Allergic asthma is a Type 2 (T2) inflammatory disease commonly presented in childhood. A complex interplay between genetic and environmental factors has been implicated in its pathogenesis.1 Environmental exposures seem to play an important role in the rising trend of the disease prevalence.1,2 There are several preventable environmental factors known to increase the risk of asthma in children such as damp and moldy housing or cigarette smoke.1,2,3
Speaker: AstraZenca, Boehringer Ingelheim, Shire
A large number of studies have described that asthma is more frequent in males during childhood, with a switch to a female predominance after adolescence. This higher frequency of asthma in adult women has been largely attributed to the increment of estrogen and progesterone concentrations, as compared with those found during childhood.1-3 This rationale is mainly based on research performed in in vitro conditions and in animal models indicating that female sexual hormones enhance the innate and...
Aspirin-exacerbated respiratory disease (AERD) is a severe respiratory syndrome characterized by asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and sensitivity to nonsteroidal anti-inflammatory drugs (NSAID) including aspirin manifested by acute upper and lower respiratory symptoms with exposure to this class of medications. (1) The prevalence of AERD is reported in 5.5% to 12.4 % of adult asthmatics, and rises to 21% when NSAID hypersensitivity is determined by provocation. (2-4)...
Mark above section as read
Publication date: Available online 24 June 2019Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Stefania Campana, Emma Di Carlo, Claudia De Pasquale, Chiara Barberi, Daniela Oliveri, Giacomo Sidoti Migliore, Serafinella Patrizia Cannavò, Bruno Galletti, Daniela Pende, Paolo Carrega, Guido Ferlazzo
Mark above section as read
Publication date: Available online 24 June 2019Source: Allergology InternationalAuthor(s): Satoshi Yamaga, Yuhki Yanase, Kaori Ishii, Shinichiro Ohshimo, Nobuaki Shime, Michihiro HideAbstractBackgroundHistamine is a crucial mediator in the development of anaphylaxis. Although histamine is promptly degraded because of its short half-life in plasma, basophils, which release histamine, remain in the blood for days. To explore basophils as a potential marker and their involvement in the pathogenesis...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου