Related ArticlesElectrode Designs for Protection of the Delicate Cochlear Structures. J Int Adv Otol. 2018 Dec;14(3):401-403 Authors: Downing M Abstract The most recent electrode introductions from Advanced Bionics, the HiFocus™ Mid-Scala and the HiFocus SlimJ arrays, have common design goals intended to provide sufficient access to the necessary frequency range while avoiding intracochlear trauma. The electrode choice, either a pre-curved (mid-scala)...
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Related ArticlesDevelopment and Clinical Introduction of the Nurotron Cochlear Implant Electrode Array. J Int Adv Otol. 2018 Dec;14(3):392-400 Authors: Rebscher S, Zhou DD, Zeng FG Abstract As the only medical device used in the treatment for deafness, the cochlear implant has benefited to more than half a million individuals worldwide. However, the device has limited penetration due to its high cost, especially in low- and middle-income countries....
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Related ArticlesWhy Pre-Curved Modiolar Hugging Electrodes Only Cover The Basal Turn of The Cochlea and Not Beyond that? J Int Adv Otol. 2018 Dec;14(3):376-381 Authors: Dhanasingh A Abstract The question of why pre-curved modiolar hugging (MH) electrodes only cover the basal turn of the cochlea and not beyond that is unanswered yet in the CI field. Therefore the aim of this article is to show what the practical limitations are with the pre-curved MH...
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Related ArticlesIntricacies of Cochlear Implant Electrode Design and Their Limitations. J Int Adv Otol. 2018 Dec;14(3):375 Authors: Gadre AK AbstractPMID: 30644377 [PubMed - indexed for MEDLINE]
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Related ArticlesImpact of Routine Plain X-ray on Postoperative Management in Cochlear Implantation. J Int Adv Otol. 2018 Dec;14(3):365-369 Authors: Çelik M, Orhan KS, Öztürk E, Avcı H, Polat B, Güldiken Y Abstract OBJECTIVES: To determine the benefit of a routine plain radiography (X-ray) for confirming the optimal electrode position in cochlear implant surgery. MATERIALS AND METHODS: In total, 245 patients (135 males and 111 females) who...
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Related ArticlesElectrically Evoked Auditory Brainstem Response over Round Window by Bipolar Stimulation. J Int Adv Otol. 2018 Dec;14(3):370-374 Authors: Fernandez NM, Vernetta CP, Garrido LC, Gomez MD, Perez CM Abstract OBJECTIVES: Auditory brainstem potentials can be elicited by electrical stimulation of the round window (RW). In this technique, extracochlear stimulation is objectively used in the selection of cochlear implant (CI) candidates to...
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Related ArticlesInteraural Time Difference Perception with a Cochlear Implant and a Normal Ear. J Assoc Res Otolaryngol. 2018 12;19(6):703-715 Authors: Francart T, Wiebe K, Wesarg T Abstract Currently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question...
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Related ArticlesEvaluation of Possible Effects of a Potassium Channel Modulator on Temporal Processing by Cochlear Implant Listeners. J Assoc Res Otolaryngol. 2018 12;19(6):669-680 Authors: Carlyon RP, Deeks JM, Guérit F, Lamping W, Billig AJ, Large CH, Saeed SR, Harris P Abstract Temporal processing by cochlear implant listeners is degraded and is affected by auditory deprivation. The fast-acting Kv3.1 potassium channel is important for sustained...
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Related ArticlesBenefit of Preoperative Temporal Bone CT for Atraumatic Cochlear Implantation. Otol Neurotol. 2018 03;39(3):e186-e194 Authors: Karkas A, Champfleur NM, Uziel A, Mondain M, Puel JL, Venail F Abstract HYPOTHESIS: Evaluate the benefit of preoperative surgical planning using computed tomography (CT) for atraumatic cochlear implantation. BACKGROUND: The surgical technique has a direct impact on hearing and structure preservation....
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Related ArticlesPreauricular Approach for Cholesteatoma Resection After Surgical Overclosure of the External Auditory Canal and Cochlear Implantation. Otol Neurotol. 2018 03;39(3):318-319 Authors: Telian SA Abstract : Chronic suppurative otitis media can have long-term effects on hearing if not managed effectively. When combined with cholesteatoma the condition may require creation of an open mastoid cavity. Recurrence of cholesteatoma is a concern...
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Related ArticlesIntraoperative Cochlear Implant Device Testing Utilizing an Automated Remote System: A Prospective Pilot Study. Otol Neurotol. 2018 03;39(3):313-317 Authors: Lohmann AR, Carlson ML, Sladen DP Abstract INTRODUCTION: Intraoperative cochlear implant device testing provides valuable information regarding device integrity, electrode position, and may assist with determining initial stimulation settings. Manual intraoperative device testing...
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Related ArticlesCochlear Implant Surgery and the Risk of Falls in an Adult Population. Otol Neurotol. 2018 02;39(2):e74-e79 Authors: Louza J, Klappert CL, Ledderose G, Gürkov R, Krause E Abstract OBJECTIVE: To determine the effect of cochlear implant surgery on the balance and risk of falls in an adult patient population using a mobile posturograph. DESIGN: Prospective clinical pilot study. SETTING: Cochlear implant center at a tertiary...
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Related ArticlesAn In-Vitro Insertion-Force Study of Magnetically Guided Lateral-Wall Cochlear-Implant Electrode Arrays. Otol Neurotol. 2018 02;39(2):e63-e73 Authors: Leon L, Warren FM, Abbott JJ Abstract HYPOTHESIS: Insertion forces can be reduced by magnetically guiding the tip of lateral-wall cochlear-implant electrode arrays during insertion via both cochleostomy and the round window. BACKGROUND: Steerable electrode arrays have the potential...
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Related ArticlesCochlear Implantation After Partial or Subtotal Cochleoectomy for Intracochlear Schwannoma Removal-A Technical Report. Otol Neurotol. 2018 03;39(3):365-371 Authors: Plontke SK, Kösling S, Rahne T Abstract OBJECTIVE: To describe the technique for surgical tumor removal, cochlear implant (CI) electrode placement and reconstruction of the surgical defect in patients with intracochlear schwannomas. STUDY DESIGN: Retrospective case...
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Related ArticlesVestibular Outcome After Cochlear Implantation Is Not Related to Surgical Technique: A Double Blinded, Randomized Clinical Trial of Round Window Approach Versus Cochleostomy. Otol Neurotol. 2018 03;39(3):306-312 Authors: Korsager LEH, Schmidt JH, Faber C, Wanscher JH Abstract OBJECTIVE: To establish whether the round window approach (RWA) leads to less vestibular dysfunction and dizziness than the standard cochleostomy approach (SCA)...
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Biomedicines, Vol. 7, Pages 74: The Role of Butyrate on Monocyte Migration and Inflammation Response in Patient with Type 2 Diabetes Mellitus Biomedicines doi: 10.3390/biomedicines7040074 Authors: Rahma Ayu Larasati Dante Saksono Harbuwono Ekowati Rahajeng Saraswati Pradipta Hanny Siti Nuraeni Andi Susilowati Heri Wibowo Type 2 Diabetes Mellitus (T2DM) is a very serious global problem. In Indonesia, this disease attacks at the most productive age; consequently, it can...
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Related ArticlesStatin use and medically attended acute respiratory illness among influenza vaccine recipients. Vaccine. 2019 Sep 19;: Authors: Cutrell JB, Drechsler H, Bedimo R, Alvarez CA, Mansi IA Abstract BACKGROUND: Previous studies have suggested that statins decrease influenza vaccine effectiveness and increase risk of medically attended acute respiratory illness (MAARI). OBJECTIVES: To examine the association of incident statin use and...
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Related ArticlesBarriers and motivations for participation in preventive vaccine clinical trials: Experience of 5 clinical research sites. Vaccine. 2019 Sep 19;: Authors: Detoc M, Launay O, Dualé C, Mutter C, Le Huec JC, Lenzi N, Lucht F, Gagneux-Brunon A, Botelho-Nevers E Abstract Recruitment in preventive vaccine trials (PVT) is challenging due to common barriers to clinical research and lack of vaccine confidence. Identifying determinants of participation...
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Related ArticlesGenetic characterization of group-A rotaviruses among children in eastern India during 2014-2016: Phylodynamics of co-circulating genotypes. Vaccine. 2019 Sep 19;: Authors: Nayak MK, Banerjee A, Sarkar R, Mitra S, Dutta K, Ganguly N, Ghosh C, Girish Kumar CP, Niyogi P, Panda S, Dutta S, Chawla-Sarkar M Abstract BACKGROUND: Group-A human rotaviruses (GARV) are among the major cause of childhood diarrhea worldwide. In lieu of monitoring...
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Related ArticlesVZV-specific cell-mediated immunity, but not humoral immunity, correlates inversely with the incidence of herpes zoster and the severity of skin symptoms and zoster-associated pain: The SHEZ study. Vaccine. 2019 Sep 19;: Authors: Asada H Abstract Onset of herpes zoster (HZ) is thought to be related to a decline in cell-mediated immunity (CMI). However, until recently, there have been no large-scale prospective studies on the relationship...
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Related ArticlesQuality of life impairment due to chronic rhinosinusitis in asthmatics is mediated by asthma control. Rhinology. 2019 Sep 23;: Authors: Phllips KM, Talat R, Caradonna DS, Gray ST, Sedaghat AR Abstract BACKGROUND: Chronic rhinosinusitis (CRS) and asthma, when comorbid, may influence each other's disease course and decrease quality of life (QOL). Our objective was to determine if poorer asthma control due to CRS symptoms could be a mechanism...
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Related ArticlesKRAS-Driven Metabolic Rewiring Reveals Novel Actionable Targets in Cancer. Front Oncol. 2019;9:848 Authors: Pupo E, Avanzato D, Middonti E, Bussolino F, Lanzetti L Abstract Tumors driven by mutant KRAS are among the most aggressive and refractory to treatment. Unfortunately, despite the efforts, targeting alterations of this GTPase, either directly or by acting on the downstream signaling cascades, has been, so far, largely unsuccessful....
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Related ArticlesA Pilot Phase 1 Study of Intrathecal Pemetrexed for Refractory Leptomeningeal Metastases From Non-small-cell Lung Cancer. Front Oncol. 2019;9:838 Authors: Pan Z, Yang G, Cui J, Li W, Li Y, Gao P, Jiang T, Sun Y, Dong L, Song Y, Zhao G Abstract Objectives: We aim to determine the feasibility, safety, maximally tolerated dose (MTD), recommended dose and potential anti-tumor activity of intrathecal pemetrexed (IP). Materials and Methods:...
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Related ArticlesExploring Radiation Response in Two Head and Neck Squamous Carcinoma Cell Lines Through Metabolic Profiling. Front Oncol. 2019;9:825 Authors: Lindell Jonsson E, Erngren I, Engskog M, Haglöf J, Arvidsson T, Hedeland M, Petterson C, Laurell G, Nestor M Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common form of cancer worldwide. Radiotherapy, with or without surgery, represents the major approach to curative...
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Related ArticlesCT-Based Radiomics Signature for the Preoperative Discrimination Between Head and Neck Squamous Cell Carcinoma Grades. Front Oncol. 2019;9:821 Authors: Wu W, Ye J, Wang Q, Luo J, Xu S Abstract Background: Radiomics has been widely used to non-invasively mine quantitative information from medical images and could potentially predict tumor phenotypes. Pathologic grade is considered a predictive prognostic factor for head and neck squamous...
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Related ArticlesAn Open-Source Tool for Anisotropic Radiation Therapy Planning in Neuro-oncology Using DW-MRI Tractography. Front Oncol. 2019;9:810 Authors: Jordan K, Morin O, Wahl M, Amirbekian B, Chapman C, Owen J, Mukherjee P, Braunstein S, Henry R Abstract There is evidence from histopathological studies that glioma tumor cells migrate preferentially along large white matter bundles. If the peritumoral white matter structures can be used to predict...
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Related ArticlesCFD analysis of the flow structure in a monkey upper airway validated by PIV experiments. Respir Physiol Neurobiol. 2019 Sep 20;:103304 Authors: Phuong NL, Van Quang T, Khoa ND, Kim JW, Ito K Abstract Inhalation exposure to airborne contaminants has adverse effects on humans; however, related research is typically conducted using in vivo/in vitro tests on animals. Extrapolating the test results is complicated by anatomical and physiological...
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Related ArticlesEffects of Angle of Epiglottis on Aerodynamic and Acoustic Parameters in Excised Canine Larynges. J Voice. 2019 Sep;33(5):627-633 Authors: Zeng Q, Jiao Y, Huang X, Wang R, Bao H, Lamb JR, Le J, Zhuang P, Jiang J Abstract OBJECTIVES: The aim of this study is to explore the effects of the angle of epiglottis (Aepi) on phonation and resonance in excised canine larynges. METHODS: The anatomic Aepi was measured for 14 excised canine...
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Related ArticlesOutcomes Following Transoral Laser Microsurgery With Resection of Cartilage for Laryngeal Cancer. Ann Otol Rhinol Laryngol. 2019 Oct;128(10):978-982 Authors: Chang BA, Lott DG, Nagel TH, Howard BE, Hayden RE, Hinni ML Abstract INTRODUCTION: The ability to treat more advanced laryngeal cancers by transoral approaches has expanded significantly in the past several decades. Transoral management of laryngeal cancers that require removal...
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Related ArticlesThe Value of Dynamic Voice CT Scan for Complex Airway Patients Undergoing Voice Surgery. Ann Otol Rhinol Laryngol. 2019 Oct;128(10):885-893 Authors: Bergeron M, Fleck RJ, Zacharias SRC, Tabangin ME, de Alarcon A Abstract INTRODUCTION: Dynamic voice computerized tomography (DVCT) is a novel technique that provides additional information to characterize laryngeal function for patients with complex airway history that may alter surgical...
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Related ArticlesCandidiasis Causing Vocal Fold Leukoplakia: Review of Clinical and Pathological Results of 289 Cases With Vocal Fold Leukoplakia. Ann Otol Rhinol Laryngol. 2019 Oct;128(10):903-910 Authors: Gumussoy M, Kucuk U Abstract OBJECTIVE: In laryngology practice, vocal fold leukoplakia is frequently evaluated by suspension laryngoscopy and biopsy examination upon the patient's complaints of hoarseness and dysphonia. The purpose of the present...
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Related ArticlesThe Ability of Human Nasal Inferior Turbinate-Derived Mesenchymal Stem Cells to Repair Vocal Fold Injuries. Otolaryngol Head Neck Surg. 2018 08;159(2):335-342 Authors: Kim CS, Choi H, Park KC, Kim SW, Sun DI Abstract Objective This study investigated the ability of implanted human nasal inferior turbinate-derived mesenchymal stem cells (hTMSCs) to repair injured vocal folds. To this end, we used quantitative real-time polymerase chain...
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Related ArticlesPoint-of-care ultrasound (POCUS) of the upper airway. Can J Anaesth. 2018 04;65(4):473-484 Authors: You-Ten KE, Siddiqui N, Teoh WH, Kristensen MS Abstract Airway management is a critical skill in the practice of several medical specialities including anesthesia, emergency medicine, and critical care. Over the years mounting evidence has showed an increasing role of ultrasound (US) in airway management. The objective of this narrative...
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Related ArticlesMucins, Mucus, and Goblet Cells. Chest. 2018 07;154(1):169-176 Authors: Ma J, Rubin BK, Voynow JA Abstract The respiratory epithelium is lined by mucus, a gel consisting of water, ions, proteins, and macromolecules. The major macromolecular components of mucus are the mucin glycoproteins, which are critical for local defense of the airway. There are three classes of mucins in the airways: those that are secreted but do not polymerize...
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Publication date: Available online 23 September 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): E.B. Vieira, J.S. Ota-Arakaki, S. Dal Corso, I. Ivanaga, A.X.C. Fonseca, R.K.F. Oliveira, J.C. Rodrigues, E.V.M. Ferreira, L.E. Nery, R.P. RamosAbstractCardiopulmonary exercise testing (CPET) on a treadmill or cycle ergometer provides an integrated assessment of the cardiorespiratory system during exertion and is widely used in clinical practice. An incremental step test (IST) can be an...
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Publication date: Available online 23 September 2019Source: Respiratory Physiology & NeurobiologyAuthor(s): Xiaoli Liu, Xiaoan Chen, Geoffrey Kline, Sarah E. Ross, James R. Hall, Yanfeng Ding, Robert T. Mallet, Xiangrong ShiAbstractBackgroundThe impact of aging on cerebrovascular function and tissue oxygenation during graded hypoxemia is incompletely known. This study compared the age effect on these variables during cyclic hypoxemia-reoxygenation.MethodsHypoxia-induced changes in arterial (SaO2)...
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Publication date: Available online 24 September 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): David B. Peden
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Publication date: Available online 24 September 2019Source: Current Problems in Diagnostic RadiologyAuthor(s): Teresa Martin-Carreras, Ronnie Sebro, Sara WeintraubAbstractIntroductionThe purpose of this study is to examine the associations between hip and acetabular morphology, clinical and demographic patient factors, and acetabular labral tear location in young adults.Materials and methodsThis study was reviewed by the local Institutional Review Board. The hip magnetic resonance imaging (MRI) arthrograms...
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Related ArticlesOsteopontin promotes rat hepatocyte proliferation both in vitro and in vivo. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3745-3757 Authors: Wang G, Chu P, Chen M, Cheng L, Zhao C, Chen S, Li X, Yang G, Chang C Abstract Aim: This study aimed to examine the effects of osteopontin (OPN) on hepatocyte growth and liver regeneration (LR). Methods: A recombinant lentivirus expressing OPN and OPN-siRNAs were used to treat BRL-3A cells, while...
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