Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Jonas E. Svensson, Martin Schain, Pontus Plavén-Sigray, Simon Cervenka, Mikael Tiger, Magdalena Nord, Christer Halldin, Lars Farde, Johan LundbergAbstract[11C]raclopride is a well established PET tracer for the quantification of dopamine 2/3 receptors (D2/3R) in the striatum. Outside of the striatum the receptor density is up to two orders of magnitude lower. In contrast to striatal binding, the characteristics of extrastriatal...
Wed Sep 11, 2019 16:04
Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts.
Wed Sep 11, 2019 03:00
Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the most important marker for the prediction of tumou...
Wed Sep 11, 2019 03:00
Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresist...
Wed Sep 11, 2019 03:00
Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral PD-L1 protein (gene name: CD274) expression is associa...
Wed Sep 11, 2019 03:00
Insurance Status Affects Extent of Treatment for Patients with Papillary Thyroid Carcinoma. Thyroid. 2019 Sep 10;: Authors: Ullmann TM, Gray KD, Limberg J, Stefanova D, Moore MD, Buicko JL, Finnerty BM, Zarnegar R, Fahey T, Beninato T Abstract Background Health insurance has been shown to be a key determinant in cancer care, but it is unknown to what extent insurance status affects treatments provided to papillary thyroid cancer (PTC) patients. We hypothesized...
Wed Sep 11, 2019 16:06
Related ArticlesmiR-200a-3p plays tumor suppressor roles in gastric cancer cells by targeting KLF12. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3697-3703 Authors: Jia C, Zhang Y, Xie Y, Ren Y, Zhang H, Zhou Y, Gao N, Ding S, Han S Abstract Background: The role of miR-200a-3p in gastric cancer (GC) remain unclear. Materials and methods: miR-200a-3p expression in 65 paired GC and adjacent tissues (AT) were evaluated by quantitative real-time PCR (qRT-PCR)...
Wed Sep 11, 2019 16:07
Related ArticlesStrawberry gingivitis: Challenges in the diagnosis of granulomatosis with polyangiitis on gingival specimens. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019 Aug 02;: Authors: Msallem B, Bassetti S, Matter MS, Thieringer FM Abstract Strawberry gingivitis is a rare oral manifestation of granulomatosis with polyangiitis (GPA, formerly known as Wegener's granulomatosis). It manifests as a red-purple hyperplastic gingivitis that frequently...
Wed Sep 11, 2019 16:13
Early Assessment of Vestibular Function after Unilateral Cochlear Implant Surgery. Audiol Neurootol. 2019 Sep 10;:1-10 Authors: Barbara M, Talamonti R, Benincasa AT, Tarentini S, Filippi C, Covelli E, Monini S Abstract INTRODUCTION: Cochlear implantation (CI) has been reported to negatively affect vestibular function. The study of vestibular function has variably been conducted using different types of diagnostic tools. The combined use of modern, rapidly...
Wed Sep 11, 2019 16:15
Characterization of pallidocortical motor network in Parkinson disease through complex network analysis. J Neural Eng. 2019 Sep 10;: Authors: Xiao R, Malekmohammadi M, Pouratian N, Hu X Abstract OBJECTIVE: Deep brain stimulation (DBS) has demonstrated to be an advanced therapy for selected patients with Parkinson disease (PD) from numerous clinical trials, while its maximal therapeutic effect is capped by the inadequate understanding of precise neuronal...
Wed Sep 11, 2019 16:15
Congruent audiovisual speech enhances auditory attention decoding with EEG. J Neural Eng. 2019 Sep 10;: Authors: Fu Z, Wu X, Chen J Abstract OBJECTIVE: The auditory attention decoding (AAD) approach can be used to determine the identity of the attended speaker during an auditory selective attention task, by analyzing measurements of electroencephalography (EEG) data. The AAD approach has the potential to guide the design of speech enhancement algorithms...
Wed Sep 11, 2019 16:15
N400 extraction from a few trials of EEG data using spatial and temporal-frequency pattern analysis.
N400 extraction from a few trials of EEG data using spatial and temporal-frequency pattern analysis. J Neural Eng. 2019 Sep 10;: Authors: Li B, Liu Z, Gao X, Lin Y Abstract OBJECTIVE: N400 plays an important role in the studies of cognitive science and clinical neuropsychology diseases. However, it is still a challenge to extract N400 component from a few trials of EEG data. APPROACH: A method was proposed to analyze the spatial and temporal-frequency...
