Related ArticlesCB002, a novel p53 tumor suppressor pathway-restoring small molecule induces tumor cell death through the pro-apoptotic protein NOXA. Cell Cycle. 2018;17(5):557-567 Authors: Hernandez-Borrero LJ, Zhang S, Lulla A, Dicker DT, El-Deiry WS Abstract P53 tumor suppressor gene mutations occur in the majority of human cancers and contribute to tumor development, progression and therapy resistance. Direct functional restoration of p53 as a...
Thu Sep 19, 2019 13:13
Related ArticlesDiscovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells. Cell Cycle. 2018;17(5):652-668 Authors: Levrier C, Rockstroh A, Gabrielli B, Kavallaris M, Lehman M, Davis RA, Sadowski MC, Nelson CC Abstract We report for the first time the mechanism of action of the natural product thalicthuberine (TH) in prostate and cervical cancer cells. TH induced...
Thu Sep 19, 2019 13:13
Related ArticlesCo-expression of RelA/p65 and ACTN4 induces apoptosis in non-small lung carcinoma cells. Cell Cycle. 2018;17(5):616-626 Authors: Lomert E, Turoverova L, Kriger D, Aksenov ND, Nikotina AD, Petukhov A, Mittenberg AG, Panyushev NV, Khotin M, Volkov K, Barlev NA, Tentler D Abstract Alpha-actinin 4 (ACTN4) is an actin-binding protein of the spectrin superfamily. ACTN4 is found both in the cytoplasm and nucleus of eukaryotic cells. The main...
Thu Sep 19, 2019 13:13
Related ArticlesIdentification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 02 19;8(1):3305 Authors: Manzoor S, Bilal A, Khan S, Ullah R, Iftikhar S, Emwas AH, Alazmi M, Gao X, Jawaid A, Saleem RSZ, Faisal A Abstract Microtubules are highly dynamic structures that form spindle fibres during mitosis and are one of the most validated cancer targets. The success of drugs targeting...
Thu Sep 19, 2019 13:13
Related ArticlesImmunologic targeting of CD30 eliminates tumourigenic human pluripotent stem cells, allowing safer clinical application of hiPSC-based cell therapy. Sci Rep. 2018 02 27;8(1):3726 Authors: Sougawa N, Miyagawa S, Fukushima S, Kawamura A, Yokoyama J, Ito E, Harada A, Okimoto K, Mochizuki-Oda N, Saito A, Sawa Y Abstract Induced pluripotent stem cells (iPSCs) are promising candidate cells for cardiomyogenesis in the failing heart. However,...
Thu Sep 19, 2019 13:13
Related ArticlesAn Unusual Prohibitin Regulates Malaria Parasite Mitochondrial Membrane Potential. Cell Rep. 2018 Apr 17;23(3):756-767 Authors: Matz JM, Goosmann C, Matuschewski K, Kooij TWA Abstract Proteins of the stomatin/prohibitin/flotillin/HfIK/C (SPFH) family are membrane-anchored and perform diverse cellular functions in different organelles. Here, we investigate the SPFH proteins of the murine malaria model parasite Plasmodium berghei, the...
Thu Sep 19, 2019 13:13
Related ArticlesDown-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. Apoptosis. 2018 06;23(5-6):356-374 Authors: Li S, Tian J, Zhang H, Zhou S, Wang X, Zhang L, Yang J, Zhang Z, Ji Z Abstract Recent studies have confirmed that IL-6/GP130 targets are closely associated with tumor growth, metastasis and drug resistance. 5-Fluorouracil (5-FU) is the most common chemotherapeutic agent for colon cancer but...
Thu Sep 19, 2019 13:13
Related ArticlesC-phycocyanin from Limnothrix Species KNUA002 Alleviates Cisplatin-Induced Ototoxicity by Blocking the Mitochondrial Apoptotic Pathway in Auditory Cells. Mar Drugs. 2019 Apr 19;17(4): Authors: Kim YR, Do JM, Kim KH, Stoica AR, Jo SW, Kim UK, Yoon HS Abstract Ototoxicity, or adverse pharmacological effects on the inner ear or auditory nerve, is a common side effect of cisplatin, a platinum-based drug widely used in anticancer chemotherapy....
Thu Sep 19, 2019 13:13
Related ArticlesCostunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9. Med Sci Monit. 2019 May 02;25:3231-3237 Authors: Fang Y, Li J, Wu Y, Gui J, Shen Y Abstract BACKGROUND Worldwide, ovarian cancer has a high mortality rate due to the difficulty in diagnosing early-stage disease and...
Thu Sep 19, 2019 13:13
Related ArticlesExpression of TMEFF2 in Human Pancreatic Cancer Tissue and the Effects of TMEFF2 Knockdown on Cell, Proliferation, and Apoptosis in Human Pancreatic Cell Lines. Med Sci Monit. 2019 May 02;25:3238-3246 Authors: Li K, Gu W, Xu J, Wang A, Han H Abstract BACKGROUND The TMEFF2 gene encodes the transmembrane protein with EGF like and two follistatin-like domains 2 and has been reported to be a tumor suppressor gene, but its role remains unknown...
Thu Sep 19, 2019 13:13
Related ArticlesGlutamine synthetase facilitates cancer cells to recover from irradiation-induced G2/M arrest. Cancer Biol Ther. 2019 Sep 17;:1-9 Authors: Peng Y, Fu S, Hu W, Qiu Y, Zhang L, Tan R, Sun LQ Abstract Resistance to radiation of cancer cells can be either intrinsic or acquired, leading to treatment failure. In response to DNA damage caused by IR, cancer cells are arrested in cell cycle showing limited proliferation and increased apoptosis....
Thu Sep 19, 2019 13:13
Related ArticlesA novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis. Biosci Rep. 2019 Sep 16;: Authors: Peng C, Sun C, Wang N, He Y, Xu J, Deng Y, Gao L, Zhong J, Xiong X, Liu L Abstract Diffuse large B-cell lymphoma (DLBCL) is a clinically aggressive B-cell non-Hodgkin's lymphoma (NHL) with high treatment difficulty and high relapse rate. The bromodomain and extra-terminal...
Thu Sep 19, 2019 13:13
Related ArticlesO-GlcNAcylation of Thr12 / Ser56 in short form O-GlcNAc transferase (sOGT) regulates its substrate selectivity. J Biol Chem. 2019 Sep 16;: Authors: Liu L, Li L, Ma C, Shi Y, Liu C, Xiao Z, Zhang Y, Tian F, Gao Y, Zhang J, Ying W, Wang PG, Zhang L Abstract O-GlcNAcylation is a ubiquitous protein glycosylation playing different roles on variant proteins. O-GlcNAc transferase (OGT) is the unique enzyme responsible for the sugar addition...
Thu Sep 19, 2019 13:13
Related ArticlesConversion of Sox2-dependent Merkel cell carcinoma to a differentiated neuron-like phenotype by T antigen inhibition. Proc Natl Acad Sci U S A. 2019 Sep 16;: Authors: Harold A, Amako Y, Hachisuka J, Bai Y, Li MY, Kubat L, Gravemeyer J, Franks J, Gibbs JR, Park HJ, Ezhkova E, Becker JC, Shuda M Abstract Viral cancers show oncogene addiction to viral oncoproteins, which are required for survival and proliferation of the dedifferentiated...
Thu Sep 19, 2019 13:13
Related ArticlesGRIM-19 over-expression represses the proliferation and invasion of orthotopically implanted hepatocarcinoma tumors associated with downregulation of Stat3 signaling. Biosci Trends. 2019;13(4):342-350 Authors: Kong D, Chen J, Sun X, Lin Y, Du Y, Huang D, Cheng H, He P, Yang L, Wu S, Zhao L, Meng X Abstract The retinoid-interferon-induced mortality-19 (GRIM-19) gene has been identified as a negative regulator associated with tumor development....
Thu Sep 19, 2019 13:13
Related ArticlesSynergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells. Mar Drugs. 2019 Sep 16;17(9): Authors: Tun JO, Salvador-Reyes LA, Velarde MC, Saito N, Suwanborirux K, Concepcion GP Abstract Renieramycin M (RM) is a KCN-stabilized tetrahydroisoquinoline purified from the blue sponge Xestospongia sp., with nanomolar IC50s against several cancer cell lines. Our goal is to evaluate its combination effects with doxorubicin...
Thu Sep 19, 2019 13:13
Related ArticlesXanthohumol, a Prenylated Flavonoid from Hops, Induces Caspase-Dependent Degradation of Oncoprotein BCR-ABL in K562 Cells. Antioxidants (Basel). 2019 Sep 16;8(9): Authors: Lu X, Geng J, Zhang J, Miao J, Liu M Abstract BCR-ABL oncoprotein drives the initiation, promotion, and progression of chronic myelogenous leukemia (CML). Tyrosine kinase inhibitors are the first choice for CML therapy, however, BCR-ABL mediated drug resistance limits...
Thu Sep 19, 2019 13:13
Anti-tumor activity of BET inhibitors in androgen-receptor-expressing triple-negative breast cancer.
Related ArticlesAnti-tumor activity of BET inhibitors in androgen-receptor-expressing triple-negative breast cancer. Sci Rep. 2019 Sep 16;9(1):13305 Authors: Park IH, Yang HN, Jeon SY, Hwang JA, Kim MK, Kong SY, Shim SH, Lee KS Abstract Triple-negative breast cancer (TNBC) is a heterogeneous disease comprising several subtypes. Androgen-receptor (AR) signaling has been targeted by several investigational agents in luminal AR subtype TNBCs. Bromodomain...
Thu Sep 19, 2019 13:13
Related ArticlesGrowth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis. World J Gastroenterol. 2019 Aug 28;25(32):4715-4726 Authors: Zhu RX, Cheng ASL, Chan HLY, Yang DY, Seto WK Abstract BACKGROUND: Growth arrest-specific gene 2 (GAS2) plays a role in modulating in reversible growth arrest cell cycle, apoptosis, and cell survival. GAS2 protein is universally expressed in most normal tissues,...
Thu Sep 19, 2019 13:13
Related ArticlesAccumulated cytotoxicity of CDK inhibitor dinaciclib with first-line chemotherapy drugs in salivary adenoid cystic carcinoma cells. Odontology. 2019 Sep 16;: Authors: Xu L, Li L, Zhang J, Cai W, Zhao S, Liu S Abstract Adenoid cystic carcinoma (ACC) is one of the most common salivary gland malignant tumors. Its treatment failure is partly due to the limitations of chemotherapeutic agents and their adverse effects. The objective of this...
Thu Sep 19, 2019 13:13
Related ArticlesNovel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1668-1677 Authors: Zhang Y, Chen L, Li X, Gao L, Hao Y, Li B, Yan Y Abstract Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have...
Thu Sep 19, 2019 14:13
Related ArticlesInvolvement of CaMKII in regulating the release of diplotene-arrested mouse oocytes by pAkt1 (Ser473). Cell Cycle. 2019 Sep 18;:1-12 Authors: Liu L, Li H, Labbe B, Wang Y, Mao S, Cao Y, Zhao M, Liu S, Yu H, Deng X Abstract Calcium (Ca2+)/calmodulin-dependent protein kinase II (CaMKII) had been reported to play a role in the process of fertilization. However, the role of CaMKII in the release of diplotene-arrested oocytes is poorly understood....
Thu Sep 19, 2019 14:13
Related ArticlesERGIC3 silencing additively enhances the growth inhibition of BFA on lung adenocarcinoma cells. Curr Cancer Drug Targets. 2019 Sep 17;: Authors: Zhao Q, Wu M, Zheng X, Yang L, Zhang Z, Li X, Chen J Abstract BACKGROUND: Brefeldin A (BFA) has been known to induce endoplasmic reticulum stress (ERS) and Golgi body stress in cancer cells. ERGIC3 (endoplasmic reticulum-Golgi intermediate compartment 3) is a type II transmembrane protein located...
