Otosyphilis: Resurgence of an Old Disease
Hailey Theeuwen BS  Mark Whipple MD, SM, FACS  Jamie R. Litvack MD, MS, FARS
First published: 28 December 2018 https://doi.org/10.1002/lary.27635
Presented as an oral presentation at the Combined Otolaryngology Spring Meeting, National Harbor, Maryland, U.S.A., April 20, 2018.
The authors have no funding, financial relationships, or conflicts of interest to disclose.
Institutional review board (IRB) approval was obtained from the University of Washington (IRB 00003583).
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Abstract
Objectives
To describe the clinical characteristics of patients presenting with a new diagnosis of otosyphilis over the past 10 years in a large, urban, safety‐net hospital affiliated with a large county sexually transmitted disease clinic.

Methods
Retrospective case series. A chart review was performed of all patients who presented to an adult otolaryngology clinic with a new diagnosis of syphilis and hearing loss from January 2008 to December 2017.

Results
Twelve patients met the criteria for “suspected” or “likely” otosyphilis based on Centers for Disease Control and Prevention definitions. The average age was 48 years (range 19–59). All were male. Nine (75%) were men who have sex with men. Eight (67%) were positive for human immunodeficiency virus. One (8%) presented with primary, nine (75%) with secondary, and two (17%) with early latent syphilis. Seven (58%) presented with bilateral audiogram‐confirmed hearing loss, two (17%) with unilateral hearing loss, and three (25%) with suspected hearing loss based on fluctuating symptoms. Nine (75%) presented with tinnitus and two (17%) with vertigo. The median duration of otologic symptoms prior to presentation was 2 weeks (range: 0–16 weeks). All presented within the last 2 years surveyed.

Conclusion
We have seen an increase in the number of otosyphilis cases in our clinic. We suspect otosyphilis may be underdiagnosed and emphasize the importance of screening for syphilis in patients with new audiologic symptoms of vertigo, tinnitus, or hearing loss.

Level of Evidence
4

Laryngoscope, 129:1680–1684, 2019