Research Models and Gene Augmentation Therapy for CRB1 Retinal Dystrophies. Front Neurosci. 2020;14:860 Authors: Boon N, Wijnholds J, Pellissier LP Abstract Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are inherited degenerative retinal dystrophies with vision loss that ultimately lead to blindness. Several genes have been shown to be involved in early onset retinal dystrophies, including CRB1 and RPE65. Gene therapy recently...
Tue Sep 15, 2020 13:51
Wheel-Running Behavior Is Negatively Impacted by Zinc Administration in a Novel Dual Transgenic Mouse Model of AD. Front Neurosci. 2020;14:854 Authors: Lippi SLP, Kakalec PA, Smith ML, Flinn JM Abstract Alzheimer's disease (AD) is a neurocognitive disorder that impacts both the brain and behavior. Metal ions, including zinc (Zn), have been seen to play an important role in AD-related pathology. In this study, we show alterations in wheel-running...
Tue Sep 15, 2020 13:51
Neuroprotective Effects of Casein-Derived Peptide Met-Lys-Pro (MKP) in a Hypertensive Model. Front Neurosci. 2020;14:845 Authors: Tada AM, Hamezah HS, Yanagisawa D, Morikawa S, Tooyama I Abstract We have previously reported that casein hydrolysate, CH-3, from bovine milk and casein-derived tripeptide Met-Lys-Pro (MKP) has ACE inhibitory activity and reduces blood pressure. In this study, we investigated the therapeutic effects of MKP in a hypertensive...
Tue Sep 15, 2020 13:51
Tyro3 Contributes to Retinal Ganglion Cell Function, Survival and Dendritic Density in the Mouse Retina. Front Neurosci. 2020;14:840 Authors: Blades F, Wong VHY, Nguyen CTO, Bui BV, Kilpatrick TJ, Binder MD Abstract Retinal ganglion cells (RGCs) are the only output neurons of the vertebrate retina, integrating signals from other retinal neurons and transmitting information to the visual centers of the brain. The death of RGCs is a common outcome...
Tue Sep 15, 2020 13:51
Exploring the Role of Chemokine Receptor 6 (Ccr6) in the BXD Mouse Model of Gulf War Illness. Front Neurosci. 2020;14:818 Authors: Gao J, Xu F, Starlard-Davenport A, Miller DB, O'Callaghan JP, Jones BC, Lu L Abstract Gulf War illness (GWI) is a chronic and multi-symptomatic disorder with persistent neuroimmune symptomatology. Chemokine receptor 6 (CCR6) has been shown to be involved in several inflammation disorders in humans. However, the...
Tue Sep 15, 2020 13:51
Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson's Disease Patients. Front Neurosci. 2020;14:814 Authors: Navratilova D, Krobot A, Otruba P, Nevrly M, Krahulik D, Kolar P, Kolarova B, Kaiserova M, Mensikova K, Vastik M, Kurcova S, Kanovsky P Abstract Background: Gait disturbance accompanies many neurodegenerative diseases; it is characteristic for Parkinson's disease (PD). Treatment of advanced PD often includes deep brain...
Tue Sep 15, 2020 13:51
Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division. Front Neurosci. 2020;14:811 Authors: Valcárcel-Martín R, Martín-Suárez S, Muro-García T, Pastor-Alonso O, Rodríguez de Fonseca F, Estivil-Torrús G, Encinas JM Abstract A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus...
Tue Sep 15, 2020 13:51
Longitudinal Electroencephalography Analysis in Subacute Stroke Patients During Intervention of Brain-Computer Interface With Exoskeleton Feedback. Front Neurosci. 2020;14:809 Authors: Chen S, Cao L, Shu X, Wang H, Ding L, Wang SH, Jia J Abstract Background: Brain-computer interface (BCI) has been regarded as a newly developing intervention in promoting motor recovery in stroke survivors. Several studies have been performed in chronic stroke...
Tue Sep 15, 2020 13:51
Editorial: A Conversation With the Brain: Can We Speak Its Language? Front Neurosci. 2020;14:794 Authors: Barriga-Rivera A, Guo T, Hayashida Y, Suaning GJ PMID: 32922253 [PubMed]
Tue Sep 15, 2020 13:51
Morphological hallmarks facilitating distinction of omental milky spots and lymph nodes: an exploratory study on their discriminative capacity. Histol Histopathol. 2020 Sep 14;:18254 Authors: Cleypool CGJ, Mackaaij C, Schurink B, Bleys RLAW Abstract BACKGROUND: Omental milky spots (OMSs) are the primary lymphoid structures of the greater omentum. However, the presence of lymph nodes (LNs) has occasionally been mentioned as well. Understanding...
Tue Sep 15, 2020 13:50
Diosgenin inhibits TGF-β1/Smad signaling and regulates epithelial mesenchymal transition in experimental pulmonary fibrosis. Drug Chem Toxicol. 2020 Sep 14;:1-12 Authors: Dinesh Babu V, Suresh Kumar A, Sudhandiran G Abstract Idiopathic Pulmonary Fibrosis (IPF) is a grave disease characterized by abnormal wound healing associated with chronic, progressive, irreversible fatal lung disease, leading to persistent injuries to the alveolar epithelium....