Thu Sep 19, 2019 14:13
Related ArticlesIdentification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors. Biochem Biophys Res Commun. 2019 Sep 14;: Authors: Yamane M, Sawada JI, Ogo N, Ohba M, Ando T, Asai A Abstract Kinesin centromere-associated protein E (CENP-E) has emerged as a potential target for the development of anticancer drugs due to its involvement in the mitotic progression of the cell cycle. Although several CENP-E inhibitors have been reported,...
Thu Sep 19, 2019 14:13
Related ArticlesAurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy. Mol Cancer Ther. 2019 Sep 17;: Authors: Du J, Yan L, Torres R, Gong X, Bian H, Marugán C, Boehnke K, Baquero C, Hui YH, Chapman SC, Yang Y, Zeng Y, Bogner SM, Foreman RT, Capen A, Donoho GP, Van Horn RD, Barnard DS, Dempsey JA, Beckmann RP, Marshall MS, Chio LC, Qian Y, Webster YW, Aggarwal A, Chu S, Bhattachar...
Thu Sep 19, 2019 14:13
Related ArticlesFolate deficiency promotes differentiation of vascular smooth muscle cells without affecting the methylation status of regulated genes. Biochem J. 2019 Sep 17;: Authors: Kolb AF, Petrie L, Mayer CD, Pirie L, Duthie SJ Abstract Elevated serum homocysteine, an intermediate of cellular one-carbon metabolism, is an independent risk factor for cardiovascular disease (CVD). Folate deficiency increases serum homocysteine and may contribute to...
Thu Sep 19, 2019 14:13
Related ArticlesReplication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nat Commun. 2019 Sep 17;10(1):4224 Authors: Masamsetti VP, Low RRJ, Mak KS, O'Connor A, Riffkin CD, Lamm N, Crabbe L, Karlseder J, Huang DCS, Hayashi MT, Cesare AJ Abstract Mitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe...
Thu Sep 19, 2019 14:13
Related ArticlesProtective Effect of Fat Extract on UVB-Induced Photoaging In Vitro and In Vivo. Oxid Med Cell Longev. 2019;2019:6146942 Authors: Deng M, Xu Y, Yu Z, Wang X, Cai Y, Zheng H, Li W, Zhang W Abstract Background: Nanofat can protect against ultraviolet B- (UVB-) induced damage in nude mice. Fat extract (FE) is a cell-free fraction isolated from nanofat that is enriched with a variety of growth factors. Objective: To determine whether...
Thu Sep 19, 2019 14:13
Related ArticlesRadiosensitization of Head and Neck Squamous Cell Carcinoma (HNSCC) by a Podophyllotoxin. ACS Med Chem Lett. 2019 Sep 12;10(9):1314-1321 Authors: Resendez A, Tailor D, Graves E, Malhotra SV Abstract Surgical resection and radiotherapy are an effective treatment in many head and neck squamous cell carcinomas (HNSCC), but in others, the development of radiotherapy resistance limits treatment efficacy and permits disease progression. We...
Thu Sep 19, 2019 14:13
Related ArticlesLNX1 contributes to tumor growth by down-regulating p53 stability. FASEB J. 2019 Sep 18;:fj201900366R Authors: Park R, Kim H, Jang M, Jo D, Park YI, Namkoong S, Lee JI, Jang IS, Park J Abstract The well-known tumor suppressor p53 inhibits the formation of various cancers by inducing cell cycle arrest and apoptosis. Although p53 mutations are commonly found in many cancers, p53 is functionally inactivated in tumor cells that retain wild-type...
Thu Sep 19, 2019 14:13
Related ArticlesIn vitro exposure to thiacloprid-based insecticide formulation promotes oxidative stress, apoptosis and genetic instability in bovine lymphocytes. Toxicol In Vitro. 2019 Sep 15;:104654 Authors: Schwarzbacherová V, Wnuk M, Deregowska A, Holečková B, Lewinska A Abstract A proprietary thiacloprid-based neonicotinoid insecticide formulation is widely used in agriculture to protect vegetables and fruit against various pests. However, its effect...
Thu Sep 19, 2019 14:13
Related ArticlesTargeting epigenetic modifications as a potential therapeutic option for diabetic retinopathy. J Cell Physiol. 2019 Sep 17;: Authors: Kumari N, Karmakar A, Ganesan SK Abstract Diabetic retinopathy (DR) is the leading cause of visual impairment in adults of working age (20-65 years) in developed countries. The metabolic memory phenomena (persistent effect of a glycemic insult even after retrieved) associated with it has increased the risk...
Thu Sep 19, 2019 15:10
Related ArticlesCBP-triggered KDM2B acetylation accelerates the carcinogenesis of colon cancer. J Cell Physiol. 2019 Sep 17;: Authors: Qi Y, Zhao Y Abstract Lysine (K)-specific demethylase 2B (KDM2B) has been testified to be an oncogene in diverse cancers, which joins in mediating the carcinogenesis of cancers. Nonetheless, the function of KDM2B in colon cancer remains unexplored. The study attempted to disclose the influences of KDM2B acetylation in...
Thu Sep 19, 2019 15:10
Related ArticlesTMEM158 promotes pancreatic cancer aggressiveness by activation of TGFβ1 and PI3K/AKT signaling pathway. J Cell Physiol. 2019 Sep 17;: Authors: Fu Y, Yao N, Ding D, Zhang X, Liu H, Ma L, Shi W, Zhu C, Tang L Abstract Pancreatic cancer (PC) is one of the most deadly digestive cancers world-wide, with a dismal five-year survival rate of <8%. Upregulation of transmembrane protein 158 (TMEM158) is known to facilitate the progression of...
Thu Sep 19, 2019 15:10
Related ArticlesMeasuring blood flow through intrapulmonary and intracardiac shunts: a technical labyrinth. J Physiol. 2019 Sep 17;: Authors: Foster GE PMID: 31529499 [PubMed - as supplied by publisher]
Thu Sep 19, 2019 13:15
Related ArticlesTopographic map refinement and synaptic strengthening of a sound localization circuit require spontaneous peripheral activity. J Physiol. 2019 Sep 16;: Authors: Müller NIC, Sonntag M, Maraslioglu A, Hirtz JJ, Friauf E Abstract KEY POINTS: •Loss of the calcium sensor otoferlin disrupts neurotransmission from inner hair cells. Central auditory nuclei are functionally denervated in Otof KOs via gene ablation confined to the periphery. •We...
Thu Sep 19, 2019 13:15
Related ArticlesSex differences in fatigability and recovery relative to the intensity-duration relationship. J Physiol. 2019 Sep 17;: Authors: Ansdell P, Brownstein CG, Škarabot J, Hicks KM, Howatson G, Thomas K, Hunter SK, Goodall S Abstract KEY POINTS: Females demonstrate greater fatigue-resistance than males during contractions at intensities relative to maximum force. However, previous studies haven't accounted for the influence of metabolic thresholds...
Thu Sep 19, 2019 13:15
Related ArticlesEarly sinusoidal heart rate patterns and heart rate variability to assess hypoxia-ischaemia in near-term fetal sheep. J Physiol. 2019 Sep 17;: Authors: Kasai M, Lear CA, Davidson JO, Beacom MJ, Drury PP, Maeda Y, Miyagi E, Ikeda T, Bennet L, Gunn AJ Abstract KEY POINTS: Therapeutic hypothermia needs to be started as early as possible in the first 6 hours after acute hypoxic-ischaemic (HI) injury, but the severity and timing of HI are...
Thu Sep 19, 2019 13:15
Related ArticlesDynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. J Physiol. 2019 Sep 18;: Authors: Krajeski RN, Macey-Dare A, van Heusden F, Ebrahimjee F, Ellender TJ Abstract KEY POINTS: Imbalances in the activity of the D1-expressing direct-pathway and D2-expressing indirect-pathway striatal projection neurons (SPNs) are thought to contribute to many basal ganglia disorders, including...
Thu Sep 19, 2019 15:14
Related ArticlesFatty vessels shed tonnes on programmed cardiovascular risk. J Physiol. 2019 Sep 18;: Authors: Giussani DA PMID: 31531985 [PubMed - as supplied by publisher]
Thu Sep 19, 2019 15:14
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