, Kim J, Xu AM, Heath JE, Noh WJ, Zhou J, Su Y, Lu Y, McLaughlin J, Cheng D, Witte ON, Baltimore D, Ribas A, Heath JR Abstract Neoantigen-specific T cells are increasingly viewed as important...
Tue Sep 15, 2020 13:01
Related Articles Different magnetic resonance imaging features between MOG antibody- and AQP4 antibody-mediated disease: A Chinese cohort study. J Neurol Sci. 2019 Oct 15;405:116430 Authors: Chen C, Liu C, Fang L, Zou Y, Ruan H, Wang Y, Cui C, Sun X, Peng L, Qiu W Abstract Few studies have compared radiological features obtained on magnetic resonance imaging (MRI) between myelin oligodendrocyte glycoprotein antibody (MOG-ab)- and aquaporin...
Tue Sep 15, 2020 13:01
Related Articles Genetic risk association of CDKN1A and RET gene SNPs with medullary thyroid carcinoma: Results from the largest MTC cohort and meta-analysis. Cancer Med. 2019 10;8(13):6151-6161 Authors: Mishra V, Kowtal P, Rane P, Sarin R Abstract BACKGROUND: Medullary thyroid carcinoma (MTC) is a rare subtype of thyroid cancer. Other than gain-of-function RET mutations, no other genetic, lifestyle or environmental risk associations have...
Tue Sep 15, 2020 13:01
Related Articles Everolimus as adjunctive therapy for tuberous sclerosis complex-associated partial-onset seizures. Expert Rev Neurother. 2019 10;19(10):913-925 Authors: Lechuga L, Franz DN Abstract Introduction: Tuberous sclerosis complex (TSC) is a rare genetic disorder resulting in benign tumors in various organs. It is caused by mutations in TSC1 or TSC2 genes causing hyperactivation of the mammalian target of rapamycin (mTOR) pathway. The...
Tue Sep 15, 2020 13:01
Related Articles Poorly differentiated thyroid carcinoma : An underdiagnosed entity. Pathologe. 2020 Jun;41(Suppl 1):1-8 Authors: Dettmer MS, Schmitt A, Komminoth P, Perren A Abstract Poorly differentiated thyroid carcinomas (PDTCs) are a rare subtype of thyroid carcinomas that are biologically situated between well-differentiated papillary/follicular thyroid carcinomas and anaplastic thyroid carcinomas (ATCs).The diagnosis of conventional...
Tue Sep 15, 2020 13:01
Related Articles 68Ga-NOTA-Aca-BBN(7-14) PET imaging of GRPR in children with optic pathway glioma. Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2152-2162 Authors: Zhang J, Tian Y, Li D, Niu G, Lang L, Li F, Liu Y, Zhu Z, Chen X Abstract PURPOSE: Optic pathway glioma (OPG) is a rare neoplasm that arises predominantly during childhood. Its location in a sensitive region involving the optic pathways, onset in young patients and controversial therapy...
Tue Sep 15, 2020 13:01
Related Articles Congenital Forearm Pseudarthrosis, a Systematic Review for a Treatment Algorithm on a Rare Condition. J Pediatr Orthop. 2020 May/Jun;40(5):e367-e374 Authors: Siebelt M, de Vos-Jakobs S, Koenrades N, van Nieuwenhoven CAV, Oostenbrink R, Bramer WM, Verhaar JAN, Bessems GJHJM, Kempink DRJ Abstract BACKGROUND: A congenital forearm pseudarthrosis is a rare condition and is strongly associated with neurofibromatosis type 1. Several...
Tue Sep 15, 2020 13:01
Related Articles Indole Diterpenoids from an Endophytic Penicillium sp. J Nat Prod. 2019 06 28;82(6):1412-1423 Authors: Ariantari NP, Ancheeva E, Wang C, Mándi A, Knedel TO, Kurtán T, Chaidir C, Müller WEG, Kassack MU, Janiak C, Daletos G, Proksch P Abstract A chemical investigation of the endophyte Penicillium sp. (strain ZO-R1-1), isolated from roots of the medicinal plant Zingiber officinale, yielded nine new indole diterpenoids (1-9), together...
Tue Sep 15, 2020 13:01
Related Articles A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity). Front Immunol. 2019;10:777 Authors: Riaz IB, Faridi W, Patnaik MM, Abraham RS Abstract Primary immunodeficiencies and immune dysregulatory disorders (PIDDs; now referred to as inborn errors in immunity) are rare disorders with a prevalence of...
