Engineering of fungal laccases with optimum catalytic activity at alkaline pH has been a long-lasting challenge. In this study, a mutant library containing 3000 clones was obtained by error-prone PCR to adapt ...
Wed Sep 18, 2019 03:00
http://authors.nejm.org/MSImageReview/15_11693_vonkeudell/von_keudell_fix.mp4
Thu Sep 19, 2019 03:00
British Journal of Cancer, Published online: 20 September 2019; doi:10.1038/s41416-019-0584-5Multicenter, randomised, open-label, non-comparative phase 2 trial on the efficacy and safety of the combination of bevacizumab and trabectedin with or without carboplatin in women with partially platinum-sensitive recurrent ovarian cancer
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Circular RNAs (circRNAs), with their crucial roles in gene regulation and disease development, have become a rising star in the RNA world. Especially, a lot of studies focused on their interactions with RNA-binding proteins (RBPs), as the knowledge of circRNA-RBP association is very important for understanding circRNA functions. Recently, the abundant CLIP-Seq experimental data has enabled the large-scale identification and analysis of circRNA-RBP interactions, while no computational tool based on...
Thu Sep 19, 2019 18:25
Authors: Xiao-Pei Xu, Wen-Ge Liu, Qian-Ming Xu, Xing-Quan Zhu and Jia Chen.<br />Parasite Vol. 26 , page 58<br />Published online: 19/09/2019<br /> Keywords: Toxoplasma gondii ; DNA vaccine ; Dense granule protein 24 ; Dense granule protein 25 ; Microneme protein 6.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/Y7KnNWcajns" height="1" width="1" alt=""/>
Thu Sep 19, 2019 03:00
Authors: Wadaka Mamai, Nanwintoum Sévérin Bimbilé Somda, Hamidou Maiga, Anna Konczal, Thomas Wallner, Mame Thierno Bakhoum, Hanano Yamada and Jérémy Bouyer.<br />Parasite Vol. 26 , page 57<br />Published online: 19/09/2019<br /> Keywords: Insect diets ; Larval diets ; Larval development ; Quality control ; Genetic control ; Vectors ; Arbovirus.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/2mmSiZ_Ehyc" height="1" width="1" alt=""/>
Thu Sep 19, 2019 03:00
Authors: Imane Derouiche, Lassad Neifar, Delphine Gey, Jean-Lou Justine and Fadila Tazerouti.<br />Parasite Vol. 26 , page 59<br />Published online: 20/09/2019<br /> Keywords: Chimaeridae ; Monocotylidae ; Holocephalocotyle n. gen. ; 28S rDNA ; Mediterranean.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/wLu1gqcd-bM" height="1" width="1" alt=""/>
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BACKGROUND AND PURPOSE:The efficacy and safety of transvenous embolization for brain arteriovenous malformations remains unclear, given the very limited number of cases reported. This prospective study was performed to assess this technique in ruptured AVMs.MATERIALS AND METHODS:Twenty-one consecutive patients with ruptured brain AVMs who underwent transvenous embolization were prospectively followed between November 2016 and November 2018. The Spetzler-Martin grade was I in 3 AVMs (14.3%), II in...
Thu Sep 19, 2019 16:53
BACKGROUND AND PURPOSE:Flow disruption with the Woven EndoBridge is increasingly used for the treatment of intracranial aneurysms. We examined factors leading to aneurysm occlusion and Woven EndoBridge shape change during a midterm follow-up.MATERIALS AND METHODS:Patients with a minimum 12-month angiographic follow-up were included. Through a univariate and multivariate analysis, independent predictors of adequate occlusion (Raymond-Roy 1/Raymond-Roy 2) and Woven EndoBridge shape change (decrease...
Thu Sep 19, 2019 16:53
BACKGROUND AND PURPOSE:Empty sella has been reported in patients with idiopathic intracranial hypertension and is thought to be a sign of elevation of intracranial pressure. However, it can also be found in patients with lateral sinus stenosis presenting with isolated pulsatile tinnitus without signs of intracranial hypertension. We hypothesized that the volume of the sella turcica would be similar in both groups of patients undergoing stent placement for lateral sinus stenosis.MATERIALS AND METHODS:Consecutive...
