CRISPR–Cas9 (clustered regularly interspaced short palindromic repeats [CRISPR]–CRISPR-associated protein 9 [Cas9]) technology has been widely applied to edit the genome of mammalian cells in vitro. Although this approach shows potential clinical usefulness and clinical trials have been initiated…
Wed Sep 11, 2019 03:00
Wed Sep 11, 2019 03:00
Oncogenesis, Published online: 11 September 2019; doi:10.1038/s41389-019-0160-0Correction: Synergistic anti-AML effects of the LSD1 inhibitor T-3775440 and the NEDD8-activating enzyme inhibitor pevonedistat via transdifferentiation and DNA rereplication
Wed Sep 11, 2019 03:00
Abstract Objectives Hydrophilic implant surfaces promote faster osseointegration of dental implants with a higher bone-implant contact (BIC) rate. Animal and in vitro studies proved that ultraviolet (UV) irradiation of titanium implants regains hydrophilicity. Clinical impact is still unclear. The objective of this RCT was to assess the removal torque (RT) required to unfix a surface-treated implant (test group) versus the original surface...
Wed Sep 11, 2019 03:00
Abstract Objectives Evidence shows that lithium, a medication commonly used for bipolar disorder treatment, presents bone anabolic activity. This study evaluated the effects of lithium chloride on periodontitis-induced bone loss (BL) and on intact alveolar bone during estrogen sufficiency and deficiency. Materials and methods Rats (24/group) received sham...
Wed Sep 11, 2019 03:00
The co-factor NADH plays an important role in butanol biosynthesis. In this study, we found that aspartate could effectively improve the butanol production of Clostridium acetobutylicum ATCC 824. Further study sh...
Tue Sep 10, 2019 03:00
Development of a genetic tool for visualization of photosynthetic bacteria (PSB) is essential for understanding microbial function during their interaction with plant and microflora. In this study, Rhodopseudomon...
Tue Sep 10, 2019 03:00
Frequent harmful cyanobacteria blooms limit the sustainable development of aquaculture. Algicidal bacteria can efficiently control harmful algae without secondary pollution. The algicidal bacteria CZBC1 can lyse
Wed Sep 11, 2019 03:00
Berberis aristata is an important part of traditional healing system from more than 2500 years. The aqueous extract of Berberis aristata root bark displayed broad spectrum activity against 13 test pathogens, rang...
Wed Sep 11, 2019 03:00
Abstract EIF4E is the rate-limiting factor in the mRNA translation of specific set of oncogenes. Snail is the core transcription factor of epithelial-mesenchymal transition (EMT), a key step of cancer metastasis. The connection between the two oncoproteins has not been well established in the human cancer tissues and in nasopharyngeal carcinoma (NPC). Here we showed that the positive correlative over-expression was seen between eIF4E and Snail in NPC tissues, and the expression...
Wed Sep 11, 2019 03:00
Abstract In this study we aim to demonstrate the value of monoclonal Caveolin 1 expression in distinguishing between malignant pleural mesothelioma and pulmonary adenocarcinoma. Total of 129 cases, consisting of 68 cases of malignant pleural mesothelioma (51 epitheloid, 12 biphasic, and 5 sarcomatoid type) and 61 cases of pulmonary adenocarcinoma were examined and stained with monoclonal Caveolin-1. Caveolin 1 expression with a membranous and /or cytoplasmic pattern was detected...
Wed Sep 11, 2019 03:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02818
Wed Sep 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01526
Wed Sep 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03426
Wed Sep 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01068
Wed Sep 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b01634
Wed Sep 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02986
Wed Sep 11, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03151
Wed Sep 11, 2019 07:00
At present, the influence factors of posttraumatic growth (PTG) in colorectal cancer (CRC) patients and the relationship between PTG, self-perceived burden (SPB), and resilience are not completely clear. Thus, the present study examined whether resilience and SPB could predict PTG in CRC patients. The role of resilience as a potential mediator was also assessed. Using a cross-sectional design, a convenience sample of 157 CRC patients was selected as subjects, from July to December 2016 in a third-grade...