Tue Sep 15, 2020 13:01
Related Articles Antigen Extraction and B Cell Activation Enable Identification of Rare Membrane Antigen Specific Human B Cells. Front Immunol. 2019;10:829 Authors: Zimmermann M, Rose N, Lindner JM, Kim H, Gonçalves AR, Callegari I, Syedbasha M, Kaufmann L, Egli A, Lindberg RLP, Kappos L, Traggiai E, Sanderson NSR, Derfuss T Abstract Determining antigen specificity is vital for understanding B cell biology and for producing human monoclonal...
Tue Sep 15, 2020 13:01
Related Articles FIGO Stage Is the Strongest Prognostic Factor in Adenocarcinoma of the Uterine Cervix. J Obstet Gynaecol Can. 2019 Sep;41(9):1318-1324 Authors: Glaze S, Duan Q, Sar A, Lee S, Köbel M, Park E, Duggan MA Abstract OBJECTIVE: This study aimed to identify clinical and pathological determinants of invasive adenocarcinoma of the uterine cervix (AC) in a large, single-centre series serving a population of 1.5 million. METHODS:...
Tue Sep 15, 2020 13:01
Related Articles Occult Vaginal Evisceration: A Case Report. J Obstet Gynaecol Can. 2019 Sep;41(9):1341-1343 Authors: Shehata F, Bougie O, Baker K, Khalil H Abstract BACKGROUND: Vaginal evisceration is a rare gynaecologic emergency that necessitates surgical intervention. It may manifest with obvious vaginal rupture, or it may be occult, specifically in patients with chronic pelvic organ prolapse. CASE: A 66-year-old woman with a history...
Tue Sep 15, 2020 13:01
Related Articles A modified DAW-22 compound F-B1 inhibits Bcr/Abl and induces apoptosis in chronic myelogenous leukemia cells. Anticancer Drugs. 2019 02;30(2):159-166 Authors: Wang F, Wang J, Chong Z, Mu Y Abstract The Bcr/Abl kinase is an oncogenic fusion protein that plays a central role in the pathogenesis of chronic myeloid leukemia (CML). Some small-molecule kinase inhibitors such as imatinib were developed in the treatment of CML; however,...
Tue Sep 15, 2020 13:01
Related Articles Ewing Sarcoma in an Infant Metacarpal. J Hand Surg Am. 2019 Aug;44(8):701.e1-701.e5 Authors: Skinner S, Conant S, Lansinger Y Abstract We describe a case of Ewing sarcoma in the metacarpal of a 5-month-old male. After pain, erythema, and swelling of the hand failed to resolve with antibiotics, radiographs and magnetic resonance imaging raised suspicion for a neoplastic condition. Open biopsy confirmed the diagnosis of Ewing...
Tue Sep 15, 2020 13:01
Related Articles Intraosseous cavernous malformations of the skull: clinical characteristics and long-term surgical outcomes. Neurosurg Rev. 2020 Feb;43(1):231-239 Authors: Wang C, Zhang D, Wang S, Zhang Y, Wang R, Zhao J Abstract Intraosseous cavernous malformations (ICMs) of the skull are relatively rare, benign, and slow-growing tumors. Knowledge of these lesions is poor. The goals of this study were to describe the clinical manifestations,...
Tue Sep 15, 2020 13:01
Objective Soft tissue metastases (STM) in head and neck cutaneous squamous cell carcinoma (HNcSCC) are non‐nodal based metastases to the parotid and cervical soft tissues of the head and neck. This is a unique subgroup of regional metastases amongst patients with cSCC and have been shown to be associated with poor prognosis. Detailed studies of this subgroup are lacking in the literature. A retrospective cohort analysis was performed to characterize the prognostic significance of STM in HNcSCC based...
Mon Sep 14, 2020 20:39
Fruit cracking is a physiological disorder in many plant species that leads to severe economic losses. The aim of this study was to investigate the effect of calcium on fruit cracking and explore the underlying mechanisms. We studied the effect of exogenous calcium on grape berry cracking, calcium absorbance and distribution, and cell wall metabolism in the cracking-susceptible cultivar ‘Xiangfei’. Calcium significantly reduced the frequency of fruit cracking, increased the break force of the berry...
