Your body is a complex organism requiring quality sleep to function optimally. Your body’s circadian rhythms are a combination of biological clocks regulating everything from your metabolism to psychological functioning. One sure way to cause dysregulation of your biological clock is to skimp on sleep. Although you have a master clock in your brain to synchronize bodily functions, every organ and cell has its own biological clock as well. In a stunning discovery published in 2017, researchers found...
02:00
Magnesium1 is involved in hundreds of biochemical reactions in your body,2,3 and deficiency can contribute to significant health problems. Two common pathologies associated with magnesium deficiency are Type 2 diabetes4,5 and heart disease. According to one scientific review,6 low magnesium may actually be the greatest predictor of heart disease, and other recent research7 published in Open Heart journal suggests even subclinical magnesium deficiency can compromise your cardiovascular health....
02:00
1 Which of the following nutrients is crucial for the prevention of osteoporosis and cardiovascular events such as heart attack and stroke? Vitamin K2 Vitamin K2 inhibits arterial calcification and improves arterial flexibility, thereby reducing your risk of a cardiovascular event (such as a heart attack) or death. It's also important for the prevention of osteoporosis. Learn more. Omega-6 Omega-3 Vitamin K1 2 Which of the following has been linked to a significantly increased...
02:00
Teatime is an honored tradition in Great Britain and much of Asia, and tea plays an important role in cultures around the world. Teatime in the West often focuses on the food served with the beverage, while in Eastern cultures, serving tea has been elevated to an art form. It’s an ancient beverage that has demonstrated dramatic and positive effects on health. Tea is one of the most popular beverages served around the world, second only to water. Nearly 80% of all U.S. households have tea in the...
02:00
Abstract A gram-stain negative, aerobic, non-motile and rod-shaped novel bacterial strain, designated MAH-19T, was isolated from bark of Pinus koraiensis. The colonies were observed to be light pink coloured, smooth, circular and 0.3–0.7 mm in diameter when grown on R2A agar for 2 days. Strain MAH-19T was found to be able to grow at 10–35 °C (optimum 28–30 °C), at pH 6.0–8.0 (optimum 7.0) and at 0–0.5% NaCl (optimum 0%). Cell growth occurs on nutrient agar and R2A agar. The strain...
02:00
Atmosphere, Vol. 10, Pages 720: Recently Strengthened Influence of ENSO on the Wintertime East Asian Surface Air Temperature Atmosphere doi: 10.3390/atmos10110720 Authors: Hainan Gong Lin Wang Wen Chen Previous studies have indicated that El Niño–Southern Oscillation (ENSO) exerts a significant influence on the East Asian winter climate. This study reveals an interdecadal strengthening of the connection between ENSO and the East Asian surface air temperature...
02:00
IJMS, Vol. 20, Pages 5789: Connexin43 Is Required for the Effective Activation of Spleen Cells and Immunoglobulin Production International Journal of Molecular Sciences doi: 10.3390/ijms20225789 Authors: Yanru Huang Zhimin Mao Xiling Zhang Xiawen Yang Norifumi Sawada Masayuki Takeda Jian Yao Gap junctions (Gjs), formed by specific protein termed connexins (Cxs), regulate many important cellular processes in cellular immunity. However, little is known about their effects...
02:00
IJMS, Vol. 20, Pages 5788: Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells International Journal of Molecular Sciences doi: 10.3390/ijms20225788 Authors: Nabil A. Alhakamy Osama A.A. Ahmed Hibah M. Aldawsari Mohammad Y. Alfaifi Basma G. Eid Ashraf B. Abdel-Naim Usama A. Fahmy Research on statins highlights their potent cytotoxicity against cancer cells and their potential for cancer prevention. The aim of the current...
02:00
IJMS, Vol. 20, Pages 5787: Inositols’ Importance in the Improvement of the Endocrine–Metabolic Profile in PCOS International Journal of Molecular Sciences doi: 10.3390/ijms20225787 Authors: Anna Wojciechowska Adam Osowski Marcin Jóźwik Ryszard Górecki Andrzej Rynkiewicz Joanna Wojtkiewicz Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility and metabolic problems among women of reproductive age. The mechanism of PCOS is associated with concurrent...
02:00
IJMS, Vol. 20, Pages 5786: S100 Calcium Binding Protein A9 Represses Angiogenic Activity and Aggravates Osteonecrosis of the Femoral Head International Journal of Molecular Sciences doi: 10.3390/ijms20225786 Authors: Re-Wen Wu Wei-Shiung Lian Chung-Wen Kuo Yu-Shan Chen Jih-Yang Ko Feng-Sheng Wang Ischemic damage aggravation of femoral head collapse is a prominent pathologic feature of osteonecrosis of the femoral head (ONFH). In this regard, S100 calcium binding protein...
02:00
IJMS, Vol. 20, Pages 5783: Genome-Wide Identification and Characterization of ABC Transporters in Nine Rosaceae Species Identifying MdABCG28 as a Possible Cytokinin Transporter linked to Dwarfing International Journal of Molecular Sciences doi: 10.3390/ijms20225783 Authors: Yi Feng Qiran Sun Guifen Zhang Ting Wu Xinzhong Zhang Xuefeng Xu Zhenhai Han Yi Wang ATP-binding cassette (ABC) transporters constitute a large, diverse, and ubiquitous superfamily that is involved...
Sun Nov 17, 2019 02:00
IJMS, Vol. 20, Pages 5785: The Effect of Schisandra chinensis Baillon on Cross-Talk between Oxidative Stress, Endoplasmic Reticulum Stress, and Mitochondrial Signaling Pathway in Testes of Varicocele-Induced SD Rat International Journal of Molecular Sciences doi: 10.3390/ijms20225785 Authors: Karna Choi Kim Kim Park Schisandra chinensis Baillon (SC) has been utilized for its antioxidants and anti-inflammatory activities in a broad variety of medical applications. However;...
Sun Nov 17, 2019 02:00
The terms “being present” and “living in the now” have become clichés on the spiritual path and in the nondual tradition that has become increasingly popular in recent years. We speak of the power of now, the timeless moment, and that “there is only now.” In the positive thinking movement, we released sin as a stumbling block, then replaced it with the charge of negative thinking. Now our greatest put-down is the accusation of being distracted and therefore not present to what is. I am being...
Sun Nov 17, 2019 23:40
Haematological indexes of both inflammation and platelet activation have been suggested as predictive markers of cardiovascular disease (CVD), which has high prevalence in Paralympic athletes (PA). Different mechanisms could play a role in increasing CVD risk in PA with spinal cord injury (PA-SCI), lower limb amputation (PA-LLA), or upper limb impairment (PA-ULI). We compared, in 4 groups of PA competing in power, intermittent (mixed metabolism), and endurance sports, Framingham Risk Score (FRS),...
08:05
This study was performed to investigate the biocompatibility (BC), magnetothermal effect, and DNA binding biological characteristics of manganese zinc ferrite nanoparticles (Mn0.6Zn0.4Fe2O4-NPs (MZF-NPs)) coated with pegylated manganese (PEG-MZF-NPs). Their functions as gene transfer carrier for gene therapy and magnetic medium for tumor hyperthermia were also explored. The manganese zinc ferrite nanoparticles were synthesized through high temperature cracking, and their characterizations were discovered....
08:05
Osteosarcoma is the most frequently diagnosed primary malignant bone sarcoma in children and adolescents. Recent studies have shown that cancer stem cells (CSCs), a cluster of tumor cells with the ability to self-renew, play an essential role in tumor recurrence and metastasis. Thus, it is necessary to develop therapeutic strategies specifically targeting CSCs. Metformin, the first-line drug for type 2 diabetes, exhibits antineoplastic activities in various kinds of tumors. New evidence has suggested...
07:05
The efficiency of nanoparticles covered with type A gel and loaded with KH2PO4, as a source of P, was evaluated on growth, phosphorus concentration and accumulation, and photosynthesis-related parameters in rice plants (Oryza sativa L. ssp. indica) cv. Morelos A-2010, under greenhouse conditions. Plants were treated for 14 days with P concentrations equivalent to 50 and 100% of those established in the Yoshida nutrient solution. Sources of P were KH2PO4, nano-KH2PO4, and nano-KH2PO4 with trypsin;...
07:05
The ultimatum game has been a prominent paradigm in studying the evolution of fairness. It predicts that responders should accept any nonzero offer and proposers should offer the smallest possible amount according to orthodox game theory. However, the prediction strongly contradicts with the experimental behaviors where the mean offer typically ranges from 0.3 to 0.5 and the mean demand tends to lie between 0.2 and 0.35. To explain the evolution of such fair behaviors, here we introduce empathy in...
07:05
Background/Aims. Hepatocellular carcinoma (HCC) is the lethal digestive cancer and the second leading cause of cancer death in men worldwide. Wnt7a, a 39Kd secreted glycoprotein composed of 349 amino acids, was reported to be related to various diseases. However, its role in HCC has not been studied yet. In this study, using gene expression data and clinical information obtained from the Oncomine and KMplot database, we acknowledged that WNT7A was underexpressed in HCC cancer tissue compared with...
07:05
Affective temperaments represent a biologically stable core of emotional reactivity and have previously been associated with hypertension and arterial stiffening. The age, when hypertension is initiated, is influenced by different factors, but the role of personality traits in this regard is not clarified yet. Our aim was to study the association between affective temperaments and the age at onset of hypertension. In this cross-sectional study, 353 patients were included. After the evaluation of...
