This study evaluates a new single-port robotic surgical system for head and neck surgery prospectively through 2 concurrent nonrandomized clinical trials.
Thu Sep 19, 2019 03:00
In their article “Association of a Multidisciplinary Care Approach With the Quality of Care After Pediatric Tracheostomy,” McKeon et al present their single-center experience of implementing a multidisciplinary tracheostomy team (MDT). Having taken the Global Tracheostomy Collaborative’s 5 key drivers for tracheostomy care to heart (standardization of care protocols, broad staff education, patient and family involvement, monitoring of outcomes, and multidisciplinary collaboration), the authors and...
Thu Sep 19, 2019 03:00
This quality improvement study assesses whether a multidisciplinary tracheostomy program is associated with the quality of care after pediatric tracheostomy by analyzing a cohort of 700 children who received a tracheostomy.
Thu Sep 19, 2019 03:00
Objectives: To assess the effect of EVES (Education for a Healthy and Efficient Voice), a voice training program aimed at promoting the use of an efficient and healthy voice in teachers. Sample and Method: Twenty-two teachers in the city of Granollers (Catalonia, Spain) were included in this research. The effect of the EVES program was evaluated focusing on the analysis of physiologic parameters on the one side (stroboscopy analysis), and on perceptual parameters on the other (Q-EVES questionnaire,...
Thu Sep 19, 2019 16:44
Introduction: Vocal nodules and cysts are frequent causes of infantile dysphonia. Vocal therapy is the first treatment. Microsurgery has restricted indications, especially for nodules. Objective: To describe our experience with microsurgery for nodules and cysts in children. Methods: Dysphonic children (aged 4–18 years) with the diagnosis of nodules and vocal cysts were initially selected. Of these children, only those were included who had undergone microsurgery. For nodules and cysts, the microsurgery...
Thu Sep 19, 2019 16:45
Publication date: Available online 18 September 2019Source: European Journal of Surgical OncologyAuthor(s): Ryungsa Kim, Ami Kawai, Megumi Wakisaka, Sayaka Sawada, Mika Shimoyama, Naomi Yasuda, Masayuki Hidaka, Yukitaka Morita, Shoichiro Ohtani, Koji ArihiroAbstractPurposeTo evaluate immune responses paralleling the pathological and therapeutic effects of neoadjuvant chemotherapy (NAC) in the tumor microenvironment of breast cancer. Patients and Methods: 38 patients with stages II and III breast...
Thu Sep 19, 2019 19:43
Publication date: Available online 19 September 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Alexandra Medellin, Glen Pridham, Stefan J. Urbanski, Saumya Jayakumar, Stephanie R. WilsonAbstractWe investigated whether ultrasound (US) could quantify steatosis and fibrosis in non-alcoholic fatty liver disease (NAFLD). Estimates of fat by gray-scale, hepatorenal index (HRI) and fibrosis by acoustic radiation force impulse (ARFI) were made using the interquartile range (IQR)/median for ARFI...
Thu Sep 19, 2019 19:52
ObjectivesIn a previous analysis of data from a French population-based case–control study (the Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE) study), ‘having ever worked’ in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not for occupational factors. The present study aimed to investigate the relationship between lung cancer risk and wood dust exposure after adjusting for occupational exposures.MethodsData...
Thu Sep 19, 2019 19:00
Journal of International Medical Research, Ahead of Print.
Mon Sep 16, 2019 12:12
Journal of International Medical Research, Ahead of Print.
Mon Sep 16, 2019 12:17
Journal of International Medical Research, Ahead of Print.
Tue Sep 17, 2019 13:01
Journal of International Medical Research, Ahead of Print.
Tue Sep 17, 2019 14:19
Journal of International Medical Research, Ahead of Print.
Tue Sep 17, 2019 14:33
Journal of International Medical Research, Ahead of Print.
Tue Sep 17, 2019 14:45
Journal of International Medical Research, Ahead of Print.
Tue Sep 17, 2019 14:48
Journal of International Medical Research, Ahead of Print.
Tue Sep 17, 2019 14:53
Journal of International Medical Research, Ahead of Print.
Wed Sep 18, 2019 08:36
Journal of International Medical Research, Ahead of Print.
Wed Sep 18, 2019 08:42
Journal of International Medical Research, Ahead of Print.
Wed Sep 18, 2019 09:15
Journal of International Medical Research, Ahead of Print.
Wed Sep 18, 2019 09:16
Journal of International Medical Research, Ahead of Print.
Wed Sep 18, 2019 13:06
Journal of International Medical Research, Ahead of Print.
Thu Sep 19, 2019 08:55
Journal of International Medical Research, Ahead of Print.
Thu Sep 19, 2019 09:02
Journal of International Medical Research, Ahead of Print.