Thu Sep 19, 2019 16:53
BACKGROUND AND PURPOSE:Our aim was to evaluate whether improved gray-white matter differentiation in cranial CT by means of 65- keV virtual monoenergetic images enables a radiation dose reduction compared to conventional images.MATERIALS AND METHODS:One hundred forty consecutive patients undergoing 171 spectral detector CTs of the head between February and November 2017 (56 ± 19 years of age; male/female ratio, 56%/44%) were retrospectively included. The tube current–time product was reduced during...
Thu Sep 19, 2019 16:53
BACKGROUND AND PURPOSE:Choroidal collateral anastomosis is associated with hemorrhage recurrence in patients with Moyamoya disease. However, the relationship between recurrent ipsilateral hemorrhage and choroidal collateral anastomosis subtypes (anterior choroidal artery anastomosis, lateral posterior choroidal artery anastomosis, and medial posterior choroidal artery anastomosis) is unclear. This study aimed to assess this potential association in adult patients with Moyamoya disease.MATERIALS AND...
Thu Sep 19, 2019 16:53
Thu Sep 19, 2019 19:10
Objective The aim of this study was to investigate the differentiation of computed tomography (CT)–based entropy parameters between minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) lesions appearing as pulmonary subsolid nodules (SSNs). Methods This study was approved by the institutional review board in our hospital. From July 2015 to November 2018, 186 consecutive patients with solitary peripheral pulmonary SSNs that were pathologically confirmed as pulmonary adenocarcinomas...
Sun Sep 01, 2019 03:00
Objective To identify the computed tomographic features to differentiate gastric schwannoma from gastric gastrointestinal stromal tumor. Methods Computed tomographic images of 103 pathologically confirmed patients with gastric schwannoma (n = 23) or gastric gastrointestinal stromal tumor (n = 80) were retrospectively studied. Sex, morphology, location, border, growth pattern, enhancement pattern, necrosis, calcification, ulceration, and perigastric lymph nodes were analyzed. Age, short diameter,...
Sun Sep 01, 2019 03:00
Objective The objective of this study was to evaluate a prototype, ultrahigh-resolution computed tomography offering higher reconstruction matrix (1024 × 1024) and spatial resolution (0.15 mm) for chest imaging. Methods Higher (1024) matrix reconstruction enabled by ultrahigh-resolution computed tomography scanner (128-detector rows; detector width, 0.25 mm; spatial resolution, 0.15 mm) was compared with conventional (512) reconstruction with image quality grading on a Likert scale (1, excellent;...
Sun Sep 01, 2019 03:00
Objective The objective of this study was to compare enhancement of the aorta and liver on hepatic dynamic computed tomography scans acquired with contrast material doses based on the lean body weight (LBW) or the total body weight (TBW). Methods We randomly divided 529 patients (279 men, 250 women; median age, 66 years) scheduled for hepatic dynamic computed tomography into 2 groups. The LBW patients (n = 278) were injected with 679 mg iodine/kg (men) or 762 mg iodine/kg (women). The TBW...
Sun Sep 01, 2019 03:00
We present 5 cases of intraosseous hibernoma, a rare benign tumor of brown fat. Our literature review reveals that the average age at presentation is 58.6 years, and 69.7% of patients are female. Lesions are most often located in the spine and pelvis. Computed tomography usually demonstrates sclerotic changes, although lesions can be lytic. Magnetic resonance imaging findings include heterogeneous T2 hyperintensity. Technetium 99m-methyl diphosphonate bone scan reveals variable radiotracer uptake,...
Sun Sep 01, 2019 03:00
Objectives The aims of this study were to compare the difference of computed tomography (CT) features between intrahepatic cholangiocarcinomas (ICCs) with and without lymph node metastasis (LNM) and to construct a nomogram to predict LNM and overall survival preoperatively. Methods Clinicopathological and contrast-enhanced CT features of 63 patients with ICC were analyzed. Multivariate logistic regression analysis was performed to construct a nomogram to predict LNM preoperatively. Survival...
Sun Sep 01, 2019 03:00
Objective To evaluate the relationship between the apparent diffusion coefficient (ADC) values of renal parenchyma and estimated glomerular filtration rates (eGFR). Methods Data on 216 patients examined by 3-T magnetic resonance imaging for various reasons were retrospectively collected. Results There was a significant linear correlation between the ADC values and eGFRs (r = 0.254, P
Sun Sep 01, 2019 03:00
Objective This study aimed to investigate the predictive and prognostic values of repeated spectral computed tomographic (CT) parameter changes for the prediction of treatment responses to the angiogenesis inhibitor AL3818 in hepatic tumors. Methods A total of 30 rabbits with VX2 hepatic tumors that underwent spectral contrast-enhanced abdominal CT before and during treatment were included in the study. The percent change (Δ, %) of the normalized iodine concentration (nIC) during the arterial...
Sun Sep 01, 2019 03:00
Background Follow-up with computed tomographic angiography is recommended after endovascular aneurysm repair, exposing patients to significant levels of radiation and iodine contrast medium. Dual-energy computed tomography allows virtual noncontrast (VNC) images to be reconstructed from contrast-enhanced images using a software algorithm. If the VNC images are a good-enough approximation of true noncontrast (TNC) images, a reduction in radiation dose can be ensured through omitting a TNC scan. ...
Sun Sep 01, 2019 03:00
Recently, a novel 3-dimensional visualization methodology for volumetric computed tomography data has become available. This method, known as cinematic rendering, uses an advanced lighting model to create photorealistic images from standard computed tomography acquisition data composed of isotropic voxels. We have observed that cinematic rendering visualizations in which patients have been administered dense, positive oral contrast do not have any substantive visual artifacts and can be used to demonstrate...
Sun Sep 01, 2019 03:00
Objectives This study aimed to evaluate the feasibility of intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting bowel inflammation in patients with Crohn disease (CD). Methods Sixteen patients who underwent intravoxel incoherent motion DW-MRI for CD and colonoscopy were recruited. Seventy-nine bowel segments were selected, and their mean D, D*, f, and apparent diffusion coefficient (ADC) values were measured. The receiver operating characteristic...
Sun Sep 01, 2019 03:00
Objective The objective of this study was to investigate the quantitative and qualitative effects of virtual monoenergetic images (VMIs) by spectral detector computed tomography (SDCT) on metal artifacts in routine examinations. Methods Fifty-nine patients with metal artifacts (caused by pacemakers, ports, screws, or prosthetic joints) affecting muscular tissue in the chest and/or abdomen were scanned using SDCT. Attenuation values around the metallic device were compared with contralateral...
Sun Sep 01, 2019 03:00
The fourth edition of World Health Organization (2017) classified odontogenic tumors according to the tissue of origin. Epithelial odontogenic tumors include ameloblastomas, calcifying epithelial odontogenic tumors, adenomatoid odontogenic tumors, and squamous odontogenic tumors. Mixed epithelial and mesenchymal odontogenic tumors include odontomas, ameloblastic fibromas, dentigenic ghost cell odontogenic tumors, and primordial odontogenic tumors. Mesenchymal odontogenic tumors include cementoblastomas,...
Sun Sep 01, 2019 03:00
Objective Meningioma-related skull magnetic resonance imaging findings other than hyperostosis are not widely recognized. We evaluated the novel findings of the skull adjacent to meningiomas. Methods Records from patients with meningiomas located adjacent to the skull on magnetic resonance imaging (n = 32) were included. Three skull findings (intramedullary prominent vessel, intramedullary enhancement, intramedullary T2-hyperintensity) and the widely known hyperostosis were retrospectively...
Sun Sep 01, 2019 03:00
Objective The aim was to determine if dual-energy computed tomography (DECT) can discriminate ferromagnetic bullets from nonferromagnetic ones. Methods The ferromagnetic properties of 29 bullets were determined. All bullets underwent a DECT evaluation, and a manual measurement of the dual-energy index was performed by 2 radiologists, followed by a fully automatic measurement, in 3 different positions in a phantom (air, water, and bone). Results Twenty-one bullets were found to be nonferromagnetic....
Sun Sep 01, 2019 03:00
Objective To explore the application value of postlabeling delay (PLD) in 3D pseudocontinuous arterial spin–labeled (3D-pcASL) perfusion imaging in normal children and to find the optimal PLD values for children at each age group. Methods Five groups of children, with 50 patients in each group, who underwent routine magnetic resonance imaging scans with normal results were included. The patients were stratified according to the following ages: younger than 1 month, more than 1 month to 6...
Sun Sep 01, 2019 03:00
Objective The aim of this study was to explore the independent clinical and magnetic resonance imaging (MRI) performance risk factors for predicting placenta accreta. Methods From January 2012 to December 2015, we retrospectively reviewed the clinical characteristics and MRI features of 97 patients. Of these, 42 were confirmed to be placenta accreta by pathological results or cesarean delivery findings. We tried to identify the independent risk factors by multivariate logistic regression...
Sun Sep 01, 2019 03:00
Purpose The aim of the study was to refine and validate the NeuroImaging Radiological Interpretation System (NIRIS), which was developed to predict management and clinical outcome based on noncontrast head computerized tomography findings in patients suspected of acute traumatic brain injury (TBI). Methods We assessed the performance of the NIRIS score in a prospective, single-center cohort of patients suspected of TBI (n = 648) and compared the performance of NIRIS with that of the Marshall...
Sun Sep 01, 2019 03:00
Objective To evaluate the visualization of gallbladder stones on susceptibility-weighted imaging (SWI). Materials and Methods Imaging data from 47 patients who underwent clinically indicated cholecystectomy was reviewed. Breath-hold SWI was added to the magnetic resonance imaging protocol and magnitude and phase data was reviewed for gall-stones visualization. Phase signature, that is, diamagnetic, paramagnetic, or mixed, was also noted in the stones. Magnetic susceptibility value of surgically...
Sun Sep 01, 2019 03:00
Background The Mount Fuji sign (MFS) is a radiological sign on computed tomographic scans depicting air between the frontal lobes. Air in this location indicates tension pneumocephalus (TP), considered a neurosurgical emergency. We evaluate the correlation between the MFS and perioperative mortality attributed to TP in nonagenarians who have undergone evacuation of chronic subdural hemorrhage (cSDH). Materials and Methods We retrospectively reviewed the records of nonagenarians who had...
Sun Sep 01, 2019 03:00
We aim to review the imaging findings of Klippel-Trenaunay syndrome. This disorder characterized clinically by a triad of capillary malformations manifesting as a port-wine stain, venous varicosities typically along the lateral aspect of the lower extremities, and bone and/or soft tissue hypertrophy. Imaging of extremities shows unilateral venous varicosities, persistent embryonic veins, anomalous of the superficial and deep venous system, low-flow venolymphatic malformations, and bony and soft tissue...
Sun Sep 01, 2019 03:00
Purpose The aim of this study was to compare coronary and carotid artery imaging and determine which one shows the strongest association with atherosclerotic cardiovascular disease (ASCVD) score. Patients and Methods Two separate series patients who underwent either coronary computed tomography angiography (CTA) or carotid CTA were included. We recorded the ASCVD scores and assessed the CTA imaging. Two thirds were used to build predictive models, and the remaining one third generated predicted...
Sun Sep 01, 2019 03:00
Objective Knowledge-based iterative model reconstruction (IMR) yields diagnostically acceptable image quality in low-dose static computed tomography (CT). We aimed to evaluate the feasibility of IMR in dynamic myocardial computed tomography perfusion (CTP). Methods We enrolled 24 patients who underwent stress dynamic CTP using a 256-slice CT. Images were reconstructed using filtered back projection (FBP), hybrid IR, and IMR. Image quality and hemodynamic parameters were compared among three...
Sun Sep 01, 2019 03:00
Objective The objective of this study was to evaluate the imaging features of a hepatic sclerosed hemangioma by comparing them with those of a cavernous hemangioma using magnetic resonance imaging with gadoxetic acid enhancement. Methods Nine patients with hepatic sclerosed hemangiomas and 36 patients with cavernous hemangiomas (control group) who underwent gadoxetic acid–enhanced magnetic resonance imaging were included. Qualitative values (imaging findings and enhancement pattern [typical...
Sun Sep 01, 2019 03:00
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