Tue Sep 15, 2020 03:00
Background Growing evidence indicates that proanthocyanidins (PACs) may be effective in treating and preventing various cancers. The fundamental mechanism of PACs inhibiting the proliferation at cellular and molecular levels in most of the cancer types remains unclear. Objective The anticancer efficacy of PACs was investigated in vitro using three human cancer cell lines: human colorectal adenocarcinoma (HT-29), human...
Tue Sep 15, 2020 03:00
Background Implementing sustainable farming practices for winter wheat (Triticum aestivum L.) in the North China Plain may be a way to reduce carbon emissions. No tillage generally results in less net CO2 loss from farmland, but no tillage also reduces the grain yield and water use efficiency (WUE) of winter wheat. Wide-precision planting of winter wheat may enhance the grain yield and WUE; however, it is not known precisely how tillage and planting patterns affect CO2 exchange,...
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18431-7Two-photon excited near-infrared fluorescence materials have garnered considerable attention because of their superior optical properties compared with other optical materials. Here, the authors use a convenient and efficient supramolecular approach to synthesize a two-photon excited near-infrared emissive co-crystalline material.
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18674-4Publisher Correction: ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18389-6Light-based modulation of the microtubule (MT) cytoskeleton is an attractive goal for spatiotemporally-resolved MT studies. Here the authors develop a first generation photoswitchable small molecule MT stabiliser based on paclitaxel, allowing optical control over cellular MT dynamics.
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18257-3RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a serine triplet is required for the negative regulation of Wnt signalling and that the phosphorylation of RNF43 suppresses cancer-associated oncogenic RNF43 mutants.
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18078-4The blooming alga Emiliania huxleyi and its viruses are a model for density-dependent virulent dynamics. However, Knowles et al. show that this host–virus system exhibits temperate dynamics at natural host densities, in a manner dependent on host physiology.
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18476-8A biologically-interpretable and robust metric that provides insight into one’s health status from a gut microbiome sample is an important clinical goal in current human microbiome research. Herein, the authors introduce a species-level index that predicts the likelihood of having a disease.
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18344-5Official data on the distribution of human population often ignores the changing spatio-temporal densities resulting from mobility. Here, authors apply an approach combining official statistics and geospatial data to assess intraday and monthly population variations at continental scale at 1 km2 resolution.
Tue Sep 15, 2020 03:00
Nature Communications, Published online: 15 September 2020; doi:10.1038/s41467-020-18224-yThe design principles underlying biomolecular phase separation of membrane-less organelles remain poorly understood. Using model homopolymers, Fisher et al. show that the formation kinetics of coexisting liquid phases can be tuned by exploiting differences between arginine and lysine residues.
Tue Sep 15, 2020 03:00
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Pancreatic cancer is an aggressive type of cancer with poor prognosis, short survival rate, and high mortality. Drug resistance is a major cause of treatment failure in the disease. MiR-331-3p has been reported to play an important role in several cancers. We previously showed that miR-331-3p is upregulated in pancreatic cancer and promotes pancreatic cancer cell proliferation and epithelial-to-mesenchymal...
Mon Sep 14, 2020 13:16
Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancer types in China. In recent years, progress has been made in various types of cancer genomics including ESCC. However, the clinical significance of genomic variation of ESCC remains poorly defined. In the present study, genomic sequencing data from 469 ESCC cases were analyzed and potential therapeutic targets in the Druggable Genome...
Mon Sep 14, 2020 12:25
Background Refractory chronic rhinosinusitis (CRS) remains a significant burden for patients, often leaving them with few therapeutic options that provide low‐morbidity, long‐term, and meaningful symptomatologic and endoscopic disease improvement. Macrolides have long been thought to offer both an immunomodulatory and antimicrobial effect. Our objective was to evaluate the efficacy of low‐dose, long‐term azithromycin in a carefully selected high‐risk population failing appropriate medical therapy...
Tue Sep 15, 2020 12:21
Comparison of Genetic Variants and Manifestations of OTUD6B-Related Disorder: The First Mexican Case
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. The intellectual disability syndrome characterized by seizures and dysmorphic features was initially described in 2017 and was associated with genetic variants in the OTUD6B gene, identified by exome sequencing (ES) in a large cohort. This multisystem disorder primarily affects the central nervous system, the gastrointestinal, and the skeletal systems. In this article, we describe the first Mexican...
Mon Sep 14, 2020 09:33
Abstract As the global COVID-19 pandemic evolves, our knowledge of the respiratory and non-respiratory symptoms continues to grow. One such symptom, anosmia, may be a neurologic marker of coronavirus infection and the initial presentation of infected patients. Because this symptom is not routinely investigated by imaging, there is conflicting literature on neuroimaging abnormalities related to COVID-19-related anosmia. We present a novel case of COVID-19 anosmia with definitive...
Tue Sep 15, 2020 03:00
Abstract Abnormal activation of Nuclear factor kappa B (NF‐κB) signaling pathway is closely implicated in triple‐negative breast cancer (TNBC) growth, metastasis and tumor immune escape. In this study, the anti‐cancer effects of icariin, a natural flavonol glycoside, towards breast cancer cells and the underlying mechanisms were investigated. This investigation showed that icariin selectively inhibited proliferation and triggered apoptosis in breast cancer cells in a concentration‐ and time‐dependent...
Mon Sep 14, 2020 14:04
Abstract This prespecified subanalysis of the global, randomized controlled phase 3 KEYNOTE‐024 study of pembrolizumab versus chemotherapy in previously untreated metastatic non–small‐cell lung cancer without EGFR/ALK alterations and a PD‐L1 tumor proportion score ≥50% evaluated clinical outcomes among patients enrolled in Japan. Treatment consisted of pembrolizumab 200 mg every 3 weeks (35 cycles) or platinum‐based chemotherapy (4‒6 cycles). The primary endpoint was progression‐free survival; secondary...
Mon Sep 14, 2020 12:39
Abstract Intracranial aneurysms arising from the distal anterior choroidal artery (AChA) are uncommon entities, with less than 30 cases reported. A 4-year-old boy was admitted to the Emergency Department with a sudden onset of severe headache and vomiting. CT scan of the head showed signs of intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH). Cerebral angiography revealed a right AChA aneurysm arising from a distal intraventricular branch with an associated microarteriovenous...
Tue Sep 15, 2020 03:00
Abstract Purpose To investigate the incidence rate of hereditary disease in patients with medulloblastoma. Methods The genetic reports of 129 patients with medulloblastoma from January 2016 to December 2019 were retrospectively analyzed. A panel sequence of 39 genes (Genetron Health) were used for all patients to evaluate the tumor subgroup. Four genes...
Tue Sep 15, 2020 03:00
Key points Type I interferon receptors are expressed by the majority of vagal C‐fibre neurons innervating the respiratory tract Interferon alpha and beta acutely and directly activate vagal C‐fibers in the airways. The interferon‐induced activation of C‐fibers occurs secondary to stimulation of type 1 interferon receptors Type 1 interferons may contribute to the symptoms as well as the spread of respiratory viral infections by causing coughing and other defensive reflexes associated with vagal...
Mon Sep 14, 2020 22:54
Key points During early postnatal development mitral cells show either irregular bursting or non‐bursting firing patterns Bursting mitral cells preferentially fire during theta bursts in the neonatal OB, being locked to the theta phase Bursting mitral cells preferentially fire during theta bursts in the neonatal lateral entorhinal cortex and are temporally related to both respiration rhythm‐ and theta phase Bursting mitral cells act as a cellular substrate of the olfactory drive that promotes...
Mon Sep 14, 2020 17:05
Abstract Background Salivary gland lymphadenoma (LAD) is a rare benign neoplasm comprising sebaceous (SLAD) and nonsebaceous (NSLAD) types. Despite established histologic criteria, limited data on cytomorphology, tumor heterogeneity, and overlap with other entities make the diagnosis of LAD by fine needle aspiration (FNA) challenging. We describe a multi‐institutional cohort of 14 LADs with cytology, clinical, radiologic, and histopathologic data. Methods Our cohort included nine SLAD and...
Mon Sep 14, 2020 16:15
Abstract Neurohypophysis granular cell tumor (NGCT) is a rare entity and is classified under thyroid transcription factor 1 (TTF‐1) expressing tumors of pituitary. It is considered as an uncommon differential during sellar and suprasellar mass evaluation. Its intraoperative squash cytology is distinct and has rarely been reported in literature. A 65‐year‐old female presented with reduced vision of right eye and history of seizures. Radiological findings revealed a sellar/suprasellar mass with mass...
Mon Sep 14, 2020 16:13
We report two fetal cases carrying a de novo MID1 mutation and presenting with severe hydrothorax, suggesting the expansion of the phenotype of Opitz GBBB syndrome
Mon Sep 14, 2020 16:31
BNAR syndrome (MIM608980) is a very rare condition: nine cases belonging to three unrelated families were reported since its first description in 2002. The distinctive clinical feature is the bifidity of the tip of the nose and its association with anorectal and/or renal anomalies. Its molecular basis consisting of biallelic FREM1 missense or nonsense mutations was elucidated after studying the original Egyptian family and was confirmed in two families originating from Afghanistan and Pakistan....
Mon Sep 14, 2020 16:09
Background This study aimed to develop an analytical method using liquid chromatography tandem mass spectrometry (LC-MS/MS) for the determination of angiotensin (Ang) I, Ang (1-9), Ang II, Ang (1-7), Ang (1-5), Ang III, Ang IV in human umbilical vein endothelial cell (HUVEC) culture supernatant. Methods HUVEC culture supernatant was added with gradient concentrations (0.05–1,000 ng/ml) of standard solutions of the Ang...
Tue Sep 15, 2020 03:00
Abstract An intermediate phenotype of a disease is a trait in the path of pathogenesis from genetic predisposition to disease manifestation. Identifying intermediate phenotypes with high heritability is helpful in delineating the genetics of a disorder. In this study, we aimed to examine various traits with regards to obesity, cardiovascular risk and upper airway structure to identify potential intermediate phenotypes of childhood obstructive sleep apnea (OSA). Children aged between 6 and 18 years...
Mon Sep 14, 2020 17:05
Abstract Several recurrent malformation associations affecting the development of the embryo have been described in which a genetic etiology has not been found, including LBWC, MURCS, OAVS, OEIS, POC, VACTERL, referred to here as “recurrent constellations of embryonic malformations” (RCEM). All are characterized by an excess of reported monozygotic discordant twins and lack of familial recurrence. We performed a comprehensive review of published twin data across all six phenotypes to allow a more...
Mon Sep 14, 2020 11:28
Abstract We identified a novel nonsense de novo pathogenic variant of the NEXMIF gene in a 29 year‐old female patient with refractory epilepsy and mild intellectual disability. The patient presented with episodic atypical absence status (AS), the longest duration of her seizures was approximately 36 hr. She also had occasional eyelid myoclonia during absence seizure. EEG highlighted a photosensitivity phenomenon and generalized epileptiform discharges that were induced by eye closure. Whole exome...
Mon Sep 14, 2020 11:18
Abstract Purpose of Review First, an anatomical and functional review of these cortical areas and subcortical connections with T-fMRI and tractography techniques; second, to demonstrate the value of this approach in neurosurgical planning in a series of patients with tumors close to the SMA. Recent Findings Implications in language and...
Tue Sep 15, 2020 03:00
Abstract Purpose of Review This review aims to discuss retinal diseases that may masquerade as neurological causes of vision loss and highlights modern ophthalmic ancillary testing that can help to establish these diagnoses. Recent Findings Retinal diseases with signs and symptoms overlapping with neurological causes of vision loss include...
Tue Sep 15, 2020 03:00
Abstract Conflicting evidence regarding the use of hydroxychloroquine and azithromycin for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection do exist. We performed a retrospective single‐center cohort study including 377 consecutive patients admitted for pneumonia related to coronavirus disease (COVID‐19). Of these 297 were in combination treatment, 17 were on hydroxychloroquine alone and 63 did not receive any of these two drugs because of contraindications....
Mon Sep 14, 2020 17:34
Abstract Objectives To analyse the treatment needs of patients who had received dental treatment under GA and the effectiveness of the treatment provided. Materials and methods Retrospective chart analysis of adult at risk and vulnerable patients requiring dental treatment under GA (2007–2017). Outcome variables were indications for GA, DMF/T, and type of...
Tue Sep 15, 2020 03:00
Abstract Purpose To test the hypothesis that surface roughening and polishing of ceramics have no effect on their surface roughness and biofilm adhesion. Materials and Methods Feldspathic ceramic Vitablocks™ TriLuxe forte (VTF), lithium disilicate glass IPS e.max Press™ (IPS) and zirconia reinforced lithium silicate Vita Suprinity™ (VS) ceramic blocks (n = 27 per group) were prepared from sintered CAD blocks using a water‐cooled saw. They were further subdivided into 3 subgroups according...
Mon Sep 14, 2020 22:33
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