Alendronate effect in esophagus, stomach and liver: an animal based pathological study. Histol Histopathol. 2019 Sep 10;:18161 Authors: Papamitsou T, Sotiriou S, Papakoulas A, Toskas A, Kamperis D, Karachrysafi S, Dietrich EM, Lialiaris S, Sioga A Abstract Bisphosphonates are commonly used in clinical practice. Their effectiveness is indisputable, however their adverse effects, especially in the GI tract, are still controversial. In our report, we demonstrate...
Wed Sep 11, 2019 15:00
Related ArticlesSubmental Island Flap versus Free Flap Reconstruction for Complex Head and Neck Defects. Otolaryngol Head Neck Surg. 2019 Sep 10;:194599819875416 Authors: Jørgensen MG, Tabatabaeifar S, Toyserkani NM, Sørensen JA Abstract OBJECTIVE: Complex soft tissue reconstruction of the head and neck requires a viable, versatile, and dependable flap. Free flaps, such as the radial forearm and anterolateral thigh flap, have been the mainstay of complex...
Wed Sep 11, 2019 15:00
Related ArticlesRhinosinusitis in Pediatric Primary Ciliary Dyskinesia: Impact of Disease. Otolaryngol Head Neck Surg. 2019 Sep 10;:194599819874842 Authors: Bhatt JM, Muhonen EG, Meier M, Sagel SD, Chan KH Abstract OBJECTIVES: Primary ciliary dyskinesia (PCD) is a genetic disorder characterized by abnormal respiratory cilia ultrastructure and/or function causing defective mucociliary clearance. We investigated the extent and severity of rhinosinusitis...
Wed Sep 11, 2019 15:00
Related ArticlesComparison of EORTC QLQ-C30 and PRO-CTCAE™ Questionnaires on Six Symptom Items. J Pain Symptom Manage. 2018 09;56(3):421-429 Authors: Taarnhøj GA, Kennedy FR, Absolom KL, Bæksted C, Vogelius IR, Johansen C, Velikova G, Pappot H Abstract CONTEXT: Clinical studies have over the past decade paid increasing attention to health-related quality of life data. Multiple questionnaires are often administered resulting in overlapping questions...
Wed Sep 11, 2019 15:00
Related ArticlesCurrent and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research. Cancers (Basel). 2019 Sep 06;11(9): Authors: Inoue A, Deem AK, Kopetz S, Heffernan TP, Draetta GF, Carugo A Abstract Our poor understanding of the intricate biology of cancer and the limited availability of preclinical models that faithfully recapitulate the complexity of tumors are primary contributors to the high failure rate...
Wed Sep 11, 2019 15:00
Related ArticlesFuture Needs in Mast Cell Biology. Int J Mol Sci. 2019 Sep 06;20(18): Authors: Varricchi G, de Paulis A, Marone G, Galli SJ Abstract The pathophysiological roles of mast cells are still not fully understood, over 140 years since their description by Paul Ehrlich in 1878. Initial studies have attempted to identify distinct "subpopulations" of mast cells based on a relatively small number of biochemical characteristics. More recently, "subtypes"...
Wed Sep 11, 2019 15:00
Related ArticlesPanoptic View of Prognostic Models for Personalized Breast Cancer Management. Cancers (Basel). 2019 Sep 07;11(9): Authors: Saini G, Mittal K, Rida P, Janssen EAM, Gogineni K, Aneja R Abstract The efforts to personalize treatment for patients with breast cancer have led to a focus on the deeper characterization of genotypic and phenotypic heterogeneity among breast cancers. Traditional pathology utilizes microscopy to profile the morphologic...
Wed Sep 11, 2019 15:00
Related ArticlesCurrent and evolving biomarkers for precision oncology in the management of metastatic colorectal cancer. Chin Clin Oncol. 2019 Sep 03;: Authors: Henry JT, Johnson B Abstract Colorectal cancer remains one of the most common cancers worldwide and is almost uniformly fatal for those with metastatic disease. Despite this, there is an increasing number of treatments and overall survival has been increasing. Utilizing increasing knowledge...