03:05
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Gan To Kagaku Ryoho"[jour] These pubmed results were generated on 2019/09/11PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
04:01
Purpose: Systemic androgen-signaling inhibition added to ongoing androgen-deprivation therapy (ADT) improved clinical outcomes in patients with nonmetastatic castration-resistant prostate cancer without detectable metastases by conventional imaging (nmCRPC). Prostate-specific membrane antigen ligand positron-emission tomography (PSMA-PET) detects prostate cancer with superior sensitivity to conventional imaging, but its performance in nmCRPC remains largely unknown. We characterized cancer burden...
Wed Sep 11, 2019 16:48
The RAS family of proteins are at the apex of several pathways implicated in a multitude of epithelial cancers, but have remained stubbornly resistant to the wave of targeted small molecules and antibodies that have revolutionized clinical oncology. KRAS, the most commonly mutated of the isoforms, represents an attractive target for treatment given its ubiquity, central role as a driver mutation and association with poor prognosis. This review is a comprehensive summary of the existing approaches...
Wed Sep 11, 2019 16:48
Related ArticlesAnatomic Landmarks to Locate the Median Nerve for Safe Wrist Block or Carpal Tunnel Steroid Injection. Eplasty. 2019;19:e19 Authors: Brooks R, Kistler A, Chowdhry S, Swiergosz A, Perlin K, Kasdan ML, Wilhelmi BJ Abstract Introduction: Carpal tunnel syndrome is the most common entrapment neuropathy involving the upper extremity. As such, various nonoperative techniques have been developed to aid in management of mild to moderate disease,...
04:41
Wed Sep 11, 2019 03:00
Wed Sep 11, 2019 03:00
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
Wed Sep 11, 2019 03:00
Wed Sep 11, 2019 03:00
Wed Sep 11, 2019 03:00
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-11931-1The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-bound PaaZ that suggest a mechanism for internal substrate channeling.
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-11400-9The circadian clock affects immune responses, but its role in influenza infection is not well understood. Here, Sengupta et al. show that time of infection and the circadian clock have no effect on lung virus titers, but affect inflammation, morbidity and mortality.
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-12153-1Surface association and quorum sensing regulate bacterial community behaviours such as biofilm formation and motility. Here, Chuang et al. show that surface association promotes stronger quorum-sensing responses in Pseudomonas aeruginosa by upregulating the master regulator LasR.
Wed Sep 11, 2019 03:00
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-11893-4The inhibitory receptors PD-1, Tim-3 and Lag-3 act as negative feedback regulators of T cell responses. Here the authors improve CAR T cell antitumor efficacy by triple knockdown of these receptors, show it requires CD56, and correlate CD56-mediated homophilic cell interactions with CAR T cell efficacy.
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-12068-xIt is unknown how endocardium growth is coordinated with that of the myocardium in the zebrafish. Here, the authors show that myocardial chamber volume expansion causes increased endocardial tissue tension, which in turn triggers Hippo signaling-mediated proliferation within the endocardium.
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-12047-2Incorporating and dispersing dense nanoparticles into metals remains a challenge. Here, the authors use nanocomposite powders containing very dense nanoparticles to print an aluminium nanocomposite with one of the highest specific modulus and yield strength among all structural materials.
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-12115-7Cable bacteria’ form long multicellular filaments that can transfer electrical currents over centimetre-long distances. Here, Meysman et al. show that the electrical currents run along highly conductive fibres embedded in the cell envelope, and charge transfer is electronic rather than ionic.
Wed Sep 11, 2019 03:00
Nature Communications, Published online: 11 September 2019; doi:10.1038/s41467-019-12059-yOligodendrocyte processes can detect and respond to axonal vesicular release. The authors here show in zebrafish that transsynaptic adhesion molecules, molecules that promote synapse formation and maturation in neurons, are expressed by oligodendrocytes and required for myelin sheath growth.
Wed Sep 11, 2019 03:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου