Safety and efficacy of Early injection laryngoplasty in pediatric patients
Caitlin Bertelsen MD  Lia Jacobson MD, MS  Beth Osterbauer MPH, CCRP  Christian Hochstim MD, PhD
First published: 23 October 2018 https://doi.org/10.1002/lary.27436
Presented as an oral presentation at the American Society of Pediatric Otolaryngologists Annual Meeting, Washington, DC, U.S.A., April 21, 2018.
The authors have no funding, financial relationships, or conflicts of interest to disclose.
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Abstract
Objective
The major morbidity of unilateral vocal fold immobility (UVFI) in children is due to aspiration. Early injection laryngoplasty (IL) can decrease aspiration risk; however, this has not been well studied in pediatric otolaryngology. This study examines safety and efficacy of early IL in children.

Methods
Retrospective review of pediatric patients undergoing IL with any injectate between 2006 and 2017 within 6 months of onset of UVFI. Outcomes included diet pre‐ and postprocedure, incidence of aspiration‐related sequelae, and adverse events.

Results
Seventeen patients met eligibility criteria. Ten (58.8%) were males. Median age was 8 months (interquartile range, 2 months–11.5 years). All patients had prior surgeries; the largest subgroup (11 patients, 64.7%) had UVFI after repair of a congenital cardiac defect. Other causes included thyroidectomy, high vagal injury, and prolonged intubation.

Sixteen patients underwent swallowing evaluation prior to IL and 14 patients required dietary modifications due to aspiration risk. Consistency and/or volume of oral intake improved after IL in 10 (71.4%) of them. Five patients underwent gastrostomy tube placement for significant oromotor incoordination. Children with congenital cardiac defects had more previous surgeries (3.0 ± 0.4 vs. 1.2 ± 0.2, P = .006) and were more likely to require G‐tube placement due to poor feeding despite IL (45% vs. 0%, P = .05). No patients experienced adverse events due to IL; in particular, none experienced airway symptoms requiring intubation.

Conclusion
Early IL in pediatric patients with UVFI is safe and can reduce aspiration and improve oral intake. Future studies should elucidate patient subgroups most likely to benefit from this intervention.

Level of Evidence
4

Laryngoscope, 129:1699–1705, 2019