Related ArticlesClinical Effectiveness - Rapid Technique for Antibiotic Selection. Clin Lab. 2019 Sep 01;65(9): Authors: Markowitz A Abstract BACKGROUND: Antimicrobial resistance is a growing problem. The current process for determining antibiotic sensitivities is time consuming and often leaves patients waiting for results while using the wrong antibiotic. Reducing inappropriate antibiotic use diminishes the development of resistance and reduces expenses....
Thu Sep 19, 2019 15:12
Related ArticlesReference Intervals for Urine Sediment Analysis of Healthy Pregnant Women. Clin Lab. 2019 Sep 01;65(9): Authors: Lu S, Han M, Wang D Abstract BACKGROUND: Urine sediment parameters of pregnant women are different from those of non-pregnant women, and it is necessary to establish reference intervals for pregnant women. The aim of this study was to establish reference intervals of white blood cell (WBC), red blood cell (RBC), bacteria (BACT),...
Thu Sep 19, 2019 15:12
Related ArticlesEarly Detection of a Colorectal Carcinoma in an Asymptomatic Patient Using a Combined DNA Stool Test. Clin Lab. 2019 Sep 01;65(9): Authors: Amani A, Weber MM, Marko C Abstract BACKGROUND: Modern, simple stool tests could close the gap regarding the recognition rate (sensitivity) between the current test methods and colonoscopy. METHODS: Here we report a case of a 68-year-old asymptomatic patient, who applied an innovative combined...
Thu Sep 19, 2019 15:12
Related ArticlesSerum Vascular Endothelial Growth Factor, Vascular Endothelial Growth Factor Receptor 2, and Osteopontin: Diagnostic and Prognostic Potential Biomarkers for Gastrointestinal Cancers. Clin Lab. 2019 Sep 01;65(9): Authors: Sharma TK PMID: 31532102 [PubMed - in process]
Thu Sep 19, 2019 15:12
Related ArticlesD-dimer: a Prognostic Indicator for Cirrhotic Patients with Hemorrhagic Ascites. Clin Lab. 2019 Sep 01;65(9): Authors: Sharma TK PMID: 31532103 [PubMed - in process]
Thu Sep 19, 2019 15:12
Related ArticlesOne Case Report of Cavernous Angioma in Posterior Sagittal Sinus. Clin Lab. 2019 Sep 01;65(9): Authors: Chi C, Yinhui H, Jinying Z, Yafang C, Jiahua L, Mingming L, Meili Y, Haimo C, Zhiqiang L, Youyu L, Wuhua W Abstract BACKGROUND: The Cavernous Angioma in Posterior Sagittal Sinus is exceedingly rare. METHODS: We report for the case of a 10-year-old male patient who was diagnosed with Cavernous Angioma in Posterior Sagittal Sinus....
Thu Sep 19, 2019 15:12
Related ArticlesComparison and Agreement Analysis of ARCHITECT i2000SR and i-CHROMATM Reader for Detecting Human Chorionic Gonadotropin Beta Subunit in Plasma. Clin Lab. 2019 Sep 01;65(9): Authors: Ma M, Zhu M, Zhuo B, Wang X, Wu Z, Xu L Abstract BACKGROUND: When a new measurement method is introduced into a clinical laboratory, a comparison study is often needed to ensure that the measurement by the existing method is reproducible by the new method...
Thu Sep 19, 2019 15:12
Related ArticlesRevisiting Bone Marrow Core Biopsy Adequacy Criteria in the Era of Extensive Ancillary Testing. Clin Lab. 2019 Sep 01;65(9): Authors: O'Neill SS, Wong TC, Parris J, Chao HH, Mathews SP, Rollins-Raval MA, Fedoriw Y Abstract BACKGROUND: Bone marrow core biopsy is a routine component of comprehensive marrow evaluation, and adequacy criteria have been recommended. However, the effectiveness of these adequacy criteria for diagnostic bone marrow...
Thu Sep 19, 2019 15:12
Related ArticlesHigh and Low WWOX Gene Expression Levels in Acute Myeloid Leukemia - a Real Time RT-PCR Study. Clin Lab. 2019 Sep 01;65(9): Authors: Elbossaty WF, Malak CAA, Elghanam D Abstract BACKGROUND: Although expression of WWOX was extensively studied in different tumors, WWOX gene expression in acute myeloid leukemia is not well-known or recognized. METHODS: Fifty control donors and fifty acute myeloid leukemia patients were enrolled...