Tue Sep 15, 2020 13:47
The evaluation of hepatoprotective effects of flavonoids from Scorzonera austriaca Wild against CCl4-induced acute liver injury in vitro and in vivo. Drug Chem Toxicol. 2020 Sep 14;:1-11 Authors: Wei E, Zhang S, Zhai J, Wu S, Wang G Abstract Scorzonera austriaca Wild is a traditional herbal medicine; however, little is known with regard to the effect of flavonoids from S. austriaca (FSA) on liver injury induced by Carbon tetrachloride (CCl4),...
Tue Sep 15, 2020 13:47
Fetal posterior cerebral artery duplication and anterior cerebral artery triplication. Surg Radiol Anat. 2020 Sep 14;: Authors: Uchino A PMID: 32926191 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:44
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Tue Sep 15, 2020 03:00
Design, synthesis and biological evaluation of thieno[3,2-d]pyrimidine derivatives containing aroyl hydrazone or aryl hydrazide moieties for PI3K and mTOR dual inhibition. Bioorg Chem. 2020 Aug 28;104:104197 Authors: Han Y, Tian Y, Wang R, Fu S, Jiang J, Dong J, Qin M, Hou Y, Zhao Y Abstract Recently, PI3K and mTOR have been regarded as promising targets for cancer treatment. Herein, we designed and synthesized four series of novel thieno[3,2-d]pyrimidine...
Tue Sep 15, 2020 13:43
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3. Life Sci. 2020 Sep 11;:118413 Authors: Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X Abstract AIMS: Berberine (BBR) is one of isoquinoline alkaloids from Coptidis Rhizoma and possesses extensive pharmacological activities, including anti-colorectal cancer (CRC) activity. However, the detailed mechanisms remain...
Tue Sep 15, 2020 13:43
IGF2BP1 silencing inhibits proliferation and induces apoptosis of high glucose-induced non-small cell lung cancer cells by regulating Netrin-1. Arch Biochem Biophys. 2020 Sep 11;:108581 Authors: Zhang J, Luo W, Chi X, Zhang L, Ren Q, Wang H, Zhang W Abstract Non-small cell lung cancer (NSCLC) accompanied by diabetes is an important risk factor affecting the prognosis of patients with NSCLC in clinical practice. However, the effect of high glucose...
Tue Sep 15, 2020 13:43
Cholesterol partially rescues the inhibition effect of pravastatin on KCs proliferation by regulating cell cycle relative proteins through AKT and ERK pathway. Dermatol Ther. 2020 Sep 14;:e14305 Authors: Li M, Jin R, Qi Y, Zhou H, Zhu T, Liu L, Gu Y, Luan K, Luo X, Zhang S Abstract Mevalonate pathway plays a key role in skin physiological process in human. Recently, it has been reported that mutation of some genes in the mevalonate pathway...
Tue Sep 15, 2020 13:43
Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cells. PLoS One. 2020;15(9):e0233477 Authors: Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA Abstract Emerging evidence indicates that a strong relationship exists between brain regenerative therapies and nutrition. Early life nutrition plays an important role during embryonic brain...
Tue Sep 15, 2020 13:43
Modulation of Brain Transcriptome By Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock. Shock. 2020 Jul 07;: Authors: Dekker SE, Biesterveld BE, Bambakidis T, Williams AM, Tagett R, Johnson CN, Sillesen M, Liu B, Li Y, Alam HB Abstract INTRODUCTION: We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP)...
Tue Sep 15, 2020 13:43
Linderolide U, a new sesquiterpene from Lindera aggregata root. Nat Prod Res. 2020 Sep 14;:1-5 Authors: Yang HJ, Kwon EB, Li W Abstract A new sesquiterpene, namely linderolide U (1), was isolated from the root of Lindera aggregata (Sims) Kosterm along with five known sesquiterpenes (2-6). The structures of the obtained compounds were identified by spectroscopic methods, specifically nuclear magnetic resonance (NMR) spectroscopy and mass...
Tue Sep 15, 2020 13:43
Synthesis of new arylazopyrazoles as apoptosis inducers: Candidates to inhibit proliferation of MCF-7 cells. Arch Pharm (Weinheim). 2020 Sep 13;:e2000214 Authors: Ismail MMF, Soliman DH, Sabour R, Farrag AM Abstract New 4-arylazo-3,5-diamino-1H-pyrazole derivatives substituted in the 4-aryl ring with the acetyl moiety were designed and synthesized. The antiproliferative activity of the novel arylazopyrazoles was examined against the MCF-7...
Tue Sep 15, 2020 13:43
Refocusing the Use of Psychiatric Drugs for Treatment of Gastrointestinal Cancers. Front Oncol. 2020;10:1452 Authors: Avendaño-Félix M, Aguilar-Medina M, Bermudez M, Lizárraga-Verdugo E, López-Camarillo C, Ramos-Payán R Abstract Gastrointestinal cancers (GICs) are the most common human tumors worldwide. Treatments have limited effects, and increasing global cancer burden makes it necessary to investigate alternative strategies such as...