06:05
A three-dimensional hierarchically structured flowerlike zeolite was synthesized using naturally occurring nanohalloysite (HNT) by hydrothermal methods. Halloysite a hydrated aluminum silicate with nanohollow morphology, microporosity, and environmentally friendly properties was chosen to be the sole precursor. The morphology and structure of the composite that was prepared was characterized using XRD, FT-IR, BET, TG, SEM, HRTEM, and NMR. SEM and HRTEM images indicated that the synthesized zeolite...
06:05
Nuclear factor erythroid 2-related factor 2 (Nrf2) is involved in tumor drug resistance, but its role in imatinib resistance of chronic myeloid leukemia (CML) remains elusive. We aimed to investigate the effects of Nrf2 on drug sensitivity, thioredoxin reductase (TrxR) expression, reactive oxygen species (ROS) production, and apoptosis induction in imatinib-resistant CML K562/G01 cells and explored their potential mechanisms. Stable K562/G01 cells with knockdown of Nrf2 were established by infection...
06:05
Background. Serine hydroxymethyltransferase 2 (SHMT2) activity ensures that cells have a survival advantage in ischemic conditions and regulates redox homeostasis. In this study, we aimed to investigate the role of SHMT2 after hepatic ischemia-reperfusion (IR), which involves hypoxia, ischemic conditions, and cell apoptosis. Methods. A 70% IR model was established in C57BL/6J mice with or without SHMT2 knockdown. H&E staining, liver weight/body weight, serum alanine aminotransferase (ALT), and...
06:05
Graphene is an excellent platform to support and stabilize silver nanoparticles (AgNPs). The reduced graphene oxide-silver nanoparticles (rGO-AgNPs) were synthesized by the chemical reduction method and characterized by using ultraviolet-visible (UV-vis) absorption, transmission electron microscopy (TEM), X-ray diffractometer (XRD), and scanning probe microscopy (SPM). The binding reaction of rGO-AgNPs with bovine serum albumin (BSA) was investigated by using fluorescence spectrometry and SPM. As...
05:05
Purpose. To report the supracrestal bone regeneration of approximately 10 mm using solvent-dehydrated mineralized cancellous bone allograft and nonresorbable membrane in rehabilitation of unsuccessful implants in the anterior maxilla and stability of the regenerated bone at the 14th-year follow-up. Case Presentation. A 24-year-old female patient with a history of anterior dentoalveolar trauma resulting in the loss of upper left incisors and canine underwent rehabilitation several years ago with three...
05:05
Myoblast fusion is an essential step in skeletal muscle development and regeneration. NADPH oxidase 4 (Nox4) regulates cellular processes such as proliferation, differentiation, and survival by producing reactive oxygen species (ROS). Insulin-like growth factor 1 induces muscle hypertrophy via Nox4, but its function in myoblast fusion remains elusive. Here, we report a ROS-dependent role of Nox4 in myoblast differentiation. Regenerating muscle fibers after injury by cardiotoxin had a lower cross-sectional...
04:05
The introduction of resin-based cements and an adhesive-bonding system in daily dental practice has given the opportunity to increase the retention of previously conventional cemented restorations and the optimal results in esthetic. This experimental study employed the 3D Digital Image Correlation Method (3D-DIC) for detecting shrinkage strain in four dual cured composite cements. The aim was to visualize measure, analyze, and compare strain fields in four resin-based cements using the 3D-DIC method....
Sun Nov 17, 2019 15:30
Keshan disease (KD) is an endemic cardiomyopathy, which mainly occurs in China. Selenium deficiency is believed to play an important role in the pathogenesis of KD, but the molecular mechanism of selenium-induced damage remains unclear. To identify the key genes involved in selenium-induced damage, we compared the expression profiles of selenium-related genes between patients with KD and normal controls. Total RNA was isolated, amplified, labeled, and hybridized to Agilent human 4 × 44 K whole genome...
Sun Nov 17, 2019 15:30
Background. Physical activity is believed to enhance body functions and sense of wellbeing in general population. Objectives. This study aimed to explore physical activity measures; and the association between those measures, and mental wellbeing among older adults in South and Southeast Asia. Methods. A systematic search was made in CINHAL, EMBASE, PubMed, and PsycINFO. Articles published between 2008 and 2018 were selected with participants aged 60 years and above, living at home, community, supported...
Sun Nov 17, 2019 15:30
Dilation and curettage: A minor operation in which the cervix is expanded enough (dilation) to permit the cervical canal and uterine lining to be scraped with a curet (or curette), an instrument shaped like a small spoon. This procedure also is called D and C. MedTerms (TM) is the Medical Dictionary of MedicineNet.com.We Bring Doctors' Knowledge To You
08:24
A discussion of changes impacting the hearing industry and audiology care, and how audiologists may consider adapting their processes and practices.
07:00
02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου