In a chronic obstructive pulmonary disease (COPD) cohort (EvA, n = 283), 12 genes, whereas in asthma cohort (UBIOPRED, n = 85), 1197 genes in bronchial epithelial brushes were correlated with a blood eosinophil count. The gene CST1 was common to eosinophilic asthma and COPD and was replicated in independent cohorts. Despite shared “treatable traits” between asthma and COPD, the molecular mechanisms underlying these clinical entities are predominately different. Abstract Background Whether the...
Tue Sep 10, 2019 18:39
Tue Sep 10, 2019 19:43
Abstract The Global Initiative for Asthma (GINA) report was primarily intended as a strategy document and not a clinical guideline. However, the 2014 update moved the report towards a "practical, clinical practice‐centred document", and has in many countries formed a basis for national guidelines. A possible limitation of the GINA report is its primary focus on evidence coming from randomised controlled trials, potentially leading to the omission of clinically important data coming from real‐life...
Tue Sep 10, 2019 22:04
Tue Sep 10, 2019 22:18
179 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2019/09/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Sep 11, 2019 15:35
Related ArticlesEvaluation of virtual surgical planning systems and customized devices in fibula free flap mandibular reconstruction. Eur Arch Otorhinolaryngol. 2019 Sep 09;: Authors: Blanc J, Fuchsmann C, Nistiriuc-Muntean V, Jacquenot P, Philouze P, Ceruse P Abstract PURPOSE: The purpose of this study was to evaluate the accuracy of virtual planning using customized surgical devices (VP3D) in fibula free flap mandibular reconstruction. METHODS:...
Wed Sep 11, 2019 15:35
Related ArticlesQuality of Life (QoL) among medical students in Saudi Arabia: a study using the WHOQOL-BREF instrument. BMC Med Educ. 2019 Sep 09;19(1):344 Authors: Malibary H, Zagzoog MM, Banjari MA, Bamashmous RO, Omer AR Abstract BACKGROUND: Poor Quality of Life (QoL) among medical students is associated with an unhealthy lifestyle, psychological distress, and academic failure, which could affect their care for patients in the future. This study aimed...
Wed Sep 11, 2019 15:39
Abstract Background Microinvasion serves as a reliable indicator of poor prognosis after hepatectomy or transplantation for hepatocellular carcinoma (HCC). However, microinvasion is difficult to detect with current imaging modalities and is usually diagnosed histopathologically. The aim of this study is to identify the preoperative clinical predictors of microinvasion of small solitary hepatitis B virus (HBV)‐related HCC. Methods From January 2000 to December 2009, 110 patients with HBV‐related...
Wed Sep 11, 2019 13:03
This is a prospective study investigating delays in assessment and treatment of acute scrotal pain in children. We identify potential delays from the time of onset of the pain to seeking medical advice at different healthcare providers Abstract Background Acute scrotal pain is a common paediatric surgical presentation. Delays in treatment can result in testicular loss from torsion. It is unclear where delays occur. We aimed to investigate presentations with an acute scrotum to identify any...
Wed Sep 11, 2019 13:04
This present study aims to evaluate the changes in adipocytokines, bile acids, fibroblast growth factor 19 and pro‐inflammatory cytokines 6 months after laparoscopic sleeve gastrectomy. Abstract Background Chronic inflammation in adipose tissue may play a substantial role in the pathogenesis of obesity‐related metabolic disorders. The present study aims to evaluate the changes in adipocytokines, bile acids, fibroblast growth factor 19 (FGF‐19) and pro‐inflammatory cytokines 6 months after...
Wed Sep 11, 2019 13:05
Structural insights for vanadium catecholates and iron‑sulfur clusters obtained from multiple data analysis methods applied to electron spin relaxation data. J Inorg Biochem. 2019 Sep 02;201:110806 Authors: Ngendahimana T, Ayikpoe R, Latham JA, Eaton GR, Eaton SS Abstract Electron paramagnetic resonance (EPR) inversion recovery curves for vanadium catecholates and iron‑sulfur clusters were analyzed with three models: the sum of two exponentials, a stretched...
Wed Sep 11, 2019 15:45
The influence of erdosteine administration on lead-induced oxidative stress in rat muscle. Drug Chem Toxicol. 2019 Sep 10;:1-5 Authors: Dobrakowski M, Machoń-Grecka A, Nowak P, Szczęsny P, Maciejczyk M, Kasperczyk A, Pryzwan T, Kasperczyk S Abstract Lead-exposure is known to disrupt the redox balance of tissues leading to oxidative stress. Due to the fact that a mucolytic drug, erdosteine, exerts also antioxidant properties, we decided to perform a pilot...
Wed Sep 11, 2019 15:46
Related ArticlesAutomatic Detection of the Pharyngeal Phase in Raw Videos for the Videofluoroscopic Swallowing Study Using Efficient Data Collection and 3D Convolutional Networks †. Sensors (Basel). 2019 Sep 07;19(18): Authors: Lee JT, Park E, Jung TD Abstract Videofluoroscopic swallowing study (VFSS) is a standard diagnostic tool for dysphagia. To detect the presence of aspiration during a swallow, a manual search is commonly used to mark the time intervals...
Wed Sep 11, 2019 15:50
Publication date: Available online 11 September 2019Source: Academic RadiologyAuthor(s): Kara Gaetke-Udager, Donna Magid, Mathew Smith, Vishal Kumar, Minhajuddin Khaja, N. Reed Dunnick
Wed Sep 11, 2019 15:51
Outcomes of primary myringoplasty in indigenous children from the Northern Territory of Australia. Int J Pediatr Otorhinolaryngol. 2019 Aug 13;127:109634 Authors: O'Leary S, Darke A, Currie K, Ozdowska K, Patel H Abstract AIM: To report the surgical and audiological outcomes of myringoplasty (Type I tympanoplasty) in Indigenous Australian children living in remote and regional communities in northern Australia. METHOD: An observational cohort...
Wed Sep 11, 2019 15:53
Zusammenfassung Das Li-Fraumeni-Syndrom (LFS; „Online Mendelian Inheritance in Man“, OMIM #151623) gilt als eines der aggressivsten derzeit bekannten Krebsprädispositionssyndrome. Das heterogene Tumorspektrum wird dominiert von Knochen- und Weichteilsarkomen, verschiedenen Hirntumoren, prämenopausalem Brustkrebs und dem adrenokortikalen Karzinom (ACC). Bereits im Kindesalter ist das Krebsrisiko sehr stark erhöht und nicht selten entwickeln Menschen mit einem LFS synchrone und metachrone...
Wed Sep 11, 2019 03:00
Publication date: Available online 10 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Henryk Skarżyński, Elżbieta Gos, Weronika Świerniak, Piotr Henryk SkarżyńskiABSTRACTBACKGROUNDHearing loss in children is a relevant health issue, both for its prevalence and for its physical, emotional and social consequences. Our aim was to estimate the national prevalence of hearing loss in school-age children from rural areas in Poland.METHODSThe study was conducted in...
Wed Sep 11, 2019 15:58
Publication date: Available online 11 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Reihane Saber-Moghadam, Maryam Faham, Fatemeh-Sadat Ghavami, Zahra Ghayoumi-AnarakiAbstractBackgroundNormative nasalance scores are essential for treatment and assessment purposes for clinicians. The purpose of the current study is to determine the normative data on nasalance scores for Farsi speaking children. Comparing to the obtained normative data, hypernasal or hyponasal...
Wed Sep 11, 2019 15:58
Publication date: Available online 11 September 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Madhan Krishnan, Hussein Walijee, Anthony Jesurasa, Su De, Ajay Sinha, Ravi Sharma, Adam DonneAbstractObjectiveAcute mastoiditis is the most common intra-temporal complication of acute otitis media. Its management remains a challenge due to potential extracranial and intracranial complications. This study was designed to evaluate the recent experience with acute mastoiditis...
Wed Sep 11, 2019 15:58
52 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: upper respiratory tract infection These pubmed results were generated on 2019/09/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Sep 11, 2019 16:02
Related ArticlesSystemic oxidative stress in congenital central hypoventilation syndrome. Eur Respir J. 2018 11;52(5): Authors: Degl'Innocenti D, Becatti M, Peruzzi M, Fiorillo C, Ramazzotti M, Nassi N, Arzilli C, Piumelli R PMID: 30209197 [PubMed - indexed for MEDLINE]
Wed Sep 11, 2019 16:04
Related ArticlesDevelopment and validation of a simple tool for the assessment of home noninvasive ventilation: the S3-NIV questionnaire. Eur Respir J. 2018 11;52(5): Authors: Dupuis-Lozeron E, Gex G, Pasquina P, Bridevaux PO, Borel JC, Soccal PM, Windisch W, Pépin JL, Janssens JP, Adler D Abstract Patient-centred outcomes are significantly modified by long-term home noninvasive ventilation (NIV), but a short, self-administered, specific tool for routine...
