Related ArticlesDuodenal variceal bleeding with large spontaneous portosystemic shunt treated with transjugular intrahepatic portosystemic shunt and embolization: A case report. World J Radiol. 2019 Aug 28;11(8):110-115 Authors: Anand R, Ali SE, Raissi D, Frandah WM Abstract BACKGROUND: Duodenal variceal bleeding is a rare cause of gastrointestinal bleeding. The most common site is the duodenal bulb. It is usually detected endoscopically but it can be...
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Horm Metab ResDOI: 10.1055/a-0972-1302This study evaluated sE-selectin, Endothelin-1, and cardiovascular autonomic neuropathy (CAN) at early stages of glucose intolerance and in metabolic syndrome (MetS). A total of 87 subjects – 39 males, of mean age 45.7±11.6 years and mean BMI 31.4±6.6 kg/m2, divided according to glucose tolerance and the presence of MetS were enrolled. Glucose tolerance was studied during OGTT. Anthropometric indices, blood pressure, HbA1c, lipids, hsCRP, sE-selectin, Endothelin-1,...
Tue Sep 17, 2019 02:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03386
Tue Sep 17, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02463
Tue Sep 17, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02476
Tue Sep 17, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03395
Tue Sep 17, 2019 07:00
J Neurol Surg BDOI: 10.1055/s-0039-1697036 Objective Intracranial meningiomas are the most common primary brain tumor. Treatment paradigms have evolved over time. There are limited number of population-based studies that examine this modern evolution. Here, we describe the trends of management of intracranial meningiomas using a national database. Methods The data were obtained from the National Cancer Database for the years 2004 to 2015, the collected variables included:...
Tue Sep 17, 2019 02:00
Colorectal cancer (CRC) influences individual health worldwide with high morbidity and mortality. Melatonin, which shows multiple physiological functions (e.g., circadian rhythm, immune modulation, and antioncogenic action), can be present in almost all organisms and found in various tissues including gastrointestinal tract. Notably, melatonin disruption is closely associated with the elevation of CRC incidence, indicating that melatonin is effective in suppressing CRC development and progression....
Tue Sep 17, 2019 13:05
Coronary artery spasm (CAS) is one of the mechanisms of angina pectoris. Unlike the diagnosis of acute myocardial infarction which is based on the elevation of cardiac markers, the diagnosis of CAS is difficult and sometimes requires sophisticated and risky provocative test which is not widely accepted in China. There is no well-established biomarker for the diagnosis or prediction of CAS. However, there are some biomarkers proven to be associated with the occurrence of CAS. For example, inflammatory...
Tue Sep 17, 2019 14:05
TNFα/CHX-induced apoptosis is dependent on caspase-8 activation and regulated by Bcl-2. However, the specific participants and precise mechanisms underlying this apoptotic pathway are poorly understood. The proapoptotic proteins Bak and Bax—members of the Bcl-2 family—are essential for the functioning of the mitochondrial apoptotic pathway. In this study, we used the CRISPR/Cas9 system to knockout Bak in the human SH-SY5Y cell line and determined the effects of this knockout on TNFα/CHX-induced apoptosis....
Tue Sep 17, 2019 17:05
Background. This study was designed to review the methodology and reporting of gastric cancer prognostic models and identify potential problems in model development. Methods. This systematic review was conducted following the CHARMS checklist. MEDLINE and EMBASE were searched. Information on patient characteristics, methodological details, and models’ performance was extracted. Descriptive statistics was used to summarize the methodological and reporting quality. Results. In total, 101 model developments...
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Australian researchers looking for a genetic lifeline to endangered hog deer species endemic to Pakistan, northern India and mainland southeast Asia have found widespread hybridization of the species in Victoria.
Tue Sep 17, 2019 17:04
RNA World is a fascinating theory but it may not hold true. The problem is that the ingredients, such as enzymes, to make RNA World work just didn't exist on early Earth.
Tue Sep 17, 2019 18:54
New results show that human-acquired antibiotic resistance genes are being transmitted to livestock, companion animals and wildlife. Researchers analyzed a global set of 901 genome sequences of the bacteria Streptococcus agalactiae (aka group B Strep) from nine different host species -- humans, cows, dogs, fish, frogs, gray seals, dolphins, goats and a camel -- to better understand the transmission process. Streptococcus agalactiae can cause life-threatening illnesses.
Tue Sep 17, 2019 20:30
A new article presents 19 high-coverage penguin genome sequences. Adding this to the two previously published penguin genomes, there are now genome sequences available for all living penguin species. Here, the Penguin Genome Consortium, made up of researchers from 10 countries, has produced an unparalleled amount of information that covers an entire biological order. Research from evolution, the impact of human activities impact, and environmental changes, will benefit from this work.
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Up till now, lung cancer remains as the leading cause of cancer-related mortality worldwide. According to the latest statistical report, there are 2.1 million new lung cancer cases and 1.8 million deaths predicted globally in 2018, nearly close to 1 in 5 (18.4%) of all cancer deaths [1]. China is among the countries with the highest lung cancer rates (above 40 per 100,000). For lung cancer patients, radiotherapy (RT) with or without chemotherapy remains to be the fundamental treatment. However, the...
Tue Sep 17, 2019 03:00
The Gleason score (GS) is key for counseling men about treatment, clinical trial enrollment, and comparison of treatment modalities [1]. However, growing evidence has suggested that the commonly utilized method of categorizing the GS into 3-groups (2–6, 7, 8–10) [2] over-simplifies stratification leading to heterogeneity, particularly in the Gleason 8–10 sub-group [3–6]. A 2014 consensus statement by the International Society of Urologic Pathologists (IUSP) adopted a modified grade grouping which...
Tue Sep 17, 2019 03:00
Regional node irradiation is an indispensable part of the adjuvant therapy in patients with lymph node positive early breast cancer. Data from the MA.20 [1] and the EORTC 22922-10925 (EORTC) trials [2] have proven that the addition of the supraclavicular (SC) and internal mammary lymph node region (IM) is effective in improving regional and distant control as well as disease specific mortality compared to whole-breast or chest-wall irradiation alone.
Tue Sep 17, 2019 03:00
Movement with breathing of all structures in the thorax and abdomen presents a major problem for thoracic MRI, PET-imaging and radiotherapy. One means of reducing this movement is for patients to hold their breath and such techniques [1–9] offer clear advantages [10].
Tue Sep 17, 2019 03:00
British Journal of Cancer, Published online: 18 September 2019; doi:10.1038/s41416-019-0574-7The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer
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Although Aurora A, B and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prometaphase arrest, while Aurora B/C inactivation primarily induces polyploidy from cytokinesis failure. Aurora B/C inactivation phenotypes are also epistatic to those of Aurora A, such that the concomitant inactivation of Aurora A and B, or all Aurora isoforms...
Tue Sep 17, 2019 17:44
Metastatic castration-resistant prostate cancer (CRPC) is currently incurable. Cancer growth and progression is intimately affected by its interaction with host microenvironment. Co-targeting of the stroma and prostate cancer is therefore an emerging therapeutic strategy for metastatic CRPC. Cancer-induced osteoclastogenesis is known to contribute to CRPC bone metastasis. This study is to extend pharmacological value of our synthesized LCC03, a derivative of 5-(2',4'-difluorophenyl)-salicylanilide...
Tue Sep 17, 2019 17:44
A new form of gene therapy termed genetic editing or gene targeting has become possible owing to advances in genetic engineering technology. The intent of genetic editing is to alter the DNA code in cells with single base-pair specificity, and thus it can be considered to be an ultimate form of…
Wed Sep 11, 2019 03:00
Related ArticlesTwo Chinese nephronophthisis pedigrees harbored a compound heterozygous deletion with a point mutation in NPHP1. Int J Mol Epidemiol Genet. 2019;10(4):53-58 Authors: Chen H, Lin H, Yue Z, Wang H, Yang J, Sun L Abstract NPHP1 is the most prevalent genetic factor in the development of juvenile nephronophthisis (NPHP). In our previous study, NPHP1 homozygous point mutations were detected by Sanger sequencing in three cases from two nonconsanguineous...
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Related ArticlesEvidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults. Int J Mol Epidemiol Genet. 2019;10(4):59-66 Authors: Camargos EF, Goncalves ID, Bretones LA, Machado MF, Morais-Junior GS, Brito AF, Henriques AD, Morais CF, Nóbrega OT Abstract This study aims to investigate alleles of the human apolipoprotein E (APOE) and of the angiotensin-converting enzyme (ACE) genes as risk factors...
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Related ArticlesActicoat versus biobrane: a retrospective review on the treatment of paediatric mid-dermal torso burns. Int J Burns Trauma. 2019;9(4):82-87 Authors: Selvarajah D, Bollu BK, Harvey J, Jacques M, Jehangir S, Fuller ES, La Hei E, Bertinetti M, Lawrence T, Holland AJ Abstract OBJECTIVES: Scalds involving toddlers commonly involve the torso and are frequently mid-dermal in depth. Initial management of a mid-dermal burn is conservative, progressing...
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Related ArticlesMechanism and adverse effects of multiple sclerosis drugs: a review article. Part 1. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):95-104 Authors: Rafiee Zadeh A, Askari M, Azadani NN, Ataei A, Ghadimi K, Tavoosi N, Falahatian M Abstract Multiple Sclerosis (MS) is chronic, inflammatory, a neurologic disorder of the central nervous system (CNS). Although the exact mechanisms of MS have not been yet discovered some drugs are found helpful...
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Related ArticlesMechanism and adverse effects of multiple sclerosis drugs: a review article. Part 2. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):105-114 Authors: Rafiee Zadeh A, Ghadimi K, Ataei A, Askari M, Sheikhinia N, Tavoosi N, Falahatian M Abstract Multiple Sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS) mostly affecting young adults. The exact mechanism and pathogenesis of MS remain still undiscovered...
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Related ArticlesNeurexin-1α regulates neurite growth of rat hippocampal neurons. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):115-125 Authors: Wang A, Xiang YY, Yang BB, Lu WY Abstract The growth of neurites underlies the axonal pathfinding and synaptic formation during neuronal development and regeneration. Neurite growth is regulated by specific interactions between growth cone receptors and their ligands that function as molecular cues existing...
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Related ArticlesGarlic antagonizes skeletal muscle ischemia reperfusion injury through regulating inflammation, apoptosis and desmin expression in adult male rats. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):126-137 Authors: Abd El-Mottaleb NA, Mahmoud GS, Negm EA, Abdel Maksoud FM Abstract BACKGROUND: Skeletal muscle injuries with subsequent bleeding is common cause of death on both sports and battle grounds. Application and removal of tourniquet...
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Related ArticlesAssociation between obesity and craniofacial muscles sensitivity: an experimental study in pain-free subjects. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):138-148 Authors: Fedders SR, Larsen LK, Huntjens P, Sondrup MA, Thomsen MK, Kjær C, Clausen LP, Bujold G, Gazerani P Abstract The objective of this study was to investigate if any association exists between obesity and muscle sensitivity in the craniofacial region of healthy individuals...
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Related ArticlesAntiretroviral drug-S for a possible HIV elimination. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):149-162 Authors: Agas A, Schuetz H, Mishra V, Szlachetka AM, Haorah J Abstract Although the combination of highly active antiretroviral therapy (cART) can remarkably control human immunodeficiency virus type-1 (HIV-1) replication, it fails to cure HIV/AIDS disease. It is attributed to the incapability of cART to eliminate persistent...
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Related ArticlesDifferences between male and female rats in alcohol drinking, negative affects and neuronal activity after acute and prolonged abstinence. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):163-176 Authors: Li J, Chen P, Han X, Zuo W, Mei Q, Bian EY, Umeugo J, Ye J Abstract Alcohol consumption afflicts men and women differently. However, the underlying neuronal mechanisms that contribute to the difference are mostly unexplored. Although...
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Related ArticlesMesenchymal stem cell-derived exosomes do not promote the proliferation of cancer cells in vitro. Int J Physiol Pathophysiol Pharmacol. 2019;11(4):177-189 Authors: Karaoz E, Sun E, Demir CS Abstract Nowadays, the use of Mesenchymal stem cells (MSCs) in clinical therapies have an increased acceleration, while it constitutes two sides of yin-yang with its ameliorating effects in regenerative medicine and promoting effects in carcinogenesis....
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Background/Purpose: The primary objective of this study is to describe the authors’ experience at the Children's National Health System with the coordination of the Fetal Medicine Institute and the Cleft and Craniofacial Center. This collaboration highlights the accuracy and completeness of prenatal diagnosis of cleft abnormalities with expedient postnatal management. Methods: With Institutional Review Board approval, the authors retrospectively reviewed 74 patients referred for potential...
Thu Sep 12, 2019 03:00
Background: The Extended Mohler cleft lip repair restores upper lip form using a columellar flap to fill the defect created by the downward rotation of Cupid's bow. The resulting columella incision is mentioned as a potential drawback. This study seeks to evaluate the morbidity of the resulting scar. Materials and methods: This retrospective study enrolled 50 unilateral cleft lip patients treated using the Extended Mohler repair. 5 reviewers examined post-operative images. Three validated...
Thu Sep 12, 2019 03:00
Hypothesis: A novel cochlea implant (CI) device magnet providing alignment to the static field of a magnetic resonance imaging (MRI) will lead to reduced torque, longitudinal forces, and demagnetization effects. The image void and distortion will be comparable to those obtained with standard CI magnets. Background: MRI investigations of CI users pose several challenges such as magnet dislocation, demagnetization, and may cause pain. The presence of a CI magnet within MRI field causes image...
Mon Sep 16, 2019 03:00
Objectives: 1) To provide information on the treatment of pulsatile tinnitus (PT) with transtemporal extraluminal sigmoid sinus angioplasty (ESSA); and 2) to discuss the current clinical management of PT. Study Design: This was a retrospective study. Settings: Multi-institutional tertiary university medical centers. Patients: Fifty-four PT patients with transverse–sigmoid sinus enlargement and prominent transverse–sigmoid junction with or without sigmoid sinus wall anomalies or...
Mon Sep 16, 2019 03:00
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