Congenital Lymphatic Malformation and Aortic Aneurysm in a Patient with TSC2 Mutation. Neuropediatrics. 2019 Sep 10;: Authors: Wiemer-Kruel A, Mayer H, Ewert P, Martinoff S, Eckstein HH, Kriebel T, Bissler J, Franz D, Bast T Abstract We present a 7-year-old boy with tuberous sclerosis and congenital segmental lymphedema (CSL) of the left leg, as well as two aortic aneurysms. He was treated with everolimus (EVE) since the age of 14 months. His CSL regressed...
Wed Sep 11, 2019 15:01
Related ArticlesNoninvasive and quantitative evaluation of movement disorder disability using an infrared depth sensor. J Clin Neurosci. 2019 Sep 06;: Authors: Tsukagoshi S, Furuta M, Hirayanagi K, Furuta N, Nakazato S, Fujii M, Yuminaka Y, Ikeda Y Abstract Cerebellar ataxia and Parkinson's disease are neurodegenerative disorders clinically characterized by motor disabilities including gait disturbance. This study aimed to investigate the usefulness...
Wed Sep 11, 2019 15:01
Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report. Int J Surg Case Rep. 2019 Aug 31;62:140-143 Authors: Kaneko Y, Saito S, Takahashi D, Ui T, Haruta H, Kurashina K, Yamaguchi H, Hosoya Y, Kitayama J, Lefor AK, Sata N Abstract INTRODUCTION: Immune thrombocytopenic purpura is an acquired thrombocytopenia. Preoperative management of thrombocytopenia...
Wed Sep 11, 2019 15:02
The current impact of water thermodynamics for small-molecule drug discovery. Expert Opin Drug Discov. 2019 Sep 10;:1-5 Authors: Geschwindner S, Ulander J PMID: 31502891 [PubMed - as supplied by publisher]
Wed Sep 11, 2019 15:03
Related ArticlesCorrection. J Dermatolog Treat. 2019 Sep 10;:1 Authors: PMID: 31500476 [PubMed - as supplied by publisher]
Wed Sep 11, 2019 15:03
Related ArticlesThe efficacy and safety of microneedle monopolar radiofrequency for the treatment of periorbital wrinkles. J Dermatolog Treat. 2019 Sep 10;:1-5 Authors: Kwon SH, Choi JY, Ahn GY, Jang WS, Shin JW, Na JI, Park KC, Huh CH Abstract Background: Treatment of periorbital wrinkles is a challenging task because of its anatomical significance and delicate nature. Objective: The aim of this study was to evaluate the efficacy and safety of a microneedle...
Wed Sep 11, 2019 15:03
Related ArticlesAnalysis of quantitative sudomotor axon reflex test patterns in patients with complex regional pain syndrome diagnosed using the Budapest criteria. Reg Anesth Pain Med. 2019 Sep 08;: Authors: Lee HJ, Kim SE, Moon JY, Shin JY, Kim YC Abstract BACKGROUND: Although the quantitative sensory axon reflex test (QSART) is used to evaluate sudomotor dysfunction in the diagnosis of complex regional pain syndrome (CRPS), its validity remains controversial....
Wed Sep 11, 2019 15:05
Related ArticlesShould erector spinae plane block applications be standardized or should we revise nomenclature? Reg Anesth Pain Med. 2019 Sep 09;: Authors: Tulgar S, Ahiskalioglu A, Thomas DT, Gurkan Y PMID: 31501248 [PubMed - as supplied by publisher]
Wed Sep 11, 2019 15:05
Related ArticlesCDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair. J Mol Cell Biol. 2018 08 01;10(4):341-357 Authors: Abu-Zhayia ER, Awwad SW, Ben-Oz BM, Khoury-Haddad H, Ayoub N Abstract Cells have evolved DNA damage response (DDR) to repair DNA lesions and thus preserving genomic stability and impeding carcinogenesis. DNA damage induction is accompanied by transient transcription repression. Here,...
Wed Sep 11, 2019 15:07
Related ArticlesTumor-targeting Salmonella typhimurium A1-R combined with recombinant methioninase and cisplatinum eradicates an osteosarcoma cisplatinum-resistant lung metastasis in a patient-derived orthotopic xenograft (PDOX) mouse model: decoy, trap and kill chemotherapy moves toward the clinic. Cell Cycle. 2018;17(6):801-809 Authors: Igarashi K, Kawaguchi K, Kiyuna T, Miyake K, Miyake M, Li S, Han Q, Tan Y, Zhao M, Li Y, Nelson SD, Dry SM, Singh AS, Elliott IA,...
Wed Sep 11, 2019 15:07
Related ArticlesSimple discrimination of sub-cycling cells by propidium iodide flow cytometric assay in Jurkat cell samples with extensive DNA fragmentation. Cell Cycle. 2018;17(6):766-779 Authors: Babes RM, Tofolean IT, Sandu RG, Baran OE, Cosoreanu V, Ilie MT, Duta AI, Ceausescu MC, Ciucur PM, Costache S, Ganea C, Baran I Abstract Human leukemia Jurkat T cells were analyzed for apoptosis and cell cycle by flow cytometry, using the Annexin V/propidium...
Wed Sep 11, 2019 15:07
Related ArticlesCancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy. J Clin Invest. 2018 04 02;128(4):1338-1354 Authors: Hailemichael Y, Woods A, Fu T, He Q, Nielsen MC, Hasan F, Roszik J, Xiao Z, Vianden C, Khong H, Singh M, Sharma M, Faak F, Moore D, Dai Z, Anthony SM, Schluns KS, Sharma P, Engelhard VH, Overwijk WW Abstract Anticancer vaccination is a promising approach to increase the efficacy of cytotoxic...
Wed Sep 11, 2019 15:07
Related ArticlesEmerging strategies for combination checkpoint modulators in cancer immunotherapy. J Clin Invest. 2018 08 01;128(8):3209-3218 Authors: Popovic A, Jaffee EM, Zaidi N Abstract Current immune checkpoint-modulating agents have demonstrated clinical efficacy in certain tumor types, particularly those with a high burden of tumor-specific neoantigens, high tumor-mutational burden, and abundant tumor-infiltrating T cells. However, these tumors...
Wed Sep 11, 2019 15:07
Related ArticlesATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer. Mol Cancer Ther. 2018 11;17(11):2462-2472 Authors: Tu X, Kahila MM, Zhou Q, Yu J, Kalari KR, Wang L, Harmsen WS, Yuan J, Boughey JC, Goetz MP, Sarkaria JN, Lou Z, Mutter RW Abstract Triple-negative breast cancer (TNBC) is characterized by elevated locoregional recurrence risk despite aggressive local therapies. New tumor-specific radiosensitizers...
Wed Sep 11, 2019 15:07
Related ArticlesRole of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin. Mol Cancer Ther. 2018 11;17(11):2341-2352 Authors: Zhang Y, Dong Y, Melkus MW, Yin S, Tang SN, Jiang P, Pramanik K, Wu W, Kim S, Ye M, Hu H, Lu J, Jiang C Abstract Bufalin is a major cardiotonic compound in the traditional Chinese medicine, Chansu, prepared from toad skin secretions. Cell culture studies have suggested an...
Wed Sep 11, 2019 15:07
Related ArticlesPPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion. Mol Biol Cell. 2018 11 15;29(23):2801-2808 Authors: Fong CS, Ozaki K, Tsou MB Abstract Centriole-to-centrosome conversion (CCC) safeguards centriole homeostasis by coupling centriole duplication with segregation, and is essential for stabilization of mature vertebrate centrioles naturally devoid of the geometric scaffold or the cartwheel. Here we...
Wed Sep 11, 2019 15:07
Related ArticlesHistone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type. Mol Cancer Ther. 2018 12;17(12):2767-2779 Authors: Wang Y, Chen SY, Colborne S, Lambert G, Shin CY, Santos ND, Orlando KA, Lang JD, Hendricks WPD, Bally MB, Karnezis AN, Hass R, Underhill TM, Morin GB, Trent JM, Weissman BE, Huntsman DG Abstract Small cell carcinoma of the...
Wed Sep 11, 2019 15:07
Related ArticlesCyclooxygenase-2 Influences Response to Cotargeting of MEK and CDK4/6 in a Subpopulation of Pancreatic Cancers. Mol Cancer Ther. 2018 12;17(12):2495-2506 Authors: Maust JD, Frankowski-McGregor CL, Bankhead A, Simeone DM, Sebolt-Leopold JS Abstract The ineffectiveness of chemotherapy in patients with pancreatic cancer highlights a critical unmet need in pancreatic cancer therapy. Two commonly mutated genes in pancreatic cancer, KRAS and...
Wed Sep 11, 2019 15:07
Related ArticlesDual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes. Mol Cancer Ther. 2018 12;17(12):2575-2585 Authors: Payton M, Cheung HK, Ninniri MSS, Marinaccio C, Wayne WC, Hanestad K, Crispino JD, Juan G, Coxon A Abstract Aurora kinase A and B have essential and non-overlapping roles in mitosis, with elevated expression in a subset of human cancers,...
Wed Sep 11, 2019 15:07
Related ArticlesCell size homeostasis: Metabolic control of growth and cell division. Biochim Biophys Acta Mol Cell Res. 2019 03;1866(3):409-417 Authors: Björklund M Abstract Joint regulation of growth rate and cell division rate determines cell size. Here we discuss how animal cells achieve cell size homeostasis potentially involving multiple signaling pathways converging at metabolic regulation of growth rate and cell cycle progression. While several...
Wed Sep 11, 2019 15:07
Related ArticlesPonicidin as a promising anticancer agent: Its biological and biopharmaceutical profile along with a molecular docking study. Biotechnol Appl Biochem. 2019 May;66(3):434-444 Authors: Islam MT, Biswas S, Bagchi R, Khan MR, Khalipha ABR, Rouf R, Uddin SJ, Shilpi JA, Bardaweel SK, Sabbah DA, Mubarak MS Abstract Ponicidin, an ent-kaurane diterpenoid derived from Rabdosia rubescens, exhibits antitumor activities against several types of cancers....
Wed Sep 11, 2019 15:07
Related ArticlesLong noncoding RNA PURPL promotes cell proliferation in liver cancer by regulating p53. Mol Med Rep. 2019 Jun;19(6):4998-5006 Authors: Fu X, Wang Y, Wu G, Zhang W, Xu S, Wang W Abstract Emerging evidence suggests that long noncoding RNAs (lncRNAs) serve a key role in malignant transformation, tumor progression and metastasis. Increased expression of lncRNA p53 upregulated regulator of P53 levels (PURPL) has been reported to promote tumorigenicity...
Wed Sep 11, 2019 15:07
Related ArticlesChinese Herbal Medicine Ganoderma tsugae Displays Potential Anti-Cancer Efficacy on Metastatic Prostate Cancer Cells. Int J Mol Sci. 2019 Sep 08;20(18): Authors: Huang WC, Chang MS, Huang SY, Tsai CJ, Kuo PH, Chang HW, Huang ST, Kuo CL, Lee SL, Kao MC Abstract Resistance to the current therapies is the main clinical challenge in the treatment of lethal metastatic prostate cancer (mPCa). Developing novel therapeutic approaches with effective...
Wed Sep 11, 2019 15:07
Related ArticlesCoelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. Int J Mol Sci. 2019 Sep 08;20(18): Authors: Jiang F, Li M, Wang H, Ding B, Zhang C, Ding Z, Yu X, Lv G Abstract Ethanol extract of Bletilla striata has remarkable anti-inflammatory and anti-pulmonary fibrosis activities in the rat silicosis model. However, its active substances and molecular mechanism are still unclear. To uncover the active...
Wed Sep 11, 2019 15:07
Related ArticlesPIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1. Cell Cycle. 2019 Sep 10;:1-14 Authors: Suleman M, Chen A, Ma H, Wen S, Zhao W, Lin D, Wu G, Li Q Abstract Pirin (PIR) protein belongs to the superfamily of cupin and is highly conserved between eukaryotic and prokaryotic organisms. It has been reported that PIR is upregulated in various tumors and involved in tumorigenesis. However, its biological functions...
Wed Sep 11, 2019 15:07
Related ArticlesCBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis. J Neurooncol. 2019 Sep 09;: Authors: Zhao SP, Wang F, Yang M, Wang XY, Jin CL, Ji QK, Li S, Zhao XL Abstract BACKGROUND: Chromobox protein homolog 3 (CBX3) is one of the heterochromatin protein 1 (HP1) family members. Among multiple cancers, it is usually overexpressed. However, the mechanism and function of CBX3 in glioma remain incompletely illustrated....
Wed Sep 11, 2019 15:07
Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. Aging (Albany NY). 2019 Sep 10;11: Authors: Chae U, Park JW, Lee SR, Lee HJ, Lee HS, Lee DS Abstract Among the many factors that promote cellular senescence, reactive oxygen species (ROS) are a focus of intense research because of their critical role in accelerating cellular senescence and initiating senescence-related diseases that can be fatal....
Wed Sep 11, 2019 15:07
Anti-tumor Effects of Liporaxel (Oral Paclitaxel) for Canine Melanoma in a Mouse Xenograft Model. Vet Comp Oncol. 2019 Sep 10;: Authors: Yang JI, Jin B, Kim SY, Li Q, Nam A, Ryu MO, Lee WW, Son MH, Park HJ, Song WJ, Youn HY Abstract Paclitaxel, a member of the taxane family, exhibits anti-tumor effects by targeting the microtubules in cancer cells. Recently, oral paclitaxel has been developed to overcome the side effects of intravenous paclitaxel administration...
Wed Sep 11, 2019 15:07
Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small cell lung cancer receiving 1st-line chemotherapy: a Phase 1b/randomized Phase 2 trial. Ann Oncol. 2019 Aug 27;: Authors: Weiss JM, Csoszi T, Maglakelidze M, Hoyer RJ, Beck JT, Gomez MD, Lowczak A, Aljumaily R, Lima CMR, Boccia RV, Hanna W, Nikolinakos P, Chiu VK, Owonikoko TK, Schuster SR, Hussein MA, Richards DA, Sawrycki P, Bulat I, Hamm JT, Hart LL, Adler S, Antal JM, Lai AY, Sorrentino...
Wed Sep 11, 2019 15:07
Selenoprotein T Promotes Proliferation and G1-to-S Transition in SK-N-SH Cells: Implications in Parkinson's Disease. J Nutr. 2019 Sep 02;: Authors: Shao ZQ, Zhang X, Fan HH, Wang XS, Wu HM, Zhang L, Cheng WH, Zhu JH Abstract BACKGROUND: Selenium is prioritized to the brain mainly for selenoprotein expression. Selenoprotein T (SELENOT) protects dopaminergic, postmitotic neurons in a mouse model of Parkinson's disease (PD). OBJECTIVE: We hypothesized...
Wed Sep 11, 2019 15:07
The plant WEE1 kinase is involved in checkpoint control activation in nematode induced galls. New Phytol. 2019 Sep 10;: Authors: Cabral D, Banora MY, Antonino JD, Rodiuc N, Vieira P, Coelho RR, Chevalier C, Eekhout T, Engler G, De Veylder L, Grossi-de-Sa MF, de Almeida Engler J Abstract Galls induced by plant-parasitic nematodes involve a hyperactivation of the plant mitotic and endocycle machinery for their profit. Dedifferentiation of host root cells...
Wed Sep 11, 2019 15:07
Kaempferia rotunda tuberous rhizome lectin induces apoptosis and growth inhibition of colon cancer cells in vitro. Int J Biol Macromol. 2019 Sep 07;: Authors: Islam F, Gopalan V, Lam AKY, Kabir SR Abstract Kaempferia rotunda Linn. is a plant of ginger family and has many medicinal values in traditional applications, including as antimicrobial and anticancer agents. The present study aims to examine the anticancer activity of Kaempferia rotunda tuberous...
Wed Sep 11, 2019 15:07
Related Articles[A specialist nurse consultation for post-transplant follow-up of patients undergoing allogeneic hematopoietic cell transplantation: Recommendations of the Francophone Society of Marrow Transplantation and Cellular Therapy (SFGM-TC)]. Bull Cancer. 2019 Sep 06;: Authors: Colledani F, Barrault S, Bayle C, Debray A, Denis V, François G, Hie S, Hounmenou N, Jezequel T, Le Bars L, Lepage N, Porcheron S, Schmitt S, Yakoub-Agha I, Coiteux V Abstract...
Wed Sep 11, 2019 15:10
37 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Future Oncology These pubmed results were generated on 2019/09/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Sep 11, 2019 15:11
Related ArticlesMolecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes. Mol Metab. 2018 11;17:17-27 Authors: Chakera AJ, Hurst PS, Spyer G, Ogunnowo-Bada EO, Marsh WJ, Riches CH, Yueh CY, Markkula SP, Dalley JW, Cox RD, Macdonald IA, Amiel SA, MacLeod KM, Heisler LK, Hattersley AT, Evans ML Abstract OBJECTIVE: Appropriate glucose levels are essential for survival; thus, the...
Wed Sep 11, 2019 15:11
Purpose: This study analyses data logs in order to investigate the usage pattern of cochlear implant (CI) recipients with single-sided deafness (SSD-CI) and bilaterally deaf, uni- or bilaterally implanted CI recipients (Uni-CI and Bil-CI). Data logging is available from SCAN, an automated auditory scene classifier which categorizes auditory input into 6 listening environments. Methods: CI usage data were retrospectively available from data logs of 206 CI recipients using the Nucleus 6 system obtained...
Wed Sep 11, 2019 11:51
Related ArticlesCNVs affecting cancer predisposing genes (CPGs) detected as incidental findings in routine germline diagnostic chromosomal microarray (CMA) testing. J Med Genet. 2018 02;55(2):89-96 Authors: Innes J, Reali L, Clayton-Smith J, Hall G, Lim DH, Burghel GJ, French K, Khan U, Walker D, Lalloo F, Evans DGR, McMullan D, Maher ER, Woodward ER Abstract BACKGROUND: Identification of CNVs through chromosomal microarray (CMA) testing is the first-line...
Wed Sep 11, 2019 15:15
Related ArticlesSurgical Management of Intrinsic Tumors of the Facial Nerve. Neurosurgery. 2018 10 01;83(4):740-752 Authors: Prasad SC, Laus M, Dandinarasaiah M, Piccirillo E, Russo A, Taibah A, Sanna M Abstract BACKGROUND: Intrinsic tumors of the facial nerve are a rare entity. Dealing with this subset of tumors is challenging both in terms of decision making and surgical intervention. OBJECTIVE: To review the outcomes of surgical management...
Wed Sep 11, 2019 15:15
Related ArticlesRegorafenib regresses an imatinib-resistant recurrent gastrointestinal stromal tumor (GIST) with a mutation in exons 11 and 17 of c-kit in a patient-derived orthotopic xenograft (PDOX) nude mouse model. Cell Cycle. 2018;17(6):722-727 Authors: Miyake K, Kawaguchi K, Kiyuna T, Miyake M, Igarashi K, Zhang Z, Murakami T, Li Y, Nelson SD, Elliott I, Russell T, Singh A, Hiroshima Y, Momiyama M, Matsuyama R, Chishima T, Endo I, Eilber FC, Hoffman RM ...
Wed Sep 11, 2019 15:15
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