Wed Sep 11, 2019 16:04
Related ArticlesObstructive sleep apnea syndrome detection based on ballistocardiogram via machine learning approach. Math Biosci Eng. 2019 Jun 19;16(5):5672-5686 Authors: Gao WD, Xu YB, Li SS, Fu YJ, Zheng DY, She YJ Abstract Obstructive sleep apnea (OSA) is a common sleep-related respiratory disease that affects people's health, especially in the elderly. In the traditional PSG-based OSA detection, people's sleep may be disturbed, meanwhile the electrode...
Wed Sep 11, 2019 16:04
Related ArticlesJapanese Cross-Sectional Multicenter Survey (JAMS) of Oral Appliance Therapy in the Management of Obstructive Sleep Apnea. Int J Environ Res Public Health. 2019 Sep 06;16(18): Authors: Okuno K, Furuhashi A, Nakamura S, Suzuki H, Arisaka T, Taga H, Tamura M, Katahira H, Furuhata M, Iida C Abstract We conducted a multicenter survey for oral appliance (OA) therapy to grasp and analyze the current situation of OA therapy, including efficacy,...
Wed Sep 11, 2019 16:04
Related ArticlesTachycardiomyopathy in Patients without Underlying Structural Heart Disease. J Clin Med. 2019 Sep 08;8(9): Authors: Stronati G, Guerra F, Urbinati A, Ciliberti G, Cipolletta L, Capucci A Abstract Tachycardiomyopathy (TCM) is an underestimated cause of reversible left ventricle dysfunction. The aim of this study was to identify the predictors of recurrence and incidence of major cardiovascular events in TCM patients without underlying...
Wed Sep 11, 2019 16:04
Related ArticlesTeenagers with obesity: Long-term results of laparoscopic adjustable gastric banding. J Pediatr Surg. 2019 Aug 29;: Authors: Furbetta N, Gragnani F, Cervelli R, Guidi F, Furbetta F Abstract BACKGROUND: Obesity is a rapidly spreading chronic disease worldwide. Long-term results are critical to assess the effectiveness of a bariatric procedure, particularly in young patients who have long life expectancy. METHODS: A retrospective...
Wed Sep 11, 2019 16:04
Related ArticlesAssociation of napping with incident cardiovascular events in a prospective cohort study. Heart. 2019 Sep 09;: Authors: Häusler N, Haba-Rubio J, Heinzer R, Marques-Vidal P Abstract OBJECTIVE: There is controversy regarding the effect of napping on cardiovascular disease (CVD), with most studies failing to consider napping frequency. We aimed to assess the relationship of napping frequency and average nap duration with fatal and non-fatal...
Wed Sep 11, 2019 16:04
Related ArticlesImpact of Intermittent Hypoxia on Sepsis Outcomes in a Murine Model. Sci Rep. 2019 Sep 09;9(1):12900 Authors: Chou KT, Cheng SC, Huang SF, Perng DW, Chang SC, Chen YM, Hsu HS, Hung SC Abstract Sleep apnea has been associated with a variety of diseases, but its impact on sepsis outcome remains unclear. This study investigated the effect of intermittent hypoxia [IH]-the principal feature of sleep apnea-on murine sepsis. 5-week-old male...
Wed Sep 11, 2019 16:04
Related ArticlesAnesthetic management in corticobasal degeneration with central sleep apnea: A case report. J Dent Anesth Pain Med. 2019 Aug;19(4):235-238 Authors: Shionoya Y, Nakamura K, Sunada K Abstract Corticobasal degeneration (CBD) is a rare neurodegenerative disease characterized by dystonia, cognitive deficits, and an asymmetric akinetic-rigid syndrome. Little information is available regarding anesthetic management for CBD patients. Our patient...
Wed Sep 11, 2019 16:04
Case of an In-Laboratory Vagal Nerve Stimulator Titration for Vagal Nerve Stimulator-Induced Pediatric Obstructive Sleep Apnea. J Clin Sleep Med. 2019 Sep 10;: Authors: Chan JHM, Owens JW, Wrede JE Abstract We present the case of a 12-year-old girl with medically refractory epilepsy and a vagal nerve stimulator (VNS), who experienced severe obstructive sleep apnea (OSA) with respiratory events closely matching her VNS settings. We demonstrated a real-time...
Wed Sep 11, 2019 16:04
Automatic Sleep Staging in Patients With Obstructive Sleep Apnea Using Single-Channel Frontal EEG. J Clin Sleep Med. 2019 Sep 10;: Authors: Lee PL, Huang YH, Lin PC, Chiao YA, Hou JW, Liu HW, Huang YL, Liu YT, Chiueh TD Abstract STUDY OBJECTIVES: Reliable sleep staging is difficult to obtain from home sleep testing for diagnosis of obstructive sleep apnea (OSA), especially when it is self-applied. Hence, the current study aimed to develop a single frontal...