Thu Sep 19, 2019 15:12
Related ArticlesSerum 1,5-Anhydroglucitol Concentration as a Biomarker for Type 1 Diabetes in Adults and Children. Clin Lab. 2019 Sep 01;65(9): Authors: Martins BR, Gomes LC, Boritza KC, Anghebem-Oliveira MI, Souza EM, França SN, Picheth G, Rego FGM Abstract BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease and the leading form of diabetes among young white people. 1,5-Anhydroglucitol (1,5-AG), a nontraditional biomarker of postprandial glycemic...
Thu Sep 19, 2019 15:12
Related ArticlesThe Changes in Coagulation Test Results in Subjects with Varying Levels of Thyroid Stimulating Hormone. Clin Lab. 2019 Sep 01;65(9): Authors: Fu G, Sun X, Yan Y, Zhang M, Ming L Abstract BACKGROUND: The aim is to investigate the changes in coagulation test results in subjects with varying serum levels of thyroid stimulating hormone. METHODS: We performed a one-year retrospective analysis to retrieve combined results of activated...
Thu Sep 19, 2019 15:12
Related ArticlesAdvantages of Chromosome X-STRs Markers in Solving a Father-Daughter Paternity Case with one Mismatch on SE33 Locus. Clin Lab. 2019 Sep 01;65(9): Authors: Dumache R, Puiu M, Parvanescu R, Rogobete AF, Enache A Abstract BACKGROUND: Genetic markers are routinely used in human identification of paternity, maternity, and kinship cases. We describe a DNA paternity case with one mismatch on SE33 locus between the alleged father (AF) and the...
Thu Sep 19, 2019 15:12
Related ArticlesAppraising Oncogenic Long Noncoding RNAs as Novel Biomarkers for Oral Tongue Squamous Cell Carcinoma: a Meta-Analysis. Clin Lab. 2019 Sep 01;65(9): Authors: Cheng Y, Wang Y, Cui Z, Lin D, Zheng M, Cheng H Abstract BACKGROUND: Long noncoding RNAs (lncRNAs) are rapidly emerging as a novel class of transcripts associated with tumorigenesis and prognosis of oral tongue squamous cell carcinoma (OTSCC). The goal of this study was to perform...
Thu Sep 19, 2019 15:12
High Expression of Serum UCA1 may be a Potential Biomarker for Clinical Diagnosis of Gastric Cancer.
Related ArticlesHigh Expression of Serum UCA1 may be a Potential Biomarker for Clinical Diagnosis of Gastric Cancer. Clin Lab. 2019 Sep 01;65(9): Authors: Shan L, Liu C, Ma C Abstract BACKGROUND: The current study aims to detect the differential expression of lncRNA UCA1 in serum of patients with gastric cancer and a normal control group and to explore its efficacy and significance in clinical diagnosis of gastric cancer. METHODS: The expression...
Thu Sep 19, 2019 15:12
Related ArticlesSemi-Quantitative Impacts of Major Step on Antigen in Pre-Treatment Required for Immunohistochemistry. Clin Lab. 2019 Sep 01;65(9): Authors: Feng X, Wang W, Liu H Abstract BACKGROUND: We investigated the impact of immunohistochemistry (IHC) pre-treatment steps on antigens. METHODS: Salmonella typhimurium was selected as the observed antigen. The antigen was subjected to IHC pre-treatment steps involving a series of reagents,...
Thu Sep 19, 2019 15:12
Related ArticlesLearning from Principles of Evidence-Based Medicine to Optimize Nonclinical Research Practices. Handb Exp Pharmacol. 2019 Sep 17;: Authors: Lefevre IA, Balice-Gordon RJ Abstract Thousands of pharmacology experiments are performed each day, generating hundreds of drug discovery programs, scientific publications, grant submissions, and other efforts. Discussions of the low reproducibility and robustness of some of this research have led...
Thu Sep 19, 2019 13:11
Cytomegalovirus (CMV) infection commonly complicates hematopoietic-cell and solid-organ transplantation and is associated with increased morbidity and mortality. The available anti-CMV agents are effective but are limited by their toxic effects, including myelosuppression (ganciclovir and…
Thu Sep 19, 2019 03:00
Related ArticlesCharity warns of future shortfall of 7,000 clinical nurse specialists. Nurs Stand. 2017 Mar 01;31(27):11 Authors: Abstract Macmillan Cancer Support has warned of an estimated shortfall of 7,000 clinical nurse specialists (CNSs) in the UK by 2030 if the workforce does not grow and cancer survival rates continue to improve.PMID: 28247805 [PubMed - indexed for MEDLINE]
Thu Sep 19, 2019 13:13
Related ArticlesTherapy of Advanced Prostate Cancer: Targeting the Androgen Receptor Axis in Earlier Lines of Treatment. Target Oncol. 2018 12;13(6):679-689 Authors: Shah H, Vaishampayan U Abstract With the decrease in PSA screening based on the 2011 United States Preventive Services Task Force guidelines and the potential approval of highly sensitive imaging techniques over the next few years, we are likely to see an increasing trend of metastatic...
Thu Sep 19, 2019 13:13
Related ArticlesDrug strategies for bladder cancer in the elderly: is there promise for the future? Expert Opin Pharmacother. 2019 08;20(11):1387-1396 Authors: Soria F, Mosca A, Gontero P Abstract INTRODUCTION: Bladder cancer (BCa) is a disease that predominantly affects adult and elderly populations. As people live longer, it will become even more frequent and consequently represents a big health problem for health-care providers and is a challenging...
Thu Sep 19, 2019 13:13
Related ArticlesExperiences of Young Children With Cancer and Their Parents With Nurses' Caring Practices During the Cancer Trajectory. J Pediatr Oncol Nurs. 2019 Sep 17;:1043454219874007 Authors: Enskär K, Darcy L, Björk M, Knutsson S, Huus K Abstract Children with cancer require repeated hospitalizations and the family's everyday life and routines undergo change. Concrete descriptions of how nurses act when caring for children with cancer throughout...
Thu Sep 19, 2019 13:13
Related ArticlesTemporal changes in survival in men with de novo metastatic prostate cancer: nationwide population-based study. Acta Oncol. 2019 Sep 17;:1-6 Authors: Westerberg M, Franck Lissbrant I, Damber JE, Robinson D, Garmo H, Stattin P Abstract Background: There have been large changes in the pattern of detection, work-up and treatment of men with prostate cancer during the last two decades. Therefore, we aimed to investigate temporal changes in...
Thu Sep 19, 2019 13:13
Related ArticlesComplex interactions between the microbiome and cancer immune therapy. Crit Rev Clin Lab Sci. 2019 Sep 17;:1-19 Authors: Schwartz DJ, Rebeck ON, Dantas G Abstract Immuno-oncology has rapidly grown in the last thirty years, and immunotherapeutic agents are now approved to treat many disparate cancers. Immune checkpoint inhibitors (ICIs) are employed to augment cytotoxic anti-cancer activity by inhibiting negative regulatory elements of...
Thu Sep 19, 2019 13:13
Related ArticlesTranslation and psychometric properties for the Demoralization Scale in Chinese breast cancer patients. Eur J Oncol Nurs. 2019 Sep 05;42:134-140 Authors: Cheng J, Chen J, Zhang Y, Kissane D, Yan J Abstract PURPOSE: To translate and validate the Chinese version of the Demoralization Scale among breast cancer patients. METHOD: A cross-sectional, descriptive correlational design was employed. From September 2016 to May 2017, 203...
Thu Sep 19, 2019 13:13
Related ArticlesTumor Microenvironment Dynamics in Clear-Cell Renal Cell Carcinoma. Cancer Discov. 2019 Sep 16;: Authors: Vuong L, Kotecha RR, Voss MH, Hakimi AA Abstract Renal cell carcinoma stands out as one of the most immune-infiltrated tumors in pan-cancer comparisons. Features of the tumor microenvironment heavily affect disease biology and may affect responses to systemic therapy. With evolving frontline options in the metastatic setting, several...
Thu Sep 19, 2019 13:13
Related ArticlesLessons Learned from De-escalation trials in favorable risk HPV-associated Squamous Cell Head and Neck Cancer - A Perspective on future trial designs. Clin Cancer Res. 2019 Sep 16;: Authors: Ventz S, Trippa L, Schoenfeld JD Abstract In recent years several clinical studies have investigated de-intensified treatments in HPV-associated head and neck squamous cell carcinoma. Two large Phase III trials, RTOG-1016 and De-ESCALaTE, which attempted...
Thu Sep 19, 2019 13:13
Related ArticlesDistinct transcriptional programming drive response to MAPK inhibition in BRAFV600 mutant melanoma patient derived xenografts. Mol Cancer Ther. 2019 Sep 16;: Authors: Feng T, Golji J, Li A, Zhang X, Ruddy DA, Rakiec DP, Geyer FC, Gu J, Gao H, Williams JA, Stuart DD, Meyer MJ Abstract Inhibitors targeting BRAF and its downstream kinase MEK produce robust response in patients with advanced BRAFV600 mutant melanoma. However, the duration...
Thu Sep 19, 2019 13:13
Related ArticlesTreatment Optimization for Brain Metastasis from Anaplastic Lymphoma Kinase Rearrangement Non-Small-Cell Lung Cancer. Oncol Res Treat. 2019 Sep 17;:1-8 Authors: Wang W, Sun X, Hui Z Abstract BACKGROUND: Brain metastasis is common in non-small-cell lung cancer (NSCLC) with driver gene mutations. Anaplastic lymphoma kinase (ALK) gene rearrangement is one of the common driver mutations in NSCLC. Tyrosine kinase inhibitor (TKI) has been the...
Thu Sep 19, 2019 13:13
Related ArticlesCT radiomics and PET radiomics: ready for clinical implementation? Q J Nucl Med Mol Imaging. 2019 Sep 13;: Authors: Bogowicz M, Vuong D, Huellner MW, Pavic M, Andratschke N, Gabrys HS, Guckenberger M, Tanadini-Lang S Abstract Today, rapid technical and clinical developments result in an increasing number of treatment options for oncological diseases. Thus, decision support systems are needed to offer the right treatment to the right patient....
Thu Sep 19, 2019 13:13
Related ArticlesMetadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019 Sep 17;10(10):682 Authors: Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner BA, Buettner GR, Spitz DR, Leslie KK, Zhang J, Meng X Abstract Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death driven by lipid hydroperoxides within biological membranes. Although therapy-resistant mesenchymal-high cancers are particularly vulnerable...
Thu Sep 19, 2019 13:13
Related ArticlesChanges in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia. PLoS One. 2019;14(9):e0221591 Authors: Oosterom N, de Jonge R, Smith DEC, Pieters R, Tissing WJE, Fiocco M, van Zelst BD, van den Heuvel-Eibrink MM, Heil SG Abstract BACKGROUND: Methotrexate (MTX) is an important anti-folate agent in pediatric acute lymphoblastic leukemia (ALL) treatment....
Thu Sep 19, 2019 13:13
Related ArticlesLocoregional treatments for hepatocellular carcinoma: Current evidence and future directions. World J Gastroenterol. 2019 Aug 28;25(32):4614-4628 Authors: Inchingolo R, Posa A, Mariappan M, Spiliopoulos S Abstract Liver cancers are the second most frequent cause of global cancer-related mortality of which 90% are attributable to hepatocellular carcinoma (HCC). Despite the advent of screening programmes for patients with known risk factors,...
Thu Sep 19, 2019 13:13
Related ArticlesLiver cirrhosis and left ventricle diastolic dysfunction: Systematic review. World J Gastroenterol. 2019 Aug 28;25(32):4779-4795 Authors: Stundiene I, Sarnelyte J, Norkute A, Aidietiene S, Liakina V, Masalaite L, Valantinas J Abstract BACKGROUND: Liver cirrhosis is a chronic hepatic disease which is associated with cardiovascular abnormalities. Hyperdynamic circulation in liver cirrhosis causes functional and structural cardiac alterations....
Thu Sep 19, 2019 13:13
Related ArticlesAdverse Effect of Lymph Node Dissection in Metastatic Renal Cell Cancer Patients Treated with Cytoreductive Nephrectomy: A Contemporary Analysis of Survival. J Cancer. 2019;10(19):4639-4646 Authors: Cao D, Huang Y, Zhang C, Wu J, Yu L, Zhang H, Shi G, Ye D Abstract Background and objectives: In patients with metastatic renal cell cancer (mRCC), cytoreductive nephrectomy (CN) may occasionally be performed. However, the role of lymph node...
Thu Sep 19, 2019 13:13
Related ArticlesThe learning experience of basic science and clinical dentistry by postgraduate students in Institute of Clinical Dentistry and Institute of Oral Biology. J Dent Sci. 2019 Sep;14(3):277-280 Authors: Yang H, Chen HY, Lin HY, Chen HM Abstract Background/purpose: Students with different undergraduate trainings may have different responses after taking a combined course with both clinical and basic topics. This study investigated the learning...
Thu Sep 19, 2019 13:13
Related ArticlesPituitary carcinomas: Rare and challenging. Surg Neurol Int. 2019;10:161 Authors: Sinclair G, Olsson M, Benmakhlouf H, Al-Saffar Y, Johnstone P, Hatiboglu MA, Shamikh A Abstract Background: Pituitary carcinomas (PCs) are defined as adenohypophyseal tumors with metastatic activity within and outside the boundaries of the central nervous system (CNS). The condition is rare and therefore seldom reported; most lesions are hormone producing...
Thu Sep 19, 2019 13:13
Related ArticlesPerspective: Creating the Evidence Base for Nutritional Support in Childhood Cancer in Low- and Middle-Income Countries: Priorities for Body Composition Research. Adv Nutr. 2019 Sep 14;: Authors: Murphy-Alford AJ, Prasad M, Slone J, Stein K, Mosby TT Abstract There is a striking disparity in survival rates for children in low- and middle-income countries (LMICs) compared with high-income countries (HICs). Many of the contributing factors...
Thu Sep 19, 2019 13:13
Related ArticlesSolitary fibrous tumor: a case series identifying pathological adverse factors-implications for risk stratification and classification. Virchows Arch. 2019 Sep 16;: Authors: Machado I, Morales GN, Cruz J, Lavernia J, Giner F, Navarro S, Ferrandez A, Llombart-Bosch A Abstract Solitary fibrous tumors (SFTs) are a rare type of mesenchymal lesion in which specific clinicopathologic factors have been related to patient outcome. We collected...
Thu Sep 19, 2019 13:13
Related ArticlesFunctional disparities within the TIMP family in cancer: hints from molecular divergence. Cancer Metastasis Rev. 2019 Sep 16;: Authors: Eckfeld C, Häußler D, Schoeps B, Hermann CD, Krüger A Abstract The members of the tissue inhibitor of metalloproteinase (TIMP) family (TIMP-1, 2, 3, 4) are prominently appreciated as natural inhibitors of cancer-promoting metalloproteinases. However, clinical and recent functional studies indicate that...
Thu Sep 19, 2019 13:13
Related ArticlesIntravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial. Stem Cells. 2019 Sep 17;: Authors: Vahidy FS, Haque ME, Rahbar MH, Zhu H, Rowan P, Aisiku IP, Lee DA, Juneja HS, Alderman S, Barreto AD, Suarez JI, Bambhroliya A, Hasan KM, Kassam MR, Aronowski J, Gee A, Cox CS, Grotta JC, Savitz SI Abstract Cellular therapy is a promising investigational modality to...
Thu Sep 19, 2019 13:13
Related ArticlesThe TLR9 agonist (GNKG168) induces a unique immune activation pattern in vivo in children with minimal residual disease positive acute leukemia: Results of the TACL T2009-008 phase I study. Pediatr Hematol Oncol. 2019 Sep 18;:1-14 Authors: Ronsley R, Kariminia A, Ng B, Mostafavi S, Reid G, Subrt P, Hijiya N, Schultz KR Abstract Background: Preclinical studies show that TLR9 agonists can eradicate leukemia by induction of immune responses...
Thu Sep 19, 2019 15:00
Related Articles[An integral view of cancer (II). Fields of investigation and emerging biomarkers]. Rev Esp Patol. 2019 Oct - Dec;52(4):222-233 Authors: Noguera R, Burgos-Panadero R, Gamero-Sandemetrio E, de la Cruz-Merino L, Álvaro Naranjo T Abstract Pathology and clinical oncology work hand in hand so that techniques and treatments, biomarkers and antibodies share the common goal of identifying integral new treatment regimens that are more effective...
Thu Sep 19, 2019 15:00
Related ArticlesAge-related changes in DNA methylation affect renal histology and post-transplant fibrosis. Kidney Int. 2019 Jul 10;: Authors: Heylen L, Thienpont B, Busschaert P, Sprangers B, Kuypers D, Moisse M, Lerut E, Lambrechts D, Naesens M Abstract During ageing, kidney function decreases due to renal tubular atrophy, interstitial fibrosis, glomerulosclerosis and arteriosclerosis. Recently, changes in DNA methylation were shown to contribute to...
Thu Sep 19, 2019 15:00
Related ArticlesIL-7R is essential for leukemia-initiating cell activity and pathogenesis of T-cell acute lymphoblastic leukemia. Blood. 2019 Sep 17;: Authors: González-García S, Mosquera M, Fuentes P, Palumbo T, Escudero A, Pérez-Martínez A, Ramírez M, Corcoran AE, Toribio ML Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy resulting from the dysregulation of signaling pathways that control intrathymic T-cell...
Thu Sep 19, 2019 15:00
Related ArticlesAmbulatory cancer care electronic symptom self-reporting (ACCESS) for surgical patients: a randomised controlled trial protocol. BMJ Open. 2019 Sep 17;9(9):e030863 Authors: Stabile C, Temple LK, Ancker JS, Basch E, Carter J, Miranda M, Stein D, Stetson PD, Vickers A, Simon BA, Pusic AL Abstract INTRODUCTION: An increasing proportion of cancer surgeries are ambulatory procedures requiring a stay of 1 day or less in the hospital. Providing...
Thu Sep 19, 2019 15:00
Related ArticlesImpact of systemic therapy on circulating leukocyte populations in patients with metastatic breast cancer. Sci Rep. 2019 Sep 17;9(1):13451 Authors: Larsson AM, Roxå A, Leandersson K, Bergenfelz C Abstract Tumors affect the immune system, locally and systemically. The frequencies of specific circulating immune cell populations correlate with disease progression as well as prognosis of the patients. Although largely neglected, conventional...
Thu Sep 19, 2019 15:00
Related ArticlesStructural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors. ACS Med Chem Lett. 2019 Sep 12;10(9):1322-1327 Authors: Collie GW, Koh CM, O'Neill DJ, Stubbs CJ, Khurana P, Eddershaw A, Snijder A, Mauritzson F, Barlind L, Dale IL, Shaw J, Phillips C, Hennessy EJ, Cheung T, Narvaez AJ Abstract Many small molecule inhibitors of the cMET receptor tyrosine kinase have been evaluated in clinical trials for...
Thu Sep 19, 2019 15:00
Related ArticlesSurgical Resection of Pheochromocytomas and Paragangliomas is Associated with Lower Cholesterol Levels. World J Surg. 2019 Sep 17;: Authors: Good ML, Malekzadeh P, Ruff SM, Gupta S, Copeland A, Pacak K, Nilubol N, Kebebew E, Patel D Abstract BACKGROUND: Catecholamine excess in patients with pheochromocytomas or paragangliomas (PPGLs) can lead to hypertension, diabetes and hyperlipidemia. The aim was to investigate the prevalence of hyperlipidemia...
Thu Sep 19, 2019 15:00
Related ArticlesHigh mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer. Breast Cancer Res Treat. 2019 Sep 17;: Authors: Gorbounov M, Carleton NM, Asch-Kendrick RJ, Xian L, Rooper L, Chia L, Cimino-Mathews A, Cope L, Meeker A, Stearns V, Veltri RW, Bae YK, Resar LMS Abstract PURPOSE: The high mobility group A1 (HMGA1) chromatin remodeling protein is required for metastatic progression...
Thu Sep 19, 2019 15:00
Related ArticlesA comprehensive catalogue of EQ-5D scores in chronic disease: results of a systematic review. Qual Life Res. 2019 Sep 17;: Authors: Van Wilder L, Rammant E, Clays E, Devleesschauwer B, Pauwels N, De Smedt D Abstract PURPOSE: Chronic diseases are associated with impaired health-related quality of life (HRQoL) outcomes. Comparison of HRQoL outcomes between different diseases and with the general population is of major importance to health...
Thu Sep 19, 2019 15:00
Related ArticlesCost Effectiveness of PD-L1-Based Test-and-Treat Strategy with Pembrolizumab as the First-Line Treatment for Metastatic NSCLC in Hong Kong. Pharmacoecon Open. 2019 Sep 17;: Authors: Loong HH, Wong CKH, Leung LKS, Dhankhar P, Insinga RP, Chandwani S, Hsu DC, Lee MYK, Huang M, Pellissier J, Rai A, Achra M, Tan SC Abstract BACKGROUND: Pembrolizumab, a monoclonal antibody against programmed death ligand 1 (PD-L1), is approved by several regulatory...
Thu Sep 19, 2019 15:00
Related ArticlesEvaluation of platelet distribution width as a diagnostic and prognostic biomarker in bladder neoplasm. Future Oncol. 2019 Sep 18;: Authors: Liu L, Zhao Y, Cui J, Chen S, Shi B Abstract Aim: To evaluate the role of preoperative platelet distribution width (PDW) as a potential biomarker for distinguishing malignancy and tumor advantage of bladder neoplasm. Methods: The study included 210 subjects with bladder cancer, 76 subjects with urothelial...
Thu Sep 19, 2019 15:00
Related ArticlesPhysician Perceptions of the Use of Social Media for Recruitment of Patients in Cancer Clinical Trials. JAMA Netw Open. 2019 Sep 04;2(9):e1911528 Authors: Sedrak MS, Sun V, Liu J, George K, Wong AR, Dale W, Dizon DS Abstract Importance: Social media campaigns have been successfully implemented in nontherapeutic trials. However, evidence to support their utility in cancer therapeutic trials is limited. Objective: To examine physician...
Thu Sep 19, 2019 15:00
Related ArticlesBody Composition in Pediatric Solid Tumors: State of the Science and Future Directions. J Natl Cancer Inst Monogr. 2019 Sep 01;2019(54):144-148 Authors: Joffe L, Schadler KL, Shen W, Ladas EJ Abstract Sarcopenia (severe skeletal muscle wasting) and sarcopenic obesity (skeletal muscle wasting in the setting of excess fat) have been increasingly recognized as important prognostic indicators in adult oncology. Unfavorable changes in lean...
Thu Sep 19, 2019 15:00
Related ArticlesNutrition & Exercise Interventions in Pediatric Patients with Brain Tumors: A Narrative Review. J Natl Cancer Inst Monogr. 2019 Sep 01;2019(54):163-168 Authors: Runco DV, Yoon L, Grooss SA, Wong CK Abstract Brain tumors have been the most common pediatric solid tumor and leading cause of morbidity and mortality. Improved survival emphasizes the importance of adverse treatment effects especially related to nutrition and exercise. Although...
Thu Sep 19, 2019 15:00
Related ArticlesThe Gut Microbiome and Pediatric Cancer: Current Research and Gaps in Knowledge. J Natl Cancer Inst Monogr. 2019 Sep 01;2019(54):169-173 Authors: Bhuta R, Nieder M, Jubelirer T, Ladas EJ Abstract The human microbiome consists of trillions of microbial cells that interact with one another and the human host to play a clinically significant role in health and disease. Gut microbial changes have been identified in cancer pathogenesis, at...
Thu Sep 19, 2019 15:00
Related ArticlesEffect of Psychological Intervention on Fear of Cancer Recurrence: A Systematic Review and Meta-Analysis. J Clin Oncol. 2019 Sep 18;:JCO1900572 Authors: Tauber NM, O'Toole MS, Dinkel A, Galica J, Humphris G, Lebel S, Maheu C, Ozakinci G, Prins J, Sharpe L, Smith AB, Thewes B, Simard S, Zachariae R Abstract PURPOSE: Fear of cancer recurrence (FCR) is a significantly distressing problem that affects a substantial number of patients with...
Thu Sep 19, 2019 15:00
Related ArticlesDevelopment and validation of a 1.5 T MR-Linac full accelerator head and cryostat model for Monte Carlo dose simulations. Med Phys. 2019 Sep 18;: Authors: Friedel M, Nachbar M, Mönnich D, Dohm O, Thorwarth D Abstract PURPOSE: To develop, implement and validate a full 1.5 T/7 MV MR-Linac accelerator head and cryostat model in EGSnrc for high precision dose calculations accounting for magnetic field effects that are independent from the...
Thu Sep 19, 2019 15:00
Related Articles[Benefits of combining chemotherapy with immuno- oncology therapies or "Is it true that chemotherapy destroys the immune system?"] Magy Onkol. 2019 Sep 18;63(3):202-207 Authors: Kocsis J Abstract In recent years widespread use of immuno-oncology drugs are in the focus of modern systemic anticancer therapies. Parallel to the evolving role of immune checkpoint inhibitors many people believe that using chemotherapy is coming to an end. Moreover...
Thu Sep 19, 2019 15:00
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