Pediatric Blood Management Protocol in Cranial Vault Surgery Background: Cranial vault surgeries are invasive, extensive procedures with blood transfusions being frequently required. Previous interventions have been described to attempt to decrease the transfusion burden. The objective of this study is to determine if a Pediatric Blood Management (PBM) team can reduce transfusion requirements in children undergoing cranial vault surgery. Methods: A protocol was developed which involved preoperative optimization of hemoglobin (Hb), intraoperative use of tranexamic acid, cell saver technology, and blood sparing operative techniques. Patients were preoperatively screened with basic laboratory testing. Retrospective data on 20 consecutive patients who underwent craniofacial surgery prior were used as controls. Prospective data on patients was collected. Results: Groups were similar in age and weight. Postoperative Hb measurements were similar, with the control group 10.9 ± 2.2 g/dL and the intervention arm 9.6 + 2.7 g/dL. Discharge Hb concentrations also were similar with 9.6 ± 1.6 g/dL and 9.7 ± 2.5 g/dL in the control and PBM group, respectively. The rate of transfusion decreased from 80% to 42% after protocol implementation (P = 0.007). During the last 6 months of data collection, the transfusion rate decreased further to 17%. Furthermore, 4 patients were found to have von Willebrand disease preoperatively with only 1 requiring a transfusion. Conclusions: The authors found that the institution of a PBM team reduced the transfusion burden of patients, including complex patients with von Willebrand disease. The use of a multimodal approach to hematologic management optimized patients for their procedures and helped minimize exposure to transfusion associated complications. Address correspondence and reprint requests to John A. Girotto, MD, FACS, 230 Michigan St NE, Grand Rapids, MI 49503; E-mail: John.Girotto@helendevoschildrens.org Received 5 November, 2018 Accepted 12 March, 2019 The authors report no conflicts of interest. © 2019 by Mutaz B. Habal, MD.