Wed Sep 11, 2019 16:04
An Unusual Cause of CPAP Intolerance. J Clin Sleep Med. 2019 Sep 10;: Authors: van Loenhout L, van der Zeijden H Abstract Continuous positive airway pressure (CPAP) is a first-line treatment for obstructive sleep apnea (OSA). However, the adherence to CPAP can be difficult for patients due to several reasons. In this case report we describe a patient with severe OSA who initially was treated successfully with CPAP, but after a few months adherence problems...
Wed Sep 11, 2019 16:04
On Not Knowing What We Don't Know to Knowing What We Don't Know: Obstructive Sleep Apnea in the Transgender Community. J Clin Sleep Med. 2019 Sep 10;: Authors: Earl DC, Brown LK PMID: 31502953 [PubMed - as supplied by publisher]
Wed Sep 11, 2019 16:04
Pediatric ambulatory anesthesia: an update. Curr Opin Anaesthesiol. 2019 Sep 09;: Authors: Lerman J Abstract PURPOSE OF REVIEW: Ambulatory surgery is the standard for the majority of pediatric surgery in 2019 and adenotonsillectomy is the second most common ambulatory surgery in children so it is an apt paradigm. Preparing and managing these children as ambulatory patients requires a thorough understanding of the current literature. RECENT FINDINGS:...
Wed Sep 11, 2019 16:04
Phenotypic approach to pharmacotherapy in the management of obstructive sleep apnoea. Curr Opin Pulm Med. 2019 Sep 09;: Authors: Aishah A, Eckert DJ Abstract PURPOSE OF REVIEW: To provide a concise synthesis of the current knowledge of obstructive sleep apnoea (OSA) phenotyping concepts and how this information is being used to develop and direct targeted pharmacotherapy for OSA. RECENT FINDINGS: The causes of OSA vary between patients and therefore...
Wed Sep 11, 2019 16:04
Sleep and interstitial lung disease. Curr Opin Pulm Med. 2019 Sep 09;: Authors: Myall KJ, West A, Kent BD Abstract PURPOSE OF REVIEW: There is an increasing recognition of the impact of sleep and sleep disorders on respiratory disease. Recent years have seen a new focus on the relationship between sleep and outcomes in patients interstitial lung disease (ILD). RECENT FINDINGS: Recent studies suggest a high prevalence of sleep issues in ILD cohorts,...
Wed Sep 11, 2019 16:04
A contemporary review of obstructive sleep apnea. Curr Opin Pulm Med. 2019 Sep 09;: Authors: Ralls F, Cutchen L Abstract PURPOSE OF REVIEW: The current review provides a contemporary review of sleep apnea with emphasis on definitions, epidemiology, and consequences. RECENT FINDINGS: Amyloid β-42 is one of the main peptides forming amyloid plaques in the brains of Alzheimer patients. Poorer sleep quality and shorter sleep duration have been associated...
Wed Sep 11, 2019 16:04
Structure and severity of pharyngeal obstruction determine oral appliance efficacy in sleep apnoea. J Physiol. 2019 Sep 10;: Authors: Marques M, Genta PR, Azarbarzin A, Taranto-Montemurro L, Messineo L, Hess LB, Demko G, White DP, Sands SA, Wellman A Abstract KEY POINTS: Some patients with obstructive sleep apnoea (OSA) respond well to oral appliance therapy but others do not for reasons that are unclear. In this study we used gold-standard measurements...
Wed Sep 11, 2019 16:04
The effectiveness of mandibular advancement devices in the treatment of obstructive sleep apnoea in adults: a methodological quality assessment of systematic reviews. Eur J Orthod. 2019 Aug 26;: Authors: Incerti Parenti S, Aroni E, Laffranchi L, Paganelli C, Alessandri-Bonetti G Abstract BACKGROUND AND OBJECTIVES: There is growing interest in the use of mandibular advancement devices (MADs) for the treatment of obstructive sleep apnoea (OSA). Many systematic...
Wed Sep 11, 2019 16:04
Mutations in MAGEL2 and L1CAM are associated with congenital hypopituitarism and arthrogryposis. J Clin Endocrinol Metab. 2019 Jul 24;: Authors: Gregory LC, Shah P, Sanner JRF, Arancibia M, Hurst J, Jones WD, Spoudeas H, Le Quesne Stabej P, Williams HJ, Ocaka LA, GOSgene, DDD study, Loureiro C, Martinez-Aguayo A, Dattani MT Abstract CONTEXT: Congenital hypopituitarism (CH) is rarely observed in combination with severe joint contractures (arthrogryposis)....
Wed Sep 11, 2019 16:04
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου