Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes
Chun-lian Tang, Yan-ru Gao, Li-xia Wang, Ya-wen Zhu, ... Ying Xiong
In Press, Corrected Proof, Available online 9 May 2019
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Abstract
Abstract
The prevalence of T1D in developed societies is partly based on the hygiene hypothesis, that is, the loss of exposure to infectious agents accompanies the loss of immune stimuli shaping the immune system during development. Indeed, the components of parasites, such as Schistosoma, have been reported to ameliorate or prevent the development of T1D, which might be associated with immune cell activity especially that of regulatory T cells (Tregs). Schistosoma infection can lead to the expansion of Treg. Herein, we provide a comprehensive overview of the involvement of Tregs in the response against Schistosoma infection and the mechanism of Schistosoma-associated host protection against T1D.