Enas Shuber, Dalia Abdulhussein, Pierre Sinclair, Murtaza KadhumJournal of Cutaneous and Aesthetic Surgery 2019 12(3):153-157Background: The incidence of melanoma and nonmelanoma skin cancers is increasing in the United Kingdom. Surgical excision carries the highest cure rates for all skin cancers and is the first-line treatment for melanomas and high-risk nonmelanoma cancers. This is most commonly performed by general practitioners (GPs), dermatologists, and plastic surgeons. Objective: The aim...
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Gianfranco M Colicchia, Verdiana Di Pietro, Valerio CervelliJournal of Cutaneous and Aesthetic Surgery 2019 12(3):164-173Context: After massive weight loss, breast changes dramatically becoming ptotic, flat in the upper pole, with significant skin excess. After mastoplasty, often ptosis can recur and the upper pole can lose its fullness again. The technique described in this study treats breast deformities ensuring stable results and avoiding ptosis recurrence. Aim: To analyze a new modality of breast...
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Gulhima Arora, Sandeep AroraJournal of Cutaneous and Aesthetic Surgery 2019 12(3):196-200
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Ashish Jagati, Raju G Chaudhary, Santoshdev P Rathod, Bhushan Madke, Kalgi D Baxi, Dixit KasundraJournal of Cutaneous and Aesthetic Surgery 2019 12(3):174-178Introduction: Platelet-rich fibrin (PRF) is compressed by using various tools to make platelet-rich fibrin membrane (PRFM). Preservation of platelets and plasma content of PRFM depends on the compression method used. To overcome limitations of compression method, we prepared PRFM over scaffold of collagen sheet without using any compression...
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Gurunathampalayam Ilango Nambi, Thirumurugan Kavin Arudhra VaranambigaiJournal of Cutaneous and Aesthetic Surgery 2019 12(3):187-190Objective: The aim of this study was to present an underutilized and underreported surgical technique in which the glomus tumors situated anywhere under the nail bed can be approached and removed with relative ease. Materials and Methods: Over 3 years, four cases of subungual glomus tumors, which were surgically managed with this technique were presented. The technical...
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Mohamed Soliman, Sidharth Sonthalia, Akmal Saad, Mohamed Elkomy, Mohamed Abdelhady, Gaurang KrishnaJournal of Cutaneous and Aesthetic Surgery 2019 12(3):179-182Correction of depigmentation of postburn leukodermic scars is daunting. In contrast to vitiligo, the success rate of skin grafting techniques is much lower in postburn scars owing to altered skin architecture and poor graft uptake. Cellular transfer techniques such as noncultured epidermal or epidermal or keratinocyte suspension suffer the...
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CP Thajudheen, Kannangath Jyothy, Priyadarshini ArulJournal of Cutaneous and Aesthetic Surgery 2019 12(3):193-195Xanthelasma palpebrarum,a benign xanthoma occurring around the eyes ,are treated using lasers like carbon dioxide, argon, pulsed dye, YAG, and diode(1450) laser .Several studies on PDL for xanthelasma palpebrarum (XP) have been reported from abroad but as per our knowledge there are no Indian studies in this regard. We report the efficacy of pulsed dye laser in the management of xanthelasma...
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Ashish Chauhan, Sukhbir SinghJournal of Cutaneous and Aesthetic Surgery 2019 12(3):183-186Facial fillers are minimally invasive aesthetic procedures performed for facial rejuvenation and contouring all over the world. Fillers even in the most experienced hands can lead to fatal complications such as vascular complications that need to be managed immediately with the help of hyaluronidase protocols mentioned in literature. In this case report, a patient was asymptomatic with no signs of vascular occlusion...
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Ângela Roda, Ana Marcos-Pinto, Rita Pimenta, João Maia-SilvaJournal of Cutaneous and Aesthetic Surgery 2019 12(3):201-202
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. (Source: Cochlear Implants International)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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. (Source: International Journal of Audiology)
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ConclusionRadiological evaluation for electrode position should extend to involve assessment of inner ear trauma using relation of the implant to cochlear internal structures which could be performed by CBCT with high resolution and least metallic artifacts. (Source: European Archives of Oto-Rhino-Laryngology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ConclusionWBDs improve word and sentence recognition in adult BCD bone recipients when they use mobile phones. WBD use provides additional benefits in “BCD with HA” patients in a bimodal situation. (Source: European Archives of Oto-Rhino-Laryngology)
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ConclusionsEndoscopic inlay butterfly myringoplasty is a safe surgical technique and has satisfactory anatomic and audiological outcomes in large tympanic perforations. (Source: European Archives of Oto-Rhino-Laryngology)
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Outer hair cells (OHCs) in the mammalian ear exhibit electromotility, electrically driven somatic length changes that are thought to mechanically amplify sound-evoked vibrations. For this amplification to work, OHCs must respond to sounds on a cycle-by-cycle basis even at frequencies that exceed the low-pass corner frequency of their cell membranes. Using in vivo optical vibrometry we tested this theory by measuring sound-evoked motility in the 13 –25 kHz region of the gerbil cochlea. OHC vibrations...
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ConclusionOur data suggests the minimal dose of radiation that the cochlear volume is exposed to is a predictor of delayed hearing loss after either SRS or fSRT. A threshold of 5 Gy/35 Gy may lead to improved hearing preservation after radiotherapy. Further prospective multi center studies can further elucidate this mechanism. (Source: Journal of Neuro-Oncology)
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ConclusionsThe hearing results after revision surgery in Sweden is somewhat inferior to those of previously published results involving large centers. Postoperative deafness may be as much as fivefold more common after revision surgery than after primary surgery. Meticulous reading of previous charts and honest counseling regarding the risks and expectations is mandatory before planning revision surgery for otosclerosis. (Source: European Archives of Oto-Rhino-Laryngology)
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Abstract Background Sugar sweetened beverages (SSB) are a major source of sugar in the diet. Although trends in consumption vary across regions, in many countries, particularly LMICs, their consumption continues to increase. In response, a growing number of governments have introduced a tax on SSBs. SSB manufacturers have opposed such taxes, disputing the role that SSBs play in diet-related diseases and the effectiveness of SSB taxation,...
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Abstract Background The early detection of skin cancer is still challenging and calls for objective, fast diagnostic, and ideally non‐invasive methods in order to leave the potentially malignant tumor cells unaltered. In this paper, the parelectric spectroscopy was applied to evaluate the potential of a non‐invasive detection of basal cell carcinoma (BCC) and malignant melanoma. Materials and Methods A prototype of parelectric spectroscopy was used to investigate non‐invasively dipole density...
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Abstract Background Acquired lymphangiectasias represent cystic dilatations of the cutaneous lymphatic vessels resulting from damage and/or obstruction of previously normal lymphatics, usually secondary to surgery, radiotherapy, and/or infections. Materials and Methods The clinical, dermoscopic, and confocal microscopy features of three cases of acquired lymphangiectasias occurring after breast surgery are described along with histopathological correlations. Results Polarized dermoscopy...
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Abstract Background Ultra‐High Frequency Ultrasound (UHFUS) is a recently introduced diagnostic technique involving the use of higher frequencies compared to conventional ultrasound. Among the several fields of application, intraoral usage of UHFUS appears still limited. We report the intraoral evaluation of Oral Lichen Planus (OLP) by means of UHFUS and describe typical UHFUS aspect of different forms of presentation of OLP. Materials and Methods Patients with clinical and histological...
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Abstract Background The accurate determination of vitamin D in skin is of considerable importance in evaluating penetration of skin health products through the different layers of the skin. Objective We report on the characterisation and quantitation of vitamin D in an idealised sample and in complex mixtures which mimic that of a typical skin cream, using qNMR, 2D NMR and DOSY techniques. Methods The characterisation and quantitation conditions were acquired over several heterogeneous...
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In The Lancet Oncology, Gianni Bisogno and colleagues1 present the results of an important frontline, phase 3 randomised study in children and adolescents with rhabdomyosarcoma. This trial was done by the European paediatric Soft tissue sarcoma Study Group (EpSSG) cooperative group, in children and adolescents with previously untreated high-risk non-metastatic rhabdomyosarcoma, and shows the benefit of six cycles of vinorelbine and oral cyclophosphamide maintenance chemotherapy in this subgroup of...
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Adding maintenance chemotherapy seems to improve survival for patients with high-risk rhabdomyosarcoma. This approach will be the new standard of care for patients with high-risk rhabdomyosarcoma in future EpSSG trials.
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A new systematic review and meta-analysis concludes that there is a linear association between the severity of gum disease and the risk of hypertension.