Wed Sep 11, 2019 15:00
Related ArticlesThe impact of somatic SMAD4 mutations in colorectal liver metastases. Chin Clin Oncol. 2019 Sep 03;: Authors: Xourafas D, Mizuno T, Cloyd JM Abstract Recent advances in cancer genomics have led to the identification of many molecular pathways involved in colorectal cancer (CRC) carcinogenesis. Pre-clinical and clinical data have shown that gene mutations involved in several of these pathways have an important prognostic impact, particularly...
Wed Sep 11, 2019 15:00
Related ArticlesTailoring ablation strategies for colorectal liver metastases based upon rat sarcoma viral oncogene mutation status. Chin Clin Oncol. 2019 Sep 06;: Authors: Calandri M, Odisio BC Abstract Rat sarcoma viral oncogene (RAS) is one of the most well-known tumor genes implicated in the oncological and surgical management of patients with colorectal liver metastases (CLM). More recently, RAS mutational status has also emerged as a relevant factor...
Wed Sep 11, 2019 15:00
Related ArticlesSarcomas and old age: few options for such a large patient population. Future Oncol. 2019 Sep 10;: Authors: Jones RL Abstract Although 40% of cases of soft tissue sarcoma (STS) are diagnosed in patients aged ≥65 years, this group is largely excluded from or under-represented in clinical trials and receives disproportionately less treatment than younger patients. Pooled analyses and subgroup analyses of Phase II and III randomized controlled...
Wed Sep 11, 2019 15:00
Related ArticlesTreatment of advanced soft tissue sarcoma by histological subtype: wish, prediction or reality? Future Oncol. 2019 Sep 10;: Authors: Blay JY Abstract Soft tissue sarcomas (STS) are heterogenous cancers encompassing more than 100 histological and molecular subtypes. Their extreme rarity underscores the need for international collaboration to identify specific treatment protocols. Increasing knowledge of STS complexity as defined by molecular...
Wed Sep 11, 2019 15:00
Related ArticlesForeword. Future Oncol. 2019 Sep 10;: Authors: Reichardt P PMID: 31500457 [PubMed - as supplied by publisher]
Wed Sep 11, 2019 15:00
Related ArticlesWhich goals should we pursue in each line of treatment for advanced soft tissue sarcoma? Future Oncol. 2019 Sep 10;: Authors: Martin-Broto J, Hindi N, Moura DS Abstract Treatment goals for advanced soft tissue sarcoma (STS) vary according to disease stage and treatment line. In potentially resectable advanced disease, the goal of treatment is tumor shrinkage to facilitate surgical resection with better margins. Doxorubicin in combination...
Wed Sep 11, 2019 15:00
Related ArticlesEvaluation of cardiomyopathy in acute myeloid leukemia patients treated with anthracyclines. J Oncol Pharm Pract. 2019 Sep 09;:1078155219873014 Authors: Mort MK, Sen JM, Morris AL, DeGregory KA, McLoughlin EM, Mort JF, Dunn SP, Abuannadi M, Keng MK Abstract BACKGROUND: Acute myeloid leukemia patients receive anthracycline-containing induction chemotherapy. Anthracyclines cause cardiotoxicity; however, there is a paucity of data reflecting...
Wed Sep 11, 2019 15:00
Related ArticlesDevelopment and validation of a patient-reported outcome tool to assess cancer-related financial toxicity in Italy: a protocol. BMJ Open. 2019 Sep 09;9(9):e031485 Authors: Riva S, Bryce J, De Lorenzo F, Del Campo L, Di Maio M, Efficace F, Frontini L, Giannarelli D, Gitto L, Iannelli E, Jommi C, Montesarchio V, Traclò F, Vaccaro CM, Gallo C, Perrone F Abstract INTRODUCTION: Financial toxicity (FT) is a well-recognised problem in oncology....
Wed Sep 11, 2019 15:00
Related Articles[Patient and Public Involvement for Cancer Treatments-Physicians' Perspectives]. Gan To Kagaku Ryoho. 2019 Aug;46(8):1230-1234 Authors: Furuse J, Ueno M, Ishii H Abstract Patient participation is defined as incorporation of opinions by patients and citizens when clinical trials are planning. It has been early established in the USA and the UK. The Japan Clinical Oncology Group(JCOG)has recently launched a subcommittee of patient participation...
Wed Sep 11, 2019 15:00
Related ArticlesTargeting the TR4 nuclear receptor-mediated lncTASR/AXL signaling with tretinoin increases the sunitinib sensitivity to better suppress the RCC progression. Oncogene. 2019 Sep 09;: Authors: Shi H, Sun Y, He M, Yang X, Hamada M, Fukunaga T, Zhang X, Chang C Abstract Renal cell carcinoma (RCC) is one of the most lethal urological tumors. Using sunitinib to improve the survival has become the first-line therapy for metastatic RCC patients....
Wed Sep 11, 2019 15:00
Related ArticlesThe Prognostic Value of Lymphovascular Invasion in Truncal and Extremity Soft Tissue Sarcomas: An Analysis from the National Cancer Database. Ann Surg Oncol. 2019 Sep 09;: Authors: Ethun CG, Lopez-Aguiar AG, Switchenko JM, Gillespie TW, Delman KA, Staley CA, Maithel SK, Cardona K Abstract OBJECTIVE: The aim of this study was to determine the association between lymphovascular invasion (LVI) and overall survival (OS) in truncal/extremity...
Wed Sep 11, 2019 15:00
Related ArticlesDevelopment of Gene Expression-Based Biomarkers on the nCounter® Platform for Immuno-Oncology Applications. Methods Mol Biol. 2020;2055:273-300 Authors: Warren S, Danaher P, Mashadi-Hossein A, Skewis L, Wallden B, Ferree S, Cesano A Abstract Biomarkers based on transcriptional profiling can be useful in the measurement of complex and/or dynamic physiological states where other profiling strategies such as genomic or proteomic characterization...
Wed Sep 11, 2019 15:00
Related ArticlesQuestion prompts to empower cancer patients: results of a randomized controlled trial. Support Care Cancer. 2019 Sep 10;: Authors: Zetzl T, Mann D, Gruner S, Schuler M, Jentschke E, Neuderth S, Roch C, van Oorschot B Abstract OBJECTIVE: In addition to question prompts for information transfer, we also used prompts to facilitate the expression of emotions. Our aim was to investigate how a question prompt list (QPL) is accepted by patients...
Wed Sep 11, 2019 15:00
A review of canakinumab and its therapeutic potential for non-small cell lung cancer. Anticancer Drugs. 2019 Sep 09;: Authors: Schenk KM, Reuss JE, Choquette K, Spira AI Abstract Inflammation is essential for our innate and adaptive immunity, but chronic inflammation can also be detrimental, playing a role in tumor development and subversion of host immunity. A multitude of proteins and cytokines are involved in chronic inflammation; interleukin-1β,...
Wed Sep 11, 2019 15:00
Salvage pelvic lymph node dissection for lymph node recurrent prostate cancer. Curr Opin Urol. 2019 Sep 09;: Authors: Rosiello G, Bandini M, Briganti A Abstract PURPOSE OF REVIEW: The aim of this article is to update on the role of salvage pelvic lymph node dissection (SLND) for patients with lymph node-only recurrent prostate cancer (PCa) after radical prostatectomy. RECENT FINDINGS: Salvage lymph-node dissection represents a possible treatment...
Wed Sep 11, 2019 15:00
Bangladesh Fistula Mission Partnership: Leveraging Assets from the United States Agency for International Development and the Department of Defense to Address a Health Care Crisis in a Developing Nation. Mil Med. 2019 Sep 10;: Authors: Gehrich AP, Dietrich C, Licina D, Satin M, Ahmed S, Huda N Abstract INTRODUCTION: Obstetric fistulae are a leading scourge for women in developing countries resulting, in severe individual suffering and devastating socio-economic...
Wed Sep 11, 2019 15:00
Comparative toxicity outcomes of proton-beam therapy versus intensity-modulated radiotherapy for prostate cancer in the postoperative setting. Cancer. 2019 Sep 10;: Authors: Santos PMG, Barsky AR, Hwang WT, Deville C, Wang X, Both S, Bekelman JE, Christodouleas JP, Vapiwala N Abstract BACKGROUND: Despite increasing utilization of proton-beam therapy (PBT) in the postprostatectomy setting, no data exist regarding toxicity outcomes relative to intensity-modulated...
Wed Sep 11, 2019 15:00
CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer. PLoS One. 2019;14(9):e0222035 Authors: Chen N, Kong Y, Wu Y, Gao Q, Fu J, Sun X, Geng Q Abstract CDK2-associated cullin domain 1 (CAC1) is as a novel cell cycle regulator widely expressed in colorectal cancer (CRC). However, its expression and function in drug resistant CRC cells remains elusive. Therefore, the present study aimed to...
Wed Sep 11, 2019 15:00
Health care use and remaining needs for support among women with breast cancer in the first 15 months after diagnosis: the role of the GP. Fam Pract. 2019 Aug 27;: Authors: Lo-Fo-Wong DN, de Haes HC, Aaronson NK, van Abbema DL, Admiraal JM, den Boer MD, Hezewijk MV, Immink M, Kaptein AA, Menke-Pluijmers MB, Russell NS, Schriek M, Sijtsema S, van Tienhoven G, Sprangers MA Abstract BACKGROUND: The number of women with breast cancer in general practice...
Wed Sep 11, 2019 15:00
Evaluating clonal hematopoiesis in tumor infiltrating leukocytes in breast cancer and secondary hematologic malignancies. J Natl Cancer Inst. 2019 Aug 27;: Authors: Comen EA, Bowman RL, Selenica P, Kleppe M, Farnoud NR, Pareja F, Weigelt B, Hill CE, Alon A, Geyer FC, Akturk G, Reis-Filho JS, Norton L, Levine RL Abstract Chemotherapy and radiation therapy are the foundations of adjuvant therapy for early-stage breast cancer. As a complication of cytotoxic...
Wed Sep 11, 2019 15:00
What is the appropriate management of non-functioning pancreatic neuroendocrine tumours disclosed on screening in adult patients with multiple endocrine neoplasia type 1? Clin Endocrinol (Oxf). 2019 Sep 10;: Authors: Challis BG, Casey RT, Grossman A, Newell-Price J, Newey P, Thakker RV Abstract Multiple endocrine neoplasia type 1 (MEN1) is an inherited tumour syndrome characterised by a predisposition to the development of endocrine tumours of the parathyroid...
Wed Sep 11, 2019 15:00
Plasmablastic lymphoma achieving sustained remission with antiretroviral therapy alone. Eur J Haematol. 2019 Sep 10;: Authors: Atallah-Yunes SA, Murphy D, Abdelmalak R, Mantle L, Ali SS Abstract Despite advances in the treatment of most Human Immunodeficiency Virus (HIV)-related lymphomas, the outcomes for patients with HIV-related plasmablastic lymphoma (PBL) remain poor. While studies have shown an increased survival for patients with most kinds of...
Wed Sep 11, 2019 15:00
Optimizing opioid prescribing and pain treatment for surgery: Review and conceptual framework. Am J Health Syst Pharm. 2019 Sep 03;76(18):1403-1412 Authors: Bicket MC, Brat GA, Hutfless S, Wu CL, Nesbit SA, Alexander GC Abstract PURPOSE: Millions of Americans who undergo surgical procedures receive opioid prescriptions as they return home. While some derive great benefit from these medicines, others experience adverse events, convert to chronic opioid...
Wed Sep 11, 2019 15:00
Related ArticlesIntra-operative cortical motor mapping using subdural grid electrodes in children undergoing epilepsy surgery evaluation and comparison with the conventional extra-operative motor mapping. Clin Neurophysiol. 2018 12;129(12):2642-2649 Authors: Jain P, Whitney R, Strantzas S, McCoy B, Ochi A, Otsubo H, Snead OC, Weiss S, Donner E, Pang E, Sharma R, Viljoen A, Keller A, Drake JM, Rutka JT, Go C Abstract OBJECTIVES: The objective of this...
Wed Sep 11, 2019 15:01
Related ArticlesDecision-making in temporal lobe epilepsy surgery based on invasive stereo-electroencephalography (sEEG). Neurosurg Rev. 2019 Sep 09;: Authors: Dührsen L, Sauvigny T, Ricklefs FL, Hamel W, Koeppen JA, Hebel JM, Lanz M, Martens T Abstract In medical refractory temporal lobe epilepsy (TLE), the epileptogenic zone can be difficult to identify and therefore difficult to treat, especially in the absence of clear MRI pathologies and specific...
Wed Sep 11, 2019 15:01
Related ArticlesThe Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer's Disease. Cell Mol Neurobiol. 2019 Sep 09;: Authors: Sahab-Negah S, Hajali V, Moradi HR, Gorji A Abstract Alzheimer's disease (AD) is described as cognitive and memory impairments with a sex-related epidemiological profile, affecting two times more women than men. There is emerging evidence that alternations in the hippocampal neurogenesis occur at the early...
Wed Sep 11, 2019 15:01
Case of an In-Laboratory Vagal Nerve Stimulator Titration for Vagal Nerve Stimulator-Induced Pediatric Obstructive Sleep Apnea. J Clin Sleep Med. 2019 Sep 10;: Authors: Chan JHM, Owens JW, Wrede JE Abstract We present the case of a 12-year-old girl with medically refractory epilepsy and a vagal nerve stimulator (VNS), who experienced severe obstructive sleep apnea (OSA) with respiratory events closely matching her VNS settings. We demonstrated a real-time...
Wed Sep 11, 2019 15:01
Lessons learned from recent clinical trials of ketogenic diet therapies in adults. Curr Opin Clin Nutr Metab Care. 2019 Sep 09;: Authors: McDonald TJW, Cervenka MC Abstract PURPOSE OF REVIEW: Although ketogenic diet therapies (KDTs) were first developed as a treatment for patients with epilepsy, their potential efficacy for a broader number of neurologic and nonneurologic disorders and conditions has been explored over the last 10-20 years. The most...
Wed Sep 11, 2019 15:01
Early neurodevelopmental characterization in children with cobalamin C/defect. J Inherit Metab Dis. 2019 Sep 10;: Authors: Ricci D, Martinelli D, Ferrantini G, Lucibello S, Gambardella ML, Olivieri G, Chieffo D, Battaglia D, Diodato D, Iarossi G, Donati A, Dionisi-Vici C, Battini R, Mercuri E Abstract Cobalamin C (cblC) defect is the most common inherited disorder of cobalamin metabolism. Developmental delay, behavioral problems and maculopathy are common...
Wed Sep 11, 2019 15:01
Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. J Clin Invest. 2019 Sep 10;: Authors: Gu B, Zhu M, Glass MR, Rougié M, Nikolova VD, Moy SS, Carney PR, Philpot BD Abstract Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, lack of speech, ataxia, EEG abnormalities, and epilepsy. Seizures in AS individuals are common, debilitating, and often drug-resistant. Therefore,...
Wed Sep 11, 2019 15:01
Caudate stimulation enhances learning. Brain. 2019 Aug 30;: Authors: Bick SK, Patel SR, Katnani HA, Peled N, Cash SS, Eskandar EN Abstract Neuromodulation is a promising treatment modality for disorders of learning and memory, offering the possibility of precise alteration of disordered neural circuits. Studies to date have failed to identify an optimal target and stimulation paradigm. Six epilepsy patients with depth electrodes implanted for seizure...
Wed Sep 11, 2019 15:01
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