Wed Sep 11, 2019 16:15
45 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "BMJ Open"[jour] These pubmed results were generated on 2019/09/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Sep 11, 2019 16:15
Publication date: Available online 10 September 2019Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Alejandro Ruiz-Moya, Araceli Lagares-Borrego, Domingo Sicilia-Castro, Fernando J. Barrera-Pulido, Jose M. Gallo-Ayala, Aurelio Santos-Rodas, Jose M. Hernandez-Beneit, Francisco Carvajo-Perez, Gorka Gomez-Ciriza, Tomas Gomez-CiaAbstractBackgroundlimb salvage is a priority in pediatric patients with bone sarcomas. The vascularized fibula flap is a versatile option, combined...
Wed Sep 11, 2019 16:16
Purine Metabolites and Carnitine Biosynthesis Intermediates Are Biomarkers for Incident Type 2 Diabetes. J Clin Endocrinol Metab. 2019 Oct 01;104(10):4921-4930 Authors: Ottosson F, Smith E, Gallo W, Fernandez C, Melander O Abstract CONTEXT: Metabolomics has the potential to generate biomarkers that can facilitate understanding relevant pathways in the pathophysiology of type 2 diabetes (T2DM). METHODS: Nontargeted metabolomics was performed,...
Wed Sep 11, 2019 16:16
Prostate Specific Antigen Levels during Testosterone Treatment of Hypogonadal Older Men: Data from a Controlled Trial. J Clin Endocrinol Metab. 2019 Jul 23;: Authors: Cunningham GR, Ellenberg SS, Bhasin S, Matsumoto AM, Parsons JK, Preston P, Cauley JA, Gill TM, Swerdloff RS, Wang C, Ensrud KE, Lewis CE, Pahor M, Crandall JP, Molitch ME, Cifelli D, Basaria S, Diem SJ, Stephens-Shields AJ, Hou X, Snyder PJ Abstract CONTEXT: Prostate specific antigen (PSA)...
Wed Sep 11, 2019 16:16
PLIN2 Functions as a Novel Link between Progesterone Signaling and Metabolism in Uterine Leiomyoma Cells. J Clin Endocrinol Metab. 2019 Jul 23;: Authors: Okeigwe I, Bulun S, Liu S, Rademaker AW, Coon V JS, Kujawa S, Robins J, Yin P Abstract CONTEXT: Uterine leiomyoma (fibroids) are the most common tumors in women. Recently, perilipin-2 (PLIN2) was identified as a critical target gene of the progesterone receptor; however, its function in the pathogenesis...
Wed Sep 11, 2019 16:16
Neither hormonal factors nor AGEs explain lower prostate cancer risk in older men with diabetes mellitus. J Clin Endocrinol Metab. 2019 Jul 23;: Authors: Chan YX, Alfonso H, Fegan PG, Flicker L, Yeap BB Abstract CONTEXT: Diabetes mellitus is conventionally associated with an increased risk of cancer; however, inverse associations of diabetes with prostate cancer are well described. Mechanisms are unclear, although hormonal factors including alterations...
Wed Sep 11, 2019 16:16
Diagnostic challenge in PLIN1-associated Familial Partial Lipodystrophy. J Clin Endocrinol Metab. 2019 Jun 27;: Authors: Jéru I, Vantyghem MC, Bismuth E, Cervera P, Barraud S, PLIN1-Study Group, Auclair M, Vatier C, Lascols O, Savage DB, Vigouroux C Abstract CONTEXT: Heterozygous frameshift variants in PLIN1 encoding perilipin-1, a key protein for lipid droplet formation and triglyceride metabolism, have been implicated in familial partial lipodystrophy...
Wed Sep 11, 2019 16:16
Genetics of Congenital Isolated TSH Deficiency: Mutation Screening of the Known Causative Genes and a Literature Review. J Clin Endocrinol Metab. 2019 Jul 24;: Authors: Sugisawa C, Takamizawa T, Abe K, Hasegawa T, Shiga K, Sugawara H, Ohsugi K, Muroya K, Asakura Y, Adachi M, Daitsu T, Numakura C, Koike A, Tsubaki J, Kitsuda K, Matsuura N, Taniyama M, Ishii S, Satoh T, Yamada M, Narumi S Abstract CONTEXT: Congenital isolated TSH deficiency (i-TSHD) is...
Wed Sep 11, 2019 16:16
Mutations in MAGEL2 and L1CAM are associated with congenital hypopituitarism and arthrogryposis. J Clin Endocrinol Metab. 2019 Jul 24;: Authors: Gregory LC, Shah P, Sanner JRF, Arancibia M, Hurst J, Jones WD, Spoudeas H, Le Quesne Stabej P, Williams HJ, Ocaka LA, GOSgene, DDD study, Loureiro C, Martinez-Aguayo A, Dattani MT Abstract CONTEXT: Congenital hypopituitarism (CH) is rarely observed in combination with severe joint contractures (arthrogryposis)....
Wed Sep 11, 2019 16:16
Metabolomic urine profile: searching for new biomarkers of SDHx-associated pheochromocytomas and paragangliomas. J Clin Endocrinol Metab. 2019 Jul 23;: Authors: Martins RG, Gonçalves LG, Cunha N, Bugalho MJ Abstract CONTEXT: Metabolomic studies of pheochromocytoma and paraganglioma tissue showed a correlation between metabolomic profile and presence of SDHx mutations, especially a pronounced increase of succinate. OBJECTIVE: To compare the metabolomic...
Wed Sep 11, 2019 16:16
Publication date: Available online 10 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Mehmet Fatih Yetkin
Wed Sep 11, 2019 16:18
Publication date: Available online 10 September 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Yuksel Guven Yorgun, Serkan OzakbasABSTRACTObjectivesPremenstrual worsening has been often complained by patients with multiple sclerosis (MS). However, there is no quantitative study in the literature regarding premenstrual worsening and there are only a few studies for its reasons. In diseases such as MS, which there are limited evidence about the etiology and the triggers, detection of the...
Wed Sep 11, 2019 16:18
Related ArticlesBINDER: computationally inferring a gene regulatory network for Mycobacterium abscessus. BMC Bioinformatics. 2019 Sep 10;20(1):466 Authors: Staunton PM, Miranda-CasoLuengo AA, Loftus BJ, Gormley IC Abstract BACKGROUND: Although many of the genic features in Mycobacterium abscessus have been fully validated, a comprehensive understanding of the regulatory elements remains lacking. Moreover, there is little understanding of how the organism...
Wed Sep 11, 2019 16:19
Related ArticlesProper evaluation of chemical cross-linking-based spatial restraints improves the precision of modeling homo-oligomeric protein complexes. BMC Bioinformatics. 2019 Sep 09;20(1):464 Authors: Gaber A, Gunčar G, Pavšič M Abstract BACKGROUND: The function of oligomeric proteins is inherently linked to their quaternary structure. In the absence of high-resolution data, low-resolution information in the form of spatial restraints can significantly...
Wed Sep 11, 2019 16:19
Related Articlesnanite: using machine learning to assess the quality of atomic force microscopy-enabled nano-indentation data. BMC Bioinformatics. 2019 Sep 10;20(1):465 Authors: Müller P, Abuhattum S, Möllmert S, Ulbricht E, Taubenberger AV, Guck J Abstract BACKGROUND: Atomic force microscopy (AFM) allows the mechanical characterization of single cells and live tissue by quantifying force-distance (FD) data in nano-indentation experiments. One of the...
Wed Sep 11, 2019 16:19
Related ArticlesPredicting links between tumor samples and genes using 2-Layered graph based diffusion approach. BMC Bioinformatics. 2019 Sep 09;20(1):462 Authors: Timilsina M, Yang H, Sahay R, Rebholz-Schuhmann D Abstract BACKGROUND: Determining the association between tumor sample and the gene is demanding because it requires a high cost for conducting genetic experiments. Thus, the discovered association between tumor sample and gene further requires...
Wed Sep 11, 2019 16:19
Related ArticlesHPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. BMC Bioinformatics. 2019 Sep 09;20(1):463 Authors: Tran AN, Dussaq AM, Kennell T, Willey CD, Hjelmeland AB Abstract BACKGROUND: The Human Protein Atlas (HPA) aims to map human proteins via multiple technologies including imaging, proteomics and transcriptomics. Access of the HPA data is mainly via web-based interface allowing views of...
Wed Sep 11, 2019 16:19
Related ArticlesRetSynth: determining all optimal and sub-optimal synthetic pathways that facilitate synthesis of target compounds in chassis organisms. BMC Bioinformatics. 2019 Sep 09;20(1):461 Authors: Whitmore LS, Nguyen B, Pinar A, George A, Hudson CM Abstract BACKGROUND: The efficient biological production of industrially and economically important compounds is a challenging problem. Brute-force determination of the optimal pathways to efficient...