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AUGUSTA, GA – Indicating to one and all he is dedicated to this internal medicine rotation and a lifelong career in medicine, third-year medical student Wayne Natalie has spent one straight hour listening to his patient’s bowel sounds. “I was told by my team to take my time, so that’s what I’m going to do,” Natalie told Gomerblog. Wisely, he pulled up a chair while he auscultated with his stethoscope. This was after spending three hours acquiring a medical history. “My attending said...
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We present the first global estimates of non-typhoidal salmonella invasive disease that have been produced as part of GBD 2017. Given the high disease burden, particularly in children, elderly people, and people with HIV infection, investigating the sources and transmission pathways of non-typhoidal salmonella invasive disease is crucial to implement effective preventive and control measures.
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In The Lancet Infectious Diseases, the GBD 2017 Non-Typhoidal Salmonella Invasive Disease Collaborators1 estimate the global burden of invasive non-typhoidal salmonella disease using Bayesian meta-regression tools. The results show a high but decreasing number of cases since 2005 with a continuously high case fatality rate, consistent with previous estimates. These findings show that serotypes of Salmonella enterica subspecies that cause invasive non-typhoidal salmonella disease are “low-incidence,...
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Patients with candida bloodstream infection receiving an infectious disease consultation have lower mortality. This finding might be attributable to these individuals receiving a higher number of non-pharmacological, evidence-based interventions and lower amounts of non-treatment. These data suggest that an infectious disease consultation should be an integral part of clinical care of patients with candida bloodstream infection.
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In The Lancet Infectious Diseases, Carlos Mejia-Chew and colleagues report the results of a retrospective cohort study investigating the effect of infectious disease consultation on mortality and management of patients with candida bloodstream infections.1 42-day (22% vs 47%; p<0·0001) and 90-day mortality (29% vs 51%; p<0·0001) was significantly lower in the infectious disease consultation group versus the group without an infectious disease consultation. In the Cox proportional hazard model...
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Background: There are no large series describing cutaneous histologic changes during treatment with vismodegib in locally advanced basal cell carcinoma (BCC). Objective: To analyze histologic changes in skin biopsy specimens from patients with locally advanced BCC treated with vismodegib. Methods: A descriptive, retrospective study of patients with locally advanced BCC treated with vismodegib between June 2012 and December 2017 at the Instituto Valenciano de Oncología, Spain. Nineteen...
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Abstract: A case of primary cutaneous anaplastic large cell lymphoma that was characterized by a striking clear cell appearance occurring in the thigh of a 38-year-old man is described. The tumor presented as a large ulcer with indurated borders and serosanguinous base measuring 9.0 × 4.0 cm. A biopsy of the lesion showed a dense mononuclear cell infiltrate replacing the dermis and focally infiltrating the epidermis. The infiltrate consisted of nests and sheets of large pleomorphic tumor cells...
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Abstract: Although classical neurofibromas are commonly encountered skin lesions, histologic variants are infrequent. We report a greater than 15-year retrospective review of a single institution's experience with the histopathologic diagnosis of neurofibroma of the female breast with a focus on the hyalinized variant. An electronic histopathology record review (CoPathPlus; Cerner Corp, North Kansas City, MO) was conducted from January 1, 2000, to October 16, 2015, for all “neurofibroma” diagnoses...
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Abstract: Both architectural and cytologic characteristics are used to distinguish benign from malignant sebaceous neoplasms; however, specific cytopathologic features of sebocytes have not been well defined. The authors assessed architectural and cytological features of 63 sebaceous neoplasms [15 sebaceous hyperplasias, 12 sebaceomas, 16 sebaceous adenomas (SA), 14 sebaceous carcinomas (SC), and 6 ocular sebaceous carcinoma (OSC)] to investigate whether cytological grading may facilitate classification...
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Abstract: The choice of appropriate therapeutic strategies may be influenced by intratumor heterogeneity and makes cancer treatment considerably more challenging. We aimed to evaluate the heterogeneity of BRAF exon 15 mutations in different areas of acral lentiginous melanoma (ALM). The entire exon 15 was sequenced in 4 different areas of paraffin-embedded samples from 26 patients with ALM. A total of 26 of 49 cases of ≥1 mm in depth of ALM identified by clinical, anatomical, and pathological...
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No abstract available
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