Vaccine,

A multi-epitope DNA vaccine co-administered with monophosphoryl lipid A adjuvant provides protection against tick transmitted <em>Ehrlichia ruminantium</em> in sheep

Publication date: Available online 25 June 2019Source: VaccineAuthor(s): S.I. Tshilwane, N. Thema, H.C. Steyn, M. van Kleef, A. PretoriusAbstractPreviously, a heartwater experimental DNA vaccine provided 100% protection following laboratory challenge with Ehrlichia ruminantium administered by needle but not against an E. ruminantium tick challenge in the field. A multi-epitope DNA vaccine incorporating both CD4+ and CD8+ cytotoxic T lymphocytes epitopes could provide a better alternative. In this...

ScienceDirect Publication: Vaccine

16h

Maternally-derived neutralizing antibodies reduce vaccine efficacy against porcine reproductive and respiratory syndrome virus infection

Publication date: Available online 24 June 2019Source: VaccineAuthor(s): Patricia Renson, Christelle Fablet, Mathieu Andraud, Valérie Normand, Arnaud Lebret, Frédéric Paboeuf, Nicolas Rose, Olivier BourryAbstractModified live virus (MLV) vaccines are commonly used to reduce the impact of porcine reproductive and respiratory syndrome (PRRS) but limited efficacy is achieved in field conditions. Here, we evaluated the impact of maternally-derived neutralizing antibodies (MDNAs) on vaccine efficacy after...

ScienceDirect Publication: Vaccine

16h

ONRAB® oral rabies vaccine is shed from, but does not persist in, captive mammals

Publication date: Available online 24 June 2019Source: VaccineAuthor(s): Kirk G. Sobey, Sarah E. Jamieson, Aaron A. Walpole, Rick C. Rosatte, Dennis Donovan, Christine Fehlner-Gardiner, Susan A. Nadin-Davis, J. Chris Davies, Christopher J. KyleAbstractONRAB® is a human adenovirus rabies glycoprotein recombinant vaccine developed to control rabies in wildlife. To support licensing and widespread use of the vaccine, safety studies are needed to assess its potential residual impact on wildlife populations....

ScienceDirect Publication: Vaccine

16h

1st WHO International Standard antiserum to RSV: Availability and benefits for RSV vaccine development (Commentary on the collaborative study report published in the vaccine journal (Vaccine 2018 36: 7641–7649))

Publication date: Available online 24 June 2019Source: VaccineAuthor(s): Ivana Knezevic

ScienceDirect Publication: Vaccine

16h

Missed Opportunities for HPV Vaccination Among Vaccine-Eligible Women with High Grade Cervical Lesions

Publication date: Available online 24 June 2019Source: VaccineAuthor(s): Savanah M. Russ, Monica Brackney, James Meek, Linda M. NiccolaiAbstractBackgroundIncidence of high-grade cervical lesions (HGCL) has declined in the U.S following the introduction of the human papillomavirus (HPV) vaccine in 2006. However, many women continue to be diagnosed with HGCLs, including those eligible to receive the vaccine but did not. We determined self-reported barriers to and correlates of HPV vaccination in vaccine-eligible...

ScienceDirect Publication: Vaccine

16h

A prime-boost concept using a T-cell epitope-driven DNA vaccine followed by a whole virus vaccine effectively protected pigs in the pandemic H1N1 pig challenge model

Publication date: Available online 24 June 2019Source: VaccineAuthor(s): Joshua S. Hewitt, Anbu K. Karuppannan, Swan Tan, Phillip Gauger, Patrick G. Halbur, Priscilla F. Gerber, Anne S. De Groot, Leonard Moise, Tanja OpriessnigAbstractInfluenza A virus (IAV) vaccines in pigs generally provide homosubtypic protection but fail to prevent heterologous infections. In this pilot study, the efficacy of an intradermal pDNA vaccine composed of conserved SLA class I and class II T cell epitopes (EPITOPE)...

ScienceDirect Publication: Vaccine