In this study, we report a novel 3D printed microfluidic device functionalized with anti-EpCAM (epithelial cell adhesion molecule) antibodies to isolate CTCs from human blood samples. A 3D printing technology was utilized with specially designed interior structures to fabricate a microfluidic device with high surface area and fluid flow manipulation, increasing the capture efficiency of tumor cells. These devices with the optimal flow rate (1 mL/h) and channel length (2 cm) were demonstrated to test...
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Abstract Introduction Evidence has demonstrated greater benefit of intra-articular hyaluronic acid (IA-HA) within earlier stages of knee osteoarthritis (OA) rather than waiting for patients to have progressed to later stages of disease progression. High molecular weight (HMW) HA has also been shown to be more effective than low molecular weight (LMW) HA products in mild to moderate knee OA, providing an important distinction to make within...
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Publication date: Available online 17 November 2019Source: Chemico-Biological InteractionsAuthor(s): Mohammadreza Gholibeikian, Abdolhamid Bamoniri, Mohammad Hassan HoushdarTehrani, Bi Bi Fatemeh Mirjalili, Hamid Reza BijanzadehAbstractCancer has emerged as the main cause of the highest rate of mortality in the world. Drugs used in cancer, although, show some beneficial effects on cancerous organs, demonstrate side effects on other normal tissues. On the other hand, anticancer peptides, being effective...
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This study demonstrated that FA-PMo4V8 is simply designed and accurate in colorimetric detection of urinary sarcosine, which could be useful for clinical applications.Graphical Abstract (Source: Sensors and Actuators B: Chemical)
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Publication date: Available online 16 November 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xueying Pei, Fangjun Huo, Yongkang Yue, Tinggui Chen, Caixia YinAbstractCancer is a leading cause of death worldwide. The discrimination of cancer cells from normal cells is of importance for early diagnosis. Designing and synthesizing fluorescent probes that precisely target cancer cells can greatly aid treatment efforts. Biotin can target over-expressed receptors on the surface of cancer cells....
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Publication date: Available online 17 November 2019Source: Journal of Environmental Chemical EngineeringAuthor(s): Mohammad Malakootian, Hakimeh Mahdizadeh, Mohamadreza Khavari, Alireza Nasiri, Majid Amiri Gharaghani, Mehrdad Khatami, Endalkachew Sahle-Demessie, Rajender S. VarmaAbstractAcid-Red 18 is one of many azo dyes that are widely used in the textile industry. Wastewater effluent stream may contain untreated dyes that are toxic, carcinogenic, or mutagenic in character and are harmful to marine...
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Publication date: Available online 16 November 2019Source: MethodsXAuthor(s): Sai P. Visweshwaran, Tanja MaritzenAbstractCellular migration plays a crucial role within multicellular organisms enabling organ development, wound healing and efficient immune responses, but also metastasis. Therefore, it is crucial to dissect the underlying mechanisms. Directed migration and invasion are most efficient in response to chemotactic signals. To study cell migration and chemotactic responses, current experimental...
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AbstractA library of 1,2,4-oxadiazole functionalized quinoline derivatives (13a –j) were synthesized and their structures were confirmed by1H NMR,13CNMR and Mass Spectral analysis. Further, these compounds were evaluated for their anticancer activity against four human cancer cell lines, namely MCF-7 (breast), A549 (lung), DU-145 (prostate) and MDA MB-231 (breast) using Etoposide as the positive control. Most of these derivatives exhibited more potent activity towards the four cancer cell lines compared...
Sun Nov 17, 2019 00:00
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Pirus Ghadjar, Thomas Wiegel (Source: European Urology)
Sun Nov 17, 2019 23:08
Publication date: Available online 17 November 2019Source: European UrologyAuthor(s): Zhengzheng Xu, Guangzhe Ge, Bao Guan, Zhentao Lei, Xueyu Hao, Yuanyuan Zhou, Yue Shi, Huan Lu, Jilu Wang, Ding Peng, XiKang Wu, Huiying He, Bao Zhang, Xuesong Li, Liqun Zhou, Weimin Ci (Source: European Urology)
Sun Nov 17, 2019 23:08
Publication date: Available online 16 November 2019Source: European UrologyAuthor(s): Elise De Bleser, Piet Ost (Source: European Urology)
Sun Nov 17, 2019 23:08
Authors: Bezzecchi Ronzio Dolfini Mantovani The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl (“long”) and NF-YAs (“short”). Little is known about the expression levels of NF-Y subunits in tumors, and nothing in lung cancer. By interrogating RNA-seq TCGA and GEO datasets, we found that, unlike NF-YB/NF-YC, NF-YAs is overexpressed in lung squamous cell carcinomas (LUSC). The ratio of the...
