New Findings What is the central question of this study? Long non‐coding RNAs (lncRNAs) are widely involved in the progression of Hirschsprung's disease (HSCR), while the role of actin filament associated protein 1 antisense RNA1 (AFAP1‐AS1), a lncRNA, in HSCR has not been previously explored. What is the main finding and its importance? Downregulation of AFAP1‐AS1 blocks enteric neural crest stem cell proliferation, differentiation, migration and invasion and promotes the occurrence of HSCR...
Tue Sep 22, 2020 14:02
Abstract Background With refinements in diagnosis and therapy of gliomas, the importance of survival time as the sole outcome parameter has decreased, and patient-centered outcome parameters have gained interest. Pursuing a profession is an indispensable component of human happiness. The aim of this study was to analyze the professional outcomes besides their neuro-oncological and functional evaluation after surgery for gliomas in eloquent...
Tue Sep 22, 2020 03:00
Abstract Purpose Establishing predictors of hospital length of stay (LOS), discharge deposition, and total hospital charges is essential to providing high-quality, value-based care. Though previous research has investigated these outcomes for patients with metastatic brain tumors, there are currently no tools that synthesize such research findings and allow for prediction of these outcomes on a patient-by-patient basis. The present...
Tue Sep 22, 2020 03:00
Abstract Introduction Ependymoma is the third most common malignant pediatric brain tumor. Although the biology that drives ependymoma is slowly being unraveled, the ability to translate these findings to clinical care remains an ongoing challenge. Epigenetic alterations appear to play a central role in the development of molecular classification of ependymoma. Methods...
Tue Sep 22, 2020 03:00
OMFS Specialty Training in the UK is usually 5 years and ‘starts’ at Specialty Training Year 3 (ST3).. In 2007 a pilot of ‘run-through’ training started with Core Training (CT) posts linked to specialty training (ST1 posts). ST1 posts are usually 12 months but may be up to 24 months.
Tue Sep 22, 2020 03:00
Temporary tracheostomies (TT) are performed in order to secure the airway peri and postoperatively in head and neck cancer patients undergoing tumour resection and free tissue reconstructive surgery. Patients report that having a TT is unpleasant and appreciate its removal at the earliest opportunity. Early removal not only improves patient satisfaction but should allow for more rapid post-operative recovery. The aim of this prospective study was to assess factors contributing to delays in decannulation...
Tue Sep 22, 2020 03:00
This study does a dynamic finite element (FE) analysis of orbital trauma mechanisms – buckling and hydraulic theories. A digital model of the orbital cavity – including eyeball, fat tissue, extraocular muscles and bone orbit – was created from Magnetic Resonance Imaging and Computed Tomography data from a real patient. An impactor hit the FE model in two scenarios: hydraulic mechanism for direct impact to the eyeball and buckling mechanism for a direct impact over the infraorbital rim. The first...
Tue Sep 22, 2020 03:00
Surgical site infections are a complication of oral and maxillofacial procedures, with the potential for significant morbidity and mortality. Use of pre-, peri- and post-operative antibiotic prophylaxis to reduce the incidence of surgical site infections must be balanced with considerations of a patients’ risk of antibiotic-related adverse events. This review aims to provide evidence-based recommendations for antibiotic prophylaxis.
Tue Sep 22, 2020 03:00
Indications for the scapula flap in head and neck reconstruction has been previously described1. Use of virtual surgical planning (VSP) is increasing2, leading to reduced operating time, greater accuracy, and improved aesthetic/functional outcomes3. However, there are as yet no reports describing the use of VSP in scapular free flaps (based on the circumflex scapula vessels). Additionally, use of a ‘bone-only’ scapula flap has, to our knowledge, not previously been described. We describe the utilisation...
Tue Sep 22, 2020 03:00
Abstract Purpose Repetitive Transcranial Magnetic Stimulation (rTMS) has been demonstrated to be effective in body weight control in individuals with obesity. Most clinical trials on rTMS provided a reassuring safety profile. In the present work, we present an extensive analysis on both severe and mild Adverse Events (AEs) in obese individuals treated with rTMS. Methods...
Tue Sep 22, 2020 03:00
Stems cells are continuously investigated as potential treatments for individuals with myocardial damage, however, their decreased viability and retention within injured tissue can impact their long-term efficacy. In this manuscript we describe an alternative method for stem cell delivery in a murine model of ischemia reperfusion injury.
Thu Sep 03, 2020 21:00
Abstract Rationale Methylphenidate and d-amphetamine, medications used for treatment of attention deficit hyperactivity disorder (ADHD), are used recreationally and self-administered by laboratory animals. Benztropine (BZT) analogs, like those medications, increase synaptic dopamine levels but are less effective in maintaining self-administration, suggesting clinical utility with less abuse liability. ...
Tue Sep 22, 2020 03:00
Abstract Rationale The hypoglossal nucleus (HN) controls the movement of the genioglossus (GG) muscle whose dysfunction leads to airway occlusion and occurrence of obstructive sleep apnea (OSA). Histamine produced by the tuberomammillary nucleus (TMN) has a potent excitatory action on GG muscle activity. Objectives The aim of the study was to investigate...
Tue Sep 22, 2020 03:00
Evolving guidelines for standards of care from the American Diabetes Association and the European Association for the Study of Diabetes recommend treatment escalation when individualized glycemic targets are not reached in patients with type 2 diabetes. Despite these recommendations, clinical…
Tue Sep 22, 2020 03:00
Philips has just unveiled its Azurion Lung Edition system that combines a number of technologies that improve how minimally invasive procedures in the lungs are performed. The system relies on Cone Beam CT imaging, to provide a high resolution 3D view of the lungs, along with X-ray guidance for clear awareness of the anatomy being worked on and the tools within. A combination of additional hardware and software features work together to help with thoracoscopic surgeries, biopsies, and lesion...
Tue Sep 22, 2020 19:31
Researchers at the Harvard Wyss Institute have developed a rapid, inexpensive, and very sensitive malaria test that harnesses the power of CRISPR. The new technique does not require complicated sample preparation or processing, and it could allow for rapid on-site testing in low resource regions, aiding the campaign to eliminate malaria. Determining where malaria is being contracted is key to eradicating and treating it. However, such regions are usually remote and typically lack medical...
Tue Sep 22, 2020 21:17
Gyroscope Therapeutics, a retinal gene therapy company, has developed the Orbit subretinal delivery system (SDS). The technology is designed to deliver therapies to the retina without the need for invasive procedures, such as vitrectomies, which involve removing the gel-like substance within the eye, or retinotomies, which involve making a hole in the retina. The company hopes that by combining medical devices that allow minimally invasive delivery with innovative gene therapies they...
Tue Sep 22, 2020 23:26
High Altitude Medicine &Biology, Ahead of Print.
Tue Sep 22, 2020 10:00
A considerable proportion of patients hospitalized with coronavirus disease 2019 (COVID-19) acquired secondary bacterial infections (SBIs). The etiology and antimicrobial resistance of bacteria were reported a...
Tue Sep 22, 2020 03:00
Currently, hospitals have been forced to divert substantial resources to cope with the ongoing coronavirus disease 2019 (COVID-19) pandemic. It is unclear if this situation will affect long-standing infection ...
Tue Sep 22, 2020 03:00
Rejuvenation Research, Ahead of Print.
Tue Sep 22, 2020 10:00
Rejuvenation Research, Ahead of Print.
Tue Sep 22, 2020 10:00
Outcome for patients with locally advanced rectal cancer(LARC) has improved over past decades, in part because of the use of neoadjuvant chemoradiotherapy (NCRT) followed by total mesorectal excision(TME) surgery[1–2]. The local recurrence(LR) rates has been dramaticallyreduced to less than 10%. Whereas, distant metastasis(DM) is remain the major cause of treatment failure in LARC[3–4]. Adjuvant chemotherapy(AC) has been recommended for LARC to reduce the incidence of DM. However, only certain subgroups...
Tue Sep 22, 2020 03:00
Patients with intermediate or locally advanced rectal carcinoma are treated according to international guidelines with neoadjuvant radiotherapy with or without concurrent chemotherapy followed by total mesorectal excision surgery.[1,2] Neoadjuvant radiotherapy leads to a reduction in local recurrence rate but is still associated with substantial toxicity as large planning volumes are needed to compensate for inter- and intrafraction movement.[3,4] Particularly the mesorectum is a nonstationary structure,...
Tue Sep 22, 2020 03:00
We thank the authors for their insightful study [1]. The fact that prostate brachytherapy is experiencing sustained utilization in Ontario, Canada is very encouraging given the excellent treatment outcomes it provides [2–4]. In contrast, recent reports in the United States suggest underutilization of brachytherapy [4]. We hypothesized that the difference between Canada and the United states may be largely because patients are increasingly unaware of brachytherapy as a treatment modality.
Tue Sep 22, 2020 03:00
Treatment planning has advanced substantially since the introduction of the first computerised treatment planning systems (TPS)[1,2]. The evolution of computer hard- and software allowed implementation of advanced algorithms for dose calculation and optimisation, and facilitated the introduction of many complex treatment techniques [3–6]. Radiotherapy treatment planning is currently in an exciting era with novel developments in, for example, automated planning, robust planning, online adaptive radiotherapy,...
Tue Sep 22, 2020 03:00
Glioblastoma (GBM) is the most common and aggressive adult primary brain tumor [1,2]. Although radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) has increased patient survival, long-term prognosis remains poor, with a median survival of 15 months [3,4]. Tumor progression most often occurs inside the irradiated tumor volume [5], showing the high radioresistance of these tumors. Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in the regulation of...
Tue Sep 22, 2020 03:00
RR secondary to ICI (nivolumab in all patients) were observed in the lung (n=1) or skin (n=3). All patients had a long-term response and are currently alive with no active disease (Median FU from ICI discontinuation:30months). RR could reflect a beneficial immune activation and constitute a predictive clinical biomarker of ICI long-term efficacy.
Tue Sep 22, 2020 03:00
Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinomas (ICC) are the most prevalent intrahepatic primary cancer and the second leading cause of cancer death [Petrick2016], [Hong2016], [Igaki2017]. Although biologically and clinically distinct entities, both share common management issues.
Tue Sep 22, 2020 03:00
The salivary gland system, with its three paired major glands and roughly 1000 minor glands spread throughout the aerodigestive tract submucosa, has been described in detail[1–4]. Its serous, mucous or mixed exocrine acini produce the saliva required for mastication, swallowing, digestion, tasting and dental hygiene. The nearby auditory tube submucosa also contains microscopic seromucous (tubal or Eustachian tube) glands[5]. The recently introduced molecular imaging modality of positron emission...
Tue Sep 22, 2020 03:00
Carbon ion radiation therapy (CIRT) is recognized as having distinctive physical and radiobiological traits that may provide advantages over traditional photon beam radiotherapy [1–4]. The unique depth-dose distribution with a finite range, along with a sharp lateral penumbra, allows increased dose to the target volume, compared to photon therapy, while minimizing the dose to surrounding normal tissues [3,5].
Tue Sep 22, 2020 03:00
Background and Purpose To enable accurate magnetic resonance imaging (MRI)-based dose calculations, synthetic computed tomography (sCT) images need to be generated. We aim at assessing the feasibility of dose calculations from MRI acquired with a heterogeneous set of imaging protocol for paediatric patients affected by brain tumours.Materials and methods Sixty paediatric patients undergoing brain radiotherapy were included. MR imaging protocols varied among patients, and data heterogeneity was maintained...
Tue Sep 22, 2020 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03335
Tue Sep 22, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01945
Tue Sep 22, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02276
Tue Sep 22, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02342
Tue Sep 22, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c02162
Tue Sep 22, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c03212
Tue Sep 22, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01827
Tue Sep 22, 2020 07:00
ABSTRACT Objectives During a public health crisis, it is important for medical journals to share information in a timely manner while maintaining a robust peer‐review process. This review reports and analyzes The Laryngoscope's publication trends and practices during the COVID‐19 pandemic, before the COVID‐19 pandemic, and during previous pandemics. Methods Comprehensive review of two databases (PubMed and The Laryngoscope) was performed. COVID‐19 manuscripts (published in The Laryngoscope...