Tue Sep 15, 2020 13:43
Demethylzeylasteral inhibits cell proliferation and enhances cell chemosensitivity to 5-fluorouracil in Colorectal Cancer cells. J Cancer. 2020;11(20):6059-6069 Authors: Yang Y, Han J, Ma Y, Zhang J, Zhang Z, Wang G Abstract Malignant growth and chemotherapy resistance to 5-fluorouracil (5-FU) are the obstacles to the treatment of Colorectal cancer (CRC). There is need to develop effective therapeutic option. Demethylzeylasteral benefits...
Tue Sep 15, 2020 13:43
Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in Human Ovarian Cancer. J Cancer. 2020;11(20):5900-5910 Authors: Zhao S, Fan S, Shi Y, Ren H, Hong H, Gao X, Zhang M, Qin Q, Li H Abstract Propranolol has a significant anti-cancer effect towards various cancers. Our study aimed at investigating the underlying mechanism of Propranolol's therapeutic effect towards ovarian cancer. Specifically, Propranolol significantly...
Tue Sep 15, 2020 13:43
Antileukemic Effect of Palladium Nanoparticles Mediated by White Tea (Camellia sinensis) Extract In Vitro and in WEHI-3B-Induced Leukemia In Vivo. Evid Based Complement Alternat Med. 2020;2020:8764096 Authors: Othman H, Rahman H, Mohan S, Aziz S, Marif H, Ford D, Abdulsamad N, Amin K, Abdullah R Abstract This study investigated the in vivo antileukemic activity of palladium nanoparticles (Pd@W.tea-NPs) mediated by white tea extract in...
Tue Sep 15, 2020 13:43
Aberrant Expression of NCAPG is Associated with Prognosis and Progression of Gastric Cancer. Cancer Manag Res. 2020;12:7837-7846 Authors: Sun DP, Lin CC, Hung ST, Kuang YY, Hseu YC, Fang CL, Lin KY Abstract Introduction: Gastric cancer (GC), one of the most prevalent malignancies, is the third-leading cause of cancer-related deaths globally. The aim of this study is to investigate the involvement of non-structural maintenance of chromosomes...
Tue Sep 15, 2020 13:43
Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo. Cancer Manag Res. 2020;12:7783-7795 Authors: Zang H, Li Y, Zhang X, Huang G Abstract Background: Breast cancer (BCa) is an overwhelming malignant tumor mainly in women globally. Circular RNAs (circRNAs) are a special type of noncoding RNAs involved in competing endogenous RNA (ceRNA) network, a classic...
Tue Sep 15, 2020 13:43
Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer. Drug Des Devel Ther. 2020;14:3535-3545 Authors: Liu Y, Zhang N, Zhang H, Wang L, Duan Y, Wang X, Chen T, Liang Y, Li Y, Song X, Li C, Han D, Chen B, Zhao W, Yang Q Abstract Background: Tamoxifen is the cornerstone of adjuvant therapy for hormone receptor-positive breast cancer. Despite its efficacy, limited drug sensitivity and endocrine...
Tue Sep 15, 2020 13:43
Dual targeting of Polo-like kinase 1 and baculoviral inhibitor of apoptosis repeat-containing 5 in TP53-mutated hepatocellular carcinoma. World J Gastroenterol. 2020 Aug 28;26(32):4786-4801 Authors: Li Y, Zhao ZG, Luo Y, Cui H, Wang HY, Jia YF, Gao YT Abstract BACKGROUND: Hepatocellular carcinoma (HCC), often diagnosed at advanced stages without curative therapies, is the fifth most common malignant cancer and the second leading cause...
Tue Sep 15, 2020 13:43
Related Articles Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer. PLoS One. 2020;15(7):e0234103 Authors: Frame S, Saladino C, MacKay C, Atrash B, Sheldrake P, McDonald E, Clarke PA, Workman P, Blake D, Zheleva D Abstract Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial...
Tue Sep 15, 2020 13:43
Related Articles Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation. J Cell Biol. 2020 02 03;219(2): Authors: Liang C, Zhang Z, Chen Q, Yan H, Zhang M, Zhou L, Xu J, Lu W, Wang F Abstract Aurora B kinase plays an essential role in chromosome bi-orientation, which is a prerequisite for equal segregation of chromosomes during mitosis. However, it remains largely unclear whether centromere-localized Aurora...
Tue Sep 15, 2020 13:43
Related Articles Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Mol Cell. 2020 02 20;77(4):825-839.e7 Authors: Du Z, Zheng H, Kawamura YK, Zhang K, Gassler J, Powell S, Xu Q, Lin Z, Xu K, Zhou Q, Ozonov EA, Véron N, Huang B, Li L, Yu G, Liu L, Au Yeung WK, Wang P, Chang L, Wang Q, He A, Sun Y, Na J, Sun Q, Sasaki H, Tachibana K, Peters AHFM, Xie W Abstract In mammals, chromatin organization undergoes...
Tue Sep 15, 2020 13:43
Related Articles CLASP2 binding to curved microtubule tips promotes flux and stabilizes kinetochore attachments. J Cell Biol. 2020 02 03;219(2): Authors: Girão H, Okada N, Rodrigues TA, Silva AO, Figueiredo AC, Garcia Z, Moutinho-Santos T, Hayashi I, Azevedo JE, Macedo-Ribeiro S, Maiato H Abstract CLASPs are conserved microtubule plus-end-tracking proteins that suppress microtubule catastrophes and independently localize to kinetochores during...
Tue Sep 15, 2020 13:43
Related Articles A siRNA-based method for efficient silencing of PYROXD1 gene expression in the colon cancer cell line HCT116. J Cell Biochem. 2019 12;120(12):19310-19317 Authors: Shabani S, Mahjoubi F, Moosavi MA Abstract PURPOSE: The aim of this study was to determine the biological function of pyridine nucleotide-disulfide oxidoreductase domain 1 (PYROXD1), a recently discovered protein, in colon cancer cell line HCT116. METHODS:...
Tue Sep 15, 2020 13:43
Related Articles Synergistic enhancement of apoptosis by coralyne and paclitaxel in combination on MDA-MB-231 a triple-negative breast cancer cell line. J Cell Biochem. 2019 10;120(10):18104-18116 Authors: Kumari S, Mohan MG, Shailender G, Badana AK, Malla RR Abstract Triple-negative breast cancer (TNBC) is the most outrageous subtype of breast cancer. Emphasizing the urge of new approach in cancer therapy, combinational drug therapy may be...
Tue Sep 15, 2020 13:43
Related Articles PRC1 gene silencing inhibits proliferation, invasion, and angiogenesis of retinoblastoma cells through the inhibition of the Wnt/β-catenin signaling pathway. J Cell Biochem. 2019 10;120(10):16840-16852 Authors: Liao YJ, Yin XL, Deng Y, Peng XW Abstract Retinoblastoma is an ocular malignancy occurring in childhood. The current study evaluates the ability of silenced PRC1 on retinoblastoma cell proliferation, and angiogenesis...
Tue Sep 15, 2020 13:43
47 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 13:43
Measurement of free glucocorticoids: quantifying corticosteroid binding capacity and its variation within and among mammal and bird species. Conserv Physiol. 2020;8(1):coaa057 Authors: Delehanty B, Bossart GD, Champagne C, Crocker DE, Elliott KH, Fair PA, Houser D, Newman AEM, Boonstra R Abstract Plasma glucocorticoid (CORT) levels are one measure of stress in wildlife and give us insight into natural processes relevant to conservation issues....
Tue Sep 15, 2020 13:40
Background As governments across Europe have issued non-pharmaceutical interventions (NPIs) such as social distancing and school closing, the mobility patterns in these countries have changed. Most states have implemented similar NPIs at similar time points. However, it is likely different countries and populations respond differently to the NPIs and that these differences cause mobility patterns and thereby the epidemic development to change. Methods We build a Bayesian model that estimates...
Tue Sep 15, 2020 03:00
Although the knowledge of bone histology of non-avian theropods has advanced considerably in recent decades, data about the bone tissue patterns, growth dynamics and ontogeny of some taxa such as abelisauroids are still limited. Here we describe the bone microstructure and growth dynamics of the Brazilian noasaurine Vespersaurus paranaensis using five femora and six tibiae and quantify the annual growth marks through retrocalculation of missing ones to estimate ontogenetic ages. The femoral series...
Tue Sep 15, 2020 03:00
Background Executive function (EF) plays an important role in controlling human actions. Shooting is a closed motor skill, characterized by high anti-interference ability and high mental intensity. However, the beneficial effects of closed exercises such as shooting on EF remain unclear. Methods We utilized an expert-novice paradigm and the Flanker task to examine the EF of shooting athletes. Participants were assigned...
Tue Sep 15, 2020 03:00
This study, concerning the epigeic fauna of carabid beetles (Coleoptera; Carabidae), was conducted in the north-east of Poland, in an area which is part of the Dąbrówka Forest Subdistrict and has been included in the “Small water retention program for the Province of Warmia and Mazury in 2006–2015”. The purpose of the study was to assess the impact of the water retention implemented within the framework of the above program on assemblages of ground beetles. These insects are highly sensitive to any...
Tue Sep 15, 2020 03:00
Background Acute-on-chronic liver failure (ACLF), which is characterized by rapid deterioration of liver function and multiorgan failure, has high mortality. This study was designed to identify prognostic scores to predict short-term and long-term outcome in patients with ACLF to facilitate early treatment and thereby improve patient survival. Materials and Methods We retrospectively analyzed 102 ACLF patients who were hospitalized in the gastroenterology department. The EASL-CLIF criteria...
Tue Sep 15, 2020 03:00
Objective To explore the blood pressure response to different ablation points of renal denervation (RDN) in patients with resistant hypertension Methods A total of 42 cases with resistant hypertension treated by RDN in our center from 2013 to 2015 were retrospectively analyzed. The patients were divided into two groups according to the different ablation points of RDN: the standard treatment group (spiral ablation from...
Tue Sep 15, 2020 03:00
N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNA and potential regulatory functions of m6A have been shown by mapping the RNA m6A modification landscape. m6A modification in active gene regulation manifests itself as altered methylation profiles. The number of reports regarding to the profiling of m6A modification and its potential role in the placenta of preeclampsia (PE) is small. In this work, placental samples were collected from PE and control patients. Expression...
Tue Sep 15, 2020 03:00
Uncanny valley research has shown that human likeness is an important consideration when designing artificial agents. It has separately been shown that artificial agents exhibiting human-like kinematics can elicit positive perceptual responses. However the kinematic characteristics underlying that perception have not been elucidated. This paper proposes kinematic jerk amplitude as a candidate metric for kinematic human likeness, and aims to determine whether a perceptual optimum exists over a range...
Tue Sep 15, 2020 03:00
Synaptic transmission from somatostatin-expressing interneurons to excitatory neurons mediated by α5-subunit-containing GABAA receptors in the developing visual cortex. Neuroscience. 2020 Sep 11;: Authors: Cao JW, Guan W, Yu YC, Fu Y Abstract Dendrite-targeting somatostatin-expressing interneurons (SST-INs) powerfully control signal integration and synaptic plasticity in pyramidal dendrites during cortical development. We previously showed...
Tue Sep 15, 2020 13:39
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Skull Base These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 13:38
Relationships between advanced cancer patients' worry about dying and illness understanding, treatment preferences, and advance care planning. J Pain Symptom Manage. 2020 Sep 11;: Authors: Rodenbach RA, Althouse AD, Schenker Y, Smith TJ, Chu E, White DB, Bakitas M, Arnold RM Abstract CONTEXT: Patients with advanced cancer often worry about dying. Less is known about the role of worry in decision making regarding future care. OBJECTIVE:...
Tue Sep 15, 2020 13:35
LINC00689 induces gastric cancer progression via modulating the miR-338-3p/HOXA3 axis. J Gene Med. 2020 Sep 14;: Authors: Lu H, Zhang Q, Sun Y, Wu D, Liu L Abstract BACKGROUND: LINC00689 acts one critical regulatory role in several tumors. However, the functional, regulatory mechanism and expression of LINC00689 remains unknown in gastric cancer. METHODS: LINC00689 and miR-338-3p level were determined with RT-qPCR analysis and ELISA...
Tue Sep 15, 2020 13:35
Radiation Research Special Issue: New Beam Delivery Modalities are Shaping the Future of Radiotherapy. Radiat Res. 2020 Sep 14;: Authors: Griffin RJ, Limoli CL, Simone CB PMID: 32926736 [PubMed - as supplied by publisher]
Tue Sep 15, 2020 13:35
Enhancing International Cancer Organization Collaborations: King Hussein Cancer Center and Princess Margaret Cancer Centre Model for Collaboration. J Cancer Educ. 2020 Sep 14;: Authors: Khader J, Glicksman RM, Mheid S, Mansour A, Giuliani ME, Gospodarowicz M, Almousa A, Abdel-Razeq H, Rodin D Abstract Collaborative partnerships, which link two health organizations with shared characteristics to achieve common goals and to improve healthcare...
Tue Sep 15, 2020 13:35
Investigating potential molecular mechanisms of serum exosomal miRNAs in colorectal cancer based on bioinformatics analysis. Medicine (Baltimore). 2020 Sep 11;99(37):e22199 Authors: Wang H, Chen X, Bao L, Zhang X Abstract Colorectal cancer (CRC) is the most common malignant gastrointestinal tumor worldwide. Serum exosomal microRNAs (miRNAs) play a critical role in tumor progression and metastasis. However, the underlying molecular mechanisms...
Tue Sep 15, 2020 13:35
Targeting HER2 heterogeneity in early-stage breast cancer. Curr Opin Oncol. 2020 Sep 08;: Authors: Pernas S, Tolaney SM Abstract PURPOSE OF REVIEW: HER2-positive (HER2+) breast cancer is clinically and biologically a heterogenous disease and not all patients benefit to the same extent from current anti-HER2 therapies. RECENT FINDINGS: Among HER2+ breast cancer, molecular intrinsic subtypes, PIK3CA mutation status, levels of HER2 gene/protein,...
Tue Sep 15, 2020 13:35
Incidental Coronary Artery Calcium on Breast Radiation Therapy Planning Scans Identifies Patients for Cardiac Preventive Therapy. Am J Clin Oncol. 2020 Sep 11;: Authors: Amin NP, Kim SM, Lasio G, Zhou J, Romar L, Shipman K, Dukes K, Amin NP Abstract PURPOSE/OBJECTIVE(S): The presence of coronary artery calcium (CAC>0) is associated with increased cardiac-related mortality and is a common indication to initiate statin therapy to prevent future...
Tue Sep 15, 2020 13:35
Beyond the bench: how inclusion and exclusion make us the scientists we are. Mol Biol Cell. 2020 Sep 15;31(20):2164-2167 Authors: Termini CM, Pang A Abstract Recent events encompassing social injustices, healthcare disparities, and police brutality against Black citizens highlight the continued need to strive toward unbiased and inclusive practices in all realms of the world. Our voices as cell biologists are powerful tools that can be used...
Tue Sep 15, 2020 13:35
Effectiveness of Combined Treatment with Traditional Chinese Medicine and Western Medicine on the Prognosis of Patients with Breast Cancer. J Altern Complement Med. 2020 Sep;26(9):833-840 Authors: Lee YC, Chen YH, Huang YC, Lee YF, Tsai MY Abstract Objective: Traditional Chinese Medicine (TCM) can be used to balance the body's immunity and tumor development during different stages of cancer treatment. Recently, TCM has been an important part...