Sun Nov 17, 2019 00:00
Publication date: Available online 16 November 2019Source: European Journal of Surgical OncologyAuthor(s): D. Moreno-Ramírez, R. Vieira, R. Kaufmann (Source: European Journal of Surgical Oncology (EJSO))
Sun Nov 17, 2019 22:40
ConclusionsTattooing of axillary LNs is safe and easily performed. Tattooing was helpful in identifying the marked LN in the majority of cases. This technique helps to ensure that metastatic LNs are identified and removed at surgery after NAT. (Source: European Journal of Surgical Oncology (EJSO))MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Nov 17, 2019 22:40
Publication date: Available online 16 November 2019Source: Gynecologic Oncology ReportsAuthor(s): Hermineh Aramin, Pratistha Koirala, Abhishek Shah, Kendall Adams, Natalia Buza, Sapna Desai, Melissa Fairbairn, David Goldenberg, Wenli Gao, Linus Chuang, Ramapriya Vidhun, Vaagn Andikyan (Source: Gynecologic Oncology Reports)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Sun Nov 17, 2019 21:03
Publication date: Available online 16 November 2019Source: American Journal of Infection ControlAuthor(s): Patrick Murphy, Le Kang, Michele Fleming, Connie Atkinson, Rachel Pryor, Kaila Cooper, Emily Godbout, Michael P. Stevens, Michelle Doll, Gonzalo BearmanWe employed an interrupted time series analysis to assess the impact of ultraviolet-C light disinfection at terminal discharge in an oncology unit and a bone marrow transplant unit on the incidence of hospital-acquired infections. The deployment...
Sun Nov 17, 2019 19:35
Publication date: Available online 17 November 2019Source: Pharmacological ResearchAuthor(s): Ali Dehshahri, Milad Ashrafizadeh, Elham Ghasemipour Afshar, Abbas Pardakhty, Ali Mandegary, Reza Mohammadinejad, Gautam SethiAbstractTopoisomerase enzymes have shown unique roles in replication and transcription. These enzymes which were initially found in Escherichia coli have attracted considerable attention as target molecules for cancer therapy. Nowadays, there are several topoisomerase inhibitors in...
Sun Nov 17, 2019 18:39
Publication date: Available online 16 November 2019Source: Journal of Evidence Based Dental PracticeAuthor(s): Walter J. Psoter, Erin T. Shope (Source: Journal of Evidence Based Dental Practice)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Sun Nov 17, 2019 18:12
ConclusionsOral HPV infection is significantly prevalent and widespread worldwide, particularly among men and among populations at risk. Prevalence has increased during the last two decades. (Source: Journal of Evidence Based Dental Practice)
Sun Nov 17, 2019 18:12
Publication date: Available online 16 November 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hiroyuki Kunishima, Kaoru Ito, Thomas Laurent, Machiko Abe
Sun Nov 17, 2019 20:02
Publication date: Available online 16 November 2019Source: Journal of Cardiology CasesAuthor(s): Lucy Grant, Ian Morgan, VaiyaPuri Sumathi, Nabeel SalmonsAbstractA 31-year-old female with a history of polycystic ovary syndrome and two recent miscarriages presented with symptoms of a transient ischemic attack. Echocardiography to assess for possible embolic source identified a 4.8 cm left atrial mass, presumed to be an atrial myxoma.At surgery the tumor was suspicious of malignancy. Histopathology...
Sun Nov 17, 2019 17:38
In conclusion, miR-142-3p overexpression may inhibit autophagy and promote the drug sensitivity of breast cancer cells to DOX by targeting HMGB1. The miR-142-3p/HMGB1 axis might be a novel target to regulate the drug resistance of breast cancer patients.Graphical abstractHigh-mobility group box 1 (HMGB1) is a direct functional target of miR-142-3p in breast cancer cells. MiR-142-3p overexpression may inhibit autophagy and promote the drug sensitivity of doxorubicin (DOX) by targeting HMGB1. The miR-142-3p/HMGB1...
Sun Nov 17, 2019 17:14
Authors: Laure Chaput Victoria Grèze Pascale Halle Nina Radosevic-Robin Bruno Pereira Lauren Véronèse Hervé Lejeune Philippe Durand Guillaume Martin Sandra Sanfilippo Michel Canis Justyna Kanold Andrei Tchirkov Florence Brugnon Ewing sarcoma (EWS) is a common pediatric solid tumor with high metastatic potential. Due to toxic effects of treatments on reproductive functions, the cryopreservation of ovarian tissue (OT) or testicular tissue (TT) is recommended...
Sun Nov 17, 2019 00:00
Authors: Melanie Kappelmann-Fenzl Silke Kuphal Rosemarie Krupar Dirk Schadendorf Viktor Umansky Lily Vardimon Claus Hellerbrand Anja-Katrin Bosserhoff Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers. They are essential for a number of cellular processes, including intracellular trafficking and mitosis. Tubulin-binding chemotherapeutics are used to treat different types of tumors, including malignant melanoma. The transcription...
Sun Nov 17, 2019 00:00
Publication date: Available online 17 November 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Sumit Kumar Hira, Kheyanath Mitra, Prateek Srivastava, Shikha Singh, Sambhav Vishwakarma, Ranjeet Singh, Biswajit Ray, Partha Pratim MannaAbstractA novel ABA-type polyethylene glycol (PEG)-b-polyketal (PK)-b-PEG block copolymer was synthesized via click reactions between the monoazido-monomethoxy-PEG and dialkyne terminated aliphatic polyketal with no carboxylic/amide linkages....
Sun Nov 17, 2019 16:02
Publication date: Available online 17 November 2019Source: Nano TodayAuthor(s): Fanxing Bu, Moustafa M. Zagho, Yasseen Ibrahim, Bing Ma, Ahmed Elzatahry, Dongyuan ZhaoAbstractDue to highly tunable metallic compositions and surface functional groups, MXenes have attracted significant interests for a wide range of applications, such as energy storage, electromagnetic interference shielding, sensors, and biomedicine. With the introduction of porous structures, which have unique advantages in tuning...
Sun Nov 17, 2019 16:02
This study aimed to evaluate the possibility of using a new disinfectant-stabilized hypobromite-in controlling membrane fouling and the formation of a particular carcinogenic disinfection byproduct (DBP)-N-nitrosodimethylamine (NDMA). Our accelerated chemical exposure tests showed that the new disinfectant reduced the permeability of a polyamide RO membrane permeability from 6.7 to 4.1 L/m2hbar; however, its treatment impact was equivalent to that of chloramine. The disinfection efficacy of stabilized...
Sun Nov 17, 2019 11:39
Authors: Emenike PC, Neris JB, Tenebe IT, Nnaji CC, Jarvis P Abstract Over twenty thousand persons rely on water from Atuwara River for drinking and other domestic purposes, hence the need to ascertain the human health risk inherent in such practice. Seventy-two water samples were collected from River Atuwara during the dry and wet seasons of 2018, and the concentration of heavy metals (Pb, As, Ni, Cr, Zn, Cu, and Cd) were measured using ICP-OES. A newly developed human health risk assessment...
Sun Nov 17, 2019 11:39
Authors: Kafaei R, Arfaeinia H, Savari A, Mahmoodi M, Rezaei M, Rayani M, Sorial GA, Fattahi N, Ramavandi B Abstract There is limited information about pesticide contamination in Iran's agricultural land, particularly in plains producing exportable fruits. The aim of this investigation was to evaluate the concentration of organochlorine pesticides (OCPs) including hexachlorocyclohexane (HCH), heptachlor, dichloro-diphenyl-trichloroethane (DDT), chlordane (CHL), and their isomers compounds...
Sun Nov 17, 2019 11:39
This study investigated fluoride concentrations in 10 districts of Tianjin, China, to illustrate their spatial distribution characteristics and potential human health risks. The results showed fluoride concentration of 0.01-6.30 mg L-1 with a mean value of 0.99 mg L-1, and 78.82% of water fluoride reaches the standard for drinking water (1.5 mg L-1). Higher fluoride levels were recorded in deep well pumps supply zones, and more potential changes in fluoride occurred was positively correlated with...
Sun Nov 17, 2019 11:39
Abstract Background Phenylalanine ammonia-lyase (PAL) catalyzes the first step in the biosynthetic phenylpropanoid pathway (PPP) via deamination of phenylalanine to trans-cinnamic acid, a precursor for the lignin and flavonoid biosynthetic pathways. Although its role is well-established in various plants, the functional significance of PAL genes in rice remains poorly understood. ...
Sun Nov 17, 2019 02:00
Abstract Background Rapid identification of new essential genes is necessary to understand biological mechanisms and identify potential targets for antimicrobial drugs. Many computational methods have been proposed. Objectives To construct an essential genes classifier which satisfies more different organisms, and to study the redundancy of features used...
Sun Nov 17, 2019 02:00
Abstract Background Ulmus davidiana (UD) is a traditional Korean herb medicine that is used to treat inflammatory disorders. UD has been shown to modulate a number of inflammatory processes in vitro or in vivo studies. However, the molecular mechanisms of UD on lipopolysaccharide (LPS)-induced acute lung injury remain to be understood. Objective The primary...
Sun Nov 17, 2019 02:00
Abstract Objectives MUC16 (mucin 16, also known as CA-125, cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) has been predicted as tumor biomarker for therapy. We determined to investigate effects and regulatory mechanism of MUC16 on cervical tumorigenesis. Methods Expression levels of MUC16 in cervical cancer cell lines was analyzed...
Sun Nov 17, 2019 02:00
Abstract Objective Aim of this study was to detect the expression of miR-15a in rats following chronic constriction injury (CCI) and to investigate the regulatory functions of miR-15a during neuropathic pain (NP) development. Methods CCI was performed in adult Sprague–Dawley rats to set up the rat model of neuropathic pain. MiR-15a agomir and scrambled control...
Sun Nov 17, 2019 02:00
Abstract The majority of breast cancers are primarily hormone‐sensitive and could be managed by endocrine therapy, although therapy‐resistant or hormone‐refractory cancers need alternative treatments. Recently, increasing attention is being paid to RNA‐binding proteins (RBPs) in cancer pathophysiology. The precise role of RBPs in breast cancer, however, remains to be clarified. We here demonstrate that an RBP non‐POU domain containing octamer binding (NONO) plays a critical role in the pathophysiology...
Sat Nov 16, 2019 17:58
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