Thu Sep 19, 2019 09:05
Journal of International Medical Research, Ahead of Print.
Thu Sep 19, 2019 09:10
Journal of International Medical Research, Ahead of Print.
Thu Sep 19, 2019 09:16
Long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP), has been demonstrated to be a vital biomarker when evaluating the prognosis of multiple cancers. Nevertheless, the potential function of...
Wed Sep 18, 2019 03:00
UFM1 has been found to be involved in the regulation of tumor development. This study aims to clarify the role and potential molecular mechanisms of UFM1 in the invasion and metastasis of gastric cancer.
Wed Sep 18, 2019 03:00
Researchers from Brigham and Women’s Hospital and UT Southwestern Medical center have developed a new machine learning algorithm that predicts the risk of heart failure hospitalization for people suffering from type 2 diabetes. Their work demonstrates that among 147 different demographic, clinical, and biological data, there is an important top 10 list of predictors, which includes BMI, age, hypertentsion, creatinine, HDL-C, and QRS duration. One day, insightful algorithms such as these will...
Thu Sep 19, 2019 16:15
Current pathology techniques for analyzing biopsy tissues are lacking in their ability to detect cancer in small samples. Being able to rapidly study the distribution of protein expression within cells, gathered from minuscule samples, could be an important tool for early diagnosis and monitoring of cancer. Now, researchers at National University of Singapore have reported in Nature Biomedical Engineering that they have been able to use programmable DNA barcodes to measure and localize...
Thu Sep 19, 2019 17:35
Transcatheter aortic valve replacement (TAVR) procedures have become a popular way of treating aortic valve stenosis, a condition in which the valve stiffens and worsens cardiac function. Following implantation of a prosthetic valve, the hearts of patients tend to undergo significant reconstruction around the treatment site, but the mechanics of this process are poorly understood. It is difficult to study the hearts of living people, so a novel laboratory solution was necessary. Researchers...
Thu Sep 19, 2019 19:55
Aggregation‐induced emission (AIE) has attracted increasingly attention in a variety of applications due to the strong fluorescence emission in solid state. However, it still remains challenging for photoresponsive AIE materials with light modulation due to the lack of proper building block. Here, we have for the first time unraveled the unprecedented dual AIE behavior based on the steric‐hindrance photochromic system with specifically incorporating one or two bulky aryl groups, thus resulting in...
Wed Sep 18, 2019 21:29
The (photo)electrochemical N2 reduction reaction (NRR) has gathered increasing attention because it provides a favorable avenue for the production of NH3 using renewable energy in mild operating conditions. Understanding and building an efficient catalytic system with high NH3 selectivity represents an area of intense interest for the early stages of development for NRR. Here, we introduce a CoOx layer to tune the local electronic structure of Au nanoparticles with positive valence sites for boosting...
Wed Sep 18, 2019 21:32
Tuning molecular weight distributions can substantially affect the properties of synthesised polymeric materials. Photoinduced atom transfer radical polymerisation (photo‐ATRP) was used to control the dispersity of homopolymers and block copolymers by varying the concentration of copper complex. A wide range of monomodal molecular weight distributions are obtained where Mn and Mw can be tuned upon demand. Abstract Dispersity significantly affects the properties of polymers. However, current...
Wed Sep 18, 2019 22:00
“When I was eighteen I wanted to be an engineer. The secret of being a successful scientist is to work hard and work smart …” Find out more about Xing Yi Ling in her Author Profile.
Wed Sep 18, 2019 22:38
The dissolution of anhydrous iron bromide in a mixture of pyridine and acetonitrile, in the presence of an organic amine, results in the formation of an [Fe 34 ] metal oxide molecule, structurally characterized by alternate layers of tetrahedral and octahedral Fe(III) ions connected by oxide and hydroxide ions. The outer shell of the cage is capped by a combination of pyridine molecules and bromide ions. Magnetic data, measured at temperatures as low as 0.4 K and fields up to 35 T, reveal competing...
Thu Sep 19, 2019 11:24
If yeasts could talk: An interactive paradigm of communication between yeasts and enzyme‐controlled Janus Au–mesoporous silica nanoparticles is reported. The fluorescent signal from the microorganism (corresponding to the production of green fluorescent protein) is governed by the biunivocal communication with the nanodevice through enzymatic reactions and the exchange of chemical messengers. Abstract The construction of communication models at the micro‐/nanoscale involving abiotic nanodevices...
Thu Sep 19, 2019 11:48
A novel nickel pincer cofactor was recently discovered in lactate racemase. Here, we report three synthetic nickel pincer complexes that are both structural and functional models of the pincer cofactor in lactate racemase. DFT computations suggest the ipso‐carbon of the pyridinium pincer ligands act as a hydride acceptor for lactate isomerization, whereas an organometallic pathway involving Ni‐mediated β‐H elimination is less favored.
Thu Sep 19, 2019 12:25
Indane formation: A one‐step organic catalytic strategy for enantioselective access to indanes with an all‐carbon quaternary center is disclosed. The reaction involves an N‐heterocyclic carbene (NHC) catalyzed process for direct arene construction, indane formation, remote‐carbon desymmetrization, and excellent chirality control. This approach enables the concise synthesis of arene‐containing molecules, including those having complex structures and challenging chiral centers. Abstract Multisubstituted...
Thu Sep 19, 2019 13:00
We report a new approach for nanosilicon‐graphene hybrids with uniquely stable solid electrolyte interphase. Expanded graphite is gently exfoliated creating “defect‐free” graphene that is non‐catalytic towards electrolyte decomposition, simultaneously introducing high mass loading (48wt.%) Si nanoparticles. Silane surface treatment creates epoxy chemical tethers, mechanically binding nano‐Si to CMC binder through epoxy ring‐opening reaction while stabilizing the Si surface chemistry. Epoxy‐tethered...
Thu Sep 19, 2019 13:12
Molten LiCl and related eutectic electrolytes are known to permit direct electrochemical reduction of N2 to N3‐ with high efficiency. It had been proposed that this could be coupled with H2 oxidation in an electrolytic cell to produce NH3 at ambient pressure. Here, this proposal is tested in a LiCl‐KCl‐Li3N cell and is found not to be the case, as the previous assumption of the direct electrochemical oxidation of N3‐ to NH3 is grossly over‐simplified. We find that Li3N added to the molten electrolyte...
Thu Sep 19, 2019 13:16
Homochiral metal‐organic framework (MOF) membranes have been recently reported for chiral separations. However, only a few high‐quality homochiral polycrystalline MOF membrane have been fabricated due to the difficulty in crystallization of a chiral MOF layer without defects on porous substrates. Alternatively, mixed matrix membranes (MMMs), which combine potential advantages of MOFs and polymers, have been widely demonstrated for gas separation and water purification. Here we report novel homochiral...
Thu Sep 19, 2019 13:17
Chalcogen bonding is the non‐covalent interaction between Lewis acidic chalcogen substituents and Lewis bases. Herein, we present the first application of dicationic tellurium‐based chalcogen bond donors in the nitro‐Michael reaction between trans‐β‐nitrostyrene and indoles. This also constitutes the first activation of nitro derivatives by chalcogen bonding (and halogen bonding). The catalysts showed rate accelerations of more than 300‐fold compared to strongly Lewis acidic hydrogen bond donors....
Thu Sep 19, 2019 13:57
We report the novel chemical design of fluorescent activatable chemokines as highly specific functional probes for imaging subpopulations of immune cells in live tumours. Activatable chemokines behave as AND‐gates since they emit only after receptor binding and intracellular activation, showing enhanced selectivity over existing agents. We have applied this strategy to produce mCCL2‐MAF as the first probe for in vivo detection of metastasis‐associated macrophages in a preclinical model of lung metastasis....
Thu Sep 19, 2019 15:26
The synthesis, structural, and spectroscopic characterization of the first transplutonium metal‐organic framework (MOF) is described. The preparation and structure of Am‐GWMOF‐6, [Am2(C6H8O4)3(H2O)2][(C10H8N2)], is analogous to that of the isostructural trivalent lanthanide‐only containing material GWMOF‐6. The presented MOF architecture is used as a platform to probe Am3+ coordination chemistry and guest‐enhanced luminescent emission, whereas the framework itself provided a means to monitor the...
Thu Sep 19, 2019 16:58
The reduction of 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine (TPT) with alkali metals resulted in the radical anion salts ( 1 , 2 , 4 and 5 ) and diradical dianion salt 3 . Single crystal X‐ray diffraction and electron paramagnetic resonance (EPR) spectroscopy reveal that 1 contains monoradical anion TPT •‐ stacked in 1D with K + (18c6), 2 can be viewed as a 1D magnetic chain of TPT •‐ , while 4 and 5 display radical‐contained metal‐organic frameworks (RMOFs). 1D pore passages of solvent molecules,...
Thu Sep 19, 2019 17:24
One stone, four birds: Various 2‐bromobiaryl derivatives undergo a smooth cyclolanthanation upon reaction with nBu2LaCl⋅4 LiCl. The resulting cyclometalated lanthanum reagents are versatile intermediates for the facile preparation of valuable polyfunctional biaryl derivatives. X‐ray absorption fine structure (XAFS) measurements rationalize the proposed structures of the involved organolanthanum species. Abstract Various aryl‐ and heteroaryl‐substituted 2‐bromobiaryls are converted to cyclometalated...
Thu Sep 19, 2019 20:26
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