Wed Sep 11, 2019 16:19
Related ArticlesLong noncoding RNA MALAT1 knockdown inhibits progression of anaplastic thyroid carcinoma by regulating miR-200a-3p/FOXA1. Cancer Biol Ther. 2019 Sep 10;:1-11 Authors: Gou L, Zou H, Li B Abstract Long noncoding RNAs (lncRNAs) have been reported to play essential roles in progression of thyroid carcinoma. However, the roles of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in anaplastic thyroid carcinoma (ATC) process...
Wed Sep 11, 2019 16:21
Abstract Purpose The role of lymph node ratio (LNR, ratio of metastatic to examined nodes) in the staging of multiple human malignancies has been reported. We aim to evaluate its value in salivary gland cancer (SGC). Methods Records of SGC patients from Surveillance, Epidemiology, and End Results database (SEER, training set, N = 4262) and Fudan University...
Wed Sep 11, 2019 03:00
Publication date: Available online 10 September 2019Source: American Journal of OtolaryngologyAuthor(s): David A. Kasle, Sina J. Torabi, Emily Savoca, Jacob I. Tower, Douglas HildrewAbstractObjectiveTo identify presiding practices among neurotologists (ORL) in the care of acute Bell's palsy, and to compare them to neurologists' treatment patterns.Study design and methodsCross-sectional survey study.SubjectsNeurotologists and neurologists.ResultsNinety-one responses to the survey were obtained. The...
Wed Sep 11, 2019 16:24
Publication date: Available online 10 September 2019Source: American Journal of OtolaryngologyAuthor(s): Anupam Mishra, Pankaj Pandey, Subhash Chandra MishraAbstractBackgroundTo study the pattern of olfactory dysfunction/recovery in juvenile nasopharyngeal angiofibroma (JNA).MethodsOlfactory assessment was undertaken in 30 patients (category1) both pre- & post-operatively and in another 18 (category 2) only postoperative. All patients underwent transpalatal excision and variables of interest...
Wed Sep 11, 2019 16:24
Publication date: Available online 10 September 2019Source: American Journal of OtolaryngologyAuthor(s): Ayaka J. Iwata, Anna S. Wertz, Spandana Alluri, Michael C. SingerAbstractObjectiveTo assess the capacity of different techniques to reduce non-operative times during parathyroid surgery. The impact of monitored anesthesia care (MAC) instead of general anesthesia, and the pre-operative placement of a second peripheral intravenous catheter (PIV) were analyzed.MethodsA retrospective case series at...
Wed Sep 11, 2019 16:24
Publication date: Available online 11 September 2019Source: American Journal of OtolaryngologyAuthor(s): J. Eric Lupo, Allison Biever, David C. KelsallAbstractPurposeTo comprehensively assess and describe functional auditory performance in a group of adults with bilateral, moderate sloping to profound sensorineural hearing loss who were dissatisfied users of well-fit bilateral hearing aids and presented for Cochlear implant evaluation. Preoperatively, participants were evaluated with bilateral hearing...
Wed Sep 11, 2019 16:24
Publication date: Available online 10 September 2019Source: European Journal of Surgical OncologyAuthor(s): B.A. Wiafe, C. Karekezi, M.T. Jaklitsch, R.A. Audisio
Wed Sep 11, 2019 16:26
Objectives: Studies have demonstrated that genetic variants in the miRNA-coding genes might be associated with cancer susceptibility and survival. Here, we aimed to investigate the influence of MIR3142HG single-nucleotide polymorphisms on the individual’s susceptibility to and patients’ prognosis of glioma. Materials and Methods: Six variants were genotyped by Agena MassARRAY iPLEX Gold assay among 529 glioma patients and 502 healthy controls. Association of MIR3142HG polymorphisms with the...
Tue Sep 10, 2019 03:00
Objective: Cancer antigen (CA)-125 influences progression, metastasis, and outcomes in pancreatic cancer. This phase I/II trial (NCT01959672) evaluated the safety, efficacy, and immunologic correlates of chemoimmunotherapy (CIT) with oregovomab (anti–CA-125), followed by stereotactic body radiotherapy (SBRT) with the radiosensitizer nelfinavir. Materials and Methods: Following imaging, pathologic confirmation, and staging laparoscopy, subjects received three 3-week cycles of CIT (gemcitabine/leucovorin/fluorouracil/oregovomab)....
Tue Sep 10, 2019 03:00
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