Mon Sep 21, 2020 11:37
Objectives Juvenile onset recurrent respiratory papillomatosis (JORRP) can cause severe or disseminated disease. Surgical treatment may be inadequate. Systemic bevacizumab has shown initial success for severe JORRP. The objective of this systematic review was to assess usage, effectiveness, and safety of this treatment. Methods We searched PubMed, Embase, and Web of Science for studies of humans with JORRP treated with systemic bevacizumab. Two researchers independently reviewed the studies...
Tue Sep 22, 2020 15:14
Objective Sinonasal squamous cell carcinoma (SCC) is rare with no consensus on treatment regimen. Our goal is to analyze treatment outcomes in poorly differentiated SCC (PDSCC) using a large national database. Study Design Retrospective database study. Methods The National Cancer Database was queried for sinonasal invasive SCC, grade 3 (poorly differentiated) from 2004 to 2014. Patient demographics and tumor and treatment characteristics were tabulated. Kaplan–Meier (KM) analysis was...
Tue Sep 22, 2020 15:24
Background. Airway stenosis is a technically challenging pathology to deal with. Various aetiologies can lead to the stenosis; however, trauma, mostly related to intubation, is the commonest so far. This study retrospectively evaluates various aetiological factors resulting in airway stenosis and the associated patient-related factors. Objectives. The objectives of this study were to evaluate the common patient-related factors, aetiology, site, and mode of presentation of airway stenosis and to evaluate...
Tue Sep 22, 2020 18:50
The aim of this study is to evaluate whether the three-dimensional (3D) morphology of the mandibular condyle, glenoid fossa, and mandible correlated with menton deviation in facial asymmetry.
Tue Sep 22, 2020 03:00
Abstract Cinnamaldehyde (CA) is an essential component of cinnamon that has been shown to exhibit anti-tumor effects through growth inhibition and induction of apoptosis in cancer cells. We have previously shown that CA could interfere with myeloid-derived suppressor cells (MDSCs), leading to cancer growth inhibition. In addition, recent studies have demonstrated that cancer-associated fibroblasts (CAFs) promote cancer development in different ways. However, the effect of CA...
Tue Sep 22, 2020 03:00
Abstract Purpose The purpose of the present study was to evaluate the radiographical outcomes and survival rate of implants placed during graftless lateral sinus lift approach (GLSLA) using an absorbable collagen sponge. Materials and methods Fourteen patients (14 sinus augmentations) were consecutively treated with GLSLA. After Schneiderian membrane...
Tue Sep 22, 2020 03:00
Related Articles Seroprevalence of Toxoplasma gondii among healthy blood donors in two locations in Tunisia and associated risk factors. Parasite. 2020;27:51 Authors: Lachkhem A, Lahmar I, Galal L, Babba O, Mezhoud H, Hassine M, Lachkhem A, Dardé ML, Mercier A, Babba H Abstract Toxoplasma gondii is a protozoan parasite that can be transmitted to humans through a variety of routes including blood transfusion. This study aimed to investigate...
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Abstract Background Orbital hypertelorism (OHT) represents a congenital condition defined by lateralization of the bony orbit, unlike soft tissue telecanthus in which there is an increase in intercanthal distance without true bony lateralization. Existing literature remains very limited in its postoperative assessment of bony versus soft tissue relapse, which may both clinically present as telecanthus. We performed a critical appraisal...
Tue Sep 22, 2020 03:00
Abstract Introduction While cases of acquired Chiari I malformation following ventriculoperitoneal shunting for posthemorrhagic hydrocephalus have been reported, true disproportionate cerebellar growth is rare, with no previous cases requiring posterior fossa decompression reported. Clinical presentation We present a premature neonate who underwent...
Tue Sep 22, 2020 03:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c04887
Mon Sep 21, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c10087
Tue Sep 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07689
Tue Sep 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07239
Tue Sep 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c07461
Tue Sep 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c08740
Tue Sep 22, 2020 07:00
Journal of the American Chemical SocietyDOI: 10.1021/jacs.0c05010
Tue Sep 22, 2020 07:00
Thorac Cardiovasc Surg Rep 2020; 09: e37-e39DOI: 10.1055/s-0040-1715432Anomalous venous connections of the left lung can either affect all of the veins or only the upper lobe. They mostly drain into the innominate vein. We present the case of a patient who underwent a coronary bypass operation and was prepared with insertion of central lines including Swan-Ganz catheter through both the internal jugular veins. Blood gas analysis obtained from these catheters suggested the presence of a left-to-right...
Tue Sep 22, 2020 02:00
Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1240-4936 Background Obesity is a major health problem worldwide, and non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty liver disease (NAFLD) are obesity-associated complications. Liraglutide, a glucagon-like peptide-1 (GLP-1) agonist, has been approved for treatment of obesity. We aimed to evaluate the therapeutic effects of liraglutide on the complications through its regulation of endoplasmic reticulum (ER) stress. Methods A high-fat...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 200-206DOI: 10.1055/s-0040-1715154Reconstruction of the lower extremity is considered a major challenge due to frequent bone exposure and the absence of local tissue redundancy, as well as often due to the presence of vascular insufficiency. Many surgeons have preferred free flaps especially for reconstructing the more distal lower limb defects until the evolution of pedicled perforator flaps and propeller flaps in particular provided a like-with-like reconstruction of...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 207-209DOI: 10.1055/s-0040-1714290A chimeric flap consists of multiple discrete tissues or flaps connected only by a common source vessel. Each component must have an independent source of circulation. Rotation of any included part only about its specific vascular supply, such as done with a propeller flap, would be possible. These characteristics, whereby the chimeric flap concept and propeller flap concept are combined, would result in a chimeric propeller flap. Such...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 161-164DOI: 10.1055/s-0040-1714291The use of thermography for the identification of cutaneous “hot spots” that coincide with perforators is not a new concept, but the required professional cameras may be prohibitively expensive. Only relatively recently, incredibly cheap but adequate thermal imaging cameras have become available that work in concert with the ubiquitous cell phone. This can now serve as a rapid, accurate, and complementary method for finding a perforator...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 192-199DOI: 10.1055/s-0040-1715155The reconstruction of soft tissue defects of the hand, as seen often after trauma or tumor excision, is a challenge due to the great differentiation of tissues depending on the hand area involved. The classical intrinsic “workhorse flaps” of the hand are associated with a significant donor-site morbidity. Capturing perforator vessels in discrete donor areas can reduce the amount of soft tissue that has to be dissected and included in what...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 152-160DOI: 10.1055/s-0040-1714271Propeller flaps are local flaps based either on a subcutaneous pedicle, a single perforator, or vessels entering the flap in such a way so as to allow the flap to rotate on their axis. Depending on the kind of pedicle and the anatomical area, the preoperative investigation and the harvesting techniques may vary.An adequate knowledge of skin and subcutaneous tissue perfusion in the different areas of the body is very important to plan a...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 176-183DOI: 10.1055/s-0040-1714086The reconstruction of complex posterior trunk defects remains challenging. But now with an increased knowledge of angiosomes and the practice of perforator flaps, the posterior trunk offers a new plethora of options for reconstruction. Propeller flaps based on such perforator(s) offer an elegant solution for managing defects while achieving primary donor-site closure without significant morbidity. We will discuss the relevant anatomy and...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 145-151DOI: 10.1055/s-0040-1715159Since propeller flaps are elevated as island flaps and most often nourished by a single perforator nearby the defect, it is challenging to change the flap design intraoperatively when a reliable perforator cannot be found where expected to exist. Thus, accurate preoperative mapping of perforators is essential in the safe planning of propeller flaps. Various methods have been reported so far: (1) handheld acoustic Doppler sonography (ADS),...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 165-170DOI: 10.1055/s-0040-1714269Propeller flaps have significantly expanded the reconstruction possibilities in the head and neck region. They allow for increased flap mobility and better scar concealing, and/or to perform a one-stage reconstruction with local tissue of similar color and texture, where multiple surgeries would be needed with traditional flaps or even free flaps would be required. This article describes the main propeller flaps for one-stage reconstruction...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 139-144DOI: 10.1055/s-0040-1715158The term propeller flap was introduced for the first time by Hyakusoku to define an island flap, based on a subcutaneous pedicle hub, that was rotated 90 degrees to correct scar contractures due to burns. With the popularization of perforator flaps, the propeller movement was applied for the first time to a skin island vascularized only by an isolated perforator, and the terms propeller and perforator flap were used together. Thereafter,...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 129-129DOI: 10.1055/s-0040-1714088Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 133-138DOI: 10.1055/s-0040-1715157Several pedicled flaps were developed by Hyakusoku at the Nippon Medical School Hospital, Tokyo, Japan, in the 1980s to treat a large number of patients with postburn contractures. In this setting, the propeller flaps were described for the first time in 1991. The term propeller was used because of the blade shape of the skin island rotating on its axis. In 1989, Koshima introduced the term perforator flaps, whereas Hallock, in 2006, applied...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 171-175DOI: 10.1055/s-0040-1714270Various types of propeller flaps from multiple donor sites can be used to reconstruct anterior trunk skin defects. The actual selection depends on the condition and location of the recipient site, especially if it is to be the chest or abdomen that requires attention. Before surgery commences, it is always important to use an imaging analyses such as computed tomography angiography to examine and identify perforators that could perfuse...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 131-132DOI: 10.1055/s-0040-1715156The editors of this issue of Seminars in Plastic Surgery dedicated to propeller flaps met in 2009 at the “1st Tokyo Meeting on Perforator and Propeller Flaps.” On that occasion, as part of the advisory panel of the meeting, they contributed to the definition and classification of these flaps. Since then, several evolutions and new applications of propeller flaps appeared in the literature. In 2019, the editors met again in Bologna, Italy,...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 184-191DOI: 10.1055/s-0040-1715153The propeller flap is an island of skin that is raised on its pedicle (most commonly a single perforator) and can rotate 180 degrees to cover a soft tissue defect. Thanks to these features, the propeller flap brings reliable tissue from outside of the zone of injury while sparing the main vessels of the upper extremity. This technique limits the donor site to the same limb, captures skin characterized by having the same color and texture,...
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 130-130DOI: 10.1055/s-0040-1714085Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
Tue Sep 22, 2020 02:00
Semin Plast Surg 2020; 34: 210-220DOI: 10.1055/s-0040-1714087Propeller perforator flaps (PPFs) have long been proven as valid reconstructive tools for a wide range of soft tissue defects in different body regions. During the last decade, despite their numerous advantages, many authors have thoroughly analyzed outcomes of these flaps, sometimes discouraging their use mainly because of a high failure rate. Accurate patient selection, adequate preoperative planning, and an appropriate dissection technique...
Tue Sep 22, 2020 02:00
The NineTeen Complex (NTC), also known as Pre-mRNA-processing factor 19 (Prp19) complex, regulates distinct spliceosome conformational changes necessary for splicing. During Drosophila midblastula transition, splicing is particularly sensitive to mutations in NTC-subunit Fandango, which suggests differential requirements of NTC during development. We show that NTC-subunit Salsa, the Drosophila orthologue of human RNA helicase Aquarius, is rate-limiting for splicing of a subset of small first introns...
Tue Sep 22, 2020 21:33
Horm Metab ResDOI: 10.1055/a-1240-5058A potential reduction of goiter volume (GV) of recombinant human thyrotropin (rhTSH) on multinodular goiters (MNG) was previously reported but controversial. Hence we conducted a meta-analysis to estimate the effect of rhTSH-stimulated radioiodine therapy in patients with MNG. PubMed, Cochrane, CNKI, VIP, and Wanfang databases were searched. Mean difference (MD) and odds ratios...
Tue Sep 22, 2020 02:00
On December 18, 2019, the Food and Drug Administration (FDA) granted accelerated approval to enfortumab vedotin-ejfv (PADCEV; Astellas and Seattle Genetics) for treatment of patients with locally advanced or metastatic urothelial cancer who have previously received a PD-1 or PD-L1 inhibitor, and a platinum-containing chemotherapy in the neoadjuvant/adjuvant, locally advanced or metastatic setting. Substantial evidence of effectiveness for this application is obtained from Cohort 1 of the single arm,...
Tue Sep 22, 2020 15:47
Purpose: Predicting prognosis in HR+/HER2-negative MBC might be clinically useful; however, no validated prognostic biomarkers exist in this setting to date. Experimental design: In phase III, EGF30008 trial, 484 patients with HER2-negative MBC who received letrozole and placebo or lapatinib were selected. PAM50 data, ECOG PS, visceral disease, number of metastasis, biopsy type, and age were evaluated. A progression-free survival (PFS) Cox model was evaluated. The final model (PAM50MET) with a prespecified...
Tue Sep 22, 2020 15:47
A team of researchers has revealed why male funnel web spiders develop much deadlier venom than their female counterparts. The team has spent 20 years investigating delta-hexatoxins, the venom peptides that make funnel web spider venom so dangerous.
Mon Sep 21, 2020 22:13
Cheating mitochondria may take advantage of cellular mechanisms for coping with food scarcity in a simple worm to persist, even though this can reduce the worm's wellbeing.
Tue Sep 22, 2020 20:57
Backgroud. Leishmaniasis is an infectious disease caused by protozoan of the genus Leishmania that can affect mucosal or cutaneous surfaces. It can manifest via buccal mucosa, associated with a skin lesion or as a secondary effect. Over the last 20 years, the number of cases of this disease is progressively increasing in Brazil. Therefore, the knowledge of this disease by health professionals is important in order to achieve a correct and early diagnosis, manly to prevent the deformities it may cause...
Tue Sep 22, 2020 19:05
British Journal of Cancer, Published online: 23 September 2020; doi:10.1038/s41416-020-01074-2Mouse–human co-clinical trials demonstrate superior anti-tumour effects of buparlisib (BKM120) and cetuximab combination in squamous cell carcinoma of head and neck
03:00
British Journal of Cancer, Published online: 23 September 2020; doi:10.1038/s41416-020-01086-yBCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair
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British Journal of Cancer, Published online: 23 September 2020; doi:10.1038/s41416-020-01081-3Examination of potential novel biochemical factors in relation to prostate cancer incidence and mortality in UK Biobank
03:00
CRISpy-Pop: A Web Tool for Designing CRISPR/Cas9-Driven Genetic Modifications in Diverse Populations
CRISPR/Cas9 is a powerful tool for editing genomes, but design decisions are generally made with respect to a single reference genome. With population genomic data becoming available for an increasing number of model organisms, researchers are interested in manipulating multiple strains and lines. CRISpy-pop is a web application that generates and filters guide RNA sequences for CRISPR/Cas9 genome editing for diverse yeast and bacterial strains. The current implementation designs and predicts the...
Tue Sep 22, 2020 23:36
Seed germination is characterized by a constant change of gene expression across different time points. These changes are related to specific processes, which eventually determine the onset of seed germination. To get a better understanding on the regulation of gene expression during seed germination, we performed a quantitative trait locus mapping of gene expression (eQTL) at four important seed germination stages (primary dormant, after-ripened, six-hour after imbibition, and radicle protrusion...
Tue Sep 22, 2020 23:36
Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators...
Tue Sep 22, 2020 03:00
Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers...
Tue Sep 22, 2020 03:00
Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate...
Tue Sep 22, 2020 03:00
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib
Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have...
Tue Sep 22, 2020 03:00
Thyroid, Ahead of Print.
Tue Sep 22, 2020 10:00
Thyroid, Ahead of Print.
Tue Sep 22, 2020 10:00
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