Tue Sep 15, 2020 13:35
Optimal Timing of CT Scanning in the Rapid Access Lung Cancer Clinic. Ir Med J. 2020 07 30;113(7):121 Authors: Hennessy M, Ryan D, Clarke S, Higgins C, Logan M, O’Brien E, Morgan R Abstract Aims To investigate whether a ‘CT first’ approach to Rapid Access Lung Cancer Clinic (RALC) review could be feasible in an Irish context. Methods A retrospective review of our institution’s Lung Cancer Database was performed. All RALC first attendances...
Tue Sep 15, 2020 13:35
Association of patient factors with time to treatment for breast cancer. Breast J. 2020 Sep 13;: Authors: Valente S, Al-Hilli Z, Liu Y, Greve N, Tu C, Grobmyer SR Abstract BACKGROUND: Studies have shown that in the United States, there is an increasing time from breast cancer diagnosis to first treatment (time to treatment or "TTT"), with concern that such delays may worsen oncologic outcomes. A component of TTT is the time from the initial...
Tue Sep 15, 2020 13:35
The future is now? Clinical and translational aspects of "Omics" technologies. Immunol Cell Biol. 2020 Sep 13;: Authors: D'Adamo GL, Widdop JT, Giles EM Abstract Big data has become a central part of medical research, as well as modern life generally. "Omics" technologies include genomics, proteomics, microbiomics, and increasingly other omics. These have been driven by rapid advances in laboratory techniques and equipment. Crucially, improved...
Tue Sep 15, 2020 13:35
Expression of the immune checkpoint molecule V-set immunoglobulin domain-containing 4 is associated with poor prognosis in patients with advanced gastric cancer. Gastric Cancer. 2020 Sep 14;: Authors: Kim SW, Roh J, Lee HS, Ryu MH, Park YS, Park CS Abstract BACKGROUND: Recent clinical studies on immune checkpoint (IC) inhibitors in the context of advanced gastric cancer (AGC) have failed to show significant survival benefits but have suggested...
Tue Sep 15, 2020 13:35
Spirometry use in Patients with Sickle Cell Disease with and without asthma and acute chest syndrome: A Multicenter Study. EJHaem. 2020 Jul;1(1):239-242 Authors: Duckworth L, Black LV, Ezmigna D, Green J, Yao Y, Grannis S, Klann J, Applegate R, Lipori G, Wallace T, Wilkie DJ Abstract A de-identified data repository of electronic medical record (EMR) data, i2b2 (Informatics for Integrating Biology and the Bedside), including 4 geographically...
Tue Sep 15, 2020 13:35
Opportunities and Challenges for Analyzing Cancer Data at the Inter- and Intra-Institutional Levels.
Opportunities and Challenges for Analyzing Cancer Data at the Inter- and Intra-Institutional Levels. JCO Precis Oncol. 2020;4: Authors: Wu J, Bryan J, Rubinstein SM, Wang L, Lenoue-Newton M, Zuhour R, Levy M, Micheel C, Xu Y, Bhavnani SK, Mackey L, Warner JL Abstract PURPOSE: Our goal was to identify the opportunities and challenges in analyzing data from the American Association of Cancer Research Project Genomics Evidence Neoplasia Information...
Tue Sep 15, 2020 13:35
Engaging Patients in Precision Oncology: Development and Usability of a Web-Based Patient-Facing Genomic Sequencing Report. JCO Precis Oncol. 2020;4: Authors: Solomon IB, McGraw S, Shen J, Albayrak A, Alterovitz G, Davies M, Del Vecchio Fitz C, Freedman RA, Lopez LN, Sholl LM, Van Allen E, Mortimer J, Fakih M, Pal S, Reckamp KL, Yuan Y, Gray SW Abstract PURPOSE: Evidence-based somatic and germline sequencing has transformed cancer care and...
Tue Sep 15, 2020 13:35
Intrahepatic Cholangiocarcinoma: Genomic Heterogeneity Between Eastern and Western Patients. JCO Precis Oncol. 2020;4: Authors: Cao J, Hu J, Liu S, Meric-Bernstam F, Abdel-Wahab R, Xu J, Li Q, Yan M, Feng Y, Lin J, Zhao S, Wang J, Kwong LN, Hu J, Carapeto F, Borad MJ, Wang K, Javle M, Zhao H Abstract PURPOSE: Intrahepatic cholangiocarcinoma (IHCCA), a global health problem, is increasing in incidence and has differing etiologies worldwide....
Tue Sep 15, 2020 13:35
Virtual care models for cancer survivorship. NPJ Digit Med. 2020;3:113 Authors: Pham Q, Hearn J, Gao B, Brown I, Hamilton RJ, Berlin A, Cafazzo JA, Feifer A Abstract Virtual care models for cancer survivorship are needed to support patients living with the chronic effects of cancer treatment, while increasing health system capacity. Characteristics that may be critical to their success have not been adequately studied. This scoping review summarizes...
Tue Sep 15, 2020 13:35
The Roles of Nanoparticles in Stem Cell-Based Therapy for Cardiovascular Disease. Front Bioeng Biotechnol. 2020;8:947 Authors: Sun Y, Lu Y, Yin L, Liu Z Abstract Cardiovascular disease (CVD) is currently one of the primary causes of mortality and morbidity worldwide. Nanoparticles (NPs) are playing increasingly important roles in regulating stem cell behavior because of their special features, including shape, size, aspect ratio, surface charge,...
Tue Sep 15, 2020 13:35
Insight Into the Function of RIPK4 in Keratinocyte Differentiation and Carcinogenesis. Front Oncol. 2020;10:1562 Authors: Xu J, Wei Q, He Z Abstract The receptor-interacting protein kinase 4 (RIPK4), a member of the RIPK family, was originally described as an interaction partner of protein kinase C (PKC) β and PKCδ. RIPK4 is identified as a key regulator of keratinocyte differentiation, cutaneous inflammation, and cutaneous wound repair. The...
Tue Sep 15, 2020 13:35
Management of Patients With Hematologic Malignancies During the COVID-19 Pandemic: Practical Considerations and Lessons to Be Learned. Front Oncol. 2020;10:1439 Authors: Isidori A, de Leval L, Gergis U, Musto P, Porcu P Abstract The COVID-19 pandemic has created unprecedented hurdles to the delivery of care to patients with cancer. Patients with hematologic malignancies appear to have a greater risk of SARS-CoV-2 infection and severe disease...
Tue Sep 15, 2020 13:35
Machine Learning-Based Radiomics Nomogram Using Magnetic Resonance Images for Prediction of Neoadjuvant Chemotherapy Efficacy in Breast Cancer Patients. Front Oncol. 2020;10:1410 Authors: Chen S, Shu Z, Li Y, Chen B, Tang L, Mo W, Shao G, Shao F Abstract Purpose: The construction and validation of a radiomics nomogram based on machine learning using magnetic resonance image (MRI) for predicting the efficacy of neoadjuvant chemotherapy (NACT)...
Tue Sep 15, 2020 13:35
Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells. Oncoimmunology. 2020 Jun 16;9(1):1773204 Authors: Aguirre LA, Montalbán-Hernández K, Avendaño-Ortiz J, Marín E, Lozano R, Toledano V, Sánchez-Maroto L, Terrón V, Valentín J, Pulido E, Casalvilla JC, Rubio C, Diekhorst L, Laso-García F, Del Fresno C, Collazo-Lorduy A, Jiménez-Munarriz B, Gómez-Campelo P, Llanos-González E, Fernández-Velasco M, Rodríguez-Antolín C, Pérez de Diego...
Tue Sep 15, 2020 13:35
Mapping metabolism of liver tissue using two-photon FLIM. Biomed Opt Express. 2020 Aug 01;11(8):4458-4470 Authors: Rodimova S, Kuznetsova D, Bobrov N, Elagin V, Shcheslavskiy V, Zagainov V, Zagaynova E Abstract Although fluorescence lifetime imaging microscopy (FLIM) has been extensively applied to study cellular metabolism in the liver, there is neither an established approach to analyze the data, nor have appropriate protocols been developed...
Tue Sep 15, 2020 13:35
A Preliminary Study of NER and MMR Pathways Involved in Chemotherapy Response in Bladder Transitional Cell Carcinoma: Impact on progression-free survival. Iran J Pharm Res. 2020;19(1):355-365 Authors: Montazeri V, Ghahremani MH, Montazeri H, Hasanzad M, Safavi DM, Ayati M, Chehrazi M, Arefi Moghaddam B, Ostad SN Abstract One of the main genotoxic drugs used in bladder cancer chemotherapy is cisplatin. While it is applied in most types of cancers,...
Tue Sep 15, 2020 13:35
Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells. Front Immunol. 2020;11:1771 Authors: Zhu C, Song Z, Wang A, Srinivasan S, Yang G, Greco R, Theilhaber J, Shehu E, Wu L, Yang ZY, Passe-Coutrin W, Fournier A, Tai YT, Anderson KC, Wiederschain D, Bahjat K, Adrián FJ, Chiron M Abstract Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly...
Tue Sep 15, 2020 13:35
Implications of Telemedicine in Oncology during the COVID-19 Pandemic. Acta Biomed. 2020 Sep 07;91(3):e2020022 Authors: Shirke MM, Shaikh SA, Harky A Abstract COVID-19 has had a catastrophic effect on healthcare systems compromising the treatment of cancer patients. It has an increased disease burden in the cancer population. As a result, tele-oncology services have become essential to reduce the risk of cancer patients being exposed to the...
Tue Sep 15, 2020 13:35
The role of cancer metabolism in defining the success of oncolytic viro-immunotherapy. Cytokine Growth Factor Rev. 2020 Sep 06;: Authors: Dyer A, Frost S, Fisher KD, Seymour LW Abstract Oncolytic viruses infect, replicate in, and kill cancer cells selectively without harming normal cells. The rapidly expanding clinical development of oncolytic virotherapy is an exciting interdisciplinary field that provides insights into virology, oncology,...
Tue Sep 15, 2020 13:35
Single- and Multifraction Stereotactic Radiosurgery Dose/Volume Tolerances of the Brain. Int J Radiat Oncol Biol Phys. 2020 Sep 10;: Authors: Milano MT, Grimm J, Niemierko A, Soltys SG, Moiseenko V, Redmond KJ, Yorke E, Sahgal A, Xue J, Mahadevan A, Muacevic A, Marks LB, Kleinberg LR Abstract PURPOSE: As part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy investigating normal tissue complication...
Tue Sep 15, 2020 13:35
The role of sentinel lymph node mapping in endometrial carcinoma. Minerva Ginecol. 2020 Sep 14;: Authors: Soderini A, De Pietri V, Crespe M, Rodriguez Y, Aragona A Abstract Endometrial cancer is the most commonly diagnosed gynecological malignancy in developing countries, and the second malignancy after cervical cancer in developing countries. The primary treatment is based on surgical and pathologic staging including extrafascial type A radical...
Tue Sep 15, 2020 13:35
Related Articles Outcomes of COVID-19 in patients with CLL: a multicenter international experience. Blood. 2020 09 03;136(10):1134-1143 Authors: Mato AR, Roeker LE, Lamanna N, Allan JN, Leslie L, Pagel JM, Patel K, Osterborg A, Wojenski D, Kamdar M, Huntington SF, Davids MS, Brown JR, Antic D, Jacobs R, Ahn IE, Pu J, Isaac KM, Barr PM, Ujjani CS, Geyer MB, Berman E, Zelenetz AD, Malakhov N, Furman RR, Koropsak M, Bailey N, Hanson L, Perini GF, Ma S, Ryan CE,...
Tue Sep 15, 2020 13:35
Related Articles Cancer Research: The Lessons to Learn from COVID-19. Cancer Discov. 2020 09;10(9):1263-1266 Authors: Bailey C, Black JRM, Swanton C Abstract The COVID-19 pandemic has caused widespread disruption of cancer clinical trials due to the restrictions on nonessential services and the reallocation of resources, and at the same time the urgent global effort toward discovering therapies that treat or prevent COVID-19 infection has led...
Tue Sep 15, 2020 13:35
An automated snoring sound classification method based on local dual octal pattern and iterative hybrid feature selector. Biomed Signal Process Control. 2021 Jan;63:102173 Authors: Tuncer T, Akbal E, Dogan S Abstract In this research, a novel snoring sound classification (SSC) method is presented by proposing a new feature generation function to yield a high classification rate. The proposed feature extractor is named as Local Dual Octal Pattern...
Tue Sep 15, 2020 13:33
[Relationship between insomnia phenotype and mild cognitive impairment in young and middle-aged patients with obstructive sleep apnea hypopnea syndrome]. Zhonghua Yi Xue Za Zhi. 2020 Sep 15;100(34):2675-2681 Authors: Guo KD, Wang J, Wang QJ, Shen JC, Chen R Abstract Objective: To explore the relationship between insomnia phenotype and mild cognitive impairment (MCI) in young and middle-aged patients with obstructive sleep apnea hypopnea syndrome...
Tue Sep 15, 2020 13:33
185 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: ALCOHOL These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 13:32
Publication date: Available online 14 September 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Onur Yilmaz, Efe Sivrikaya, Fatih Taskesen, Cagasan Pirpir, Sezai Ciftci
Tue Sep 15, 2020 13:29
Publication date: Available online 14 September 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Sabine S. Linsen, Andreas Schön, Louis G. Mercuri, Marcus Teschke
Tue Sep 15, 2020 13:29
Publication date: Available online 14 September 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Pinar Yuce, Hatice Hosgor, Selenay Furat rencber, Yusufhan Yazir
Tue Sep 15, 2020 13:29
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 13:26
Publication date: Available online 15 September 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Steven John Lo, Yen-Chun Lee, Jennifer Hsu, Chung-Chen Hsu, Chih-Hung Lin, Cheng-Hung Lin
Tue Sep 15, 2020 13:25
Ocular and cervical vestibular evoked myogenic potentials elicited by air-conducted, low-frequency sound. J Vestib Res. 2020 Aug 27;: Authors: Luecke VN, Buchwieser L, Zu Eulenburg P, Marquardt T, Drexl M Abstract BACKGROUND: Sound is not only detected by the cochlea, but also, at high intensities, by the vestibular system. Acoustic activation of the vestibular system can manifest itself in vestibular evoked myogenic potentials (VEMPs)....
Tue Sep 15, 2020 13:22
Topography of the lesion in idiopathic sudden sensorineural hearing loss. Acta Otolaryngol. 2020 Sep 12;:1-5 Authors: Yigider AP, Keskin M, Kufeciler L, Kocak HE Abstract INTRODUCTION: Etiology of ISSNHL includes cessation of vascular perfusion, viral infection and cochlear membrane injury. Precise location of injury should be defined for a target-oriented treatment. Vestibular complaints in ISSNHL are hypothesized as involvement of vestibule....
Tue Sep 15, 2020 13:22
Related Articles Sound-evoked vestibular projections to the splenius capitis in humans: comparison with the sternocleidomastoid muscle. J Appl Physiol (1985). 2019 06 01;126(6):1619-1629 Authors: Rosengren SM, Weber KP, Govender S, Welgampola MS, Dennis DL, Colebatch JG Abstract The short-latency vestibulo-collic reflex in humans is well defined for only the sternocleidomastoid (SCM) neck muscle. However, other neck muscles also receive input...
Tue Sep 15, 2020 13:22
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